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The map label for this gene is fba [H]

Identifier: 188587468

GI number: 188587468

Start: 3109425

End: 3110279

Strand: Reverse

Name: fba [H]

Synonym: Nther_2878

Alternate gene names: 188587468

Gene position: 3110279-3109425 (Counterclockwise)

Preceding gene: 188587469

Following gene: 188587467

Centisome position: 98.25

GC content: 39.53

Gene sequence:

>855_bases
ATGCCATTAGTTAAAGGCAAACAACTGGTAGATATAGCGGAGCGGAATGGCTTTGCTGTTGGTGCATTTAATGTGAACAA
TCTTGAAATTATCAAAGCTATCATTGAATCTGCTCAAGAAGAACGTTCACCTGCAATTTTACAGGCTAGTCAGGGAGCTA
TTAAATATGCCGGAATTGATTTTATCGTTGCCATGGTAAAAGCTGCTAGTGAACAAGTTGATGTTCCCCTTGCGCTACAT
TTAGATCATGGAACTAGCTTTGAACAAAACATGCAGTGTATCAGGAAAGGATTCACTTCTGTTATGTTTGACGGCTCTAA
ATACTCTCTAGAGGAAAATATTCACAAAACTCGACAAGTGGTTCAAGTAGGGCAAGCTGCTGGTGTATCCGTTGAAGGTG
AACTGGGTAAAATTGCAGGTACAGAGGATGATATTTCTGTTGATGAAAGAGAGGCTTTCATGACAGATCCTAAGGAAGCT
GAACGATTTATGCGAGAGACAGAAGTTGATTATTTGGCTGTTGCCATTGGGACTGCCCATGGTCCATATAAAGGTGAGCC
AAAATTGGACTTTGACAGACTTAAAAAAATCAGAGAATTGACTGAAGCTCCCATTGTGATGCACGGTGCTTCAGGAGTAC
CAGAAGAATCTATTAAAAAAGGGATTGAGCTAGGAGTTCGAAAGATCAATATTGATACTGAATTGCGACAGGCCTTTACT
TCTGGATTAAAAGGGGTTATTTCAGAAAAACCGGAAGAATATGACCCAAGAAAACTATTAGGCCCTGCCAAGGACTCTAT
GAAAGAAGTTATTAAAGAAAAAATGCGATTATTTGGGTCTTCAGGAAAAGTATAA

Upstream 100 bases:

>100_bases
ACAGCCTAATTATAATATTATTGTAGGGAGTTTCCGCTTCTTAGGAAGCGGAGAATTTTTGTTAGTTAGTTTAAACGATA
CATAATAGGAGGGAGTACCA

Downstream 100 bases:

>100_bases
TATTACACCACTGAAGGGTGATGAAGTATATGAAAATATTTTTAGACACTGCCAACTTAAATGATATAAAAGCGGGAGTA
TCTTTAGGTGTCGTAGATGG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MPLVKGKQLVDIAERNGFAVGAFNVNNLEIIKAIIESAQEERSPAILQASQGAIKYAGIDFIVAMVKAASEQVDVPLALH
LDHGTSFEQNMQCIRKGFTSVMFDGSKYSLEENIHKTRQVVQVGQAAGVSVEGELGKIAGTEDDISVDEREAFMTDPKEA
ERFMRETEVDYLAVAIGTAHGPYKGEPKLDFDRLKKIRELTEAPIVMHGASGVPEESIKKGIELGVRKINIDTELRQAFT
SGLKGVISEKPEEYDPRKLLGPAKDSMKEVIKEKMRLFGSSGKV

Sequences:

>Translated_284_residues
MPLVKGKQLVDIAERNGFAVGAFNVNNLEIIKAIIESAQEERSPAILQASQGAIKYAGIDFIVAMVKAASEQVDVPLALH
LDHGTSFEQNMQCIRKGFTSVMFDGSKYSLEENIHKTRQVVQVGQAAGVSVEGELGKIAGTEDDISVDEREAFMTDPKEA
ERFMRETEVDYLAVAIGTAHGPYKGEPKLDFDRLKKIRELTEAPIVMHGASGVPEESIKKGIELGVRKINIDTELRQAFT
SGLKGVISEKPEEYDPRKLLGPAKDSMKEVIKEKMRLFGSSGKV
>Mature_283_residues
PLVKGKQLVDIAERNGFAVGAFNVNNLEIIKAIIESAQEERSPAILQASQGAIKYAGIDFIVAMVKAASEQVDVPLALHL
DHGTSFEQNMQCIRKGFTSVMFDGSKYSLEENIHKTRQVVQVGQAAGVSVEGELGKIAGTEDDISVDEREAFMTDPKEAE
RFMRETEVDYLAVAIGTAHGPYKGEPKLDFDRLKKIRELTEAPIVMHGASGVPEESIKKGIELGVRKINIDTELRQAFTS
GLKGVISEKPEEYDPRKLLGPAKDSMKEVIKEKMRLFGSSGKV

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=284, Percent_Identity=45.0704225352113, Blast_Score=267, Evalue=6e-73,
Organism=Escherichia coli, GI87082041, Length=283, Percent_Identity=42.4028268551237, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1788072, Length=271, Percent_Identity=36.1623616236162, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1789293, Length=324, Percent_Identity=26.2345679012346, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322790, Length=342, Percent_Identity=24.2690058479532, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31148; Mature: 31017

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00602 ALDOLASE_CLASS_II_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVKGKQLVDIAERNGFAVGAFNVNNLEIIKAIIESAQEERSPAILQASQGAIKYAGID
CCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEHHHHH
FIVAMVKAASEQVDVPLALHLDHGTSFEQNMQCIRKGFTSVMFDGSKYSLEENIHKTRQV
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
VQVGQAAGVSVEGELGKIAGTEDDISVDEREAFMTDPKEAERFMRETEVDYLAVAIGTAH
HHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCC
GPYKGEPKLDFDRLKKIRELTEAPIVMHGASGVPEESIKKGIELGVRKINIDTELRQAFT
CCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCEEECCCHHHHHHHH
SGLKGVISEKPEEYDPRKLLGPAKDSMKEVIKEKMRLFGSSGKV
HHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLVKGKQLVDIAERNGFAVGAFNVNNLEIIKAIIESAQEERSPAILQASQGAIKYAGID
CCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEHHHHH
FIVAMVKAASEQVDVPLALHLDHGTSFEQNMQCIRKGFTSVMFDGSKYSLEENIHKTRQV
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
VQVGQAAGVSVEGELGKIAGTEDDISVDEREAFMTDPKEAERFMRETEVDYLAVAIGTAH
HHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCC
GPYKGEPKLDFDRLKKIRELTEAPIVMHGASGVPEESIKKGIELGVRKINIDTELRQAFT
CCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCEEECCCHHHHHHHH
SGLKGVISEKPEEYDPRKLLGPAKDSMKEVIKEKMRLFGSSGKV
HHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]