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Identifier: 189025680

GI number: 189025680

Start: 476140

End: 477222

Strand: Direct

Name: upp

Synonym: TPASS_0448

Alternate gene names: 189025680

Gene position: 476140-477222 (Clockwise)

Preceding gene: 189025679

Following gene: 189025681

Centisome position: 41.79

GC content: 44.78

Gene sequence:

>1083_bases
ATGGAAGGGCAGACGGCGCGCAGAGTGATCACGGAGGCAAAGTTTCTTGATGACTGTTTGACAGAACGTGACAGCTATTA
TCTGAGTAAATTGGACGAGTTGTACTCATCTGCGATGAGTTCTTTTGCGCAGTTTGAAGATCAGCAGAATGGAGCGCGTA
GCGCACGCGCTGAAGAAAATATCATCGCTACATATGACAGTATCGGGAATCTGATGCAGGAGATCTGTAAAGAATTACCC
GCGCTGAAGGTATATTCGTTTGAAACGCAACGAGAGAACCATGCAGAAGTTTCTCGAGTTGTTTCAAAGCTGCGTAATAT
TCATACCGGATATAGTGAATTCATCTACTACACACAGCGTGCGTTTGAAATGCTGTTTAGGCTTGCCTACGGCGGCTCTC
ATGAAGAGCATAAAACATATCTTATTACAAAAACACCGGTTGCTTTTCCTGTACAAAACTATGCAGTACATAAAATTGCA
AACGTGGATTATAAAATTGAGAACACGGTGATGTGTGTCATGTTACGAGGAGCGCTGTTACCTTCGATGATTGTTTCTAA
GGAGATAGAAGAATATTCTTCGCATGGGTACGTAACGCCGTTTGCGCTTTTTAAAATCAAGCGAGATGATCTCCGTGATG
AGCGCGATATGCAGTATGTGTTTGATCTGGATAAATCATACTTTTCTGCACGAGAGTTGGATGGTAAGGATCTGGTTTTC
GCCGATCCCATGAACGCCACCGGTGGTAGTTTGGTTACCATAGTGCGTTATTTGCAAGATCTCGGTGTGAAACCAAAATC
TATCAGCTGTTTTCACATGATTTCTGCACTGAAAGGTGCGATTCGTGTAGTGCGTTCCCTAGAGAATTGCACGGTGTATA
CGCTGTGGATGGATCCCGTACTCAACGCGCGTGCGTATATTATGCCTGGTCTTGGCGATGCTGGTGATCGAGTTAACGGG
GTTGATGTTGAAGACTATCCGCGGAATATTATCCAGCTTTTGGCAGACTATGGTTCAAATATTTCTGGCCTGTACCGGTC
CCAGCTCCGCAAGATAGAGGAAACGGTATTAGGTTCTCGCTGA

Upstream 100 bases:

>100_bases
GTACGCGCGGCGTGCTGCGTATAAGCTTTCTCTCACGCTGTAAGTGGTGTAGGGTATAGCACACGCGCGAGGAACGTGAA
TTGGGGGATGAGGAGTTTAT

Downstream 100 bases:

>100_bases
CTGATGAACGGTAAGCAGTGTTTTTGCTTTTTTTTGTTTCACCTGTTTTATACAGGACTATTTGCATGCGGAAAGCCTGA
GTCGTCTCTTGCGCCAGAGT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MEGQTARRVITEAKFLDDCLTERDSYYLSKLDELYSSAMSSFAQFEDQQNGARSARAEENIIATYDSIGNLMQEICKELP
ALKVYSFETQRENHAEVSRVVSKLRNIHTGYSEFIYYTQRAFEMLFRLAYGGSHEEHKTYLITKTPVAFPVQNYAVHKIA
NVDYKIENTVMCVMLRGALLPSMIVSKEIEEYSSHGYVTPFALFKIKRDDLRDERDMQYVFDLDKSYFSARELDGKDLVF
ADPMNATGGSLVTIVRYLQDLGVKPKSISCFHMISALKGAIRVVRSLENCTVYTLWMDPVLNARAYIMPGLGDAGDRVNG
VDVEDYPRNIIQLLADYGSNISGLYRSQLRKIEETVLGSR

Sequences:

>Translated_360_residues
MEGQTARRVITEAKFLDDCLTERDSYYLSKLDELYSSAMSSFAQFEDQQNGARSARAEENIIATYDSIGNLMQEICKELP
ALKVYSFETQRENHAEVSRVVSKLRNIHTGYSEFIYYTQRAFEMLFRLAYGGSHEEHKTYLITKTPVAFPVQNYAVHKIA
NVDYKIENTVMCVMLRGALLPSMIVSKEIEEYSSHGYVTPFALFKIKRDDLRDERDMQYVFDLDKSYFSARELDGKDLVF
ADPMNATGGSLVTIVRYLQDLGVKPKSISCFHMISALKGAIRVVRSLENCTVYTLWMDPVLNARAYIMPGLGDAGDRVNG
VDVEDYPRNIIQLLADYGSNISGLYRSQLRKIEETVLGSR
>Mature_360_residues
MEGQTARRVITEAKFLDDCLTERDSYYLSKLDELYSSAMSSFAQFEDQQNGARSARAEENIIATYDSIGNLMQEICKELP
ALKVYSFETQRENHAEVSRVVSKLRNIHTGYSEFIYYTQRAFEMLFRLAYGGSHEEHKTYLITKTPVAFPVQNYAVHKIA
NVDYKIENTVMCVMLRGALLPSMIVSKEIEEYSSHGYVTPFALFKIKRDDLRDERDMQYVFDLDKSYFSARELDGKDLVF
ADPMNATGGSLVTIVRYLQDLGVKPKSISCFHMISALKGAIRVVRSLENCTVYTLWMDPVLNARAYIMPGLGDAGDRVNG
VDVEDYPRNIIQLLADYGSNISGLYRSQLRKIEETVLGSR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (Potential)

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family. Highly divergent

Homologues:

None

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_TREPA (O83462)

Other databases:

- EMBL:   AE000520
- PIR:   H71324
- RefSeq:   NP_218888.1
- ProteinModelPortal:   O83462
- SMR:   O83462
- GeneID:   2611011
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0448
- NMPDR:   fig|243276.1.peg.447
- TIGR:   TP_0448
- HOGENOM:   HBG250973
- OMA:   TEHENHA
- ProtClustDB:   CLSK218708
- BioCyc:   TPAL243276:TP_0448-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B

Pfam domain/function: NA

EC number: =2.4.2.9

Molecular weight: Translated: 41018; Mature: 41018

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: BINDING 205-205 BINDING 307-307 BINDING 313-313

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGQTARRVITEAKFLDDCLTERDSYYLSKLDELYSSAMSSFAQFEDQQNGARSARAEEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
IIATYDSIGNLMQEICKELPALKVYSFETQRENHAEVSRVVSKLRNIHTGYSEFIYYTQR
CEEHHHHHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AFEMLFRLAYGGSHEEHKTYLITKTPVAFPVQNYAVHKIANVDYKIENTVMCVMLRGALL
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
PSMIVSKEIEEYSSHGYVTPFALFKIKRDDLRDERDMQYVFDLDKSYFSARELDGKDLVF
HHHHHHHHHHHHHCCCCCCHHHHEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
ADPMNATGGSLVTIVRYLQDLGVKPKSISCFHMISALKGAIRVVRSLENCTVYTLWMDPV
ECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCH
LNARAYIMPGLGDAGDRVNGVDVEDYPRNIIQLLADYGSNISGLYRSQLRKIEETVLGSR
HCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEGQTARRVITEAKFLDDCLTERDSYYLSKLDELYSSAMSSFAQFEDQQNGARSARAEEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
IIATYDSIGNLMQEICKELPALKVYSFETQRENHAEVSRVVSKLRNIHTGYSEFIYYTQR
CEEHHHHHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AFEMLFRLAYGGSHEEHKTYLITKTPVAFPVQNYAVHKIANVDYKIENTVMCVMLRGALL
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
PSMIVSKEIEEYSSHGYVTPFALFKIKRDDLRDERDMQYVFDLDKSYFSARELDGKDLVF
HHHHHHHHHHHHHCCCCCCHHHHEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
ADPMNATGGSLVTIVRYLQDLGVKPKSISCFHMISALKGAIRVVRSLENCTVYTLWMDPV
ECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCH
LNARAYIMPGLGDAGDRVNGVDVEDYPRNIIQLLADYGSNISGLYRSQLRKIEETVLGSR
HCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876