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The map label for this gene is sstT [H]

Identifier: 188587278

GI number: 188587278

Start: 2889522

End: 2890724

Strand: Direct

Name: sstT [H]

Synonym: Nther_2680

Alternate gene names: 188587278

Gene position: 2889522-2890724 (Clockwise)

Preceding gene: 188587275

Following gene: 188587281

Centisome position: 91.28

GC content: 39.4

Gene sequence:

>1203_bases
ATGAGTAAGTTAGGACTAATTCCCAGGTTAATTATTGCAATCATTCTGGGTACTCTTATTGGTCTTTATTTCCCAGAATG
GGTAGGGAACTTGTTGTTTACTGTTTCCAGCATTTTTGGTGAATTGCTATTTTACATTGTTCCTCTTATTATTTTGGCCT
TTATTATCCCAGGTATCGCAGAATTAGCAGAGAGTCCAGGTAAAATGCTGGGTGCCACCGCAGGTGTAGCTTATTTATCG
ACTATCATTGCAGGTACAATAGCCTTTTTCGTGGCAATGATGATTATTCCGGCTATTGCACCCGAAATCGTGGAAGTTGA
AGAGGATGCAGGACTTTCCCAGTTTATTGAAATTGAAATAGCACCTATGATGGAAATCATGACAGCTCTTGTAACGGCCT
TTATCTTTGGTGTTGGTGTAAATTACTTAAAAAATATCCGCGGTAATAAAACTCTGTATAATTTCATGATGGAATTTCGA
GAGGTTGTGCGCTTGGTAATTCAAAAAATAATCATTCCTTTACTACCACTTTACATAGCAGGTATCTTTGCAGATATGGC
TGCTGAGGGTACTGTGTTTAGAACTATAGGTCTGTTTGCGCCTCTCTTCGCCTTGGTAATCGGATTACAAATACTATACT
TAATTTTACATTTCACTGTTGCAAACAGATTGCGACCTGAAAACCCTATTTTCGGTAGCTTAAAGCAAATGATTCCAGCT
TATACAACTGCCTTGGGGACAGTTTCTAGTGCAGCTACCTTACCAGTAACTTTAAGAAGTGCCAAGAAATTAAAAGTGCC
AGATAATATAGTAGATTTAGTAGTACCTTTAGGAGCTACAATTCATCTAGCTGGTAGTACTATTGCCATAACCATCAGTG
CCGTAACTGTGTATTTGCTTCATCTCGGTACACCAGAATTCACCAGCTTTTTCCCTTTTATTTTGATGCTTGGAATAGTA
ATGATAGGAGCTCCAGGAGTTCCAGGAGGGGCGGTAATGGCCGCTCTAGGCTTATTGAGCACTATGTTAGGATTTGGAGA
AACAGAACAAGCATTGATGATTGCAATTTACATGGGACAGGATCCCTTTGGAACTGCTTGTAACGTAACAGGAGACGGTG
CCAATTCCATTATTGTGAGTTCTATAGCCAAAAGAGTGGAAGGTAATAAAGGCAAGAACTCAGAAACAGAAGAAGAAGCT
TAA

Upstream 100 bases:

>100_bases
TACTTAAGAAAATTGTTAATATTATTTTGATGCTTTTCAAAATAATTTTTTATGGTAAAATCAGTGAAACAAATTTTATC
ACTTTAAGGAGGTGCAGTTA

Downstream 100 bases:

