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The map label for this gene is tktA [H]

Identifier: 189025788

GI number: 189025788

Start: 607844

End: 609829

Strand: Reverse

Name: tktA [H]

Synonym: TPASS_0560

Alternate gene names: 189025788

Gene position: 609829-607844 (Counterclockwise)

Preceding gene: 189025789

Following gene: 189025784

Centisome position: 53.52

GC content: 54.76

Gene sequence:

>1986_bases
ATGACTGAAGAAGCTATGCGCGCGATGGCACTTTCCATCCGCAGTTTGACGATAGACGCCATCGAACGGGCGAATTCTGG
TCACCCTGGTTTGCCGCTGGGCGCAGCAGAGCTTGCTGCCTGTTTATATGGGACGATCTTAAAGCATAATCCGGCGAATC
CTAGCTGGTTTAATCGGGATCGTTTCGTCCTGTCTGCAGGACACGGGTCTATGCTCTTGTATGCTGCGCTCCACCTTTCT
GGGTACGACGTTTCGCTTGAGGATATTAAGAACTTTAGGCAGGTAGGCTCCCGGTGTCCTGGCCATCCTGAATACGGTTG
TACCCCCGGTGTGGAAGCAACAACCGGTCCATTGGGTCAGGGTATCTCTATGGCGGTGGGTTTTGCGCTTGCAGAGGCAA
TGCTTGCGGCACGTTTTAATACTGATGAGCATGCCGTTGTAGATCACCACACCTATGCGCTTGTGGGGGAAGGCTGCCTT
ATGGAGGGCGTTGCCTCAGAGGCTTCTAGCTTTGCCGGCACTATGCGTCTGGGCAAGCTCATCGTTTTTTATGATGAGAA
CCACATCAGCATAGACGGATCTACCGATCTGACCTTTAGCGAGGATGTGGCTAAGCGCTACGAAGCGTATGGCTGGCAGG
TGCTGCGCGGTTCTATGTATTCGTATACGGATATTATGGATCTCACTGCGTGTGCAAAGCGTGACGATCGGCCTTCTCTC
ATTATCCTGCGTTCGATTATTGGAAAGGGTGCGCCTACCGTTGAAGGGAGCGCGCGTGCCCACGGCGCCCCGCTTGGGGA
AGCGGGGGTGAGAGAGGCAAAAAAGGCATTGGGACTTGATCCTGCGTGCTCTTTTTTTGTAGCGCCTGAGCTTACCGCTG
TTCTCCAGAAACGAAAGTGTGAATGTGCGCATGTCGAGGACTCGTGGAATGAGCTCTTTGAAGCATGGAGCACGCAGTAT
CCTGAAAAACGTGCTGACTGGGACGCTGCTTTTGTTCCCGGAGGGGTAAGTACTTCGCAGCTAGCTCGTGTTGTCTGTCC
CCATTTTGAGAAGGGTTCGTCACTTGCTACTCGGACTGCTTCTGGAAAGGTGCTCGACGCGCTCTGCTCTGTGCTACCGA
ATCTGGTAGGTGGCTCTGCAGATTTACGCGGGCCGAATGCGGTAGCGGTCTCTTCGTTAAGACCATTTTCTGCAGAGCAT
CGTGCAGGCGGCTACTGTTATTTTGGTGTGCGCGAGTTTGCCATGGCAGCCATTGTGAACGGAATGCAGTTGCACGGCGG
TTTGCGTGCGTTTGGCGCTACGTTTATGGTTTTTTCAGACTACTTTCGCCCTGCGCTCCGTCTTGCGGCGCTCATGCGCA
TCCCTTCTGTTTTCGTTTTAACACATGACTCTATTTTTGTAGGAGAAGATGGGCCGACGCACCAACCGGTGGAGACGCTC
GCTGCGCTGCGTGCGATTCCCAACGTGCTTGTTCTGCGCCCTGCTGACGCAGAAGAAACGTTTGAAGCTTGGAAAATAGC
GTTGCTGCACCGCAATGGTCCTGTGTGTATCGTTTTGAGTCGGCAGAACGTGCCGGTTTTTGAGAAAAGTGACAGTTCGT
GGCGCTCTACGGTGGAGGAGTCGGGGGCCTATGTAGTGCGCGAAGGGGGTGCTACGCCTGAGCTGACTGTCTTGGCAAGT
GGCTCTGAGGTGGATTTGGCGTTGCGTGCCGCGCAGCTGAGTAAAAGACGTGTGCGTGTGGTGTCTGTACTGTGCAAGGA
GCGTTTTGAGGCAGCAGGGGACGAGGTGCAGCGGCGCATACAGGGAGGAGCACGCGTTGTAGTGGCTGAGGCAGGGGTGT
ATCAAGGCTGGGGAGCGTGGGCAAAGCGGGAAAAATGCCTTGTGCTCGACCGTTTCGGARAGTCAGGCCCTGGTACGCAG
GTGGCACAGGCGCTGGAATTTACCGCCGAAGCGCTGGTGGAAATAATCCTTGATTGGTTAGCATAA

