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The map label for this gene is appC [H]

Identifier: 188587379

GI number: 188587379

Start: 3011664

End: 3012596

Strand: Reverse

Name: appC [H]

Synonym: Nther_2788

Alternate gene names: 188587379

Gene position: 3012596-3011664 (Counterclockwise)

Preceding gene: 188587380

Following gene: 188587378

Centisome position: 95.17

GC content: 39.44

Gene sequence:

>933_bases
ATGGCTCAAAGTACTGATATCAACAATTCAGATCACCGTGAAAATGGATCTGGAATCATCAATAGTTTACAAGAAAAAGA
TTATATTCTTTGGGTGAGACAGCTCTTAAAAAGTAAGACAGGTACTGTGGGTTTACTGATAGTTCTTGGAGTGGTCCTCC
TTGCTATTTTTGCACCCTATATTACTCCCCATGAACCTGATGCAATGAATGCGGCTGAAAGGCTCTCACCTCCAAGTTTT
ATAGAGGGAGGGAGTGGAGAACACATTTTGGGTACTGATAATGTCGGTAGAGATATATTTACCAGAATTTTATATGGAAC
GAGAATATCATTGTTTGTGGGAATCACATCAGTGGTTGTGGCAGGTATTATCGGAGTCACCTTAGGACTAATAGCTGGTT
ACTTTGGAGGAATTGTTGACAATATAATTATGAGAGTTGTGGATGCTTTTTTAGCTATCCCCAACATCTTACTTATACTG
GTAATACTTGCAGTCTTTGGGCCGAGCTTATGGACAGTTATCGGGGTTTTAGGAGCCACCAATTGGGTGGTTTATGCCAG
AATGATCCGGGGCGAGGTTTTGAGCGTTAAAGAACAGGAATATGTAAAAGCCAGTAAAACCATTGGTACTAAAAATACAG
CTATTATATTCAAGCATATTTTACCCAATGTTATGTCTACTTTTATTGTGATTTCGACTTTAAGAGTAGCAACTACTATA
ATCTTAGAAGCTTCATTGAGTTTTTTAGGACTGGGCATTCAGCCACCTCAAGTTTCCTGGGGTGGAATGTTAAGTGACGG
TAGAGACTATCTTGCTACTGCATGGTGGATTTCCACTTTTCCCGGAATAGCCATAACGATTACAGTATTGGGAATCATTT
TTTTGGGTGACTGGCTAAGAGATGTCTTGGACCCTAAAAGTCAAAATGCTTGA

Upstream 100 bases:

>100_bases
TAATTTCTTTTATGGTCATAATCGTGAATTTATTGGCAGATATTTTATACGGATTTGTTGATCCAAGGATAAATTACAGT
TAATGAAAGGAGGGCTCCTA

Downstream 100 bases:

>100_bases
TTAAACTTTATATTGTTGATTATATCAACTTTAACGGATAAACTTTAACGGATAAATGTATTAGAGTTAGAGGTAATAAT
TATAGATATAATTATTAAAC

Product: binding-protein-dependent transport systems inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MAQSTDINNSDHRENGSGIINSLQEKDYILWVRQLLKSKTGTVGLLIVLGVVLLAIFAPYITPHEPDAMNAAERLSPPSF
IEGGSGEHILGTDNVGRDIFTRILYGTRISLFVGITSVVVAGIIGVTLGLIAGYFGGIVDNIIMRVVDAFLAIPNILLIL
VILAVFGPSLWTVIGVLGATNWVVYARMIRGEVLSVKEQEYVKASKTIGTKNTAIIFKHILPNVMSTFIVISTLRVATTI
ILEASLSFLGLGIQPPQVSWGGMLSDGRDYLATAWWISTFPGIAITITVLGIIFLGDWLRDVLDPKSQNA

Sequences:

>Translated_310_residues
MAQSTDINNSDHRENGSGIINSLQEKDYILWVRQLLKSKTGTVGLLIVLGVVLLAIFAPYITPHEPDAMNAAERLSPPSF
IEGGSGEHILGTDNVGRDIFTRILYGTRISLFVGITSVVVAGIIGVTLGLIAGYFGGIVDNIIMRVVDAFLAIPNILLIL
VILAVFGPSLWTVIGVLGATNWVVYARMIRGEVLSVKEQEYVKASKTIGTKNTAIIFKHILPNVMSTFIVISTLRVATTI
ILEASLSFLGLGIQPPQVSWGGMLSDGRDYLATAWWISTFPGIAITITVLGIIFLGDWLRDVLDPKSQNA
>Mature_309_residues
AQSTDINNSDHRENGSGIINSLQEKDYILWVRQLLKSKTGTVGLLIVLGVVLLAIFAPYITPHEPDAMNAAERLSPPSFI
EGGSGEHILGTDNVGRDIFTRILYGTRISLFVGITSVVVAGIIGVTLGLIAGYFGGIVDNIIMRVVDAFLAIPNILLILV
ILAVFGPSLWTVIGVLGATNWVVYARMIRGEVLSVKEQEYVKASKTIGTKNTAIIFKHILPNVMSTFIVISTLRVATTII
LEASLSFLGLGIQPPQVSWGGMLSDGRDYLATAWWISTFPGIAITITVLGIIFLGDWLRDVLDPKSQNA

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787760, Length=268, Percent_Identity=40.2985074626866, Blast_Score=217, Evalue=8e-58,
Organism=Escherichia coli, GI1787054, Length=274, Percent_Identity=39.051094890511, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI1789964, Length=255, Percent_Identity=48.2352941176471, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1787498, Length=304, Percent_Identity=33.5526315789474, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1789889, Length=244, Percent_Identity=35.655737704918, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788505, Length=233, Percent_Identity=32.1888412017167, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787549, Length=271, Percent_Identity=32.1033210332103, Blast_Score=132, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33489; Mature: 33358

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSTDINNSDHRENGSGIINSLQEKDYILWVRQLLKSKTGTVGLLIVLGVVLLAIFAPY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
ITPHEPDAMNAAERLSPPSFIEGGSGEHILGTDNVGRDIFTRILYGTRISLFVGITSVVV
CCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AGIIGVTLGLIAGYFGGIVDNIIMRVVDAFLAIPNILLILVILAVFGPSLWTVIGVLGAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
NWVVYARMIRGEVLSVKEQEYVKASKTIGTKNTAIIFKHILPNVMSTFIVISTLRVATTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILEASLSFLGLGIQPPQVSWGGMLSDGRDYLATAWWISTFPGIAITITVLGIIFLGDWLR
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DVLDPKSQNA
HHCCCCCCCC
>Mature Secondary Structure 
AQSTDINNSDHRENGSGIINSLQEKDYILWVRQLLKSKTGTVGLLIVLGVVLLAIFAPY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC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HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]