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The map label for this gene is gapB [H]

Identifier: 188587035

GI number: 188587035

Start: 2600556

End: 2601557

Strand: Reverse

Name: gapB [H]

Synonym: Nther_2427

Alternate gene names: 188587035

Gene position: 2601557-2600556 (Counterclockwise)

Preceding gene: 188587036

Following gene: 188587034

Centisome position: 82.18

GC content: 39.42

Gene sequence:

>1002_bases
ATGGTTAAAATAGGTGTAAACGGCTTTGGTAGAATAGCAAGAGCCGTAATTAGAATTGCCCATTATAGAGAAGATGTAGA
AGTAGTGGCAGTAAATAGTGATCGGGATCCAGAATTACTGGCACACTTACTAAAATACGATTCCCTTTATGGTGAATTAT
CTGAAGATGTAACTCCTGGTAAGGATTACTTAATGGTTGGTGATAATAAAATAAATCTTTTAGGAGATAGAAATCCAGAA
AATCTAAATTGGGATGATTACGATGTGGAAGTGGTAATCGAGGCTACAGGGAAATTTAGAGACAGGAACGATGCCCAAAA
ACATTTAGGGGACAAAGTCAAGCGTGTAGTTATTAGTGCTCCCGGCAAAAACGAGGATCTAACAGTAGTTATGGGAGTTA
ATGAACAAAACTTTGACCCTGATCGGCACTTTGTACTTTCCAATGCATCATGTACTACTAATTGTTTAGCACCTTTGGTA
AAGGTCTTGGATGAAAATTTCGGGGTTTCCAAGGGAATGATGACAACTGTTCATTCTTATACCATGGATCAGCAGCTTCT
TGATGGCTCGCATAAAGATATCCGAAGAGCCAGAGCAGCTAACTTGTCAATTATCCCTACAACTACAGGAGCTGCCAAGG
CCGTTTCTAAAGTACTCCCACATTTAGAAGGAAGATTAGATGGAATGGCCTTTAGAGTGCCTACTCCCACGGTATCTACT
GTGGACTTAGTAGCTAATCTTAACAAAAATACCAGTAAGGAAGAAATTAATGAAGCATTTAGGGAAGCTTCCCAATCGAA
ATTGAAAGGGATTTTAGATTACACCGATCTTCCACTGGTATCTGCTGATTATACAGGGAATCCTCATTCAACAATAATTG
ATGGTCTCAGTACTGGCATGGTAGACGATAATATGGTCAAGGTGATTGCCTGGTACGATAATGAATGGGGATATTCCGAG
CGAACCGTAGATCTTTGTTCGTATATTAGCCAAAAATCATAG

Upstream 100 bases:

>100_bases
TTATAACATTTCTTTATCAGGCTGTCGCCATTGAATAAAAGGTTTTTAAGGGTAAGAACAATTTCAAAAATATTTTATTA
AAATAAGGAGGTAGCTCATT

Downstream 100 bases:

>100_bases
TTAAGTGGATACTCTTTAAACATGTGTAAGCGGCTAAGGAACTATAGGCTTAGCCGCTTACTTATTGTGCGCCATGCATG
ACGATTAGCTAGGTGGTGTA

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase; GAPDH [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVKIGVNGFGRIARAVIRIAHYREDVEVVAVNSDRDPELLAHLLKYDSLYGELSEDVTPGKDYLMVGDNKINLLGDRNPE
NLNWDDYDVEVVIEATGKFRDRNDAQKHLGDKVKRVVISAPGKNEDLTVVMGVNEQNFDPDRHFVLSNASCTTNCLAPLV
KVLDENFGVSKGMMTTVHSYTMDQQLLDGSHKDIRRARAANLSIIPTTTGAAKAVSKVLPHLEGRLDGMAFRVPTPTVST
VDLVANLNKNTSKEEINEAFREASQSKLKGILDYTDLPLVSADYTGNPHSTIIDGLSTGMVDDNMVKVIAWYDNEWGYSE
RTVDLCSYISQKS

Sequences:

>Translated_333_residues
MVKIGVNGFGRIARAVIRIAHYREDVEVVAVNSDRDPELLAHLLKYDSLYGELSEDVTPGKDYLMVGDNKINLLGDRNPE
NLNWDDYDVEVVIEATGKFRDRNDAQKHLGDKVKRVVISAPGKNEDLTVVMGVNEQNFDPDRHFVLSNASCTTNCLAPLV
KVLDENFGVSKGMMTTVHSYTMDQQLLDGSHKDIRRARAANLSIIPTTTGAAKAVSKVLPHLEGRLDGMAFRVPTPTVST
VDLVANLNKNTSKEEINEAFREASQSKLKGILDYTDLPLVSADYTGNPHSTIIDGLSTGMVDDNMVKVIAWYDNEWGYSE
RTVDLCSYISQKS
>Mature_333_residues
MVKIGVNGFGRIARAVIRIAHYREDVEVVAVNSDRDPELLAHLLKYDSLYGELSEDVTPGKDYLMVGDNKINLLGDRNPE
NLNWDDYDVEVVIEATGKFRDRNDAQKHLGDKVKRVVISAPGKNEDLTVVMGVNEQNFDPDRHFVLSNASCTTNCLAPLV
KVLDENFGVSKGMMTTVHSYTMDQQLLDGSHKDIRRARAANLSIIPTTTGAAKAVSKVLPHLEGRLDGMAFRVPTPTVST
VDLVANLNKNTSKEEINEAFREASQSKLKGILDYTDLPLVSADYTGNPHSTIIDGLSTGMVDDNMVKVIAWYDNEWGYSE
RTVDLCSYISQKS

Specific function: More active in anabolism [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=331, Percent_Identity=45.9214501510574, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI7669492, Length=333, Percent_Identity=45.045045045045, Blast_Score=288, Evalue=5e-78,
Organism=Escherichia coli, GI1788079, Length=331, Percent_Identity=46.5256797583082, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1789295, Length=327, Percent_Identity=40.9785932721713, Blast_Score=285, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17534677, Length=339, Percent_Identity=45.4277286135693, Blast_Score=297, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17534679, Length=339, Percent_Identity=45.4277286135693, Blast_Score=296, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=45, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=45, Blast_Score=288, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6321631, Length=336, Percent_Identity=47.9166666666667, Blast_Score=316, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6322468, Length=336, Percent_Identity=47.3214285714286, Blast_Score=315, Evalue=7e-87,
Organism=Saccharomyces cerevisiae, GI6322409, Length=336, Percent_Identity=46.4285714285714, Blast_Score=311, Evalue=9e-86,
Organism=Drosophila melanogaster, GI85725000, Length=334, Percent_Identity=47.0059880239521, Blast_Score=294, Evalue=5e-80,
Organism=Drosophila melanogaster, GI22023983, Length=334, Percent_Identity=47.0059880239521, Blast_Score=294, Evalue=5e-80,
Organism=Drosophila melanogaster, GI17933600, Length=334, Percent_Identity=46.7065868263473, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI18110149, Length=334, Percent_Identity=46.7065868263473, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=44.5454545454545, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.59 [H]

Molecular weight: Translated: 36877; Mature: 36877

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00071 GAPDH ; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIGVNGFGRIARAVIRIAHYREDVEVVAVNSDRDPELLAHLLKYDSLYGELSEDVTPG
CEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC
KDYLMVGDNKINLLGDRNPENLNWDDYDVEVVIEATGKFRDRNDAQKHLGDKVKRVVISA
CCEEEECCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHEEEEEC
PGKNEDLTVVMGVNEQNFDPDRHFVLSNASCTTNCLAPLVKVLDENFGVSKGMMTTVHSY
CCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TMDQQLLDGSHKDIRRARAANLSIIPTTTGAAKAVSKVLPHLEGRLDGMAFRVPTPTVST
HHHHHHHCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
VDLVANLNKNTSKEEINEAFREASQSKLKGILDYTDLPLVSADYTGNPHSTIIDGLSTGM
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCC
VDDNMVKVIAWYDNEWGYSERTVDLCSYISQKS
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MVKIGVNGFGRIARAVIRIAHYREDVEVVAVNSDRDPELLAHLLKYDSLYGELSEDVTPG
CEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC
KDYLMVGDNKINLLGDRNPENLNWDDYDVEVVIEATGKFRDRNDAQKHLGDKVKRVVISA
CCEEEECCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHEEEEEC
PGKNEDLTVVMGVNEQNFDPDRHFVLSNASCTTNCLAPLVKVLDENFGVSKGMMTTVHSY
CCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TMDQQLLDGSHKDIRRARAANLSIIPTTTGAAKAVSKVLPHLEGRLDGMAFRVPTPTVST
HHHHHHHCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
VDLVANLNKNTSKEEINEAFREASQSKLKGILDYTDLPLVSADYTGNPHSTIIDGLSTGM
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCC
VDDNMVKVIAWYDNEWGYSERTVDLCSYISQKS
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10799476 [H]