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The map label for this gene is apt

Identifier: 189026262

GI number: 189026262

Start: 1137015

End: 1137587

Strand: Direct

Name: apt

Synonym: TPASS_1039

Alternate gene names: 189026262

Gene position: 1137015-1137587 (Clockwise)

Preceding gene: 189026259

Following gene: NA

Centisome position: 99.79

GC content: 53.4

Gene sequence:

>573_bases
GTGCGTGGTATTGGACGTTACCATGCCCCTGTGGACGGACACGCGGCGCTGGACCGCGCAATTCGTAAGCGGATTGATTT
CCCTAAAAAAGGAATTCTCTACTACGACATTACTGGCGTGCTGATGAACGCGGCTGTATTTCGTTACTGTCTTGATCAAA
TGGTGGAATTCTACCGCGATGAGCACGTTACCGCGGTCGCAGCAATCGAATCACGTGGCTTTATTTTTGCCGCGCCTTTT
GCAGATCGCATGGGAATACCTCTTATTTTAGTTCGGAAGGCGGGGAAACTACCGGGGGATACGTACTCGTGCTCCTATTC
CTTAGAGTATGGAAAGGCGACCGTTGAGGTTCACAAGAGCGATGTAGTCGCGGGGGCCCGCGTGCTGTTAACAGACGACC
TGATTGCCACCGGTGGAACGCTGAATGCAGCGCGCACGATGCTCCGGGCTGGCGGGGCAGAAGTGGTGGGCTTCTTCGCC
GTTGTGGGTTTACCATTCCTACGGTACCATGAGCTGATTGGGGATCTTCCCGTGAGAACGCTCATCGAATACAACCAGGA
AACTTCCAATTAA

Upstream 100 bases:

>100_bases
ATTTTCACCGAGATTTCGTGAAGTTTCAGCGAAATCTTTTTTCCAGGAGACGTAATTCTCAATCCACCAAGCCTCCCAAC
AAACCGGTAAGATCATTGAC

Downstream 100 bases:

>100_bases
CTTCTCCAAGGCAGGAGGAGTGTCACTGATCATACACAAACGCATCTAATGAGTGCCGACCGGCTAGCAGCGCAACCAGG
CGATCAAATCCGAGTGCTGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MRGIGRYHAPVDGHAALDRAIRKRIDFPKKGILYYDITGVLMNAAVFRYCLDQMVEFYRDEHVTAVAAIESRGFIFAAPF
ADRMGIPLILVRKAGKLPGDTYSCSYSLEYGKATVEVHKSDVVAGARVLLTDDLIATGGTLNAARTMLRAGGAEVVGFFA
VVGLPFLRYHELIGDLPVRTLIEYNQETSN

Sequences:

>Translated_190_residues
MRGIGRYHAPVDGHAALDRAIRKRIDFPKKGILYYDITGVLMNAAVFRYCLDQMVEFYRDEHVTAVAAIESRGFIFAAPF
ADRMGIPLILVRKAGKLPGDTYSCSYSLEYGKATVEVHKSDVVAGARVLLTDDLIATGGTLNAARTMLRAGGAEVVGFFA
VVGLPFLRYHELIGDLPVRTLIEYNQETSN
>Mature_190_residues
MRGIGRYHAPVDGHAALDRAIRKRIDFPKKGILYYDITGVLMNAAVFRYCLDQMVEFYRDEHVTAVAAIESRGFIFAAPF
ADRMGIPLILVRKAGKLPGDTYSCSYSLEYGKATVEVHKSDVVAGARVLLTDDLIATGGTLNAARTMLRAGGAEVVGFFA
VVGLPFLRYHELIGDLPVRTLIEYNQETSN

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=38.953488372093, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=40.8, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1786675, Length=139, Percent_Identity=41.726618705036, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=37.4269005847953, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323619, Length=176, Percent_Identity=32.3863636363636, Blast_Score=91, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320649, Length=146, Percent_Identity=27.3972602739726, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=37.888198757764, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_TREPA (O84001)

Other databases:

- EMBL:   AE000520
- PIR:   F71250
- RefSeq:   NP_219476.1
- ProteinModelPortal:   O84001
- SMR:   O84001
- IntAct:   O84001
- GeneID:   2611342
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1039
- NMPDR:   fig|243276.1.peg.1034
- TIGR:   TP_1039
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   TPAL243276:TP_1039-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20902; Mature: 20902

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGIGRYHAPVDGHAALDRAIRKRIDFPKKGILYYDITGVLMNAAVFRYCLDQMVEFYRD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
EHVTAVAAIESRGFIFAAPFADRMGIPLILVRKAGKLPGDTYSCSYSLEYGKATVEVHKS
CCCEEEEEECCCCCEEECCCHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCEEEEEECC
DVVAGARVLLTDDLIATGGTLNAARTMLRAGGAEVVGFFAVVGLPFLRYHELIGDLPVRT
HHHHCCEEEEECCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LIEYNQETSN
HHHHCCCCCC
>Mature Secondary Structure
MRGIGRYHAPVDGHAALDRAIRKRIDFPKKGILYYDITGVLMNAAVFRYCLDQMVEFYRD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
EHVTAVAAIESRGFIFAAPFADRMGIPLILVRKAGKLPGDTYSCSYSLEYGKATVEVHKS
CCCEEEEEECCCCCEEECCCHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCEEEEEECC
DVVAGARVLLTDDLIATGGTLNAARTMLRAGGAEVVGFFAVVGLPFLRYHELIGDLPVRT
HHHHCCEEEEECCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LIEYNQETSN
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876