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The map label for this gene is atpI2

Identifier: 189025761

GI number: 189025761

Start: 577197

End: 578561

Strand: Reverse

Name: atpI2

Synonym: TPASS_0533

Alternate gene names: 189025761

Gene position: 578561-577197 (Counterclockwise)

Preceding gene: 189025762

Following gene: 189025760

Centisome position: 50.78

GC content: 53.41

Gene sequence:

>1365_bases
ATGTTTAGATCGCAGAGGATGAAGTTCCTCGAACTTGTAGTGCTTGAACGGGATGTGGACCGAGTACTGGAGTACCTGGG
AAAGACGGCGCTTGTCCATTTGCGTCTTTCCGCCGCGGCGCGTGGCAGTTCTTCCCACTGTGCGCAGAGCAAAGAGTATG
TCGGCCGTCTTGAAGAAGCGTGTAAGTACCTGGGTGTCTCTGGCGAGTGCGCGTTTTCTCCAGGGGATTCTTTGCCTACC
GAAGAAGACTACACGTTGGCACAGCAGATACTTGCAGAAGTTGACGCTTTGCACGCACGCGAACGAGAGGGTGATGCTCC
CTCAGTTCCCCGTGGGAAGAGTTCTGTAGCCCATGATTCTGCCAACGAAGAGCAGTTTCAGGGTGAGAAATGTGCGCTCG
GCTCGATGCGAGGCCCGGCACTGTGTGCGCTGCTTAGGCGTTTTGCGCTGCAGGAACGTGTGCACCGCACGCGTGATGCG
CTTGAGTCTACCCGGCATACCTATCGTATAGCTGGCTGGTTGCCAGCACATGAGGCGAAGGACCTCGTTGCAGGATTGGA
CAACGTGACCACAGGGAGGATGGCAGTCCGCCTGTTTGAACCACAGGAGCTGTCTTTTATCAGGGATGGCAGCGAGCATG
TGCCGGTGTGTTACCAGCATGGCCGTTTTGTGCGTAGTTACGAGCGTATGGTGTCTAGTTATGGTTGTCCCCCCTACGGG
CTCGTCGATCCGACTCCTTTCGTTGCTTTCTCCTATGCGCTGCTTTTTGGGATTATGTTTGGGGACCTCGGGCAGGGTCT
CCTCTTTTTCGTACTTGGTTTGCTACTGCGGACGCGGCGTGTACGTGCGCTAAATAGATGGGCACACCTTGACTACGTGT
TCTTGTCCGTAGGTTTCTCTAGCATGGTGATGGGTTTTCTGACGGGGGAGTTTTTCGCTCATGGTACGCTCCTCGCTCCG
TTGATTCGCAGCGTTACTGCGCTATGTGGTGGAGTACCACGCGATCACATCTTGCACCTAATGCCTTCTCATGGCTCTCT
GCACACGCTTATGGCCTTTTTCGGCTTCACGCTTTTTTTAGGATTTGTTATTAATTCGCTGGGCCTTATCATCAACATTG
TCAATCAGGTGAGACTGCGCCATGCGTTGCAGCAGTGTGTTCAAAAACGGGAGTGTGCGGACTCCTCTTTTTTTGGTACA
TGGTTGCCCTTGCAGTGCGCATACCACTTTTTGGAATTCCATTCGGGGTCTTTGATGCGGTTGCAATGGGCGTGCCTCTC
GTGGGTATTTTTTGTCAAGAGTTTTTGGAGCGTGTGTGCAAGCGTGTGCGTCCGTGGTTTCCTGAAGGTGTTGGCATGTA
TCTAA

Upstream 100 bases:

>100_bases
ATGAAGCGCTTTGAAGCGCGTGGCATCTGTGCGCTTGCAGAATGTATACATGCAGGGAGTGCGCGTACGCTGCCACGTGA
GTTCTTGGGGGAAGCAGCTT

Downstream 100 bases:

>100_bases
TGCACGGTGTTATCGAAATGGTCGATGTGGTGTCGGGATTTTTCTCCAACTCCATGAGTTTTTTGCGCGTGGGAGCCTTT
GCCTTGTCCCATGCGGTACT

Product: V-type ATPase, subunit I

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit I 2

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFRSQRMKFLELVVLERDVDRVLEYLGKTALVHLRLSAAARGSSSHCAQSKEYVGRLEEACKYLGVSGECAFSPGDSLPT
EEDYTLAQQILAEVDALHAREREGDAPSVPRGKSSVAHDSANEEQFQGEKCALGSMRGPALCALLRRFALQERVHRTRDA
LESTRHTYRIAGWLPAHEAKDLVAGLDNVTTGRMAVRLFEPQELSFIRDGSEHVPVCYQHGRFVRSYERMVSSYGCPPYG
LVDPTPFVAFSYALLFGIMFGDLGQGLLFFVLGLLLRTRRVRALNRWAHLDYVFLSVGFSSMVMGFLTGEFFAHGTLLAP
LIRSVTALCGGVPRDHILHLMPSHGSLHTLMAFFGFTLFLGFVINSLGLIINIVNQVRLRHALQQCVQKRECADSSFFGT
WLPLQCAYHFLEFHSGSLMRLQWACLSWVFFVKSFWSVCASVCVRGFLKVLACI

Sequences:

