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The map label for this gene is tmk

Identifier: 189025587

GI number: 189025587

Start: 379150

End: 379776

Strand: Direct

Name: tmk

Synonym: TPASS_0354

Alternate gene names: 189025587

Gene position: 379150-379776 (Clockwise)

Preceding gene: 189025585

Following gene: 189025589

Centisome position: 33.27

GC content: 47.21

Gene sequence:

>627_bases
ATGAATATTCTGCATAACTTTGTTGTATTCGAAGGTATTGATGGCACAGGCACGAGTACACAGTTGCGTGCGCTCGAACG
CCATTTTCAGGCCCGTAAGGACATGGTCTTTACTCAAGAGCCTACCGGAGGGGAGATTGGCACTCTCATTCGGGATGTGC
TGCAAAAGCGTGTGATCATGAGCTCTAAGGCATTGGGATTGCTCTTTGCCGCAGATAGACACGAGCACTTGGAAGGTGCA
GGAGGCATTAACGATTGTCTTGCAGAAGGAAAGATAGTGCTCTGCGATCGGTATGTTTTTTCCAGTTTGGTGTACCAAGG
CATGGCGGTGTCGGGTAGTTTCGCGTATGAATTAAATAAAGAGTTTCCGCTTCCTGAAGTTGTGTTCTATTTTGACGCGC
CTATCGAAGTATGTGTTGAGCGTATCACCGCACGTGGGCTGCAAACGGAACTGTATGAGTACACGTCTTTTCAAGAAAAG
GCGCGCAAGGGGTATGAAACTATATTTCGCAAGTGCCGTCATTTGTACCCTGCAATGAAAGTGATTGAAATAGACGCGCG
CGAGGAAATTGAAGTTGTGCATGAGCGTATTCTTCACCATCTGCGCGAATACAGGCGTCTAAAATAG

Upstream 100 bases:

>100_bases
TCTTATTCTGCAAGGCGGTGTACACGTGCGCGTTGCACTTTCTCCTCGGGTGTACATGCTGCACTGTTTTTAGAGGAAAG
CTAACACGGAGAGGGCACAG

Downstream 100 bases:

>100_bases
TGTGTGGACGTAGATACACTATCTGAGGAGCAGTGGAGAGTATATATCAGGAACGTGCTTTGCAAGCGGAAGGCGCGTGC
TCGGTAAAACGGTGCTGCAC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNILHNFVVFEGIDGTGTSTQLRALERHFQARKDMVFTQEPTGGEIGTLIRDVLQKRVIMSSKALGLLFAADRHEHLEGA
GGINDCLAEGKIVLCDRYVFSSLVYQGMAVSGSFAYELNKEFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEK
ARKGYETIFRKCRHLYPAMKVIEIDAREEIEVVHERILHHLREYRRLK

Sequences:

>Translated_208_residues
MNILHNFVVFEGIDGTGTSTQLRALERHFQARKDMVFTQEPTGGEIGTLIRDVLQKRVIMSSKALGLLFAADRHEHLEGA
GGINDCLAEGKIVLCDRYVFSSLVYQGMAVSGSFAYELNKEFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEK
ARKGYETIFRKCRHLYPAMKVIEIDAREEIEVVHERILHHLREYRRLK
>Mature_208_residues
MNILHNFVVFEGIDGTGTSTQLRALERHFQARKDMVFTQEPTGGEIGTLIRDVLQKRVIMSSKALGLLFAADRHEHLEGA
GGINDCLAEGKIVLCDRYVFSSLVYQGMAVSGSFAYELNKEFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEK
ARKGYETIFRKCRHLYPAMKVIEIDAREEIEVVHERILHHLREYRRLK

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=197, Percent_Identity=28.4263959390863, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17535647, Length=166, Percent_Identity=30.7228915662651, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_TREPA (O83373)

Other databases:

- EMBL:   AE000520
- PIR:   H71333
- RefSeq:   NP_218794.1
- ProteinModelPortal:   O83373
- IntAct:   O83373
- GeneID:   2611500
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0354
- NMPDR:   fig|243276.1.peg.353
- TIGR:   TP_0354
- HOGENOM:   HBG626009
- OMA:   FTFEPTD
- ProtClustDB:   CLSK218653
- BioCyc:   TPAL243276:TP_0354-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23948; Mature: 23948

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILHNFVVFEGIDGTGTSTQLRALERHFQARKDMVFTQEPTGGEIGTLIRDVLQKRVIM
CCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHH
SSKALGLLFAADRHEHLEGAGGINDCLAEGKIVLCDRYVFSSLVYQGMAVSGSFAYELNK
HHHHHHHHEECCCHHHHCCCCCHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCEEEECCC
EFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEKARKGYETIFRKCRHLYPAMK
CCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEIDAREEIEVVHERILHHLREYRRLK
EEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNILHNFVVFEGIDGTGTSTQLRALERHFQARKDMVFTQEPTGGEIGTLIRDVLQKRVIM
CCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHH
SSKALGLLFAADRHEHLEGAGGINDCLAEGKIVLCDRYVFSSLVYQGMAVSGSFAYELNK
HHHHHHHHEECCCHHHHCCCCCHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCEEEECCC
EFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEKARKGYETIFRKCRHLYPAMK
CCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEIDAREEIEVVHERILHHLREYRRLK
EEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876