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The map label for this gene is tlpC [H]

Identifier: 188587061

GI number: 188587061

Start: 2633613

End: 2635331

Strand: Direct

Name: tlpC [H]

Synonym: Nther_2453

Alternate gene names: 188587061

Gene position: 2633613-2635331 (Clockwise)

Preceding gene: 188587054

Following gene: 188587064

Centisome position: 83.2

GC content: 34.67

Gene sequence:

>1719_bases
ATGAAAAAGTTAGTCCAAAGAAGTATTAAGAACAGGTTAATATCAGGAGTCGTAGCCTTGACAATTATTATGGTAGTTGC
CCTAATACTATTAAATAACTATACTATCGAAGATATAGTAGAAACCACAGTTAATGATAAATTAGAGGGAGACCATGAGA
TGGGACTAAGAGTCGTTGAAAACAACTTTAGCGGAAATTGGCATATATTAGGAGACGAATTATATAAAGGAAATGTAACT
GCAGATGAAATGACAGGAACTTTAGATAATATCCAAGAAAGTACCGGATCTGTAGCAACTATTTTCAAAGGTGACACCAG
TGTGGCTAGTAATCTTACAGATAGTGAAGGAGAAAGGGCAATCGGAACTCAAGTTGATGAAGAAGTATCCCAGACTGTTT
TGGAAGAAGGAGAACGGTTTACTGGTCAAATAGAAATTTTAGGAACCCCCCATGAAGTTATGTATTCTCCTATAGAAAAT
CCCGAAGGTGAAGAAATCGGTATTTGGTTCACAGGTGTGCCCATTGATGATGTCAATAACTTGATCAATCAAGGAAATAT
GAGTTTTATTTTTTTCTCTTCCATAATAATTATTATCGCCTTAATACTCTTTTATATTGCAATCAATAAAATTGTTAAGC
CAATTAAAGGGTTGACCTCTTTGTTAGATAAATTTTCCACATTAGATTTATCATCAAGTGAAGAAGATAATACTAATAGT
TATTTAAAACGTTCAGATGAAATAGGTAAAATGGCTAAAGCCATGATGAACATGCAAGAAGCAGTTGTACAGTTGATTAA
AAATATTAATGATAAATCAAACCAGGTCACTTCCTCGGCAGAGGAATTAAGTGCAAACGCCGAAGAAAATACCAGTGCAG
CTAATGAAGTTTCAAAGGCAGTAGAAGAAATTGCTCAAGGTGCCACCAGCCAAGCCGAGAAAACAGATCAAAGCTCTAAT
GTTACTGAAGAACTTGGAAAAATCATTGAAAAAGAACAGAGCTGTGTAGATAGTTTAAATCAAGCTATTGAAGAAGTAAC
CAATAAAAAAGAAGAGGGTACTGAAGCAGTTAAAAACTTGCACGAAAAAACAAATGAGACTAACAGTGCCATCAAAGAAA
TCACAGAAGTAATTGAAAAAACTCACTCAAGAACCCAAGAGATTAAAGAAGCAAGTAGTCACATAACAGATATAGCTGAG
CAAACAAACTTATTAGCCCTTAACGCCAGTATTGAAGCTGCTCGGGCAGGCGAGCATGGACAAGGTTTTGCAGTGGTAGC
TAACGAAATTAGACAACTTGCAGAAAAGTCAAATGAATACTCAGAAAATATCTTGAACAATATCGATGGGTTAAATAAAC
AGGCAAATGATGCAGTTAAAACAATGGAAAATGTAAAGCAAATAATAAAAGAACAAAGTGTTTATGTGGAAGAAACCGGT
TCCAAGTTCGATGGAATTTCTAATGCCATAGAAGGAGTAGAAAGTCAGTTATCCGAACTCAATGAATTTGGAAAAGAAAT
GAATAATAAGAAACAAGAGATTATAAACGCACTACAAGACCTGTCTTCAATAGCTGAAGAAAACTCATCAAGTACTGAAG
AAATTTCATCAACTGTGGAAGAACAAACTGCAAGTATGGATGAAATCGCTTCAGCCAGTGAACAATTGACAAAATTAGCT
GAAGAAATGCAAGAAGAAATAAATAAGTTTTCGTATTAA

