Click here to switch to the map view.

The map label for this gene is pncB [H]

Identifier: 189025854

GI number: 189025854

Start: 686767

End: 688248

Strand: Direct

Name: pncB [H]

Synonym: TPASS_0628

Alternate gene names: 189025854

Gene position: 686767-688248 (Clockwise)

Preceding gene: 189025853

Following gene: 189025855

Centisome position: 60.27

GC content: 51.55

Gene sequence:

>1482_bases
ATGAAAACGAGCGCGCTCTTTCTTGATTTTTACGAATTGACTATGGCGCAGGGATACTTTTTTCACAAGCCGCACGAGTG
TGCGGTGTTTGAAGTATTCTTTCGTAAACACCCCTTCGCGGGAGGGTACTCCATTTTTGCAGGACTCGATCCGCTCCTGA
CGGCAATAGAGCAGTTCCGCTTCAGTGGAGAAGATATCGATTATTTGCGCACCTTGCACTTATTTCATGATGACTTTTTG
TCTTACCTTGCTTCCTTCCGCTTTTCAGGAGATATACACGCGCTAGAAGAAGGTTCAGTAATATTTCCTCACGAACCGAT
CATCCGCGTGCACGCGCGCTTGGTTGAAGCACTTCTGCTTGAAGGATTGATACTCAACACCATTAATTTCCAAAGCCTCA
TCGCAACAAAGACTGCACGGATGTGGCGCGCGTCAGGTGAAGGTGTTCTTATGGAGTTTGGCCTCAGAAGAGCACAGGGC
TATGACGGCGCGTTGAGCGCCACACGCGCTGCTGCAATAGGTGGCGCAACAGGGACAAGCAATACACTTGCTGCAAAGCT
CTACGGTATTCGGCCAATGGGAACTATGGCGCACGCGTGGGTGATGTCTTTTGACAGTGAAGAAGAGGCCTTCGAACGCT
ATGCTGCACTCTATGGAAGCGCGTCCGTATTCCTCATCGATACGTACCATACCCTGGAATCAGGGATACAGAATGCAATT
GCAATAGGCACACGTTTGAAGGCGGCAGGAAAATCTTTTGGGGTACGCCTGGACTCAGGAGACATGCAGTATCTTAGCGT
GCAGGTGCGTGCAGCACTAGACGCAGCGGGATTGCCCGAAGCACGCATTGCAGTTTCAAATGAGCTGGATGAGACGATCA
TCGAATCTTTAGTTTTAAGCGGTGCTCCCATCGATGCTTGGGGTGTAGGCACACACCTGGTAACCGGAGGAGCAGACTCT
GCCTTTACCGGAGTGTACAAGATGAGTGCACGCGCTACGACACAGCCGGCGCACACTCAACACGGGCATGCAGCATCCCA
ACGCCTCCCCCACTGGGACGATGCACACTGGCTGCCAGTCATGAAAGTCTCGGATAACCCGGCAAAGACTACCACACCTG
GAATAAAGCAGGTATGGCGTCTGTATGATGCAGCGGGGCAATACAAGGCGGATGTTATAGGACTTGCAGATGAGGTGATA
GAGCCGCAGGTGGCACAGCGATACATACATCCTTTTTATAATCTTCAATCATTCACGTTCGCAGCGCACCAGGTGGAACC
GCTTTTGCGCACGGTCATGCAGGCGGGCAATCGGTTACGTGCCGGCGAATCAGTACAAGAAATCCATGCACGGATGCGCG
CACAACTGCAACGATTGGATAAAAGCTATGTGCGACTGTTAAATCCACACGTTTATAAGGTTTCGCTCACGGAGCGACTT
GCGCAGTTAAAGAACACGCTCATCACAGCGCTCCGCCGCTAA

Upstream 100 bases:

>100_bases
GCATCATTTCTCATGTTCATGAATTGCGCACGCGCATCCCTCACAAAATTCTGATAAAAAAAACAAACGCAGGATCACAC
GTAATGCAGGGGGATGCAGA

Downstream 100 bases:

>100_bases
GTCAACAGATGCTGGTTATTTTGCGCGCTCCACAGCAGCACGGTGCAGGCGCGCAAAGGAGAGTGAGAAAAAAGAGCAAT
GGCTTGACAGAAGTACCCGC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MKTSALFLDFYELTMAQGYFFHKPHECAVFEVFFRKHPFAGGYSIFAGLDPLLTAIEQFRFSGEDIDYLRTLHLFHDDFL
SYLASFRFSGDIHALEEGSVIFPHEPIIRVHARLVEALLLEGLILNTINFQSLIATKTARMWRASGEGVLMEFGLRRAQG
YDGALSATRAAAIGGATGTSNTLAAKLYGIRPMGTMAHAWVMSFDSEEEAFERYAALYGSASVFLIDTYHTLESGIQNAI
AIGTRLKAAGKSFGVRLDSGDMQYLSVQVRAALDAAGLPEARIAVSNELDETIIESLVLSGAPIDAWGVGTHLVTGGADS
AFTGVYKMSARATTQPAHTQHGHAASQRLPHWDDAHWLPVMKVSDNPAKTTTPGIKQVWRLYDAAGQYKADVIGLADEVI
EPQVAQRYIHPFYNLQSFTFAAHQVEPLLRTVMQAGNRLRAGESVQEIHARMRAQLQRLDKSYVRLLNPHVYKVSLTERL
AQLKNTLITALRR

Sequences:

>Translated_493_residues
MKTSALFLDFYELTMAQGYFFHKPHECAVFEVFFRKHPFAGGYSIFAGLDPLLTAIEQFRFSGEDIDYLRTLHLFHDDFL
SYLASFRFSGDIHALEEGSVIFPHEPIIRVHARLVEALLLEGLILNTINFQSLIATKTARMWRASGEGVLMEFGLRRAQG
YDGALSATRAAAIGGATGTSNTLAAKLYGIRPMGTMAHAWVMSFDSEEEAFERYAALYGSASVFLIDTYHTLESGIQNAI
AIGTRLKAAGKSFGVRLDSGDMQYLSVQVRAALDAAGLPEARIAVSNELDETIIESLVLSGAPIDAWGVGTHLVTGGADS
AFTGVYKMSARATTQPAHTQHGHAASQRLPHWDDAHWLPVMKVSDNPAKTTTPGIKQVWRLYDAAGQYKADVIGLADEVI
EPQVAQRYIHPFYNLQSFTFAAHQVEPLLRTVMQAGNRLRAGESVQEIHARMRAQLQRLDKSYVRLLNPHVYKVSLTERL
AQLKNTLITALRR
>Mature_493_residues
MKTSALFLDFYELTMAQGYFFHKPHECAVFEVFFRKHPFAGGYSIFAGLDPLLTAIEQFRFSGEDIDYLRTLHLFHDDFL
SYLASFRFSGDIHALEEGSVIFPHEPIIRVHARLVEALLLEGLILNTINFQSLIATKTARMWRASGEGVLMEFGLRRAQG
YDGALSATRAAAIGGATGTSNTLAAKLYGIRPMGTMAHAWVMSFDSEEEAFERYAALYGSASVFLIDTYHTLESGIQNAI
AIGTRLKAAGKSFGVRLDSGDMQYLSVQVRAALDAAGLPEARIAVSNELDETIIESLVLSGAPIDAWGVGTHLVTGGADS
AFTGVYKMSARATTQPAHTQHGHAASQRLPHWDDAHWLPVMKVSDNPAKTTTPGIKQVWRLYDAAGQYKADVIGLADEVI
EPQVAQRYIHPFYNLQSFTFAAHQVEPLLRTVMQAGNRLRAGESVQEIHARMRAQLQRLDKSYVRLLNPHVYKVSLTERL
AQLKNTLITALRR

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=543, Percent_Identity=31.6758747697974, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI71997947, Length=547, Percent_Identity=33.8208409506399, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI71997952, Length=547, Percent_Identity=33.8208409506399, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI71997955, Length=219, Percent_Identity=45.2054794520548, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24581587, Length=535, Percent_Identity=32.3364485981308, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=43.2038834951456, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=43.2038834951456, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=43.2038834951456, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=43.2038834951456, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=43.2038834951456, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 54579; Mature: 54579

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSALFLDFYELTMAQGYFFHKPHECAVFEVFFRKHPFAGGYSIFAGLDPLLTAIEQFR
CCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCHHHHHCHHHHHHHHHHHH
FSGEDIDYLRTLHLFHDDFLSYLASFRFSGDIHALEEGSVIFPHEPIIRVHARLVEALLL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEECCCCHHHHHHHHHHHHHHH
EGLILNTINFQSLIATKTARMWRASGEGVLMEFGLRRAQGYDGALSATRAAAIGGATGTS
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
NTLAAKLYGIRPMGTMAHAWVMSFDSEEEAFERYAALYGSASVFLIDTYHTLESGIQNAI
CCCEEHEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHH
AIGTRLKAAGKSFGVRLDSGDMQYLSVQVRAALDAAGLPEARIAVSNELDETIIESLVLS
HHHHHHHHCCCCCCEEECCCCCEEEEEEHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHHC
GAPIDAWGVGTHLVTGGADSAFTGVYKMSARATTQPAHTQHGHAASQRLPHWDDAHWLPV
CCCCCCCCCCCEEEECCCCCHHHHHHEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEE
MKVSDNPAKTTTPGIKQVWRLYDAAGQYKADVIGLADEVIEPQVAQRYIHPFYNLQSFTF
EEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
AAHQVEPLLRTVMQAGNRLRAGESVQEIHARMRAQLQRLDKSYVRLLNPHVYKVSLTERL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHH
AQLKNTLITALRR
HHHHHHHHHHHCC
>Mature Secondary Structure
MKTSALFLDFYELTMAQGYFFHKPHECAVFEVFFRKHPFAGGYSIFAGLDPLLTAIEQFR
CCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCHHHHHCHHHHHHHHHHHH
FSGEDIDYLRTLHLFHDDFLSYLASFRFSGDIHALEEGSVIFPHEPIIRVHARLVEALLL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEECCCCHHHHHHHHHHHHHHH
EGLILNTINFQSLIATKTARMWRASGEGVLMEFGLRRAQGYDGALSATRAAAIGGATGTS
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
NTLAAKLYGIRPMGTMAHAWVMSFDSEEEAFERYAALYGSASVFLIDTYHTLESGIQNAI
CCCEEHEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHH
AIGTRLKAAGKSFGVRLDSGDMQYLSVQVRAALDAAGLPEARIAVSNELDETIIESLVLS
HHHHHHHHCCCCCCEEECCCCCEEEEEEHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHHC
GAPIDAWGVGTHLVTGGADSAFTGVYKMSARATTQPAHTQHGHAASQRLPHWDDAHWLPV
CCCCCCCCCCCEEEECCCCCHHHHHHEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEE
MKVSDNPAKTTTPGIKQVWRLYDAAGQYKADVIGLADEVIEPQVAQRYIHPFYNLQSFTF
EEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
AAHQVEPLLRTVMQAGNRLRAGESVQEIHARMRAQLQRLDKSYVRLLNPHVYKVSLTERL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHH
AQLKNTLITALRR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]