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The map label for this gene is nhaC [H]

Identifier: 188587318

GI number: 188587318

Start: 2939247

End: 2940665

Strand: Direct

Name: nhaC [H]

Synonym: Nther_2723

Alternate gene names: 188587318

Gene position: 2939247-2940665 (Clockwise)

Preceding gene: 188587315

Following gene: 188587321

Centisome position: 92.85

GC content: 39.39

Gene sequence:

>1419_bases
ATGAATGAAGAAGCTAATTTAAAGCCCACTCTCGGGCAAGCACTAATACCTATTATATTTGTAATTATAGCTCTAAGTTA
CGGTATTATTGTTTGGGAAGTTGACCCTCACATTCCACTATTAATTGCAGGAGCTGTGGCAGCTTTTGTAGCCATAGTTA
TGGTTGGATACAAATGGGATACAATTGAAGACGGAATATTCAAAGGAATTATGCTTGCTATGCAGGCAATTGTCATACTA
ATGATTGTTGGTACTTTAATTGGCAGTTGGATCGAAGGCGGAGTTGTACCTGCCATGATTTATTACGGGTTACAAATCTT
ATCACCACAGATTTTCTTAGTAGCAGCAGCAATCATTTCAACTATAGTTGCCTTATTTGTTGGAAGTTCCTGGTCAACAG
CTGGAACAATTGGTATTGCCTTATTGGGAATTGGTGAAGGTTTAGGCGTGCCAGCAGCAATGACTGCCGGTGCAGTAGTT
TCAGGTGCTTATGTTGGGGACAAAATGTCACCATTATCAGATACTACAAACCTGGCACCTGGTACAACAGGTGATGTTAA
CGTATTCGATCACATCCGTCACATGCTGTATGTTACAATTCCAGCATATATTATTTCCCTGATTATTTTTGCTTTACTAG
GACTACAGTTCGCAGGACAATCTATGGAGCAGGGAGATATTGTTCTAATTAGTGAAACTATATCTGAACACTTTACAATT
AATCCAATCATGTTAATCCCAGTTCTATTTGTATTAGTACTAATTGGACTTAAAGTTCCTCCAATCCCAGGCTTACTTGG
AGGCAGTATCTTAGGCGGAATTTTTGCCTTGATATTCCAAGGAGCAGCTCCAGCTGATGTGATTGGATCAATGCATTACG
GTTATGTAATGGATTCAGGAGTGGAAGTTGTGGACGACCTACTTTCCGAAGGTGGACTTGACGGAATGATGTGGACCATT
TCATTAATTTTCGTTGCCCTTTCCTTTGGAGGAATCTTGGAACGAGCTAACTTCTTAGAAGTCATTCTAGAAAATATCTT
AAAAGTTGCTAAAACTGTCGGATCACTGTCCTTAGTAACCCATCTAACTTCTATTTTTGTCAACCTGGTAACTGCCGATC
AGTACCTAGCAATCGTCTTAAGTGCTAGAATGTATAGGGACGCATTTAAAGAAATGGGATCACATCCTAAAAACTTATCA
AGGATTGTAGAATCTTCTGGAACAATTACATCACCATTAATTCCTTGGAATACATGTGGTGCTTTCATGTACGGTGCTCT
AGGTGTTAATCCATTTGCTTATCTACCATACGCTTTCTTTAACTTAATTGCCCTGTTACTTTCAATTATATACGGCTTCA
CCGGATTTACCATGGAGAAATGGGAAGGTAACGAAGAACAAACCGCTGACGCCGATTAA

Upstream 100 bases:

>100_bases
GGAGGTGATTAGTAAAATAAATGTAATATGAATAGTCACTTTGGTAAAAATTGTCTAAAAATTTTAACCAATCTAAAATT
TTGGAGAGGGAGGAATACCT

Downstream 100 bases:

>100_bases
ATCTATAAAATTAAATATAATACTTGTTAAAGCATTATATTAGCTAATTTAAAGGGGGATCCCAAAGCTTAGTAAAAGAC
TTGGGATCCCCCTTTTCTAA

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNEEANLKPTLGQALIPIIFVIIALSYGIIVWEVDPHIPLLIAGAVAAFVAIVMVGYKWDTIEDGIFKGIMLAMQAIVIL
MIVGTLIGSWIEGGVVPAMIYYGLQILSPQIFLVAAAIISTIVALFVGSSWSTAGTIGIALLGIGEGLGVPAAMTAGAVV
SGAYVGDKMSPLSDTTNLAPGTTGDVNVFDHIRHMLYVTIPAYIISLIIFALLGLQFAGQSMEQGDIVLISETISEHFTI
NPIMLIPVLFVLVLIGLKVPPIPGLLGGSILGGIFALIFQGAAPADVIGSMHYGYVMDSGVEVVDDLLSEGGLDGMMWTI
SLIFVALSFGGILERANFLEVILENILKVAKTVGSLSLVTHLTSIFVNLVTADQYLAIVLSARMYRDAFKEMGSHPKNLS
RIVESSGTITSPLIPWNTCGAFMYGALGVNPFAYLPYAFFNLIALLLSIIYGFTGFTMEKWEGNEEQTADAD

Sequences:

>Translated_472_residues
MNEEANLKPTLGQALIPIIFVIIALSYGIIVWEVDPHIPLLIAGAVAAFVAIVMVGYKWDTIEDGIFKGIMLAMQAIVIL
MIVGTLIGSWIEGGVVPAMIYYGLQILSPQIFLVAAAIISTIVALFVGSSWSTAGTIGIALLGIGEGLGVPAAMTAGAVV
SGAYVGDKMSPLSDTTNLAPGTTGDVNVFDHIRHMLYVTIPAYIISLIIFALLGLQFAGQSMEQGDIVLISETISEHFTI
NPIMLIPVLFVLVLIGLKVPPIPGLLGGSILGGIFALIFQGAAPADVIGSMHYGYVMDSGVEVVDDLLSEGGLDGMMWTI
SLIFVALSFGGILERANFLEVILENILKVAKTVGSLSLVTHLTSIFVNLVTADQYLAIVLSARMYRDAFKEMGSHPKNLS
RIVESSGTITSPLIPWNTCGAFMYGALGVNPFAYLPYAFFNLIALLLSIIYGFTGFTMEKWEGNEEQTADAD
>Mature_472_residues
MNEEANLKPTLGQALIPIIFVIIALSYGIIVWEVDPHIPLLIAGAVAAFVAIVMVGYKWDTIEDGIFKGIMLAMQAIVIL
MIVGTLIGSWIEGGVVPAMIYYGLQILSPQIFLVAAAIISTIVALFVGSSWSTAGTIGIALLGIGEGLGVPAAMTAGAVV
SGAYVGDKMSPLSDTTNLAPGTTGDVNVFDHIRHMLYVTIPAYIISLIIFALLGLQFAGQSMEQGDIVLISETISEHFTI
NPIMLIPVLFVLVLIGLKVPPIPGLLGGSILGGIFALIFQGAAPADVIGSMHYGYVMDSGVEVVDDLLSEGGLDGMMWTI
SLIFVALSFGGILERANFLEVILENILKVAKTVGSLSLVTHLTSIFVNLVTADQYLAIVLSARMYRDAFKEMGSHPKNLS
RIVESSGTITSPLIPWNTCGAFMYGALGVNPFAYLPYAFFNLIALLLSIIYGFTGFTMEKWEGNEEQTADAD

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50201; Mature: 50201

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEEANLKPTLGQALIPIIFVIIALSYGIIVWEVDPHIPLLIAGAVAAFVAIVMVGYKWD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
TIEDGIFKGIMLAMQAIVILMIVGTLIGSWIEGGVVPAMIYYGLQILSPQIFLVAAAIIS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHH
TIVALFVGSSWSTAGTIGIALLGIGEGLGVPAAMTAGAVVSGAYVGDKMSPLSDTTNLAP
HHHHHHHCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHCHHCCCCCCCCCCCCCCCC
GTTGDVNVFDHIRHMLYVTIPAYIISLIIFALLGLQFAGQSMEQGDIVLISETISEHFTI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCC
NPIMLIPVLFVLVLIGLKVPPIPGLLGGSILGGIFALIFQGAAPADVIGSMHYGYVMDSG
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHCCC
VEVVDDLLSEGGLDGMMWTISLIFVALSFGGILERANFLEVILENILKVAKTVGSLSLVT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLTSIFVNLVTADQYLAIVLSARMYRDAFKEMGSHPKNLSRIVESSGTITSPLIPWNTCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHH
AFMYGALGVNPFAYLPYAFFNLIALLLSIIYGFTGFTMEKWEGNEEQTADAD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNEEANLKPTLGQALIPIIFVIIALSYGIIVWEVDPHIPLLIAGAVAAFVAIVMVGYKWD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
TIEDGIFKGIMLAMQAIVILMIVGTLIGSWIEGGVVPAMIYYGLQILSPQIFLVAAAIIS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHH
TIVALFVGSSWSTAGTIGIALLGIGEGLGVPAAMTAGAVVSGAYVGDKMSPLSDTTNLAP
HHHHHHHCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHCHHCCCCCCCCCCCCCCCC
GTTGDVNVFDHIRHMLYVTIPAYIISLIIFALLGLQFAGQSMEQGDIVLISETISEHFTI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCC
NPIMLIPVLFVLVLIGLKVPPIPGLLGGSILGGIFALIFQGAAPADVIGSMHYGYVMDSG
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHCCC
VEVVDDLLSEGGLDGMMWTISLIFVALSFGGILERANFLEVILENILKVAKTVGSLSLVT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLTSIFVNLVTADQYLAIVLSARMYRDAFKEMGSHPKNLSRIVESSGTITSPLIPWNTCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHH
AFMYGALGVNPFAYLPYAFFNLIALLLSIIYGFTGFTMEKWEGNEEQTADAD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]