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The map label for this gene is galK [C]

Identifier: 189025651

GI number: 189025651

Start: 446921

End: 448114

Strand: Direct

Name: galK [C]

Synonym: TPASS_0418

Alternate gene names: 189025651

Gene position: 446921-448114 (Clockwise)

Preceding gene: 189025648

Following gene: 189025652

Centisome position: 39.22

GC content: 54.52

Gene sequence:

>1194_bases
TTGTTGTATTATTTCAATACACTGGCTATGATGCTGCGCATGCAGCGGGTAGAGTCCTGCCACACAGAGGAGTACGGCGA
CGAGCCTGAGGCGATTGCAGTCGTTCCGGGTCGTTTTCACCTGTTGGGGGAGTATCTGTGGTTTGCTCAGGGCAACACCC
TGTCGATGGCTATCGATCAAACCCTTACGCTGTGTGTCTCGCGCCGAAAGGATAGCACCTTTCGCCTTTTCTCCTTAACG
CTTGGGGAGCGGAGGAAGATTTCCACCGCTAATTTACGCTATCGTAAGGAGGATCGCTGGGCTAATTCGGTAAAGGCGGT
CATTCTCTCCTTCATGGATGGTGGGTATCACCTGACGGGGTTGAACTGCACTATCCTTTCTCAGATTCCTCCTGATGCGG
GGCTGGGTACTCCCAATGCGCTGAAGGTTGCCATGGCCCTTGTGCTTGGAAGGTTGTTTGCCGCTACGCTGCCAAAGGAA
AGTGTTGTTTCGATCGTGGAACACGCAAATGAGCGCTATCTCAAGACCCACGCACATCGCGCGGATATTCTGTGCGTGTT
GTTTGCAAAGCAGGGTAGCTGCGTGCGCACTGATCACCGCAAGAAGCAGGCGGAACTGTGTCAATTTCCCTCGGAGGGGA
AGCGTATTGTGCTTACTGACTCGCGTGTTCCCCGTTTCATCGCGCGTGAGGAGTTCACCGCGCGTTTGAAGCGTTGCGTG
GATGCTTATGAATTGGTGAAGCGCAATCCCGATATGCCTCGCGCTATGTCTAAGCTCATGGCAGCAGCGTTGGAGGAAAT
AGATGTGCCTGAGGGAATACGGAGGCGAGTGATCAGTTTGGTGCGCGAGTCGCTGGGCGTTGATGAGGCGATTGAAGCCC
TGCGTAAGCGGGATTTTGCTGCGTTCTCAAGAGTAGTGAACCGCTCTCATGAGCGCCTGCGGGACCGCTTTGAAATTTCT
TGTCCAGAACTCGATTGGTTGGTGAAGCGTGCGCTTGAGTTTGTAGATCCTGATGCGCCGGATGTGGTCTGCTCGCGCCT
CACGGGTCGGGGCTTTGGTGGGTGCACCTATGCGATTTTGCGCGATCAAGACTTTGAGCCGTACCTAGAAAGGCTCGACG
AGTACGAGCGCATCTTCGGTTTCAAAGCAGCGGCGTATGAGGTACAGTGCTCTGAAGGGGCCCGGGTGTTATGA

Upstream 100 bases:

>100_bases
AACTCGTTGGGAATCGCAAATGCCAAGAGCACCGCCGAGGCGGCGCTTGAAACAAGAGGCGCTGTGCAAAGCATAACTTT
CCCCTGCCAGAAAAGCATTT

Downstream 100 bases:

>100_bases
GGATACTACTGACAAACGATGATGGGTATCAGGCAGCAGGCATTCGCGCGCTGCATGCGGCGCTGAAAGCAGCGCCTGAG
GGGTATGAGGTGACGGTAGT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLYYFNTLAMMLRMQRVESCHTEEYGDEPEAIAVVPGRFHLLGEYLWFAQGNTLSMAIDQTLTLCVSRRKDSTFRLFSLT
LGERRKISTANLRYRKEDRWANSVKAVILSFMDGGYHLTGLNCTILSQIPPDAGLGTPNALKVAMALVLGRLFAATLPKE
SVVSIVEHANERYLKTHAHRADILCVLFAKQGSCVRTDHRKKQAELCQFPSEGKRIVLTDSRVPRFIAREEFTARLKRCV
DAYELVKRNPDMPRAMSKLMAAALEEIDVPEGIRRRVISLVRESLGVDEAIEALRKRDFAAFSRVVNRSHERLRDRFEIS
CPELDWLVKRALEFVDPDAPDVVCSRLTGRGFGGCTYAILRDQDFEPYLERLDEYERIFGFKAAAYEVQCSEGARVL

Sequences:

>Translated_397_residues
MLYYFNTLAMMLRMQRVESCHTEEYGDEPEAIAVVPGRFHLLGEYLWFAQGNTLSMAIDQTLTLCVSRRKDSTFRLFSLT
LGERRKISTANLRYRKEDRWANSVKAVILSFMDGGYHLTGLNCTILSQIPPDAGLGTPNALKVAMALVLGRLFAATLPKE
SVVSIVEHANERYLKTHAHRADILCVLFAKQGSCVRTDHRKKQAELCQFPSEGKRIVLTDSRVPRFIAREEFTARLKRCV
DAYELVKRNPDMPRAMSKLMAAALEEIDVPEGIRRRVISLVRESLGVDEAIEALRKRDFAAFSRVVNRSHERLRDRFEIS
CPELDWLVKRALEFVDPDAPDVVCSRLTGRGFGGCTYAILRDQDFEPYLERLDEYERIFGFKAAAYEVQCSEGARVL
>Mature_397_residues
MLYYFNTLAMMLRMQRVESCHTEEYGDEPEAIAVVPGRFHLLGEYLWFAQGNTLSMAIDQTLTLCVSRRKDSTFRLFSLT
LGERRKISTANLRYRKEDRWANSVKAVILSFMDGGYHLTGLNCTILSQIPPDAGLGTPNALKVAMALVLGRLFAATLPKE
SVVSIVEHANERYLKTHAHRADILCVLFAKQGSCVRTDHRKKQAELCQFPSEGKRIVLTDSRVPRFIAREEFTARLKRCV
DAYELVKRNPDMPRAMSKLMAAALEEIDVPEGIRRRVISLVRESLGVDEAIEALRKRDFAAFSRVVNRSHERLRDRFEIS
CPELDWLVKRALEFVDPDAPDVVCSRLTGRGFGGCTYAILRDQDFEPYLERLDEYERIFGFKAAAYEVQCSEGARVL

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=392, Percent_Identity=30.1020408163265, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI48527957, Length=448, Percent_Identity=23.8839285714286, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503897, Length=448, Percent_Identity=23.8839285714286, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786972, Length=384, Percent_Identity=24.21875, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_TREPA (O83433)

Other databases:

- EMBL:   AE000520
- PIR:   H71327
- RefSeq:   NP_218858.1
- ProteinModelPortal:   O83433
- SMR:   O83433
- IntAct:   O83433
- GeneID:   2610894
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0418
- NMPDR:   fig|243276.1.peg.417
- TIGR:   TP_0418
- HOGENOM:   HBG732005
- OMA:   DIPIGAG
- ProtClustDB:   CLSK218693
- BioCyc:   TPAL243276:TP_0418-MONOMER
- BRENDA:   2.7.1.6
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR019539
- InterPro:   IPR013750
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00959

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 45256; Mature: 45256

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYYFNTLAMMLRMQRVESCHTEEYGDEPEAIAVVPGRFHLLGEYLWFAQGNTLSMAIDQ
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEHHHHH
TLTLCVSRRKDSTFRLFSLTLGERRKISTANLRYRKEDRWANSVKAVILSFMDGGYHLTG
HHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCEECHHHHHHHHHHHHHHHHHCCCEEEEC
LNCTILSQIPPDAGLGTPNALKVAMALVLGRLFAATLPKESVVSIVEHANERYLKTHAHR
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ADILCVLFAKQGSCVRTDHRKKQAELCQFPSEGKRIVLTDSRVPRFIAREEFTARLKRCV
HCEEEEEEECCCCEECCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
DAYELVKRNPDMPRAMSKLMAAALEEIDVPEGIRRRVISLVRESLGVDEAIEALRKRDFA
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AFSRVVNRSHERLRDRFEISCPELDWLVKRALEFVDPDAPDVVCSRLTGRGFGGCTYAIL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEE
RDQDFEPYLERLDEYERIFGFKAAAYEVQCSEGARVL
ECCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCC
>Mature Secondary Structure
MLYYFNTLAMMLRMQRVESCHTEEYGDEPEAIAVVPGRFHLLGEYLWFAQGNTLSMAIDQ
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEHHHHH
TLTLCVSRRKDSTFRLFSLTLGERRKISTANLRYRKEDRWANSVKAVILSFMDGGYHLTG
HHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCEECHHHHHHHHHHHHHHHHHCCCEEEEC
LNCTILSQIPPDAGLGTPNALKVAMALVLGRLFAATLPKESVVSIVEHANERYLKTHAHR
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ADILCVLFAKQGSCVRTDHRKKQAELCQFPSEGKRIVLTDSRVPRFIAREEFTARLKRCV
HCEEEEEEECCCCEECCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
DAYELVKRNPDMPRAMSKLMAAALEEIDVPEGIRRRVISLVRESLGVDEAIEALRKRDFA
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AFSRVVNRSHERLRDRFEISCPELDWLVKRALEFVDPDAPDVVCSRLTGRGFGGCTYAIL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEE
RDQDFEPYLERLDEYERIFGFKAAAYEVQCSEGARVL
ECCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876