Upstream 100 bases:

>100_bases
CACAGCACGGTTTCTTTTTCTGTACGGGCAGTCTCTCTTGGAAGAGGTGTATCTATAGTGTGCTCGGTGACGCACGGGAA
AAGCATAAGGAGTGAGAACA

Downstream 100 bases:

>100_bases
ACGCGTCAGTAAAGAAGGGGCGGACGGTGCTGCCGCGTAAGATAAGCGGTACTCATTCGCCTGACTCCTGTACCCCATAG
TTTCCGTATATGCGCGTGCG

Product: transketolase A

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MTEEAMRAMALSIRSLTIDAIERANSGHPGLPLGAAELAACLYGTILKHNPANPSWFNRDRFVLSAGHGSMLLYAALHLS
GYDVSLEDIKNFRQVGSRCPGHPEYGCTPGVEATTGPLGQGISMAVGFALAEAMLAARFNTDEHAVVDHHTYALVGEGCL
MEGVASEASSFAGTMRLGKLIVFYDENHISIDGSTDLTFSEDVAKRYEAYGWQVLRGSMYSYTDIMDLTACAKRDDRPSL
IILRSIIGKGAPTVEGSARAHGAPLGEAGVREAKKALGLDPACSFFVAPELTAVLQKRKCECAHVEDSWNELFEAWSTQY
PEKRADWDAAFVPGGVSTSQLARVVCPHFEKGSSLATRTASGKVLDALCSVLPNLVGGSADLRGPNAVAVSSLRPFSAEH
RAGGYCYFGVREFAMAAIVNGMQLHGGLRAFGATFMVFSDYFRPALRLAALMRIPSVFVLTHDSIFVGEDGPTHQPVETL
AALRAIPNVLVLRPADAEETFEAWKIALLHRNGPVCIVLSRQNVPVFEKSDSSWRSTVEESGAYVVREGGATPELTVLAS
GSEVDLALRAAQLSKRRVRVVSVLCKERFEAAGDEVQRRIQGGARVVVAEAGVYQGWGAWAKREKCLVLDRFGXSGPGTQ
VAQALEFTAEALVEIILDWLA

Sequences:

>Translated_661_residues
MTEEAMRAMALSIRSLTIDAIERANSGHPGLPLGAAELAACLYGTILKHNPANPSWFNRDRFVLSAGHGSMLLYAALHLS
GYDVSLEDIKNFRQVGSRCPGHPEYGCTPGVEATTGPLGQGISMAVGFALAEAMLAARFNTDEHAVVDHHTYALVGEGCL
MEGVASEASSFAGTMRLGKLIVFYDENHISIDGSTDLTFSEDVAKRYEAYGWQVLRGSMYSYTDIMDLTACAKRDDRPSL
IILRSIIGKGAPTVEGSARAHGAPLGEAGVREAKKALGLDPACSFFVAPELTAVLQKRKCECAHVEDSWNELFEAWSTQY
PEKRADWDAAFVPGGVSTSQLARVVCPHFEKGSSLATRTASGKVLDALCSVLPNLVGGSADLRGPNAVAVSSLRPFSAEH
RAGGYCYFGVREFAMAAIVNGMQLHGGLRAFGATFMVFSDYFRPALRLAALMRIPSVFVLTHDSIFVGEDGPTHQPVETL
AALRAIPNVLVLRPADAEETFEAWKIALLHRNGPVCIVLSRQNVPVFEKSDSSWRSTVEESGAYVVREGGATPELTVLAS
GSEVDLALRAAQLSKRRVRVVSVLCKERFEAAGDEVQRRIQGGARVVVAEAGVYQGWGAWAKREKCLVLDRFGXSGPGTQ
VAQALEFTAEALVEIILDWLA
>Mature_660_residues
TEEAMRAMALSIRSLTIDAIERANSGHPGLPLGAAELAACLYGTILKHNPANPSWFNRDRFVLSAGHGSMLLYAALHLSG
YDVSLEDIKNFRQVGSRCPGHPEYGCTPGVEATTGPLGQGISMAVGFALAEAMLAARFNTDEHAVVDHHTYALVGEGCLM
EGVASEASSFAGTMRLGKLIVFYDENHISIDGSTDLTFSEDVAKRYEAYGWQVLRGSMYSYTDIMDLTACAKRDDRPSLI
ILRSIIGKGAPTVEGSARAHGAPLGEAGVREAKKALGLDPACSFFVAPELTAVLQKRKCECAHVEDSWNELFEAWSTQYP
EKRADWDAAFVPGGVSTSQLARVVCPHFEKGSSLATRTASGKVLDALCSVLPNLVGGSADLRGPNAVAVSSLRPFSAEHR
AGGYCYFGVREFAMAAIVNGMQLHGGLRAFGATFMVFSDYFRPALRLAALMRIPSVFVLTHDSIFVGEDGPTHQPVETLA
ALRAIPNVLVLRPADAEETFEAWKIALLHRNGPVCIVLSRQNVPVFEKSDSSWRSTVEESGAYVVREGGATPELTVLASG
SEVDLALRAAQLSKRRVRVVSVLCKERFEAAGDEVQRRIQGGARVVVAEAGVYQGWGAWAKREKCLVLDRFGXSGPGTQV
AQALEFTAEALVEIILDWLA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=586, Percent_Identity=25.5972696245734, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI4507521, Length=586, Percent_Identity=25.5972696245734, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI133778974, Length=650, Percent_Identity=24.9230769230769, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=43.2432432432432, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI48994911, Length=665, Percent_Identity=43.0075187969925, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17539652, Length=575, Percent_Identity=24.695652173913, Blast_Score=144, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325331, Length=661, Percent_Identity=42.3600605143722, Blast_Score=482, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6319593, Length=662, Percent_Identity=41.9939577039275, Blast_Score=470, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45551847, Length=623, Percent_Identity=26.3242375601926, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45550715, Length=623, Percent_Identity=26.3242375601926, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24645119, Length=578, Percent_Identity=26.8166089965398, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24666278, Length=509, Percent_Identity=26.3261296660118, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71099; Mature: 70967

