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The map label for this gene is ywrD [H]

Identifier: 188587400

GI number: 188587400

Start: 3034425

End: 3036038

Strand: Reverse

Name: ywrD [H]

Synonym: Nther_2809

Alternate gene names: 188587400

Gene position: 3036038-3034425 (Counterclockwise)

Preceding gene: 188587401

Following gene: 188587399

Centisome position: 95.91

GC content: 41.76

Gene sequence:

>1614_bases
ATGCTGAAGTTTGACTCTTTGAATCATCCGTATTCGTCTCGAAGAAGTGTTACAATGGCTCGGAACGGAATGGTAGCCAC
TTCACAACCATTGGCTGCCAATGCTGGCTTAGAAATTTTAAAACAAGGTGGAAATGCCATTGATGCCGCTGTTGCAACTG
CTGCCTGCTTGACTGTCGTTGAACCCACTTCAAATGGTATAGGTGGTGATGCATTTGCCCTGGTATGGCATCAAGGGAAA
CTCCACGGTTTAAATTCTAGTGGGCCTTCTCCAGAACAAATTTCTAGAGAGGCATTAATCAAAAAAGGATATGATAAAGT
TCCCAATTTTGGGGTTTTACCTGTTACAGTACCTGGAGCACCAGCTTCTTGGGTAGAACTTAATGAACAAATGGGGAGGT
TACCTCTGGAAAAGGTTTTAGAACCCGCCATTGAATATGCCCGGAAAGGATTCCCCATAACTCCAGTACTCGGCAAGAAC
TGGGATAGAGCTTTCAATAAATATAAGCAAGAATGGCAAGGTGAAGAGTATTCCGAATGGTTTCGTGTGTTTGCTCCCCA
TGGTCGTGCGCCGATGATTGGTGAAATGTGGAGTTCCCAGGACCATGGTGACACTCTAGAAAAAATTGCAGAAACCCGGG
GGGATTACTTTTATAAAGGTGAGTTAGCAGATAATGTAGATTATTTCTTTAAAAAATACGGTGGTTATCTTAGGGGAAGT
GATTTAGAGTCATTTACCCCAGAGTGGGTGGACCCTATTAGTTTAAATTATCGTGGTTATGATATTTGGGAAATACCACC
TAATGGGCAGGGGATAGTTGCACTAATGGCTTTAAATATACTTCAGCATGACGACTTTGAATCCAAGGAACTTTTATCTA
CTTATCATCGCCAGATTGAAGCTTTAAAGCTTGCTTTTATAGACGGAAAAAAATATATTACGGATCCTCATCACATGAAA
GTTGATATTGATGATTTATTATCTGAAGACTATGCCCGGGAGCGAAGAGCTTTAATTAAGGATGAAGCTATAACTCCAGA
ACCTGGTTCTCCTCCTCGAGGTGGTACAGTGTATTTAGCTACAGCAGATGGAGAGGGCAATATGGTATCCTTTATTCAGA
GTAATTATATGGGTTTCGGATCTGGAATTGTATTGCCAGGAACTGGGGTAGCCTTTCAAAATAGAGGCTGTAGTTTTTCA
CTTGACTCTTCCCATGATAATGTCCTGGAATCAGGCAAGAAAACGTACCATACCATTATTCCTGGTTTCATGTCTAAAGG
TAAAGATCCAATTGGTCCCTTTGGAGTCATGGGTGGTTTTATGCAGCCTCAAGGTCATTTACAAGTTGTGATGAATACTG
TGGACTTTGATTTAAATCCACAAGCAGCTCTGGATGCACCTAGATGGCAGTGGATAAAAGATAAACAAGTTTCCGTAGAA
AGAAAACTTCCTGCTCACATTGCGGAAGGATTATATCGCAGAGGACATGATATTAACGTTAGTCTGGATTCTGGAAGCTT
CGGGCGAGGGCAAATCATCTGGCGTGATCCTCAAAGTGGAGTACTTTTTGGTGGTACAGAACCACGGACAGATGGTTCTA
TAGCAGTTTATTAA

Upstream 100 bases:

>100_bases
TACATTTGATAAGATATTCATAAATTTAGAAAGTTAGCATAAATTTAGAAGGTTAGATAGCTTTGTAGATTTTAAAGGAT
ACTAAACTGGAGGGGTTGTT

Downstream 100 bases:

