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The map label for this gene is degP [H]

Identifier: 189025774

GI number: 189025774

Start: 590131

End: 592131

Strand: Reverse

Name: degP [H]

Synonym: TPASS_0546

Alternate gene names: 189025774

Gene position: 592131-590131 (Counterclockwise)

Preceding gene: 189025775

Following gene: 189025773

Centisome position: 51.97

GC content: 55.17

Gene sequence:

>2001_bases
GTGGCTGGTAGAGCGTGTAGAAGATATTCCCCCCGATATCTATGCCTTCAGTGCGGTGGGCATCAGTGCAGGGGCTTCCA
CCCCAGACTGTGTTATCGCTGCTGTGGAGCAGGCGCTGCGCACGGGCGGCGCGCCTGTCGCTTCTCGGGTGTCTTCCTCT
GCTCTGCCCAAGGTGAGTACCTGCAGGGCTGTTTGTGCGGCGGCTACTTCTTCCGTCGGTTCAGCGGGTGCATCCGGCGC
GGTGTCGCCCGGTGCTGTCCGACCTTTTGCTGTAGGCTCCGTGCGGTGAAAACCGCTTCCCTTTGTCTGCGAAGTGCATG
GCTGAACGTTGCGCTCGGCGGGGTGCTGGGTGTCCTTTCCGGTTGTCGTGTCTTCGACGAAAGGGCGGATGTGCGCGTCG
ACCGTACGGGAAAAGAATACCTCGATGCACAGGTTGCGTGTGCAAAAGAGGAGCTGCGCGCGCGTCCTCTGCGGGCGCTT
ATGTGTGCAATTGCGCTCAAAAGAAATGCCCCAGCACATCAGAAGGTGGCTCAGCTGTATGCCCAGGCGCTTGCGCGCGT
CAAAGAGGCGTTTCGCTATTCAGTGGAGAAACAGAAGTGGTCGGAGGCACTTGTGTTTTTTCGTTCCCTCTCGGCACTTC
GCATTCCGCTGAAGGACTGGACGGAGCGATCGCTGCATCGTGCGCAAATTGAACAGTGGAAAAAGGAGGGTGCGCACGTA
TTGGTTGCGGCGCAAGAGAAGCGCGCCGGAACTTCTGCTGCGCGGAGTCCGGCAGCCATGATAAAGGGGACGGTCACCAT
TTTGGTAGATCGAGGAATTCGCGTAGAGCACGGACGCGGGTTTGCAGATCGAGTTATCGGGTCAGGTTTTTTCATCGACA
AGAGGGGCTATATCGTCACTAACTACCACGTTATCAGAAGCGAGGTAGATCCTGCGTACGAAGGGTATTCGCGTGCGTAC
ATCAAGCTCCCCTCAGACAACACCGTGAAAGTTCCGGTGCGCGTTGTCGGGTGGGATGCGCTTGCAGATCTTGCATTGCT
AAAAACAGAAATTACTCCTGAGGTGGTGTTTGGCTTAGGTTCCTCAAAGAATTTGGACGTGGGGAGTAAAATCTACGCGA
TAGGATCGCCTGCTGGGCTTGAACGAACGCTTACTTCTGGCATCGTGTCTGCGAAAAAGCGCAAACTGCTTTCAGTCGGT
GGGGGAGTGCTGCAGATAGACGCATCCATTAATCGAGGGAACTCAGGCGGTCCAGTTATCGACGAGGAAGGGTGCGTTCA
GGCAGTAGCGTTTGCAGGTGTGGAGCAGCATGCAGGGCTTAATTTTGCCATTCCTGTAGAATTGCTCAAGCAGGTGCTGC
CAAGCTTGTACCGCGGGGGATTGGTGACGCATCCGTGGCTTGGTGCGTTTGGTGAAACACACCGTGTGTGGAAAAATGCT
GGCGTCGGCGGTGTGCTTTCTTCGTACGTTATTCCTGGCAGTCCTCTCTCGTACGCAGGAATACCAGAAGGGGCAATTAT
TACCACGGTCAATGATGCATCCGTTTCTTGTGTAGCTGACTTACAGGCAGAGTTGGAAAAATACGTGCCCGAAACTATCG
TCCGTCTTGCAGGGTACCGACTGCGGGACAAGAGCAAACTGCATGATCTGGCCGCCTATGAGCAGGATGAATGGTACTGC
CAGTTAGGAGTACGGCCGGAACATCCTGCCCGGATCCTGTATAAGTACGACTTATCGTACCGGGCCTTCTTGCCCCTTTT
TGGGATGCGCTTGGCGCGCACCGGCACGCGCAACACCTACCGTGTGGAGTCACTGGTTCCTGGCAATTTTGCAGATGAGC
ATGGCTTTAGCACGTACGACGTAATAGAAATCCAAAACATATACATGATTGAGGCAAGTGAGGCGATTGTCGCAGACGTG
TACGCTAAACGGCGCAAGGCCGGGTACATAGACACGTTCATGCGATTGGTGGCAGCACTGGATAATCCATCCTTTTTCTA
A

