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The map label for this gene is putP [H]

Identifier: 188587307

GI number: 188587307

Start: 2926153

End: 2927541

Strand: Direct

Name: putP [H]

Synonym: Nther_2710

Alternate gene names: 188587307

Gene position: 2926153-2927541 (Clockwise)

Preceding gene: 188587306

Following gene: 188587308

Centisome position: 92.44

GC content: 39.81

Gene sequence:

>1389_bases
ATGGAATTAACACATCAACCTGAACTATTATTTTTCTTAATAATCTATTTCGTTCTCATGATAGGTATTGGTTTGTATTA
TTCCAGAAGAATTAAAAACAGTGAGGATTTTATGTTGGCCGGAAGGGGTTTGGGACCAATTGTCTTAATGGGTACACTCC
TGGCTACATGGGTAGGAAGTGGTACGGTTACAGGAGGTAGTACGTCCATAGGGTATTCTTATGGTCTTTGGCCCGCGATA
CTATTCGGACTATCTAGCTTACTCGGTGTTAGCATTTTGTACATCATTGCACCAAAAATCAGAGCTTCAGGTAAGTACAC
AATTGCGGAAGCTTTAGAAACAAAATACGGTGAAACAGCCAAAATCATTGCCAGTATTATAATTATCCTGGCTTTTGTCG
GGATAGTTTCTTATCAGTATACTGGCCTAGGAATGGTATTGAACGTAACTACAGGTGTTTCCGTTGATGCAGGTACAGCA
ATAGCAGCTGTAATTGTAATCTTCTTGGCTACCGTTGGAGGATTAATGTCAGTTGCACCTACTGATGCTCTCAGTGCTTT
TATCATAGTCATTGGATTGATAGTAGCTATCCCATCTGCTTTGATTCAGGCTGGAGGATGGGAAAATGTTGTAACCCAGG
TTCCAGAAACTAGTTTATCAGCTTTGGGAGAGCTAGATTTCATTGGATTTTTAGGATATTTTTTACCAACTTTATTTTTA
CTACTGGGTGATCAAAACATGTATCAGAGATTAGCTTCATCAAAGGGTGATAGTGAAACTAAGATGGGAACAATTGGCTG
GGCCGTTGGACTATTGGTCATTTATCCCGCTATTTCACTAATAGCTTTTTCAGCTAGAGTTAACTTCCCTGACATTGATC
CTGGGCAGGCACTAATAGCTACTACGACAATTATGCCGACTTTTATTGGTGGATTAATGCTGGCTTCAATCACCGCCTTT
ATTATCACTACTGGTAGTTCCTATTTGTTATCATCTGCAACTAATATAACTATGGATATCTACAGAAACTACGTCAACAA
AAATGCCAGCAGTAAAGAACAGCTATTGTTAACCCGGGGACTGATAGTAGTCTTAGGAATTCTAGCCTATATCCTGATAC
AGTATTTCCCTTCAATATTAGAGGCTCAGATGTACGCTTATACAGTCTATGCGGCAGGAATCACCCCTGCTATTTTAGGT
GTTTATCTATGGGGCAATAAGGTTACGAAAATAGGCGGTATTGCCTCCATGTTAAGTGGAGTTATTGTGACTCTGGGAAT
TGAATTTTTTGACATTGTAGGCTATGACCCGGCCCTGATATCCGTTCCTGTGGCTATTATAGTCTTGGTAGTAGTTAGTT
TGATGACCCAAAGTTCAAGGAGGGAGTAA

Upstream 100 bases:

>100_bases
TTCGAAAACAAGTTTTAGGAAGGAAAATATCAAGTTTACTAGAATATTAATCAGTTAAACAGTTTTGTTTTAACAAATTA
AAGCATAAGGAGGTATGAAG

Downstream 100 bases:

>100_bases
CTTGAATCGAACTGGACAGGAACCTTTGTTAATTAGATCTGTCAATGTAATCACCGGACAGAATGACGAAATATTAGAAC
AGTACGATGTTTATATAGAG

Product: Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Proline permease [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MELTHQPELLFFLIIYFVLMIGIGLYYSRRIKNSEDFMLAGRGLGPIVLMGTLLATWVGSGTVTGGSTSIGYSYGLWPAI
LFGLSSLLGVSILYIIAPKIRASGKYTIAEALETKYGETAKIIASIIIILAFVGIVSYQYTGLGMVLNVTTGVSVDAGTA
IAAVIVIFLATVGGLMSVAPTDALSAFIIVIGLIVAIPSALIQAGGWENVVTQVPETSLSALGELDFIGFLGYFLPTLFL
LLGDQNMYQRLASSKGDSETKMGTIGWAVGLLVIYPAISLIAFSARVNFPDIDPGQALIATTTIMPTFIGGLMLASITAF
IITTGSSYLLSSATNITMDIYRNYVNKNASSKEQLLLTRGLIVVLGILAYILIQYFPSILEAQMYAYTVYAAGITPAILG
VYLWGNKVTKIGGIASMLSGVIVTLGIEFFDIVGYDPALISVPVAIIVLVVVSLMTQSSRRE

Sequences:

>Translated_462_residues
MELTHQPELLFFLIIYFVLMIGIGLYYSRRIKNSEDFMLAGRGLGPIVLMGTLLATWVGSGTVTGGSTSIGYSYGLWPAI
LFGLSSLLGVSILYIIAPKIRASGKYTIAEALETKYGETAKIIASIIIILAFVGIVSYQYTGLGMVLNVTTGVSVDAGTA
IAAVIVIFLATVGGLMSVAPTDALSAFIIVIGLIVAIPSALIQAGGWENVVTQVPETSLSALGELDFIGFLGYFLPTLFL
LLGDQNMYQRLASSKGDSETKMGTIGWAVGLLVIYPAISLIAFSARVNFPDIDPGQALIATTTIMPTFIGGLMLASITAF
IITTGSSYLLSSATNITMDIYRNYVNKNASSKEQLLLTRGLIVVLGILAYILIQYFPSILEAQMYAYTVYAAGITPAILG
VYLWGNKVTKIGGIASMLSGVIVTLGIEFFDIVGYDPALISVPVAIIVLVVVSLMTQSSRRE
>Mature_462_residues
MELTHQPELLFFLIIYFVLMIGIGLYYSRRIKNSEDFMLAGRGLGPIVLMGTLLATWVGSGTVTGGSTSIGYSYGLWPAI
LFGLSSLLGVSILYIIAPKIRASGKYTIAEALETKYGETAKIIASIIIILAFVGIVSYQYTGLGMVLNVTTGVSVDAGTA
IAAVIVIFLATVGGLMSVAPTDALSAFIIVIGLIVAIPSALIQAGGWENVVTQVPETSLSALGELDFIGFLGYFLPTLFL
LLGDQNMYQRLASSKGDSETKMGTIGWAVGLLVIYPAISLIAFSARVNFPDIDPGQALIATTTIMPTFIGGLMLASITAF
IITTGSSYLLSSATNITMDIYRNYVNKNASSKEQLLLTRGLIVVLGILAYILIQYFPSILEAQMYAYTVYAAGITPAILG
VYLWGNKVTKIGGIASMLSGVIVTLGIEFFDIVGYDPALISVPVAIIVLVVVSLMTQSSRRE

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI11141885, Length=391, Percent_Identity=27.1099744245524, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310128183, Length=483, Percent_Identity=26.9151138716356, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI157671931, Length=384, Percent_Identity=23.9583333333333, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI110835708, Length=458, Percent_Identity=22.2707423580786, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082237, Length=458, Percent_Identity=24.6724890829694, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787251, Length=484, Percent_Identity=25.8264462809917, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790113, Length=375, Percent_Identity=25.3333333333333, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539284, Length=411, Percent_Identity=27.007299270073, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24648033, Length=397, Percent_Identity=28.7153652392947, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356865, Length=397, Percent_Identity=28.7153652392947, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645928, Length=368, Percent_Identity=24.1847826086957, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 49114; Mature: 49114

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTHQPELLFFLIIYFVLMIGIGLYYSRRIKNSEDFMLAGRGLGPIVLMGTLLATWVGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCC
GTVTGGSTSIGYSYGLWPAILFGLSSLLGVSILYIIAPKIRASGKYTIAEALETKYGETA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHH
KIIASIIIILAFVGIVSYQYTGLGMVLNVTTGVSVDAGTAIAAVIVIFLATVGGLMSVAP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
TDALSAFIIVIGLIVAIPSALIQAGGWENVVTQVPETSLSALGELDFIGFLGYFLPTLFL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
LLGDQNMYQRLASSKGDSETKMGTIGWAVGLLVIYPAISLIAFSARVNFPDIDPGQALIA
HHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
TTTIMPTFIGGLMLASITAFIITTGSSYLLSSATNITMDIYRNYVNKNASSKEQLLLTRG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
LIVVLGILAYILIQYFPSILEAQMYAYTVYAAGITPAILGVYLWGNKVTKIGGIASMLSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VIVTLGIEFFDIVGYDPALISVPVAIIVLVVVSLMTQSSRRE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MELTHQPELLFFLIIYFVLMIGIGLYYSRRIKNSEDFMLAGRGLGPIVLMGTLLATWVGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCC
GTVTGGSTSIGYSYGLWPAILFGLSSLLGVSILYIIAPKIRASGKYTIAEALETKYGETA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHH
KIIASIIIILAFVGIVSYQYTGLGMVLNVTTGVSVDAGTAIAAVIVIFLATVGGLMSVAP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
TDALSAFIIVIGLIVAIPSALIQAGGWENVVTQVPETSLSALGELDFIGFLGYFLPTLFL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
LLGDQNMYQRLASSKGDSETKMGTIGWAVGLLVIYPAISLIAFSARVNFPDIDPGQALIA
HHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
TTTIMPTFIGGLMLASITAFIITTGSSYLLSSATNITMDIYRNYVNKNASSKEQLLLTRG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
LIVVLGILAYILIQYFPSILEAQMYAYTVYAAGITPAILGVYLWGNKVTKIGGIASMLSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VIVTLGIEFFDIVGYDPALISVPVAIIVLVVVSLMTQSSRRE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA