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The map label for this gene is gds [H]

Identifier: 189025908

GI number: 189025908

Start: 748323

End: 749417

Strand: Direct

Name: gds [H]

Synonym: TPASS_0683

Alternate gene names: 189025908

Gene position: 748323-749417 (Clockwise)

Preceding gene: 189025904

Following gene: 189025909

Centisome position: 65.67

GC content: 53.88

Gene sequence:

>1095_bases
ATGAAACGTGCACTTGCTCAACGACTCAGAAATATTGAACGAGCACTCGCCGATGCACTTCCTGCGCAACCTACGCGCTC
GTGGATGGGAACGCGGCTCCGTGTCCTTGCGTCCGAAGATACGCGCGTCCTGCGCACCGTGTGCAACGCGTGTGTCAGCT
GCGGCGGAAAGCGCTGGAGACCGTTGTTACTGATACTTTCTGCAGAACTTGCACACGCGTGTGTGCAGTGCACGCATCGG
AAACTCCAAGGACACAAGAGGAAGAAAATTTCCGAACGCGAATGGTACACACTGAGCGCGGTAGTAGAGCTCATTCACAC
AGCCAGCCTTTTGCACGATGATATTGAGGACCATTCGTCTACGCGGCGTGGTAAGCCATGTGCGTATCTGCGCTACGGTA
CTGACTGCGTTCTTAATGCAGCAAGCTGGTTGTATTTTCATGCACACGCACTCATTGACACGCTCAGCATAGAACCTGCC
CTTAAGGCGGCTCTTTTTTCTGCCACGATAAGTGCAACGCGTGCTCTTCATATGGGTCAGGCGCTTGATATTGCATGGCA
TCGCAGCCCAGAACTTATTCCCTCGCGTGCGCAGTATCTGCGTATGGTTGCACTGAAAACTGGCGCACTCATCGCTCTAT
CAGGCGAATTGGGGTTTTTGTGTGCAGGTTATTCTGCGCGTGAGGCGCGCTCCTTTGGAGCGCAAGTCATGCCTATTGGG
ATAGGATTTCAGATTCTCGATGATGTACAAGGCATTGACGGAGGTGTTTCAGGCAAAGCGCACGCTGATGACATCGTCGA
AGGAAAGAAGAGCTTTCCTGTTATCCTTCACGTGCACACGCATCCTCAAGACGCACCTACATTTGCACGTCTTTTTGCTG
CCGCACGCGCAGAAGGACTGCACTCTCCTGCAGTCAAACAGGCACAACGGATACTGTATTCTTCAGAGGCACTTACTCAC
GCGCGCGCGTACGGCCTGCGCATGATAGAGCGCACACTCACACGGGTGCACGCACATTTTCCTTGCAATCCTGCATGCCA
GCTGTGGTGTACTGCAGTGCAGTATGGGGTACGCGCGCACCTGCACGCGCACTAA

Upstream 100 bases:

>100_bases
ACGTTCACACCTTCCTACACGCCCCCCATGCTATGTGTTACACTGACAGCTCCCACACATCGTGCTCGCACAAAAGGCAA
ACACGCCGTATAACGGTACT

Downstream 100 bases:

>100_bases
CTTTACCGCGTCGCATGTACTGAAGGTGATCACAAAAGGTGACCCCGTGCGACAGAAACGGACTGGAGGCACGGCACGAC
AAGTCGCCCGGAAGAAGACT

Product: octaprenyl-diphosphate synthase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKRALAQRLRNIERALADALPAQPTRSWMGTRLRVLASEDTRVLRTVCNACVSCGGKRWRPLLLILSAELAHACVQCTHR
KLQGHKRKKISEREWYTLSAVVELIHTASLLHDDIEDHSSTRRGKPCAYLRYGTDCVLNAASWLYFHAHALIDTLSIEPA
LKAALFSATISATRALHMGQALDIAWHRSPELIPSRAQYLRMVALKTGALIALSGELGFLCAGYSAREARSFGAQVMPIG
IGFQILDDVQGIDGGVSGKAHADDIVEGKKSFPVILHVHTHPQDAPTFARLFAAARAEGLHSPAVKQAQRILYSSEALTH
ARAYGLRMIERTLTRVHAHFPCNPACQLWCTAVQYGVRAHLHAH

Sequences:

>Translated_364_residues
MKRALAQRLRNIERALADALPAQPTRSWMGTRLRVLASEDTRVLRTVCNACVSCGGKRWRPLLLILSAELAHACVQCTHR
KLQGHKRKKISEREWYTLSAVVELIHTASLLHDDIEDHSSTRRGKPCAYLRYGTDCVLNAASWLYFHAHALIDTLSIEPA
LKAALFSATISATRALHMGQALDIAWHRSPELIPSRAQYLRMVALKTGALIALSGELGFLCAGYSAREARSFGAQVMPIG
IGFQILDDVQGIDGGVSGKAHADDIVEGKKSFPVILHVHTHPQDAPTFARLFAAARAEGLHSPAVKQAQRILYSSEALTH
ARAYGLRMIERTLTRVHAHFPCNPACQLWCTAVQYGVRAHLHAH
>Mature_364_residues
MKRALAQRLRNIERALADALPAQPTRSWMGTRLRVLASEDTRVLRTVCNACVSCGGKRWRPLLLILSAELAHACVQCTHR
KLQGHKRKKISEREWYTLSAVVELIHTASLLHDDIEDHSSTRRGKPCAYLRYGTDCVLNAASWLYFHAHALIDTLSIEPA
LKAALFSATISATRALHMGQALDIAWHRSPELIPSRAQYLRMVALKTGALIALSGELGFLCAGYSAREARSFGAQVMPIG
IGFQILDDVQGIDGGVSGKAHADDIVEGKKSFPVILHVHTHPQDAPTFARLFAAARAEGLHSPAVKQAQRILYSSEALTH
ARAYGLRMIERTLTRVHAHFPCNPACQLWCTAVQYGVRAHLHAH

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=197, Percent_Identity=35.5329949238579, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI83700220, Length=197, Percent_Identity=35.5329949238579, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1789578, Length=291, Percent_Identity=27.1477663230241, Blast_Score=95, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6325188, Length=181, Percent_Identity=38.121546961326, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI281365769, Length=186, Percent_Identity=35.4838709677419, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24660002, Length=186, Percent_Identity=35.4838709677419, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 40171; Mature: 40171

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRALAQRLRNIERALADALPAQPTRSWMGTRLRVLASEDTRVLRTVCNACVSCGGKRWR
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCCC
PLLLILSAELAHACVQCTHRKLQGHKRKKISEREWYTLSAVVELIHTASLLHDDIEDHSS
HHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TRRGKPCAYLRYGTDCVLNAASWLYFHAHALIDTLSIEPALKAALFSATISATRALHMGQ
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
ALDIAWHRSPELIPSRAQYLRMVALKTGALIALSGELGFLCAGYSAREARSFGAQVMPIG
CEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHHHHCCCEEEEEC
IGFQILDDVQGIDGGVSGKAHADDIVEGKKSFPVILHVHTHPQDAPTFARLFAAARAEGL
CCHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
HSPAVKQAQRILYSSEALTHARAYGLRMIERTLTRVHAHFPCNPACQLWCTAVQYGVRAH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LHAH
CCCC
>Mature Secondary Structure
MKRALAQRLRNIERALADALPAQPTRSWMGTRLRVLASEDTRVLRTVCNACVSCGGKRWR
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCCC
PLLLILSAELAHACVQCTHRKLQGHKRKKISEREWYTLSAVVELIHTASLLHDDIEDHSS
HHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TRRGKPCAYLRYGTDCVLNAASWLYFHAHALIDTLSIEPALKAALFSATISATRALHMGQ
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
ALDIAWHRSPELIPSRAQYLRMVALKTGALIALSGELGFLCAGYSAREARSFGAQVMPIG
CEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHHHHCCCEEEEEC
IGFQILDDVQGIDGGVSGKAHADDIVEGKKSFPVILHVHTHPQDAPTFARLFAAARAEGL
CCHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
HSPAVKQAQRILYSSEALTHARAYGLRMIERTLTRVHAHFPCNPACQLWCTAVQYGVRAH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LHAH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8182085 [H]