>Translated_454_residues
MFRSQRMKFLELVVLERDVDRVLEYLGKTALVHLRLSAAARGSSSHCAQSKEYVGRLEEACKYLGVSGECAFSPGDSLPT
EEDYTLAQQILAEVDALHAREREGDAPSVPRGKSSVAHDSANEEQFQGEKCALGSMRGPALCALLRRFALQERVHRTRDA
LESTRHTYRIAGWLPAHEAKDLVAGLDNVTTGRMAVRLFEPQELSFIRDGSEHVPVCYQHGRFVRSYERMVSSYGCPPYG
LVDPTPFVAFSYALLFGIMFGDLGQGLLFFVLGLLLRTRRVRALNRWAHLDYVFLSVGFSSMVMGFLTGEFFAHGTLLAP
LIRSVTALCGGVPRDHILHLMPSHGSLHTLMAFFGFTLFLGFVINSLGLIINIVNQVRLRHALQQCVQKRECADSSFFGT
WLPLQCAYHFLEFHSGSLMRLQWACLSWVFFVKSFWSVCASVCVRGFLKVLACI
>Mature_454_residues
MFRSQRMKFLELVVLERDVDRVLEYLGKTALVHLRLSAAARGSSSHCAQSKEYVGRLEEACKYLGVSGECAFSPGDSLPT
EEDYTLAQQILAEVDALHAREREGDAPSVPRGKSSVAHDSANEEQFQGEKCALGSMRGPALCALLRRFALQERVHRTRDA
LESTRHTYRIAGWLPAHEAKDLVAGLDNVTTGRMAVRLFEPQELSFIRDGSEHVPVCYQHGRFVRSYERMVSSYGCPPYG
LVDPTPFVAFSYALLFGIMFGDLGQGLLFFVLGLLLRTRRVRALNRWAHLDYVFLSVGFSSMVMGFLTGEFFAHGTLLAP
LIRSVTALCGGVPRDHILHLMPSHGSLHTLMAFFGFTLFLGFVINSLGLIINIVNQVRLRHALQQCVQKRECADSSFFGT
WLPLQCAYHFLEFHSGSLMRLQWACLSWVFFVKSFWSVCASVCVRGFLKVLACI

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane

COG id: COG1269

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase 116 kDa subunit family

Homologues:

Organism=Homo sapiens, GI19924145, Length=125, Percent_Identity=30.4, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI5174717, Length=125, Percent_Identity=30.4, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VATI2_TREPA (O83544)

Other databases:

- EMBL:   AE000520
- PIR:   F71313
- RefSeq:   NP_218972.1
- ProteinModelPortal:   O83544
- IntAct:   O83544
- GeneID:   2610824
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0533
- NMPDR:   fig|243276.1.peg.531
- TIGR:   TP_0533
- HOGENOM:   HBG250989
- ProtClustDB:   CLSK2300238
- BioCyc:   TPAL243276:TP_0533-MONOMER
- BRENDA:   3.6.3.14
- InterPro:   IPR002490
- PANTHER:   PTHR11629

Pfam domain/function: PF01496 V_ATPase_I

EC number: 3.6.3.14

Molecular weight: Translated: 50848; Mature: 50848

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20a5a1f4)-; HASH(0x2139baf0)-; HASH(0x2123ce98)-; HASH(0x1fccf654)-;

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRSQRMKFLELVVLERDVDRVLEYLGKTALVHLRLSAAARGSSSHCAQSKEYVGRLEEA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEHHHHHCCCCHHHHHHHHHHHHHHHH
CKYLGVSGECAFSPGDSLPTEEDYTLAQQILAEVDALHAREREGDAPSVPRGKSSVAHDS
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
ANEEQFQGEKCALGSMRGPALCALLRRFALQERVHRTRDALESTRHTYRIAGWLPAHEAK
CCHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
DLVAGLDNVTTGRMAVRLFEPQELSFIRDGSEHVPVCYQHGRFVRSYERMVSSYGCPPYG
HHHHHHCCCCCCHHEEEEECCHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCC
LVDPTPFVAFSYALLFGIMFGDLGQGLLFFVLGLLLRTRRVRALNRWAHLDYVFLSVGFS
CCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
SMVMGFLTGEFFAHGTLLAPLIRSVTALCGGVPRDHILHLMPSHGSLHTLMAFFGFTLFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCHHHHHHHHHHHHHHH
GFVINSLGLIINIVNQVRLRHALQQCVQKRECADSSFFGTWLPLQCAYHFLEFHSGSLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LQWACLSWVFFVKSFWSVCASVCVRGFLKVLACI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MFRSQRMKFLELVVLERDVDRVLEYLGKTALVHLRLSAAARGSSSHCAQSKEYVGRLEEA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEHHHHHCCCCHHHHHHHHHHHHHHHH
CKYLGVSGECAFSPGDSLPTEEDYTLAQQILAEVDALHAREREGDAPSVPRGKSSVAHDS
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
ANEEQFQGEKCALGSMRGPALCALLRRFALQERVHRTRDALESTRHTYRIAGWLPAHEAK
CCHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
DLVAGLDNVTTGRMAVRLFEPQELSFIRDGSEHVPVCYQHGRFVRSYERMVSSYGCPPYG
HHHHHHCCCCCCHHEEEEECCHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCC
LVDPTPFVAFSYALLFGIMFGDLGQGLLFFVLGLLLRTRRVRALNRWAHLDYVFLSVGFS
CCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
SMVMGFLTGEFFAHGTLLAPLIRSVTALCGGVPRDHILHLMPSHGSLHTLMAFFGFTLFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCHHHHHHHHHHHHHHH
GFVINSLGLIINIVNQVRLRHALQQCVQKRECADSSFFGTWLPLQCAYHFLEFHSGSLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LQWACLSWVFFVKSFWSVCASVCVRGFLKVLACI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9665876