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The map label for this gene is ldhD

Identifier: 189025271

GI number: 189025271

Start: 44559

End: 45554

Strand: Reverse

Name: ldhD

Synonym: TPASS_0037

Alternate gene names: 189025271

Gene position: 45554-44559 (Counterclockwise)

Preceding gene: 189025272

Following gene: 189025268

Centisome position: 4.0

GC content: 51.51

Gene sequence:

>996_bases
ATGAGGTGTGTTGTCTTTAATCTTCGAGAAGAAGAAGCCCCTTACGTGGAGAAGTGGAAGCAGTCCCATCCAGGGGTAGT
CGTGGACACTTACGAGGAACCGTTGACCGCAAAGAACAAGGAGTTGCTTAAGGGGTATGAAGGGCTCGTGGTTATGCAGT
TTCTCGCTATGGAAGACGAGGTGTATGACTACATGGGTGCGTGCAAACTAAAAGTCCTTTCCACACGTACCGCAGGCTTT
GATATGTATAATGCAACTTTGCTGAAAAAGCACGGCATCCGGCTGACGAACGTACCGTCCTATTCACCGAATGCTATCGG
GGAATATGCACTCGCCGCCGCGTTGCAGCTGACGCGACATGCGCGCGAGATTGAAACTTTTGTAAGGAAGCGTGATTTTC
GCTGGCAAAAACCAATTCTCTCGAAGGAGCTCCGCTGCTCACGCGTAGGTATCTTGGGAACGGGCAGGATTGGACAGGCA
GCAGCAAGGCTCTTCAAAGGGGTTGGTGCTCAGGTAGTTGGTTTTGATCCGTACCCGAACGATGCCGCAAAGGAATGGTT
AACCTACGTGAGTATGGACGAGCTGCTGTCCACTAGCGACGTGATCAGCTTGCACATGCCTGCGACAAAGGACAGTCATC
ACCTGATCAATGCGAAAACAATCGCGCAGATGAAAGATGGCGTGTACCTGGTGAACACGGCACGCGGAGCAGTGATCGAC
AGTCAGGCGCTCTTAGACAGCTTGGACAAAGGCAAGATTGCAGGTGCTGCACTGGATGCGTACGAGTTTGAGGGTCCGTA
TATTCCTAAAGACAACGGGAACAACCCTATTACCGATACGGTCTATGCTCGGCTTGTCGCACATGAGCGTATCATCTATA
CCCCTCATATCGCCTTCTACACAGAAACAGCGATAGAGAACATGGTATTCAATTCGCTTGACGCCTGCACCACGGTGCTG
CGTGGGGAGCCTTGTGCCGCTGAAATCAAGCTGTAA

Upstream 100 bases:

>100_bases
GTAGATATCCTATATGTTATGTGTTTCCGCCCAGGTCCTGCGTGAGATACGTGCAGAACGTGGGTAAGGAATGTTGTTTG
CCTTACCAAGGAGGTGCGAA

Downstream 100 bases:

>100_bases
CTGACGCCAGGTGTCCCTGGTCCCGTGTGAGTCTGACTGGCTAATCGGTCAGTCTGGAGTCGCCAGCTCAGGGTGGGTTG
TGGGCTCCGCGGGACCCCGT

Product: D-specific D-2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGF
DMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQA
AARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVID
SQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVL
RGEPCAAEIKL

Sequences:

>Translated_331_residues
MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGF
DMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQA
AARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVID
SQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVL
RGEPCAAEIKL
>Mature_331_residues
MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGF
DMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQA
AARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVID
SQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVL
RGEPCAAEIKL

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

Homologues:

Organism=Homo sapiens, GI61743967, Length=244, Percent_Identity=33.1967213114754, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557497, Length=244, Percent_Identity=33.1967213114754, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI23308577, Length=266, Percent_Identity=31.203007518797, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI145580578, Length=244, Percent_Identity=31.9672131147541, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4557499, Length=244, Percent_Identity=31.9672131147541, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI6912396, Length=322, Percent_Identity=31.055900621118, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI145580575, Length=248, Percent_Identity=31.8548387096774, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1787645, Length=331, Percent_Identity=32.9305135951662, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI87082289, Length=262, Percent_Identity=28.2442748091603, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789279, Length=248, Percent_Identity=30.241935483871, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788660, Length=199, Percent_Identity=28.643216080402, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081824, Length=203, Percent_Identity=28.0788177339901, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=238, Percent_Identity=28.1512605042017, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=289, Percent_Identity=28.3737024221453, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=220, Percent_Identity=34.0909090909091, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=256, Percent_Identity=32.8125, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=220, Percent_Identity=33.6363636363636, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=279, Percent_Identity=25.8064516129032, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=124, Percent_Identity=33.8709677419355, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=81, Percent_Identity=39.5061728395062, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646446, Length=244, Percent_Identity=31.5573770491803, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646448, Length=244, Percent_Identity=31.5573770491803, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646452, Length=244, Percent_Identity=31.5573770491803, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646450, Length=244, Percent_Identity=31.5573770491803, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI62472511, Length=244, Percent_Identity=31.5573770491803, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI19921140, Length=265, Percent_Identity=29.0566037735849, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571528, Length=319, Percent_Identity=28.5266457680251, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585514, Length=290, Percent_Identity=27.5862068965517, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574282, Length=290, Percent_Identity=27.5862068965517, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552429, Length=290, Percent_Identity=27.5862068965517, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574284, Length=290, Percent_Identity=27.5862068965517, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551003, Length=290, Percent_Identity=27.5862068965517, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=27.0916334661355, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585516, Length=225, Percent_Identity=25.7777777777778, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LDHD_TREPA (O83080)

Other databases:

- EMBL:   AE000520
- PIR:   D71373
- RefSeq:   NP_218477.1
- ProteinModelPortal:   O83080
- SMR:   O83080
- IntAct:   O83080
- GeneID:   2611300
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0037
- NMPDR:   fig|243276.1.peg.36
- TIGR:   TP_0037
- HOGENOM:   HBG731446
- OMA:   THRAYAR
- ProtClustDB:   CLSK2300116
- BioCyc:   TPAL243276:TP_0037-MONOMER
- BRENDA:   1.1.1.28
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.28

Molecular weight: Translated: 36874; Mature: 36874

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 235-235 ACT_SITE 264-264 ACT_SITE 296-296 BINDING 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDE
CEEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHCHHHHHHHHHHHHH
VYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRH
HHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
AREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPN
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCEEEECCCCCC
DAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVID
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECHHHHHHHHCCEEEEECCCCCEEC
SQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFY
HHHHHHHHCCCCCCCEEEECEECCCCCCCCCCCCCCCHHHHHHHHHHHCEEEECCCHHHH
TETAIENMVFNSLDACTTVLRGEPCAAEIKL
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
>Mature Secondary Structure
MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDE
CEEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHCHHHHHHHHHHHHH
VYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRH
HHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
AREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPN
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCEEEECCCCCC
DAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVID
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECHHHHHHHHCCEEEEECCCCCEEC
SQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFY
HHHHHHHHCCCCCCCEEEECEECCCCCCCCCCCCCCCHHHHHHHHHHHCEEEECCCHHHH
TETAIENMVFNSLDACTTVLRGEPCAAEIKL
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876