>100_bases
ATTTAAAAAAGCCGATTGTTTTAATCAATATGTTGAAAATAATATATTGCCTCGAAAGGAAGTGAATTTTGGATAATCAG
GCAACAGGCACAGCCTATTT

Product: gamma-glutamyltransferase 2. Threonine peptidase. MEROPS family T03

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MLKFDSLNHPYSSRRSVTMARNGMVATSQPLAANAGLEILKQGGNAIDAAVATAACLTVVEPTSNGIGGDAFALVWHQGK
LHGLNSSGPSPEQISREALIKKGYDKVPNFGVLPVTVPGAPASWVELNEQMGRLPLEKVLEPAIEYARKGFPITPVLGKN
WDRAFNKYKQEWQGEEYSEWFRVFAPHGRAPMIGEMWSSQDHGDTLEKIAETRGDYFYKGELADNVDYFFKKYGGYLRGS
DLESFTPEWVDPISLNYRGYDIWEIPPNGQGIVALMALNILQHDDFESKELLSTYHRQIEALKLAFIDGKKYITDPHHMK
VDIDDLLSEDYARERRALIKDEAITPEPGSPPRGGTVYLATADGEGNMVSFIQSNYMGFGSGIVLPGTGVAFQNRGCSFS
LDSSHDNVLESGKKTYHTIIPGFMSKGKDPIGPFGVMGGFMQPQGHLQVVMNTVDFDLNPQAALDAPRWQWIKDKQVSVE
RKLPAHIAEGLYRRGHDINVSLDSGSFGRGQIIWRDPQSGVLFGGTEPRTDGSIAVY

Sequences:

>Translated_537_residues
MLKFDSLNHPYSSRRSVTMARNGMVATSQPLAANAGLEILKQGGNAIDAAVATAACLTVVEPTSNGIGGDAFALVWHQGK
LHGLNSSGPSPEQISREALIKKGYDKVPNFGVLPVTVPGAPASWVELNEQMGRLPLEKVLEPAIEYARKGFPITPVLGKN
WDRAFNKYKQEWQGEEYSEWFRVFAPHGRAPMIGEMWSSQDHGDTLEKIAETRGDYFYKGELADNVDYFFKKYGGYLRGS
DLESFTPEWVDPISLNYRGYDIWEIPPNGQGIVALMALNILQHDDFESKELLSTYHRQIEALKLAFIDGKKYITDPHHMK
VDIDDLLSEDYARERRALIKDEAITPEPGSPPRGGTVYLATADGEGNMVSFIQSNYMGFGSGIVLPGTGVAFQNRGCSFS
LDSSHDNVLESGKKTYHTIIPGFMSKGKDPIGPFGVMGGFMQPQGHLQVVMNTVDFDLNPQAALDAPRWQWIKDKQVSVE
RKLPAHIAEGLYRRGHDINVSLDSGSFGRGQIIWRDPQSGVLFGGTEPRTDGSIAVY
>Mature_537_residues
MLKFDSLNHPYSSRRSVTMARNGMVATSQPLAANAGLEILKQGGNAIDAAVATAACLTVVEPTSNGIGGDAFALVWHQGK
LHGLNSSGPSPEQISREALIKKGYDKVPNFGVLPVTVPGAPASWVELNEQMGRLPLEKVLEPAIEYARKGFPITPVLGKN
WDRAFNKYKQEWQGEEYSEWFRVFAPHGRAPMIGEMWSSQDHGDTLEKIAETRGDYFYKGELADNVDYFFKKYGGYLRGS
DLESFTPEWVDPISLNYRGYDIWEIPPNGQGIVALMALNILQHDDFESKELLSTYHRQIEALKLAFIDGKKYITDPHHMK
VDIDDLLSEDYARERRALIKDEAITPEPGSPPRGGTVYLATADGEGNMVSFIQSNYMGFGSGIVLPGTGVAFQNRGCSFS
LDSSHDNVLESGKKTYHTIIPGFMSKGKDPIGPFGVMGGFMQPQGHLQVVMNTVDFDLNPQAALDAPRWQWIKDKQVSVE
RKLPAHIAEGLYRRGHDINVSLDSGSFGRGQIIWRDPQSGVLFGGTEPRTDGSIAVY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=510, Percent_Identity=25.0980392156863, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI73915090, Length=510, Percent_Identity=25.0980392156863, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI73915096, Length=510, Percent_Identity=25.0980392156863, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI73915094, Length=510, Percent_Identity=25.0980392156863, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI113429324, Length=514, Percent_Identity=24.5136186770428, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=24.5714285714286, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI109148539, Length=542, Percent_Identity=26.5682656826568, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1789856, Length=540, Percent_Identity=28.7037037037037, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI193208245, Length=515, Percent_Identity=23.3009708737864, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI193208247, Length=515, Percent_Identity=23.3009708737864, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17506189, Length=516, Percent_Identity=23.8372093023256, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212646519, Length=491, Percent_Identity=23.2179226069246, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI72000294, Length=491, Percent_Identity=23.2179226069246, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17542894, Length=407, Percent_Identity=25.5528255528256, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161077880, Length=521, Percent_Identity=24.1842610364683, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45551474, Length=521, Percent_Identity=24.1842610364683, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI161077878, Length=520, Percent_Identity=24.2307692307692, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24642670, Length=521, Percent_Identity=24.1842610364683, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24642666, Length=521, Percent_Identity=24.1842610364683, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18859893, Length=512, Percent_Identity=23.046875, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161077496, Length=536, Percent_Identity=22.3880597014925, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59321; Mature: 59321