Upstream 100 bases:

>100_bases
CTCTTGCGCCCACGGTGGAAGCGCTCCTGGTGATCGGCGGCGCACACTCGGCAAATACCCAGCGTCTACTCCACACCGCG
CGCGAAACGTCGCTGCCTAC

Downstream 100 bases:

>100_bases
TTTCTATATTCCTCGCGCGGGTATCAGGGTGTGAGGGGAAAGAAGTGTCAAATCAGAATGCGCTGGTGAACATGAGGAGG
AAATATGAAAGGTACAGGGA

Product: periplasmic serine protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MAGRACRRYSPRYLCLQCGGHQCRGFHPRLCYRCCGAGAAHGRRACRFSGVFLCSAQGEYLQGCLCGGYFFRRFSGCIRR
GVARCCPTFCCRLRAVKTASLCLRSAWLNVALGGVLGVLSGCRVFDERADVRVDRTGKEYLDAQVACAKEELRARPLRAL
MCAIALKRNAPAHQKVAQLYAQALARVKEAFRYSVEKQKWSEALVFFRSLSALRIPLKDWTERSLHRAQIEQWKKEGAHV
LVAAQEKRAGTSAARSPAAMIKGTVTILVDRGIRVEHGRGFADRVIGSGFFIDKRGYIVTNYHVIRSEVDPAYEGYSRAY
IKLPSDNTVKVPVRVVGWDALADLALLKTEITPEVVFGLGSSKNLDVGSKIYAIGSPAGLERTLTSGIVSAKKRKLLSVG
GGVLQIDASINRGNSGGPVIDEEGCVQAVAFAGVEQHAGLNFAIPVELLKQVLPSLYRGGLVTHPWLGAFGETHRVWKNA
GVGGVLSSYVIPGSPLSYAGIPEGAIITTVNDASVSCVADLQAELEKYVPETIVRLAGYRLRDKSKLHDLAAYEQDEWYC
QLGVRPEHPARILYKYDLSYRAFLPLFGMRLARTGTRNTYRVESLVPGNFADEHGFSTYDVIEIQNIYMIEASEAIVADV
YAKRRKAGYIDTFMRLVAALDNPSFF

Sequences:

>Translated_666_residues
MAGRACRRYSPRYLCLQCGGHQCRGFHPRLCYRCCGAGAAHGRRACRFSGVFLCSAQGEYLQGCLCGGYFFRRFSGCIRR
GVARCCPTFCCRLRAVKTASLCLRSAWLNVALGGVLGVLSGCRVFDERADVRVDRTGKEYLDAQVACAKEELRARPLRAL
MCAIALKRNAPAHQKVAQLYAQALARVKEAFRYSVEKQKWSEALVFFRSLSALRIPLKDWTERSLHRAQIEQWKKEGAHV
LVAAQEKRAGTSAARSPAAMIKGTVTILVDRGIRVEHGRGFADRVIGSGFFIDKRGYIVTNYHVIRSEVDPAYEGYSRAY
IKLPSDNTVKVPVRVVGWDALADLALLKTEITPEVVFGLGSSKNLDVGSKIYAIGSPAGLERTLTSGIVSAKKRKLLSVG
GGVLQIDASINRGNSGGPVIDEEGCVQAVAFAGVEQHAGLNFAIPVELLKQVLPSLYRGGLVTHPWLGAFGETHRVWKNA
GVGGVLSSYVIPGSPLSYAGIPEGAIITTVNDASVSCVADLQAELEKYVPETIVRLAGYRLRDKSKLHDLAAYEQDEWYC
QLGVRPEHPARILYKYDLSYRAFLPLFGMRLARTGTRNTYRVESLVPGNFADEHGFSTYDVIEIQNIYMIEASEAIVADV
YAKRRKAGYIDTFMRLVAALDNPSFF
>Mature_665_residues
AGRACRRYSPRYLCLQCGGHQCRGFHPRLCYRCCGAGAAHGRRACRFSGVFLCSAQGEYLQGCLCGGYFFRRFSGCIRRG
VARCCPTFCCRLRAVKTASLCLRSAWLNVALGGVLGVLSGCRVFDERADVRVDRTGKEYLDAQVACAKEELRARPLRALM
CAIALKRNAPAHQKVAQLYAQALARVKEAFRYSVEKQKWSEALVFFRSLSALRIPLKDWTERSLHRAQIEQWKKEGAHVL
VAAQEKRAGTSAARSPAAMIKGTVTILVDRGIRVEHGRGFADRVIGSGFFIDKRGYIVTNYHVIRSEVDPAYEGYSRAYI
KLPSDNTVKVPVRVVGWDALADLALLKTEITPEVVFGLGSSKNLDVGSKIYAIGSPAGLERTLTSGIVSAKKRKLLSVGG
GVLQIDASINRGNSGGPVIDEEGCVQAVAFAGVEQHAGLNFAIPVELLKQVLPSLYRGGLVTHPWLGAFGETHRVWKNAG
VGGVLSSYVIPGSPLSYAGIPEGAIITTVNDASVSCVADLQAELEKYVPETIVRLAGYRLRDKSKLHDLAAYEQDEWYCQ
LGVRPEHPARILYKYDLSYRAFLPLFGMRLARTGTRNTYRVESLVPGNFADEHGFSTYDVIEIQNIYMIEASEAIVADVY
AKRRKAGYIDTFMRLVAALDNPSFF