>100_bases
TAAAAGAAGAATTTTCGTACTGTACAAGGTTCGCAGAAGTTTTGCAAACTTGATTCAACCCCCTCCGGTTATTGATAGCC
GAGAGGGGGTGGGTTATTTA

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Na(+)/serine-threonine symporter [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSKLGLIPRLIIAIILGTLIGLYFPEWVGNLLFTVSSIFGELLFYIVPLIILAFIIPGIAELAESPGKMLGATAGVAYLS
TIIAGTIAFFVAMMIIPAIAPEIVEVEEDAGLSQFIEIEIAPMMEIMTALVTAFIFGVGVNYLKNIRGNKTLYNFMMEFR
EVVRLVIQKIIIPLLPLYIAGIFADMAAEGTVFRTIGLFAPLFALVIGLQILYLILHFTVANRLRPENPIFGSLKQMIPA
YTTALGTVSSAATLPVTLRSAKKLKVPDNIVDLVVPLGATIHLAGSTIAITISAVTVYLLHLGTPEFTSFFPFILMLGIV
MIGAPGVPGGAVMAALGLLSTMLGFGETEQALMIAIYMGQDPFGTACNVTGDGANSIIVSSIAKRVEGNKGKNSETEEEA

Sequences:

>Translated_400_residues
MSKLGLIPRLIIAIILGTLIGLYFPEWVGNLLFTVSSIFGELLFYIVPLIILAFIIPGIAELAESPGKMLGATAGVAYLS
TIIAGTIAFFVAMMIIPAIAPEIVEVEEDAGLSQFIEIEIAPMMEIMTALVTAFIFGVGVNYLKNIRGNKTLYNFMMEFR
EVVRLVIQKIIIPLLPLYIAGIFADMAAEGTVFRTIGLFAPLFALVIGLQILYLILHFTVANRLRPENPIFGSLKQMIPA
YTTALGTVSSAATLPVTLRSAKKLKVPDNIVDLVVPLGATIHLAGSTIAITISAVTVYLLHLGTPEFTSFFPFILMLGIV
MIGAPGVPGGAVMAALGLLSTMLGFGETEQALMIAIYMGQDPFGTACNVTGDGANSIIVSSIAKRVEGNKGKNSETEEEA
>Mature_399_residues
SKLGLIPRLIIAIILGTLIGLYFPEWVGNLLFTVSSIFGELLFYIVPLIILAFIIPGIAELAESPGKMLGATAGVAYLST
IIAGTIAFFVAMMIIPAIAPEIVEVEEDAGLSQFIEIEIAPMMEIMTALVTAFIFGVGVNYLKNIRGNKTLYNFMMEFRE
VVRLVIQKIIIPLLPLYIAGIFADMAAEGTVFRTIGLFAPLFALVIGLQILYLILHFTVANRLRPENPIFGSLKQMIPAY
TTALGTVSSAATLPVTLRSAKKLKVPDNIVDLVVPLGATIHLAGSTIAITISAVTVYLLHLGTPEFTSFFPFILMLGIVM
IGAPGVPGGAVMAALGLLSTMLGFGETEQALMIAIYMGQDPFGTACNVTGDGANSIIVSSIAKRVEGNKGKNSETEEEA

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789947, Length=430, Percent_Identity=24.1860465116279, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789473, Length=263, Percent_Identity=28.5171102661597, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR023025 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42676; Mature: 42545

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKLGLIPRLIIAIILGTLIGLYFPEWVGNLLFTVSSIFGELLFYIVPLIILAFIIPGIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELAESPGKMLGATAGVAYLSTIIAGTIAFFVAMMIIPAIAPEIVEVEEDAGLSQFIEIEI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHH
APMMEIMTALVTAFIFGVGVNYLKNIRGNKTLYNFMMEFREVVRLVIQKIIIPLLPLYIA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFADMAAEGTVFRTIGLFAPLFALVIGLQILYLILHFTVANRLRPENPIFGSLKQMIPA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YTTALGTVSSAATLPVTLRSAKKLKVPDNIVDLVVPLGATIHLAGSTIAITISAVTVYLL
HHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHHH
HLGTPEFTSFFPFILMLGIVMIGAPGVPGGAVMAALGLLSTMLGFGETEQALMIAIYMGQ
HCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHEEEEEEECC
DPFGTACNVTGDGANSIIVSSIAKRVEGNKGKNSETEEEA
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA