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The map label for this gene is pgsA

Identifier: 189025490

GI number: 189025490

Start: 268626

End: 269276

Strand: Direct

Name: pgsA

Synonym: TPASS_0256

Alternate gene names: 189025490

Gene position: 268626-269276 (Clockwise)

Preceding gene: 189025489

Following gene: 189025491

Centisome position: 23.57

GC content: 47.77

Gene sequence:

>651_bases
ATGAGGCTTTCTGACTTTTATACTGCGCTGAGACTGGCGTTGGTTCTCCCTTTCTTTGCACTCTATCATATGTCACGTTG
GGTTGTTATGTACTTTCCTGCTGCCAATGTGGGGCGTGTGGTGTCTATCGCGTCGGTGCTGCTTTTTCTTTTCATTGCGT
GCACTGATTTCCTCGACGGTTATTACGCGCGCAAGTCAGGGAAGTATTCTAGTTTTGGGAAGGTTTTCGATCCCTTTGCT
GATGTGATAGCGAATGTAACTGTCATGCTTTGCCTCGTGGCAGACAACTTCATGCCGGTTTTTCTTTTTCTGTGTATTTT
GTATCGGGAATTTGGAATGATGTTCCTGAGAATGCTTGCGTGTGGCGAAGGTCACGTAGTTGGTGCCCAGAGAATGGGAA
AGCTGAAAACAGCCTCGTATATGGGTGCGGTCCTTTTTTCGCTTCTTTTGAAAGCATTGTACGCCTTTGAATTGGCTGGC
GCGGATTGGTATGAGCGCATGCGTGCGGTTGGCCGCCTGGTGTACGTGGTGCCAGTGGTATTGGCTCTTGCTTCTTTTTT
TTCTTACTTGAAGACTTTTTTCCCCATTCTCAAGCGCGTGTGTGGGCGTACCCGTTACCCTGTATGCAAGACATGTCGTG
AATGGGATTAA

Upstream 100 bases:

>100_bases
TAGATTCAGCAGGACGCATTGACAGGTTCAATAGGCGATACAAAATTCGAGGCTAGGAGTACACCTGTGGTGTACCATTA
CGTCTTTCCCCTAGGTGAGT

Downstream 100 bases:

>100_bases
AACTGAAGGTAGGATCAGCGCTCAGTGGAGATATGCGGCGTGCTACTATGCACGGTGACGATCTGTGCATTCTATAACAG
GGGAGGAGAGAAGTTTATGC

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRLSDFYTALRLALVLPFFALYHMSRWVVMYFPAANVGRVVSIASVLLFLFIACTDFLDGYYARKSGKYSSFGKVFDPFA
DVIANVTVMLCLVADNFMPVFLFLCILYREFGMMFLRMLACGEGHVVGAQRMGKLKTASYMGAVLFSLLLKALYAFELAG
ADWYERMRAVGRLVYVVPVVLALASFFSYLKTFFPILKRVCGRTRYPVCKTCREWD

Sequences:

>Translated_216_residues
MRLSDFYTALRLALVLPFFALYHMSRWVVMYFPAANVGRVVSIASVLLFLFIACTDFLDGYYARKSGKYSSFGKVFDPFA
DVIANVTVMLCLVADNFMPVFLFLCILYREFGMMFLRMLACGEGHVVGAQRMGKLKTASYMGAVLFSLLLKALYAFELAG
ADWYERMRAVGRLVYVVPVVLALASFFSYLKTFFPILKRVCGRTRYPVCKTCREWD
>Mature_216_residues
MRLSDFYTALRLALVLPFFALYHMSRWVVMYFPAANVGRVVSIASVLLFLFIACTDFLDGYYARKSGKYSSFGKVFDPFA
DVIANVTVMLCLVADNFMPVFLFLCILYREFGMMFLRMLACGEGHVVGAQRMGKLKTASYMGAVLFSLLLKALYAFELAG
ADWYERMRAVGRLVYVVPVVLALASFFSYLKTFFPILKRVCGRTRYPVCKTCREWD

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGSA_TREPA (O66076)

Other databases:

- EMBL:   U95744
- EMBL:   AE000520
- PIR:   E71346
- RefSeq:   NP_218697.1
- ProteinModelPortal:   O66076
- IntAct:   O66076
- GeneID:   2611722
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0256
- NMPDR:   fig|243276.1.peg.256
- TIGR:   TP_0256
- HOGENOM:   HBG686655
- OMA:   AAATIFI
- ProtClustDB:   CLSK218612
- BioCyc:   TPAL243276:TP_0256-MONOMER
- BRENDA:   2.7.8.5
- InterPro:   IPR000462
- InterPro:   IPR004570
- PIRSF:   PIRSF000847
- TIGRFAMs:   TIGR00560

Pfam domain/function: PF01066 CDP-OH_P_transf

EC number: =2.7.8.5

Molecular weight: Translated: 24639; Mature: 24639

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1fe15118)-; HASH(0x20bd8f04)-; HASH(0x208d22a4)-; HASH(0x1f263c70)-;

Cys/Met content:

3.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSDFYTALRLALVLPFFALYHMSRWVVMYFPAANVGRVVSIASVLLFLFIACTDFLDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
YYARKSGKYSSFGKVFDPFADVIANVTVMLCLVADNFMPVFLFLCILYREFGMMFLRMLA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
CGEGHVVGAQRMGKLKTASYMGAVLFSLLLKALYAFELAGADWYERMRAVGRLVYVVPVV
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LALASFFSYLKTFFPILKRVCGRTRYPVCKTCREWD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCH
>Mature Secondary Structure
MRLSDFYTALRLALVLPFFALYHMSRWVVMYFPAANVGRVVSIASVLLFLFIACTDFLDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
YYARKSGKYSSFGKVFDPFADVIANVTVMLCLVADNFMPVFLFLCILYREFGMMFLRMLA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
CGEGHVVGAQRMGKLKTASYMGAVLFSLLLKALYAFELAGADWYERMRAVGRLVYVVPVV
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LALASFFSYLKTFFPILKRVCGRTRYPVCKTCREWD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9665876