Click here to switch to the map view.

The map label for this gene is engA

Identifier: 189025914

GI number: 189025914

Start: 757399

End: 758781

Strand: Reverse

Name: engA

Synonym: TPASS_0689

Alternate gene names: 189025914

Gene position: 758781-757399 (Counterclockwise)

Preceding gene: 189025915

Following gene: 189025913

Centisome position: 66.59

GC content: 43.82

Gene sequence:

>1383_bases
ATGAAAGGTCAAGATGTCATCCTGTGCGACGGGGGACGTCATTTTTCATATAAGGTACTTCCTCGTGTGGTCATTGTGGG
AAGACCGAATGTAGGTAAGTCGACATTATTCAACCGCCTGCTCGGTAGACGGCGCTCTATCACCAGCAATACGTCAGGGG
TTACAAGAGATTCGATTGAAGAAACCGTGATTCTGCGAGGGTTTCCTCTTAGACTTGTTGACACGAGCGGTTTTACCGTT
TTTTCTGAAAAAAAGGCATCGAGACAACATATCGATACTCTCGTGTTAGAACAAACGTATAAATCAATACAGTGTGCGGA
CAAAATCCTTCTTGTGCTTGATGGAACGTGTGAAAGTGCAGAAGACGAGGAGGTTATCCAGTATCTGAGGCCCTACTGGG
GCAAACTCATCGCTGCGGTTAATAAGACGGAGGGAGGAGAGGAGGTGCATTATAATTATGCACGGTACGGTTTTTCTACC
CTTATCTGTGTCAGCGCCGAGCACGGTAGGAACATAGACGCGTTGGAAAGGGCGATTATCCAAAATCTGTTTTCTGTCGA
TGAGCGCCGGGAACTGCCGAAAGATGATGTTGTTCGTCTTGCAATAGTGGGTAAGCCGAACACAGGAAAATCCACTTTGA
TGAATTATCTCATGCGCCGTACCGTTTCTCTGGTGTGTGATAGAGCAGGTACTACCAGAGACGTGGTAACCGGTCATGTT
GAGTTCAAACAGTACAAATTCATTATCGCAGATACGGCGGGTATCAGAAAAAGACAGAAGGTATATGAGAGTATAGAGTA
CTACTCGGTAATACGAGCAATTAGCATCCTGAATGCCGTTGACATTGTATTGTACATCGTCGATGCCCGAGATGGATTTT
CTGAACAAGACAAGAAGATTGTTTCGCAAATCTCAAAGAGAAATTTAGGTGTGATCTTCCTTTTGAACAAGTGGGATTTG
TTGGAAGGAAGTACCTCTCTAATAGCTAAGAAAAAGCGTGATGTACGGACTGCTTTTGGGAAAATGAATTTTGTTCCCGT
GGTACCTGTATCAGCTAAAACGGGGCACGGTATTTCTGATGCATTACATTGTGTATGTAAGATCTTTGCACAACTAAATA
CAAAAGTGGAGACTTCCGCTCTCAATACTGCATTGAAAGATTGGGTAACGTCGTATCCTCCTCCAAGAAAGTATGGACAC
GTTTCGTTAAAGTACCTGGTGCAGGTATCGGTTAGACCTATTGAATTTTTGCTTTTTGCAAATAGGCCAGATCGTATACC
GGAAAACTACGTTCGATTTTTACAGAATCGTATTCGTGAAGACCTAGGATTAGACTCTATCCCTGTGAAGCTAACCATAC
GGAAAAACTGTCGGAAGCGATAG

Upstream 100 bases:

>100_bases
AGGAGAATTGGAAACTATTCCAATTTTTATTTAAAGAGGATCGCGCGCATCTTGCTGTCTTGTAAGTGATGTCTGAGTCT
GTAAAGGAGATGGCCGGAGG

Downstream 100 bases:

>100_bases
ATGCAAGATGAAGGAGTGGATATGAAAAAACTTCTTTTACGTTCTTCTGATGAAGTTCGAGTAATCGCGCCCTCGTGCTC
AATGCGTAAGATTGATTCAT

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKGQDVILCDGGRHFSYKVLPRVVIVGRPNVGKSTLFNRLLGRRRSITSNTSGVTRDSIEETVILRGFPLRLVDTSGFTV
FSEKKASRQHIDTLVLEQTYKSIQCADKILLVLDGTCESAEDEEVIQYLRPYWGKLIAAVNKTEGGEEVHYNYARYGFST
LICVSAEHGRNIDALERAIIQNLFSVDERRELPKDDVVRLAIVGKPNTGKSTLMNYLMRRTVSLVCDRAGTTRDVVTGHV
EFKQYKFIIADTAGIRKRQKVYESIEYYSVIRAISILNAVDIVLYIVDARDGFSEQDKKIVSQISKRNLGVIFLLNKWDL
LEGSTSLIAKKKRDVRTAFGKMNFVPVVPVSAKTGHGISDALHCVCKIFAQLNTKVETSALNTALKDWVTSYPPPRKYGH
VSLKYLVQVSVRPIEFLLFANRPDRIPENYVRFLQNRIREDLGLDSIPVKLTIRKNCRKR

Sequences:

>Translated_460_residues
MKGQDVILCDGGRHFSYKVLPRVVIVGRPNVGKSTLFNRLLGRRRSITSNTSGVTRDSIEETVILRGFPLRLVDTSGFTV
FSEKKASRQHIDTLVLEQTYKSIQCADKILLVLDGTCESAEDEEVIQYLRPYWGKLIAAVNKTEGGEEVHYNYARYGFST
LICVSAEHGRNIDALERAIIQNLFSVDERRELPKDDVVRLAIVGKPNTGKSTLMNYLMRRTVSLVCDRAGTTRDVVTGHV
EFKQYKFIIADTAGIRKRQKVYESIEYYSVIRAISILNAVDIVLYIVDARDGFSEQDKKIVSQISKRNLGVIFLLNKWDL
LEGSTSLIAKKKRDVRTAFGKMNFVPVVPVSAKTGHGISDALHCVCKIFAQLNTKVETSALNTALKDWVTSYPPPRKYGH
VSLKYLVQVSVRPIEFLLFANRPDRIPENYVRFLQNRIREDLGLDSIPVKLTIRKNCRKR
>Mature_460_residues
MKGQDVILCDGGRHFSYKVLPRVVIVGRPNVGKSTLFNRLLGRRRSITSNTSGVTRDSIEETVILRGFPLRLVDTSGFTV
FSEKKASRQHIDTLVLEQTYKSIQCADKILLVLDGTCESAEDEEVIQYLRPYWGKLIAAVNKTEGGEEVHYNYARYGFST
LICVSAEHGRNIDALERAIIQNLFSVDERRELPKDDVVRLAIVGKPNTGKSTLMNYLMRRTVSLVCDRAGTTRDVVTGHV
EFKQYKFIIADTAGIRKRQKVYESIEYYSVIRAISILNAVDIVLYIVDARDGFSEQDKKIVSQISKRNLGVIFLLNKWDL
LEGSTSLIAKKKRDVRTAFGKMNFVPVVPVSAKTGHGISDALHCVCKIFAQLNTKVETSALNTALKDWVTSYPPPRKYGH
VSLKYLVQVSVRPIEFLLFANRPDRIPENYVRFLQNRIREDLGLDSIPVKLTIRKNCRKR

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Homo sapiens, GI193082991, Length=144, Percent_Identity=32.6388888888889, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI193082988, Length=144, Percent_Identity=32.6388888888889, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI87082120, Length=468, Percent_Identity=28.4188034188034, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI2367268, Length=166, Percent_Identity=31.9277108433735, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788919, Length=168, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323665, Length=179, Percent_Identity=33.5195530726257, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550813, Length=123, Percent_Identity=38.2113821138211, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_TREPA (P96128)

Other databases:

- EMBL:   U70661
- EMBL:   AE000520
- PIR:   F71292
- RefSeq:   NP_219126.1
- ProteinModelPortal:   P96128
- SMR:   P96128
- GeneID:   2611772
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0689
- NMPDR:   fig|243276.1.peg.685
- TIGR:   TP_0689
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   TPAL243276:TP_0689-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 52122; Mature: 52122

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGQDVILCDGGRHFSYKVLPRVVIVGRPNVGKSTLFNRLLGRRRSITSNTSGVTRDSIE
CCCCEEEEECCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ETVILRGFPLRLVDTSGFTVFSEKKASRQHIDTLVLEQTYKSIQCADKILLVLDGTCESA
HEEEEECCCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCC
EDEEVIQYLRPYWGKLIAAVNKTEGGEEVHYNYARYGFSTLICVSAEHGRNIDALERAII
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCEEEEEEECCCCCCHHHHHHHHH
QNLFSVDERRELPKDDVVRLAIVGKPNTGKSTLMNYLMRRTVSLVCDRAGTTRDVVTGHV
HHHHCCHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEE
EFKQYKFIIADTAGIRKRQKVYESIEYYSVIRAISILNAVDIVLYIVDARDGFSEQDKKI
EEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHH
VSQISKRNLGVIFLLNKWDLLEGSTSLIAKKKRDVRTAFGKMNFVPVVPVSAKTGHGISD
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHH
ALHCVCKIFAQLNTKVETSALNTALKDWVTSYPPPRKYGHVSLKYLVQVSVRPIEFLLFA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCEEEEEEC
NRPDRIPENYVRFLQNRIREDLGLDSIPVKLTIRKNCRKR
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKGQDVILCDGGRHFSYKVLPRVVIVGRPNVGKSTLFNRLLGRRRSITSNTSGVTRDSIE
CCCCEEEEECCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ETVILRGFPLRLVDTSGFTVFSEKKASRQHIDTLVLEQTYKSIQCADKILLVLDGTCESA
HEEEEECCCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCC
EDEEVIQYLRPYWGKLIAAVNKTEGGEEVHYNYARYGFSTLICVSAEHGRNIDALERAII
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCEEEEEEECCCCCCHHHHHHHHH
QNLFSVDERRELPKDDVVRLAIVGKPNTGKSTLMNYLMRRTVSLVCDRAGTTRDVVTGHV
HHHHCCHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEE
EFKQYKFIIADTAGIRKRQKVYESIEYYSVIRAISILNAVDIVLYIVDARDGFSEQDKKI
EEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHH
VSQISKRNLGVIFLLNKWDLLEGSTSLIAKKKRDVRTAFGKMNFVPVVPVSAKTGHGISD
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHH
ALHCVCKIFAQLNTKVETSALNTALKDWVTSYPPPRKYGHVSLKYLVQVSVRPIEFLLFA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCEEEEEEC
NRPDRIPENYVRFLQNRIREDLGLDSIPVKLTIRKNCRKR
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876