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The map label for this gene is gltP [H]

Identifier: 189182929

GI number: 189182929

Start: 28031

End: 29230

Strand: Direct

Name: gltP [H]

Synonym: OTT_0022

Alternate gene names: 189182929

Gene position: 28031-29230 (Clockwise)

Preceding gene: 189182928

Following gene: 189182930

Centisome position: 1.4

GC content: 30.5

Gene sequence:

>1200_bases
ATGATGTTATGGCAAAAAGTAATATTAGGTCTTGTATTAGGAGTAATCACTGGAATCGCATTTCCTGAATATGTTGATTA
TATTAAACCAATAGGTGATATATTTCTACGCTTAATAAAAATGATTATTGCTCCATTGATATTTTTTTCATTAGTATCTG
GCATTGTTAGTGTAAATGATTCAGACTCTTTAGGTAGGCTTGGTATTAAAGCTACTATTGCTTTTACATTGACAACTTTA
TTTGCTGTATTGTTTGGCATTGGAATTGCTATTATTTTAAAGCCTGGAGTGGGTATAACTATTGATTTGCCTGTAAACCA
TACTAATTTAGAGAGAGAAAAATTTGATGTAGTTAACTTTTTAATAAATATTGTTCCTGATAATGCTTTAGGAGCTATTG
TTTACAGCAACATACTACAAGTTGTCTTTTTAGCAATATTTACTGGCATAACTCTTAATAAGATGTCTAACTCATCTACA
TTACGTCAATTATTTAGTATTATTTCTAAAATGATTATGAAAATGATTTCGTTGATCATTTTATTGGCACCTTACGGAGC
ATTTGCACTAACTGCATGGGTTGTTGGTAATCATGGTATTGGTATATTATTTGGGTTGTCTAAACTGATGTTTGCAATAG
TATTAGCAATGATTATGCAATATTTAATTTTTGGTGTATTAATTATGGTGTTTTGTCGTATTTCTCCACTGCCGTTTTAT
AGAAAAAGTATAGAATACCAAATTCTAGCTTTATCTACTAGTAGTAGCAAAGCTAGTTTAGTGACAACTATGGATGTTTG
TAAGAATAAATTGGGAGTATCGAGTGCTACTACTAATTTTATTTTACCATTAGGAGCTTCTATTAATATGGATGGCTTTG
CTATTAATCTAGCTTTAACTACAATTTTCTTTGCTCAACTTTTTGGCGTAACTTTACAGTTACATGATTATTTTGTCATA
ATATTAATGGTGACAATAGGTACTATTGGTGGAGCAGGTATACCAGGTGCGTCATTAATTATGTTGCCTATGGTTCTTTC
TGCTGTTAATCTACCTATTGAAGGTGTGGCAATTTTGGTTGGAATTGATAGAATACTTGATATGCTTAGAACTGTAATTA
ATATTACAGGAGATGCAACTATTACACTGATTATTGATCAGTCAGAAGGAACTTTTGATGAAGAAACTTATTATTCTTAA

Upstream 100 bases:

>100_bases
GAATGCGACTTTGCTTAATGCTAGCGCAGGTAACTTTAACCTATAGTATTAGTTTAAGATTGCGTTAATCTTATATTTTT
AACTAAAAATGTCTTGTTTT

Downstream 100 bases:

>100_bases
TAAAACATTAGCCTATTATATAGTGCTGATGTTTGTTGATATTTTGTAATACATGACAGAAATTCCTATCTGCATAATAT
TTCCATCGCAAAATATTGAA

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: C4-dicarboxylate permease [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MMLWQKVILGLVLGVITGIAFPEYVDYIKPIGDIFLRLIKMIIAPLIFFSLVSGIVSVNDSDSLGRLGIKATIAFTLTTL
FAVLFGIGIAIILKPGVGITIDLPVNHTNLEREKFDVVNFLINIVPDNALGAIVYSNILQVVFLAIFTGITLNKMSNSST
LRQLFSIISKMIMKMISLIILLAPYGAFALTAWVVGNHGIGILFGLSKLMFAIVLAMIMQYLIFGVLIMVFCRISPLPFY
RKSIEYQILALSTSSSKASLVTTMDVCKNKLGVSSATTNFILPLGASINMDGFAINLALTTIFFAQLFGVTLQLHDYFVI
ILMVTIGTIGGAGIPGASLIMLPMVLSAVNLPIEGVAILVGIDRILDMLRTVINITGDATITLIIDQSEGTFDEETYYS

Sequences:

>Translated_399_residues
MMLWQKVILGLVLGVITGIAFPEYVDYIKPIGDIFLRLIKMIIAPLIFFSLVSGIVSVNDSDSLGRLGIKATIAFTLTTL
FAVLFGIGIAIILKPGVGITIDLPVNHTNLEREKFDVVNFLINIVPDNALGAIVYSNILQVVFLAIFTGITLNKMSNSST
LRQLFSIISKMIMKMISLIILLAPYGAFALTAWVVGNHGIGILFGLSKLMFAIVLAMIMQYLIFGVLIMVFCRISPLPFY
RKSIEYQILALSTSSSKASLVTTMDVCKNKLGVSSATTNFILPLGASINMDGFAINLALTTIFFAQLFGVTLQLHDYFVI
ILMVTIGTIGGAGIPGASLIMLPMVLSAVNLPIEGVAILVGIDRILDMLRTVINITGDATITLIIDQSEGTFDEETYYS
>Mature_399_residues
MMLWQKVILGLVLGVITGIAFPEYVDYIKPIGDIFLRLIKMIIAPLIFFSLVSGIVSVNDSDSLGRLGIKATIAFTLTTL
FAVLFGIGIAIILKPGVGITIDLPVNHTNLEREKFDVVNFLINIVPDNALGAIVYSNILQVVFLAIFTGITLNKMSNSST
LRQLFSIISKMIMKMISLIILLAPYGAFALTAWVVGNHGIGILFGLSKLMFAIVLAMIMQYLIFGVLIMVFCRISPLPFY
RKSIEYQILALSTSSSKASLVTTMDVCKNKLGVSSATTNFILPLGASINMDGFAINLALTTIFFAQLFGVTLQLHDYFVI
ILMVTIGTIGGAGIPGASLIMLPMVLSAVNLPIEGVAILVGIDRILDMLRTVINITGDATITLIIDQSEGTFDEETYYS

Specific function: Responsible for the transport of succinate and fumarate, but not malate, across the membrane (Probable) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=435, Percent_Identity=28.9655172413793, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI21314632, Length=407, Percent_Identity=29.97542997543, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI169790839, Length=443, Percent_Identity=28.4424379232506, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI5032093, Length=375, Percent_Identity=29.8666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI66773030, Length=441, Percent_Identity=28.1179138321995, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4827012, Length=264, Percent_Identity=31.4393939393939, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=31.2, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=31.2, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI194239697, Length=284, Percent_Identity=29.2253521126761, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI262359914, Length=404, Percent_Identity=27.2277227722772, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI301601644, Length=122, Percent_Identity=35.2459016393443, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=31.3106796116505, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789947, Length=405, Percent_Identity=29.6296296296296, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1788024, Length=390, Percent_Identity=26.4102564102564, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789473, Length=269, Percent_Identity=25.6505576208178, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71996953, Length=440, Percent_Identity=28.4090909090909, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71983099, Length=435, Percent_Identity=30.3448275862069, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983106, Length=435, Percent_Identity=30.3448275862069, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=29.6650717703349, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI193206505, Length=447, Percent_Identity=26.1744966442953, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=401, Percent_Identity=28.1795511221945, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=27.25, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24583025, Length=426, Percent_Identity=26.7605633802817, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17137668, Length=426, Percent_Identity=26.7605633802817, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24583023, Length=426, Percent_Identity=26.7605633802817, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281360481, Length=447, Percent_Identity=25.9507829977629, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360483, Length=447, Percent_Identity=25.9507829977629, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137666, Length=447, Percent_Identity=25.9507829977629, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43252; Mature: 43252

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLWQKVILGLVLGVITGIAFPEYVDYIKPIGDIFLRLIKMIIAPLIFFSLVSGIVSVND
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
SDSLGRLGIKATIAFTLTTLFAVLFGIGIAIILKPGVGITIDLPVNHTNLEREKFDVVNF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCCHHHHHHHHHH
LINIVPDNALGAIVYSNILQVVFLAIFTGITLNKMSNSSTLRQLFSIISKMIMKMISLII
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLAPYGAFALTAWVVGNHGIGILFGLSKLMFAIVLAMIMQYLIFGVLIMVFCRISPLPFY
HHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RKSIEYQILALSTSSSKASLVTTMDVCKNKLGVSSATTNFILPLGASINMDGFAINLALT
HHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHH
TIFFAQLFGVTLQLHDYFVIILMVTIGTIGGAGIPGASLIMLPMVLSAVNLPIEGVAILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
GIDRILDMLRTVINITGDATITLIIDQSEGTFDEETYYS
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MMLWQKVILGLVLGVITGIAFPEYVDYIKPIGDIFLRLIKMIIAPLIFFSLVSGIVSVND
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
SDSLGRLGIKATIAFTLTTLFAVLFGIGIAIILKPGVGITIDLPVNHTNLEREKFDVVNF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCCHHHHHHHHHH
LINIVPDNALGAIVYSNILQVVFLAIFTGITLNKMSNSSTLRQLFSIISKMIMKMISLII
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLAPYGAFALTAWVVGNHGIGILFGLSKLMFAIVLAMIMQYLIFGVLIMVFCRISPLPFY
HHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RKSIEYQILALSTSSSKASLVTTMDVCKNKLGVSSATTNFILPLGASINMDGFAINLALT
HHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHH
TIFFAQLFGVTLQLHDYFVIILMVTIGTIGGAGIPGASLIMLPMVLSAVNLPIEGVAILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
GIDRILDMLRTVINITGDATITLIIDQSEGTFDEETYYS
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10708364 [H]