Upstream 100 bases:

>100_bases
ATAAGAGAAAAGTTTTATAGAAATAATTTTAAAGTTAAAGTACAATATTACCAGACAATATTAGACAATATATACCAAAT
TATAAGGAGGGAGGAAAAAT

Downstream 100 bases:

>100_bases
TAAGACTCATATTGCGATATTGACGGTCTTTTCTCCGTGCTCCGATTTTATGTGTGCCGTAGGAATAAGAATGATGACAC
TTACATTTAATTGGGCTGTT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MKKLVQRSIKNRLISGVVALTIIMVVALILLNNYTIEDIVETTVNDKLEGDHEMGLRVVENNFSGNWHILGDELYKGNVT
ADEMTGTLDNIQESTGSVATIFKGDTSVASNLTDSEGERAIGTQVDEEVSQTVLEEGERFTGQIEILGTPHEVMYSPIEN
PEGEEIGIWFTGVPIDDVNNLINQGNMSFIFFSSIIIIIALILFYIAINKIVKPIKGLTSLLDKFSTLDLSSSEEDNTNS
YLKRSDEIGKMAKAMMNMQEAVVQLIKNINDKSNQVTSSAEELSANAEENTSAANEVSKAVEEIAQGATSQAEKTDQSSN
VTEELGKIIEKEQSCVDSLNQAIEEVTNKKEEGTEAVKNLHEKTNETNSAIKEITEVIEKTHSRTQEIKEASSHITDIAE
QTNLLALNASIEAARAGEHGQGFAVVANEIRQLAEKSNEYSENILNNIDGLNKQANDAVKTMENVKQIIKEQSVYVEETG
SKFDGISNAIEGVESQLSELNEFGKEMNNKKQEIINALQDLSSIAEENSSSTEEISSTVEEQTASMDEIASASEQLTKLA
EEMQEEINKFSY

Sequences:

>Translated_572_residues
MKKLVQRSIKNRLISGVVALTIIMVVALILLNNYTIEDIVETTVNDKLEGDHEMGLRVVENNFSGNWHILGDELYKGNVT
ADEMTGTLDNIQESTGSVATIFKGDTSVASNLTDSEGERAIGTQVDEEVSQTVLEEGERFTGQIEILGTPHEVMYSPIEN
PEGEEIGIWFTGVPIDDVNNLINQGNMSFIFFSSIIIIIALILFYIAINKIVKPIKGLTSLLDKFSTLDLSSSEEDNTNS
YLKRSDEIGKMAKAMMNMQEAVVQLIKNINDKSNQVTSSAEELSANAEENTSAANEVSKAVEEIAQGATSQAEKTDQSSN
VTEELGKIIEKEQSCVDSLNQAIEEVTNKKEEGTEAVKNLHEKTNETNSAIKEITEVIEKTHSRTQEIKEASSHITDIAE
QTNLLALNASIEAARAGEHGQGFAVVANEIRQLAEKSNEYSENILNNIDGLNKQANDAVKTMENVKQIIKEQSVYVEETG
SKFDGISNAIEGVESQLSELNEFGKEMNNKKQEIINALQDLSSIAEENSSSTEEISSTVEEQTASMDEIASASEQLTKLA
EEMQEEINKFSY
>Mature_572_residues
MKKLVQRSIKNRLISGVVALTIIMVVALILLNNYTIEDIVETTVNDKLEGDHEMGLRVVENNFSGNWHILGDELYKGNVT
ADEMTGTLDNIQESTGSVATIFKGDTSVASNLTDSEGERAIGTQVDEEVSQTVLEEGERFTGQIEILGTPHEVMYSPIEN
PEGEEIGIWFTGVPIDDVNNLINQGNMSFIFFSSIIIIIALILFYIAINKIVKPIKGLTSLLDKFSTLDLSSSEEDNTNS
YLKRSDEIGKMAKAMMNMQEAVVQLIKNINDKSNQVTSSAEELSANAEENTSAANEVSKAVEEIAQGATSQAEKTDQSSN
VTEELGKIIEKEQSCVDSLNQAIEEVTNKKEEGTEAVKNLHEKTNETNSAIKEITEVIEKTHSRTQEIKEASSHITDIAE
QTNLLALNASIEAARAGEHGQGFAVVANEIRQLAEKSNEYSENILNNIDGLNKQANDAVKTMENVKQIIKEQSVYVEETG
SKFDGISNAIEGVESQLSELNEFGKEMNNKKQEIINALQDLSSIAEENSSSTEEISSTVEEQTASMDEIASASEQLTKLA
EEMQEEINKFSY

Specific function: Mediates Taxis To The Sugars Ribose And Galactose VIa An Interaction With The Periplasmic Ribose- Or Galactose-Binding Proteins. Chemotactic-Signal Transducers Respond To Changes In The Concentration Of Attractants And Repellents In The Environment, Trans

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=460, Percent_Identity=23.2608695652174, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789453, Length=384, Percent_Identity=27.0833333333333, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI2367378, Length=265, Percent_Identity=25.2830188679245, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788195, Length=291, Percent_Identity=25.7731958762887, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788194, Length=354, Percent_Identity=24.0112994350282, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 62843; Mature: 62843

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVQRSIKNRLISGVVALTIIMVVALILLNNYTIEDIVETTVNDKLEGDHEMGLRVVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCHHHEE
NNFSGNWHILGDELYKGNVTADEMTGTLDNIQESTGSVATIFKGDTSVASNLTDSEGERA
CCCCCCEEEECCHHHCCCCCHHHHHCHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCCH
IGTQVDEEVSQTVLEEGERFTGQIEILGTPHEVMYSPIENPEGEEIGIWFTGVPIDDVNN
HCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHCCCCCCCCCEEEEEEECCCHHHHHH
LINQGNMSFIFFSSIIIIIALILFYIAINKIVKPIKGLTSLLDKFSTLDLSSSEEDNTNS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YLKRSDEIGKMAKAMMNMQEAVVQLIKNINDKSNQVTSSAEELSANAEENTSAANEVSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VEEIAQGATSQAEKTDQSSNVTEELGKIIEKEQSCVDSLNQAIEEVTNKKEEGTEAVKNL
HHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
HEKTNETNSAIKEITEVIEKTHSRTQEIKEASSHITDIAEQTNLLALNASIEAARAGEHG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCC
QGFAVVANEIRQLAEKSNEYSENILNNIDGLNKQANDAVKTMENVKQIIKEQSVYVEETG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SKFDGISNAIEGVESQLSELNEFGKEMNNKKQEIINALQDLSSIAEENSSSTEEISSTVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EQTASMDEIASASEQLTKLAEEMQEEINKFSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLVQRSIKNRLISGVVALTIIMVVALILLNNYTIEDIVETTVNDKLEGDHEMGLRVVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCHHHEE
NNFSGNWHILGDELYKGNVTADEMTGTLDNIQESTGSVATIFKGDTSVASNLTDSEGERA
CCCCCCEEEECCHHHCCCCCHHHHHCHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCCH
IGTQVDEEVSQTVLEEGERFTGQIEILGTPHEVMYSPIENPEGEEIGIWFTGVPIDDVNN
HCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHCCCCCCCCCEEEEEEECCCHHHHHH
LINQGNMSFIFFSSIIIIIALILFYIAINKIVKPIKGLTSLLDKFSTLDLSSSEEDNTNS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YLKRSDEIGKMAKAMMNMQEAVVQLIKNINDKSNQVTSSAEELSANAEENTSAANEVSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VEEIAQGATSQAEKTDQSSNVTEELGKIIEKEQSCVDSLNQAIEEVTNKKEEGTEAVKNL
HHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
HEKTNETNSAIKEITEVIEKTHSRTQEIKEASSHITDIAEQTNLLALNASIEAARAGEHG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCC
QGFAVVANEIRQLAEKSNEYSENILNNIDGLNKQANDAVKTMENVKQIIKEQSVYVEETG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SKFDGISNAIEGVESQLSELNEFGKEMNNKKQEIINALQDLSSIAEENSSSTEEISSTVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EQTASMDEIASASEQLTKLAEEMQEEINKFSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]