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The map label for this gene is murC

Identifier: 189025574

GI number: 189025574

Start: 364681

End: 366126

Strand: Direct

Name: murC

Synonym: TPASS_0341

Alternate gene names: 189025574

Gene position: 364681-366126 (Clockwise)

Preceding gene: 189025572

Following gene: 189025575

Centisome position: 32.0

GC content: 49.79

Gene sequence:

>1446_bases
ATGAAGCGGGGGACTCTACCAAAAGATGTGTCAGGTATCAAGATTCACATGATTGGTATCAAGGGCACTGGCATGTCTGC
GCTTGCAGAGCTACTGTGTGCACGGGGTGCCCGTGTGTCAGGTAGTGATGTTGCAGATGTGTTTTACACGGATAGGATTC
TCGCCCGTTTGGGTGTTCCCGTGCGTACTCCCTTTTCTTGCCAGAACCTTGCTGACGCTCCCGATGTGGTTATCCACTCT
GCAGCCTATGTGCCTGAAGAAAACGACGAGTTGGCAGAGGCGTACCGGCGGGGTATTCCTACCCTTACCTACCCAGAAGC
GCTGGGGGACATTTCCTGTGCGCGGTTTTCGTGTGGTATTGCAGGTGTTCATGGAAAGACGACCACGACCGCGATGATTG
CTCAAATGGTAAAGGAGCTGCGCCTTGATGCGTCCGTCCTTGTGGGGAGCGCTGTTTCGGGAAACAATGATTCTTGTGTG
GTTCTTAACGGAGATACCTTTTTTATCGCAGAAACGTGCGAGTACCGTCGGCATTTCCTGCATTTTCATCCTCAAAAGAT
TGTCCTCACCAGTGTTGAGCACGATCACCAGGATTATTACTCCTCGTACGAGGATATACTCGCGGCATACTTTCATTACA
TAGATAGGCTTCCTCAATTTGGTGAGTTATTTTATTGCGTGGATGACCAGGGCGTGCGGGAGGTAGTGCAGCTTGCGTTT
TTCAGTAGACCGGACCTGGTGTATGTTCCTTATGGGGAACGTGCGTGGGGCGATTATGGGGTCAGTATTCACGGTGTTCA
AGACCGGAAGATAAGCTTCTCATTGCGGGGTTTTGCAGGTGAGTTTTATGTTGCGCTCCCCGGTGAGCATAGTGTTTTGA
ATGCAACCGGTGCGCTCGCATTAGCACTGAGTTTAGTGAAGAAGCAGTATGGAGAGGTTACCGTTGAGCACCTCACCGCT
CTGCGGAAGGTACTCGCTCTTTTTCAGGGATGCCGGCGAAGGAGTGAAGTTCTTGGGGAAGTGCGCGGTATTTTGTTCAT
GGACGATTATGGACATCATCCGACTGCAATTAAAAAGACGCTCCGCGGGTTAAAAACGTTCTTTCCGGAAAGAAGAATTG
TCGTCGATTTTATGTCCCATACATATTCGCGTACCGCAGCCCTCCTCACCGAATTTGCTGAGTCTTTTCAGGATGCGGAT
GTAGTTATTTTGCATGAGATTTACGCCTCTGCTCGGGAAGTGTATCAGGGCGAGGTGAACGGTGAACATCTTTTTGAATT
AACTAAACGGAAGCACCGGCGGGTGTATTATTACGAGGCTGTCATGCAGGCAGTGCCTTTTTTGCAGGCTGAATTGAAAG
AGGGCGACCTGTTCGTTACGCTCGGCGCTGGAGACAATTGCAAATTGGGTGAGGTGTTGTTCAATTATTTTAAAGAGGAG
GTGTAA

Upstream 100 bases:

>100_bases
GTCGCACTATAATATGCGGTACGGAAGAGGCAGCAATCCTTGCCGGGAAAGAGAACTGATGTACATTGCTAAGGTCTGAC
ATTTGAGCTAAAATCCGCCC

Downstream 100 bases:

>100_bases
AGTTCGGTTGCGGTTTCGCCAACATGGTGGTGGTGCCGGCTGTGGATCTGGTGGATATAGGGTGAAGTGAGACAGGCTGC
GAATGGATGGTGATGCAAAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKRGTLPKDVSGIKIHMIGIKGTGMSALAELLCARGARVSGSDVADVFYTDRILARLGVPVRTPFSCQNLADAPDVVIHS
AAYVPEENDELAEAYRRGIPTLTYPEALGDISCARFSCGIAGVHGKTTTTAMIAQMVKELRLDASVLVGSAVSGNNDSCV
VLNGDTFFIAETCEYRRHFLHFHPQKIVLTSVEHDHQDYYSSYEDILAAYFHYIDRLPQFGELFYCVDDQGVREVVQLAF
FSRPDLVYVPYGERAWGDYGVSIHGVQDRKISFSLRGFAGEFYVALPGEHSVLNATGALALALSLVKKQYGEVTVEHLTA
LRKVLALFQGCRRRSEVLGEVRGILFMDDYGHHPTAIKKTLRGLKTFFPERRIVVDFMSHTYSRTAALLTEFAESFQDAD
VVILHEIYASAREVYQGEVNGEHLFELTKRKHRRVYYYEAVMQAVPFLQAELKEGDLFVTLGAGDNCKLGEVLFNYFKEE
V

Sequences:

>Translated_481_residues
MKRGTLPKDVSGIKIHMIGIKGTGMSALAELLCARGARVSGSDVADVFYTDRILARLGVPVRTPFSCQNLADAPDVVIHS
AAYVPEENDELAEAYRRGIPTLTYPEALGDISCARFSCGIAGVHGKTTTTAMIAQMVKELRLDASVLVGSAVSGNNDSCV
VLNGDTFFIAETCEYRRHFLHFHPQKIVLTSVEHDHQDYYSSYEDILAAYFHYIDRLPQFGELFYCVDDQGVREVVQLAF
FSRPDLVYVPYGERAWGDYGVSIHGVQDRKISFSLRGFAGEFYVALPGEHSVLNATGALALALSLVKKQYGEVTVEHLTA
LRKVLALFQGCRRRSEVLGEVRGILFMDDYGHHPTAIKKTLRGLKTFFPERRIVVDFMSHTYSRTAALLTEFAESFQDAD
VVILHEIYASAREVYQGEVNGEHLFELTKRKHRRVYYYEAVMQAVPFLQAELKEGDLFVTLGAGDNCKLGEVLFNYFKEE
V
>Mature_481_residues
MKRGTLPKDVSGIKIHMIGIKGTGMSALAELLCARGARVSGSDVADVFYTDRILARLGVPVRTPFSCQNLADAPDVVIHS
AAYVPEENDELAEAYRRGIPTLTYPEALGDISCARFSCGIAGVHGKTTTTAMIAQMVKELRLDASVLVGSAVSGNNDSCV
VLNGDTFFIAETCEYRRHFLHFHPQKIVLTSVEHDHQDYYSSYEDILAAYFHYIDRLPQFGELFYCVDDQGVREVVQLAF
FSRPDLVYVPYGERAWGDYGVSIHGVQDRKISFSLRGFAGEFYVALPGEHSVLNATGALALALSLVKKQYGEVTVEHLTA
LRKVLALFQGCRRRSEVLGEVRGILFMDDYGHHPTAIKKTLRGLKTFFPERRIVVDFMSHTYSRTAALLTEFAESFQDAD
VVILHEIYASAREVYQGEVNGEHLFELTKRKHRRVYYYEAVMQAVPFLQAELKEGDLFVTLGAGDNCKLGEVLFNYFKEE
V

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=472, Percent_Identity=27.5423728813559, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1790680, Length=362, Percent_Identity=28.4530386740331, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_TREPA (O83361)

Other databases:

- EMBL:   AE000520
- PIR:   C71338
- RefSeq:   NP_218781.1
- ProteinModelPortal:   O83361
- SMR:   O83361
- IntAct:   O83361
- MINT:   MINT-6481349
- GeneID:   2611429
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0341
- NMPDR:   fig|243276.1.peg.340
- TIGR:   TP_0341
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   TPAL243276:TP_0341-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53763; Mature: 53763

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGTLPKDVSGIKIHMIGIKGTGMSALAELLCARGARVSGSDVADVFYTDRILARLGVP
CCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
VRTPFSCQNLADAPDVVIHSAAYVPEENDELAEAYRRGIPTLTYPEALGDISCARFSCGI
CCCCCCCCCCCCCCHHHEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHCCCHHHHHCCCE
AGVHGKTTTTAMIAQMVKELRLDASVLVGSAVSGNNDSCVVLNGDTFFIAETCEYRRHFL
ECCCCCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCEEEEEECCEEEEEHHHHHHHHHH
HFHPQKIVLTSVEHDHQDYYSSYEDILAAYFHYIDRLPQFGELFYCVDDQGVREVVQLAF
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHH
FSRPDLVYVPYGERAWGDYGVSIHGVQDRKISFSLRGFAGEFYVALPGEHSVLNATGALA
CCCCCEEEECCCCCCCCCCCCEEECCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHH
LALSLVKKQYGEVTVEHLTALRKVLALFQGCRRRSEVLGEVRGILFMDDYGHHPTAIKKT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
LRGLKTFFPERRIVVDFMSHTYSRTAALLTEFAESFQDADVVILHEIYASAREVYQGEVN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
GEHLFELTKRKHRRVYYYEAVMQAVPFLQAELKEGDLFVTLGAGDNCKLGEVLFNYFKEE
HHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHC
V
C
>Mature Secondary Structure
MKRGTLPKDVSGIKIHMIGIKGTGMSALAELLCARGARVSGSDVADVFYTDRILARLGVP
CCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
VRTPFSCQNLADAPDVVIHSAAYVPEENDELAEAYRRGIPTLTYPEALGDISCARFSCGI
CCCCCCCCCCCCCCHHHEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHCCCHHHHHCCCE
AGVHGKTTTTAMIAQMVKELRLDASVLVGSAVSGNNDSCVVLNGDTFFIAETCEYRRHFL
ECCCCCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCEEEEEECCEEEEEHHHHHHHHHH
HFHPQKIVLTSVEHDHQDYYSSYEDILAAYFHYIDRLPQFGELFYCVDDQGVREVVQLAF
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHH
FSRPDLVYVPYGERAWGDYGVSIHGVQDRKISFSLRGFAGEFYVALPGEHSVLNATGALA
CCCCCEEEECCCCCCCCCCCCEEECCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHH
LALSLVKKQYGEVTVEHLTALRKVLALFQGCRRRSEVLGEVRGILFMDDYGHHPTAIKKT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
LRGLKTFFPERRIVVDFMSHTYSRTAALLTEFAESFQDADVVILHEIYASAREVYQGEVN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
GEHLFELTKRKHRRVYYYEAVMQAVPFLQAELKEGDLFVTLGAGDNCKLGEVLFNYFKEE
HHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876