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The map label for this gene is pbp1 [H]

Identifier: 189025730

GI number: 189025730

Start: 535727

End: 537601

Strand: Direct

Name: pbp1 [H]

Synonym: TPASS_0500

Alternate gene names: 189025730

Gene position: 535727-537601 (Clockwise)

Preceding gene: 189025729

Following gene: 189025731

Centisome position: 47.02

GC content: 48.37

Gene sequence:

>1875_bases
ATGCGTTATTTTTCTCTCCTTCCTGATCGTCATATGCTTTTTAGGATAAAGGTTCTCACCTGGCTCGTCGTGCTGGTTAT
GCTGTTGTACATGCGGCAGCTGTTTGTCATTCAAATCGTGCGGGGGGATTCGTTCAAAAAAAAATCGCTGAACATATCTC
AGCGTAGTAAAGTAATTCCTGCACAACGGGGGGAGATTTTTGATCGCCACGCGGATCTGCCCATGGTGCTGAATGTCAAT
TCGTTTGCAGTTGATATGATCCCCGGAGAGGTTCCGCCTGAGCAGTTCGATACGGTGCTCAACAAATTGTCGCATATTCT
GCGCGTACCTATTTCGGATATTCGAAAGAAAATTCCTGATGCGGTCCGCCGTTCATTTCAAACGGTGGAGTTGCGCAGTA
ACGTGAGTTACGAGGACATCACTGCTATCGCCCAAATAATTGATGAACTGCCGGGCGTTTCTTGGTATTCAAAACCAGTA
CGAAATTACGTTGAAACAGGATCATTCGCTCACGTTATCGGATATGTGGGGGAGATTACAAAAGAAGAGCTCAAACGATT
TTACAGTAAAGGGTACAGGCCCAACAGTCTCATTGGAAAGGCTGGAATTGAAAAAGAATACGACGAGGTCCTGAGAGGGA
AAGAGGGACACGAGTACCGGACCGTCGATGCCCGTGGGCGATACATAGAAAACACTTCGGTTACTAACCCTCCTCGCATG
GGTAATAACCTCGTGCTCACCATCGATCGGCGTATACAAAAACTTGCAGAAGACGCGCTCGGTCCTCGTATCGGAGCGGC
AGTGGTACTGAAACCGACAACGGGAGAAGTACTTGCTATGGTATCTTATCCGTACTTTGACCAAAACATTTTCACTCAGC
ATAACGCCCACGAACTGTATGCGCAGCTTTCACATGATACACGGTTCCCTCTGCTTAACCGTGTTGTGAATGCAAGTTAC
CCGCCTGCGTCGACGTTCAAGATTGTCATGTCAACCGCTATTTTGGCAGAGAAGGCATTCCCCCATGAAAAGACGGTGGA
CTGTCCAGGAGAGATCGAGTATGGCAATCGCTTATTTCGCTGTCATATCAGAAAGCCTGGGCACGGCAAGGTAGATCTCC
GTCGTGCGCTTGAGCAGTCGTGTGATATTTATTACTGGACAGTCTGTCGAGACTATCTTGGCATCGACCGCATGATTTCG
TACATCAACGATTTTGGATTTGGCAAATCGGCGCGCATCGATTTACCCAGTCAAACAGAGGGTATGGTTCCAACACCGAA
ATGGAAAGAACGTCGGTTTCATGAAAAATGGTTGGATGGAGACACTATGAATCTCGCTATCGGGCAGGGTTACATGCTTG
TCTCGCCTCTGCAGGTGGCAAACATGGTCGCGATGACCGTTAACAATGGCGTCATTTATCGGCCCCATTTACTCAAGGAA
ATTCGGGACTCTCGTACTAACGAAGTGCTATTTAGGCATAAACCTGAGGTATTAAAGACAGCAAAAATTCCTGCAGAGAT
ATTCGAGCACGTGCGCGCAGATATGCATTCGGTTGTCACGCGTGGCTCCTCCCAGTATGCAATGAAAAATAAGACCGTGT
CCCTGGCAGGGAAAACTGGTACTGCAGAAGTAGGTTTTCACAATCGGTGGCATTCGTGGATGGCAGCGTATGGGCCTTAT
CATCGCCCCCTGGATGAAGCGGTGGTCGTTGTGGTACTGGTAGAGGCAAGAAACGAATGGGAATGGTGGGCGCCGTTTGC
AACCAATATCATTTTTCAGGGTATTTTTGCGAATGAGGATTATGAGCAAGCAGTTGAGTCGCTCAAGTCGTACGGCATTT
CCCTTGGGGTGCCGGCAAGGAGTCGGCAGGAATGA

Upstream 100 bases:

>100_bases
TTGGATAGAAATGACGTTGAATATTGTGTTTGTCCCCTTTGTATTCGGGCTTTTGAATATGTTTCCGACCACTTTTCTTT
ATAAGAGGTTTTCTTCGTAG

Downstream 100 bases:

>100_bases
GGATTCGCGGTGTCAGTGATTTTGACTACCTATTGCTTCTGACCATGCTGGCGTTGACCAGCATTGGTATCTTGTTCATC
TATTCTTCCGTGGTAAATTC

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MRYFSLLPDRHMLFRIKVLTWLVVLVMLLYMRQLFVIQIVRGDSFKKKSLNISQRSKVIPAQRGEIFDRHADLPMVLNVN
SFAVDMIPGEVPPEQFDTVLNKLSHILRVPISDIRKKIPDAVRRSFQTVELRSNVSYEDITAIAQIIDELPGVSWYSKPV
RNYVETGSFAHVIGYVGEITKEELKRFYSKGYRPNSLIGKAGIEKEYDEVLRGKEGHEYRTVDARGRYIENTSVTNPPRM
GNNLVLTIDRRIQKLAEDALGPRIGAAVVLKPTTGEVLAMVSYPYFDQNIFTQHNAHELYAQLSHDTRFPLLNRVVNASY
PPASTFKIVMSTAILAEKAFPHEKTVDCPGEIEYGNRLFRCHIRKPGHGKVDLRRALEQSCDIYYWTVCRDYLGIDRMIS
YINDFGFGKSARIDLPSQTEGMVPTPKWKERRFHEKWLDGDTMNLAIGQGYMLVSPLQVANMVAMTVNNGVIYRPHLLKE
IRDSRTNEVLFRHKPEVLKTAKIPAEIFEHVRADMHSVVTRGSSQYAMKNKTVSLAGKTGTAEVGFHNRWHSWMAAYGPY
HRPLDEAVVVVVLVEARNEWEWWAPFATNIIFQGIFANEDYEQAVESLKSYGISLGVPARSRQE

Sequences:

>Translated_624_residues
MRYFSLLPDRHMLFRIKVLTWLVVLVMLLYMRQLFVIQIVRGDSFKKKSLNISQRSKVIPAQRGEIFDRHADLPMVLNVN
SFAVDMIPGEVPPEQFDTVLNKLSHILRVPISDIRKKIPDAVRRSFQTVELRSNVSYEDITAIAQIIDELPGVSWYSKPV
RNYVETGSFAHVIGYVGEITKEELKRFYSKGYRPNSLIGKAGIEKEYDEVLRGKEGHEYRTVDARGRYIENTSVTNPPRM
GNNLVLTIDRRIQKLAEDALGPRIGAAVVLKPTTGEVLAMVSYPYFDQNIFTQHNAHELYAQLSHDTRFPLLNRVVNASY
PPASTFKIVMSTAILAEKAFPHEKTVDCPGEIEYGNRLFRCHIRKPGHGKVDLRRALEQSCDIYYWTVCRDYLGIDRMIS
YINDFGFGKSARIDLPSQTEGMVPTPKWKERRFHEKWLDGDTMNLAIGQGYMLVSPLQVANMVAMTVNNGVIYRPHLLKE
IRDSRTNEVLFRHKPEVLKTAKIPAEIFEHVRADMHSVVTRGSSQYAMKNKTVSLAGKTGTAEVGFHNRWHSWMAAYGPY
HRPLDEAVVVVVLVEARNEWEWWAPFATNIIFQGIFANEDYEQAVESLKSYGISLGVPARSRQE
>Mature_624_residues
MRYFSLLPDRHMLFRIKVLTWLVVLVMLLYMRQLFVIQIVRGDSFKKKSLNISQRSKVIPAQRGEIFDRHADLPMVLNVN
SFAVDMIPGEVPPEQFDTVLNKLSHILRVPISDIRKKIPDAVRRSFQTVELRSNVSYEDITAIAQIIDELPGVSWYSKPV
RNYVETGSFAHVIGYVGEITKEELKRFYSKGYRPNSLIGKAGIEKEYDEVLRGKEGHEYRTVDARGRYIENTSVTNPPRM
GNNLVLTIDRRIQKLAEDALGPRIGAAVVLKPTTGEVLAMVSYPYFDQNIFTQHNAHELYAQLSHDTRFPLLNRVVNASY
PPASTFKIVMSTAILAEKAFPHEKTVDCPGEIEYGNRLFRCHIRKPGHGKVDLRRALEQSCDIYYWTVCRDYLGIDRMIS
YINDFGFGKSARIDLPSQTEGMVPTPKWKERRFHEKWLDGDTMNLAIGQGYMLVSPLQVANMVAMTVNNGVIYRPHLLKE
IRDSRTNEVLFRHKPEVLKTAKIPAEIFEHVRADMHSVVTRGSSQYAMKNKTVSLAGKTGTAEVGFHNRWHSWMAAYGPY
HRPLDEAVVVVVLVEARNEWEWWAPFATNIIFQGIFANEDYEQAVESLKSYGISLGVPARSRQE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=591, Percent_Identity=30.1184433164129, Blast_Score=265, Evalue=8e-72,
Organism=Escherichia coli, GI1786272, Length=584, Percent_Identity=24.6575342465753, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71424; Mature: 71424

