| Definition | Orientia tsutsugamushi str. Ikeda, complete genome. |
|---|---|
| Accession | NC_010793 |
| Length | 2,008,987 |
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The map label for this gene is virB4 [H]
Identifier: 189183677
GI number: 189183677
Start: 799570
End: 801987
Strand: Direct
Name: virB4 [H]
Synonym: OTT_0770
Alternate gene names: 189183677
Gene position: 799570-801987 (Clockwise)
Preceding gene: 189183676
Following gene: 189183678
Centisome position: 39.8
GC content: 33.46
Gene sequence:
>2418_bases ATGAAATTTTTTAAGACTAAAGTAGCAAGGGAGTACTATTCTAAGAGAGAGGTTCATGTTGCTAAGTTTATTCCATATGC TTATCATTGGAATAAATCTACTATTATTACAAAAAAAAATGAGCTAATTAAGGTTATTAAAATTAGCGGTTTTGCTTTTG AAACAGCAGATGATCAAGATTTAGACATTAGAAAAAGGCTTCGAAATCTTTTATTTAAAGGTATGGCTTCAGGTAGCCTA AATTTATATTTTCACATAATTAGACGTCGAAAGCAGCTAGCTTCAGCTATGGATGAAGGTGATGTTGATCCTACTGTAGG TATGGCAAAAGATTTTGTTACTTATGTTGATAATGAGTGGAAAAAGAAATATTCTGATTTTCAGTCTTTTATAAATGATA TTTATATCACTATTTTATATAAACCTGATGTTGAAGGTGGGGAAATTTTAAAGTATTTTTACAATAAGTTATTGCAAAAG TCTGATAAAAATGCATGGATGCAAAGTATGAATGAAATGTATGCTAACCTTGATGAGATGGTATCAAGAGTAGTGACTAC ATTTAGCGATTATGATGCACAAATATTAAAGGTTAAAAATGAACCTAATGGAGTTTTTTGTGAGATATTGGAATTTTTAG CTACTATAGTTAATTGCGGCAGTTCTATGCCTGTACTTTTACCTAGAGGATCAATAGATAGTTATATACCTACACATAGG TTATTTTTTGGAGATCGTTCAATTGAAGCTAGAGGGGCAGGGCAGCGTAGATATGCTGGTATAGTTAGCATTCAAGAATA TGGACCAAAAACTTCAGCTGGAGTATTAGATTCATTTTTGCAACTTCCTTTTGAGCTTATTATTAGCCAAAGTTTTCAGT TTTCTAGTCGTACAGCTGCAATTAATAAAATGCAATTGCAACAAAATAGAATGATTCAAACTGAAGATAAAGCAGTATCC CAGATTGCTGAGATTTCTCAGGCATTAGATATGGCGACCAGTGGTGAAATTGGTTTTGGCGAACATCATTTAACAGTATT ATGTATAGCTGATAGTTTGAAAGCCTTGGAAAACGCACTTTCTATTGCTTCAGTTGAAATTGCAAACACTGGTATGCAGC CAGTACGTGAAAAAGTGAATTTAGAAGCTGCTTATTGGGCGCAATTACCAGGGAATATAGAATATGCTGTAAGAAAATCA GTAATTAATACTTTAAATCTTGCAGGGTTTGCATCTATGCATAATTACTTGCCAGGAAAAGCTAAAGGAAATCATTGGGG AGATAGCGTTACAGTATTGGATACAAGCTCTGGTACTCCGTTTTACTTTAACTTCCACGTACGTGATGTTGGACATACTT TATTAATTGGGCCTACTGGAGCTGGGAAAACAGTGTTAATGAATTTTTTATGCGCTCAAGCTCAAAAATTTTATCCTCGA ACTTTCTTTTTTGATAAAGATAGAGGTGCAGAGATTTTTATCAGAGCTCTAGATGGAAAGTATACTGTGATTAATCCGTT TCAACAATGTAATTTTAATCCTTTACAATTGCCTGATACTAATGAAAATCGTAATTTTTTAGTAGAATGGATAAAAACGT TAGTTACTTCAAACGGTGAATCTATTAGCGCCGACGATATGCATTATATTACGTTAGCTGTGGAAGGGAATTATAAGCTT AATCCATCTGATCGTTACTTAAGTAATATAGTAGCATTTTTAGGAATTGGAGGTCCTGATACTCTAGCTGGAAGGATTGC AATGTGGCATGGCACAGGTGCTAAAGCTGGAATATTTGATAATATTCATGATAATATGGATTTGCAAAGTGGTAGAGTTT TTGGTTTTGAGATGGGGGAGTTATTAAAAGATCCTGTTAGCTTAGCTCCAGTATTATTATATTTGTTTCACCGTATCAAT TTATCGTTGGATGGTTCACCAACTATGATAGTATTAGATGAGGCATGGGCTTTGATTGATAATCCTGTTTTTGCTCCTAA GATTAAAGATTGGTTGAAGGTATTGCGTAAGTTAAATACTTTTGTTATATTTGCTACTCAGAGTGTAGAAGATGCTTCAA AGAGCTCAATTAGTGATACTCTGATTCAGCAAACTGCTACTCAGATTTTTTTACCAAATTTAAAAGCAACCGATATCTAT AGAACTGCTTTTATGTTGAGTGAAAGGGAATTTTCTATTATTAAATCCACAGATCCTGGTTCACGGTATTTTCTAATAAA ACAAGGAATTGGTTCTGTAGTTGCTAAATTAAATTTAGCGGGCATGAATAATATTATAGGAGTGCTCTCAGGCCGAGTTG AAACTGTAATATTATTAGATCAGTTAAGAAGCGAATATGGAGATGATTCTAGAAAGTGGTTGCCTAAATTTTATAAGCAC TTGGAAACAGCAAAATAA
Upstream 100 bases:
>100_bases CGTTTTATGGAAATTTACTTAATGAGAGCTCAAAAGTTTAATAAATGTCCTAATAGACTTTATTATGGTGCTAATTCATA TGGTATATAGTATTTAAATA
Downstream 100 bases:
>100_bases TGCAGTGGTTGTATCAATTAGCTAAAATAGTTATATTAGTATCAGTATTTGCACTACAAACTGAAGCTGTTAAAGCTATA TCTGGAATTGATATGATTAA
Product: type IV secretion system ATPase VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 805; Mature: 805
Protein sequence:
>805_residues MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQDLDIRKRLRNLLFKGMASGSL NLYFHIIRRRKQLASAMDEGDVDPTVGMAKDFVTYVDNEWKKKYSDFQSFINDIYITILYKPDVEGGEILKYFYNKLLQK SDKNAWMQSMNEMYANLDEMVSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAAINKMQLQQNRMIQTEDKAVS QIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENALSIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKS VINTLNLAGFASMHNYLPGKAKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGESISADDMHYITLAVEGNYKL NPSDRYLSNIVAFLGIGGPDTLAGRIAMWHGTGAKAGIFDNIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRIN LSLDGSPTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLDQLRSEYGDDSRKWLPKFYKH LETAK
Sequences:
>Translated_805_residues MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQDLDIRKRLRNLLFKGMASGSL NLYFHIIRRRKQLASAMDEGDVDPTVGMAKDFVTYVDNEWKKKYSDFQSFINDIYITILYKPDVEGGEILKYFYNKLLQK SDKNAWMQSMNEMYANLDEMVSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAAINKMQLQQNRMIQTEDKAVS QIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENALSIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKS VINTLNLAGFASMHNYLPGKAKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGESISADDMHYITLAVEGNYKL NPSDRYLSNIVAFLGIGGPDTLAGRIAMWHGTGAKAGIFDNIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRIN LSLDGSPTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLDQLRSEYGDDSRKWLPKFYKH LETAK >Mature_805_residues MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQDLDIRKRLRNLLFKGMASGSL NLYFHIIRRRKQLASAMDEGDVDPTVGMAKDFVTYVDNEWKKKYSDFQSFINDIYITILYKPDVEGGEILKYFYNKLLQK SDKNAWMQSMNEMYANLDEMVSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAAINKMQLQQNRMIQTEDKAVS QIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENALSIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKS VINTLNLAGFASMHNYLPGKAKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGESISADDMHYITLAVEGNYKL NPSDRYLSNIVAFLGIGGPDTLAGRIAMWHGTGAKAGIFDNIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRIN LSLDGSPTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLDQLRSEYGDDSRKWLPKFYKH LETAK
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 90643; Mature: 90643
Theoretical pI: Translated: 7.94; Mature: 7.94
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQD CCHHHHHHHHHHHHHCCEEHHHHCCEEEEECCEEEEEECCCEEEEEEEECEEEECCCCCC LDIRKRLRNLLFKGMASGSLNLYFHIIRRRKQLASAMDEGDVDPTVGMAKDFVTYVDNEW CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHH KKKYSDFQSFINDIYITILYKPDVEGGEILKYFYNKLLQKSDKNAWMQSMNEMYANLDEM HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHH VSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAA EEECCCCCCCCCCCCCHHEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH INKMQLQQNRMIQTEDKAVSQIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENAL HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHH SIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKSVINTLNLAGFASMHNYLPGK HHHEEEHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC AKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR CCCCCCCCEEEEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCC TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGE EEEEECCCCCEEEEEEECCCEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC SISADDMHYITLAVEGNYKLNPSDRYLSNIVAFLGIGGPDTLAGRIAMWHGTGAKAGIFD CCCCCCEEEEEEEEECCEEECCHHHHHHHHHHHHCCCCCHHHHCEEEEEECCCCCCCCCC NIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRINLSLDGSPTMIVLDEAWALID CCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHCEEECCCCCEEEEECCHHHHC NPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY CCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLD HHHHHHCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH QLRSEYGDDSRKWLPKFYKHLETAK HHHHHHCCCHHHHHHHHHHHHHCCC >Mature Secondary Structure MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQD CCHHHHHHHHHHHHHCCEEHHHHCCEEEEECCEEEEEECCCEEEEEEEECEEEECCCCCC LDIRKRLRNLLFKGMASGSLNLYFHIIRRRKQLASAMDEGDVDPTVGMAKDFVTYVDNEW CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHH KKKYSDFQSFINDIYITILYKPDVEGGEILKYFYNKLLQKSDKNAWMQSMNEMYANLDEM HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHH VSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAA EEECCCCCCCCCCCCCHHEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH INKMQLQQNRMIQTEDKAVSQIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENAL HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHH SIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKSVINTLNLAGFASMHNYLPGK HHHEEEHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC AKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR CCCCCCCCEEEEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCC TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGE EEEEECCCCCEEEEEEECCCEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC SISADDMHYITLAVEGNYKLNPSDRYLSNIVAFLGIGGPDTLAGRIAMWHGTGAKAGIFD CCCCCCEEEEEEEEECCEEECCHHHHHHHHHHHHCCCCCHHHHCEEEEEECCCCCCCCCC NIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRINLSLDGSPTMIVLDEAWALID CCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHCEEECCCCCEEEEECCHHHHC NPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY CCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLD HHHHHHCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH QLRSEYGDDSRKWLPKFYKHLETAK HHHHHHCCCHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]