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKFDSLNHPYSSRRSVTMARNGMVATSQPLAANAGLEILKQGGNAIDAAVATAACLTVV
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHEEE
EPTSNGIGGDAFALVWHQGKLHGLNSSGPSPEQISREALIKKGYDKVPNFGVLPVTVPGA
CCCCCCCCCCEEEEEEECCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
PASWVELNEQMGRLPLEKVLEPAIEYARKGFPITPVLGKNWDRAFNKYKQEWQGEEYSEW
CHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
FRVFAPHGRAPMIGEMWSSQDHGDTLEKIAETRGDYFYKGELADNVDYFFKKYGGYLRGS
HHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCC
DLESFTPEWVDPISLNYRGYDIWEIPPNGQGIVALMALNILQHDDFESKELLSTYHRQIE
CCCCCCCCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ALKLAFIDGKKYITDPHHMKVDIDDLLSEDYARERRALIKDEAITPEPGSPPRGGTVYLA
HEEEEEECCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
TADGEGNMVSFIQSNYMGFGSGIVLPGTGVAFQNRGCSFSLDSSHDNVLESGKKTYHTII
EECCCCCEEHHHHHCCCCCCCCEEECCCCCEECCCCCEEEECCCCHHHHHCCCHHHHHHH
PGFMSKGKDPIGPFGVMGGFMQPQGHLQVVMNTVDFDLNPQAALDAPRWQWIKDKQVSVE
HHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCEECCCCCCCHH
RKLPAHIAEGLYRRGHDINVSLDSGSFGRGQIIWRDPQSGVLFGGTEPRTDGSIAVY
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEC
>Mature Secondary Structure
MLKFDSLNHPYSSRRSVTMARNGMVATSQPLAANAGLEILKQGGNAIDAAVATAACLTVV
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHEEE
EPTSNGIGGDAFALVWHQGKLHGLNSSGPSPEQISREALIKKGYDKVPNFGVLPVTVPGA
CCCCCCCCCCEEEEEEECCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
PASWVELNEQMGRLPLEKVLEPAIEYARKGFPITPVLGKNWDRAFNKYKQEWQGEEYSEW
CHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
FRVFAPHGRAPMIGEMWSSQDHGDTLEKIAETRGDYFYKGELADNVDYFFKKYGGYLRGS
HHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCC
DLESFTPEWVDPISLNYRGYDIWEIPPNGQGIVALMALNILQHDDFESKELLSTYHRQIE
CCCCCCCCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ALKLAFIDGKKYITDPHHMKVDIDDLLSEDYARERRALIKDEAITPEPGSPPRGGTVYLA
HEEEEEECCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
TADGEGNMVSFIQSNYMGFGSGIVLPGTGVAFQNRGCSFSLDSSHDNVLESGKKTYHTII
EECCCCCEEHHHHHCCCCCCCCEEECCCCCEECCCCCEEEECCCCHHHHHCCCHHHHHHH
PGFMSKGKDPIGPFGVMGGFMQPQGHLQVVMNTVDFDLNPQAALDAPRWQWIKDKQVSVE
HHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCEECCCCCCCHH
RKLPAHIAEGLYRRGHDINVSLDSGSFGRGQIIWRDPQSGVLFGGTEPRTDGSIAVY
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]