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFSLLPDRHMLFRIKVLTWLVVLVMLLYMRQLFVIQIVRGDSFKKKSLNISQRSKVIP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC
AQRGEIFDRHADLPMVLNVNSFAVDMIPGEVPPEQFDTVLNKLSHILRVPISDIRKKIPD
CCCCCHHHHCCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVRRSFQTVELRSNVSYEDITAIAQIIDELPGVSWYSKPVRNYVETGSFAHVIGYVGEIT
HHHHHHHEEEHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
KEELKRFYSKGYRPNSLIGKAGIEKEYDEVLRGKEGHEYRTVDARGRYIENTSVTNPPRM
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCCC
GNNLVLTIDRRIQKLAEDALGPRIGAAVVLKPTTGEVLAMVSYPYFDQNIFTQHNAHELY
CCCEEEEEHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHCCCCHHHHH
AQLSHDTRFPLLNRVVNASYPPASTFKIVMSTAILAEKAFPHEKTVDCPGEIEYGNRLFR
HHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
CHIRKPGHGKVDLRRALEQSCDIYYWTVCRDYLGIDRMISYINDFGFGKSARIDLPSQTE
EEECCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
GMVPTPKWKERRFHEKWLDGDTMNLAIGQGYMLVSPLQVANMVAMTVNNGVIYRPHLLKE
CCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEECHHHHHHEEEEEECCCEEECHHHHHH
IRDSRTNEVLFRHKPEVLKTAKIPAEIFEHVRADMHSVVTRGSSQYAMKNKTVSLAGKTG
HHHCCCCCCHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHEECCCEEEEECCCC
TAEVGFHNRWHSWMAAYGPYHRPLDEAVVVVVLVEARNEWEWWAPFATNIIFQGIFANED
CEECCCCHHHHHHHHHCCCCCCCHHHHEEEEEEEECCCCCCEECHHHHHHHHHHHCCCCH
YEQAVESLKSYGISLGVPARSRQE
HHHHHHHHHHCCCEECCCCCCCCC
>Mature Secondary Structure
MRYFSLLPDRHMLFRIKVLTWLVVLVMLLYMRQLFVIQIVRGDSFKKKSLNISQRSKVIP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC
AQRGEIFDRHADLPMVLNVNSFAVDMIPGEVPPEQFDTVLNKLSHILRVPISDIRKKIPD
CCCCCHHHHCCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVRRSFQTVELRSNVSYEDITAIAQIIDELPGVSWYSKPVRNYVETGSFAHVIGYVGEIT
HHHHHHHEEEHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
KEELKRFYSKGYRPNSLIGKAGIEKEYDEVLRGKEGHEYRTVDARGRYIENTSVTNPPRM
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCCC
GNNLVLTIDRRIQKLAEDALGPRIGAAVVLKPTTGEVLAMVSYPYFDQNIFTQHNAHELY
CCCEEEEEHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHCCCCHHHHH
AQLSHDTRFPLLNRVVNASYPPASTFKIVMSTAILAEKAFPHEKTVDCPGEIEYGNRLFR
HHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
CHIRKPGHGKVDLRRALEQSCDIYYWTVCRDYLGIDRMISYINDFGFGKSARIDLPSQTE
EEECCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
GMVPTPKWKERRFHEKWLDGDTMNLAIGQGYMLVSPLQVANMVAMTVNNGVIYRPHLLKE
CCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEECHHHHHHEEEEEECCCEEECHHHHHH
IRDSRTNEVLFRHKPEVLKTAKIPAEIFEHVRADMHSVVTRGSSQYAMKNKTVSLAGKTG
HHHCCCCCCHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHEECCCEEEEECCCC
TAEVGFHNRWHSWMAAYGPYHRPLDEAVVVVVLVEARNEWEWWAPFATNIIFQGIFANED
CEECCCCHHHHHHHHHCCCCCCCHHHHEEEEEEEECCCCCCEECHHHHHHHHHHHCCCCH
YEQAVESLKSYGISLGVPARSRQE
HHHHHHHHHHCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]