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=258, Percent_Identity=30.2325581395349, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI24308541, Length=186, Percent_Identity=36.0215053763441, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI22129776, Length=256, Percent_Identity=28.515625, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI7019477, Length=173, Percent_Identity=35.8381502890173, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786356, Length=253, Percent_Identity=34.3873517786561, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789630, Length=294, Percent_Identity=28.9115646258503, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1789629, Length=267, Percent_Identity=31.0861423220974, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646839, Length=261, Percent_Identity=29.1187739463602, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 73321; Mature: 73190

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRACRRYSPRYLCLQCGGHQCRGFHPRLCYRCCGAGAAHGRRACRFSGVFLCSAQGEY
CCCCCCHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCEEEECCCCHH
LQGCLCGGYFFRRFSGCIRRGVARCCPTFCCRLRAVKTASLCLRSAWLNVALGGVLGVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCRVFDERADVRVDRTGKEYLDAQVACAKEELRARPLRALMCAIALKRNAPAHQKVAQLY
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQALARVKEAFRYSVEKQKWSEALVFFRSLSALRIPLKDWTERSLHRAQIEQWKKEGAHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEE
LVAAQEKRAGTSAARSPAAMIKGTVTILVDRGIRVEHGRGFADRVIGSGFFIDKRGYIVT
EEEECCCCCCCHHHCCCHHHHCCEEEEEEECCEEEECCCCHHHHHHCCCEEEECCCEEEE
NYHVIRSEVDPAYEGYSRAYIKLPSDNTVKVPVRVVGWDALADLALLKTEITPEVVFGLG
EEEEEECCCCHHHCCCCEEEEECCCCCEEEEEEEEECHHHHHHHHHHHHCCCHHHEEECC
SSKNLDVGSKIYAIGSPAGLERTLTSGIVSAKKRKLLSVGGGVLQIDASINRGNSGGPVI
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
DEEGCVQAVAFAGVEQHAGLNFAIPVELLKQVLPSLYRGGLVTHPWLGAFGETHRVWKNA
CCCHHHHHHHHHCHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHCC
GVGGVLSSYVIPGSPLSYAGIPEGAIITTVNDASVSCVADLQAELEKYVPETIVRLAGYR
CCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LRDKSKLHDLAAYEQDEWYCQLGVRPEHPARILYKYDLSYRAFLPLFGMRLARTGTRNTY
CCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCE
RVESLVPGNFADEHGFSTYDVIEIQNIYMIEASEAIVADVYAKRRKAGYIDTFMRLVAAL
EEEEECCCCCCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHH
DNPSFF
CCCCCC
>Mature Secondary Structure 
AGRACRRYSPRYLCLQCGGHQCRGFHPRLCYRCCGAGAAHGRRACRFSGVFLCSAQGEY
CCCCCHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCEEEECCCCHH
LQGCLCGGYFFRRFSGCIRRGVARCCPTFCCRLRAVKTASLCLRSAWLNVALGGVLGVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCRVFDERADVRVDRTGKEYLDAQVACAKEELRARPLRALMCAIALKRNAPAHQKVAQLY
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQALARVKEAFRYSVEKQKWSEALVFFRSLSALRIPLKDWTERSLHRAQIEQWKKEGAHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEE
LVAAQEKRAGTSAARSPAAMIKGTVTILVDRGIRVEHGRGFADRVIGSGFFIDKRGYIVT
EEEECCCCCCCHHHCCCHHHHCCEEEEEEECCEEEECCCCHHHHHHCCCEEEECCCEEEE
NYHVIRSEVDPAYEGYSRAYIKLPSDNTVKVPVRVVGWDALADLALLKTEITPEVVFGLG
EEEEEECCCCHHHCCCCEEEEECCCCCEEEEEEEEECHHHHHHHHHHHHCCCHHHEEECC
SSKNLDVGSKIYAIGSPAGLERTLTSGIVSAKKRKLLSVGGGVLQIDASINRGNSGGPVI
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
DEEGCVQAVAFAGVEQHAGLNFAIPVELLKQVLPSLYRGGLVTHPWLGAFGETHRVWKNA
CCCHHHHHHHHHCHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHCC
GVGGVLSSYVIPGSPLSYAGIPEGAIITTVNDASVSCVADLQAELEKYVPETIVRLAGYR
CCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LRDKSKLHDLAAYEQDEWYCQLGVRPEHPARILYKYDLSYRAFLPLFGMRLARTGTRNTY
CCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCE
RVESLVPGNFADEHGFSTYDVIEIQNIYMIEASEAIVADVYAKRRKAGYIDTFMRLVAAL
EEEEECCCCCCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHH
DNPSFF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]