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEAMRAMALSIRSLTIDAIERANSGHPGLPLGAAELAACLYGTILKHNPANPSWFNRD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYAALHLSGYDVSLEDIKNFRQVGSRCPGHPEYGCTPGVEATTGPLGQ
EEEEECCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GISMAVGFALAEAMLAARFNTDEHAVVDHHTYALVGEGCLMEGVASEASSFAGTMRLGKL
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHCEE
IVFYDENHISIDGSTDLTFSEDVAKRYEAYGWQVLRGSMYSYTDIMDLTACAKRDDRPSL
EEEEECCEEEECCCCCCCCCHHHHHHHHHHCHHEECCCHHHHHHHHHHHHHHCCCCCCCE
IILRSIIGKGAPTVEGSARAHGAPLGEAGVREAKKALGLDPACSFFVAPELTAVLQKRKC
EHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHEEECHHHHHHHHHHCC
ECAHVEDSWNELFEAWSTQYPEKRADWDAAFVPGGVSTSQLARVVCPHFEKGSSLATRTA
CCCCCHHHHHHHHHHHHCCCCCHHCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCEEECC
SGKVLDALCSVLPNLVGGSADLRGPNAVAVSSLRPFSAEHRAGGYCYFGVREFAMAAIVN
CCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEECHHHHHHHHHHC
GMQLHGGLRAFGATFMVFSDYFRPALRLAALMRIPSVFVLTHDSIFVGEDGPTHQPVETL
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECEEEECCCCCCCCHHHHH
AALRAIPNVLVLRPADAEETFEAWKIALLHRNGPVCIVLSRQNVPVFEKSDSSWRSTVEE
HHHHHCCCEEEECCCCHHHHHHHHEEEEEECCCCEEEEEECCCCCCEECCCCHHHHHHHH
SGAYVVREGGATPELTVLASGSEVDLALRAAQLSKRRVRVVSVLCKERFEAAGDEVQRRI
CCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
QGGARVVVAEAGVYQGWGAWAKREKCLVLDRFGXSGPGTQVAQALEFTAEALVEIILDWL
CCCCEEEEEECCCCCCCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
A
C
>Mature Secondary Structure 
TEEAMRAMALSIRSLTIDAIERANSGHPGLPLGAAELAACLYGTILKHNPANPSWFNRD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYAALHLSGYDVSLEDIKNFRQVGSRCPGHPEYGCTPGVEATTGPLGQ
EEEEECCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GISMAVGFALAEAMLAARFNTDEHAVVDHHTYALVGEGCLMEGVASEASSFAGTMRLGKL
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHCEE
IVFYDENHISIDGSTDLTFSEDVAKRYEAYGWQVLRGSMYSYTDIMDLTACAKRDDRPSL
EEEEECCEEEECCCCCCCCCHHHHHHHHHHCHHEECCCHHHHHHHHHHHHHHCCCCCCCE
IILRSIIGKGAPTVEGSARAHGAPLGEAGVREAKKALGLDPACSFFVAPELTAVLQKRKC
EHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHEEECHHHHHHHHHHCC
ECAHVEDSWNELFEAWSTQYPEKRADWDAAFVPGGVSTSQLARVVCPHFEKGSSLATRTA
CCCCCHHHHHHHHHHHHCCCCCHHCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCEEECC
SGKVLDALCSVLPNLVGGSADLRGPNAVAVSSLRPFSAEHRAGGYCYFGVREFAMAAIVN
CCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEECHHHHHHHHHHC
GMQLHGGLRAFGATFMVFSDYFRPALRLAALMRIPSVFVLTHDSIFVGEDGPTHQPVETL
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECEEEECCCCCCCCHHHHH
AALRAIPNVLVLRPADAEETFEAWKIALLHRNGPVCIVLSRQNVPVFEKSDSSWRSTVEE
HHHHHCCCEEEECCCCHHHHHHHHEEEEEECCCCEEEEEECCCCCCEECCCCHHHHHHHH
SGAYVVREGGATPELTVLASGSEVDLALRAAQLSKRRVRVVSVLCKERFEAAGDEVQRRI
CCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
QGGARVVVAEAGVYQGWGAWAKREKCLVLDRFGXSGPGTQVAQALEFTAEALVEIILDWL
CCCCEEEEEECCCCCCCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]