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The map label for this gene is yhcK [H]

Identifier: 188586921

GI number: 188586921

Start: 2458801

End: 2460594

Strand: Reverse

Name: yhcK [H]

Synonym: Nther_2312

Alternate gene names: 188586921

Gene position: 2460594-2458801 (Counterclockwise)

Preceding gene: 188586922

Following gene: 188586920

Centisome position: 77.73

GC content: 38.18

Gene sequence:

>1794_bases
GTGGGTAAAATTCTGGAGAAACGACTTAATCAAGGGGTAGCACTGGCCTCTAGCCTGGTACTTTTGACTTTGTTATGGAT
AACTTTAGTCAATGCCGGTTATCGCGAAAATGTGTTTACTTACGAGTTTATCGTTTTACTTGCTTTAACAATAGTAATGG
AAAGAATTCGAATTCCGGCAGGTAGAATTAGTCTATCTCTTAATTTTGCACTAGTATTTTCGGCATTAGTCATATTAGGT
TTTTATCCTTCTATTTGGATTGCCACTGTGGGAATTGCCTTTCATTCCGCAGTTTTTTCAAATAGACCAGGAAGTGTAGC
GCTTTTTAACGGAGCTATGTTTGGAGTTACATTTTATGTGGCAGGCTTGGCTTATCAGCAGGCTGGAGGTGTAGTAGGTT
TAGGTGAAATGACTGGCCCATTGCCAGTAATTATTTATGGACTGGTCAGTCTAGCGGTTAATCATACAATTTTAACCACT
TATATCAAATTTGTTGTAAGTTATCGGGAATACAGCTTTTCAGATGTGTTAAAAAACGTTGGGTGGGATGTGGTTACATA
CGGAGTTAGTTTACCTGTAGCTGTGTTGATGATAATGTTGTACAATAATATTGGTATTTTAGGTATTGTAGTCATGGTTA
TGGCACTAGGACTTAACAGTTATATTTTTCGCCTGTACAAAAAGCTTGATCAGTTTCATCAAGAACTTCATTCATTACAA
AAAACTTCTGTTAACTTAATTGAGAGTATGGAACTGGATGATGTTTTACAGGCTATCACCAGAGCTAGTAAAACCATGTT
TGATACTAAAAAATGTGGGATTTGGATTTACGATGACAAGCAGGGATTTAAACTTACCTTAATTAACGGGGAATCTCCAG
AGCGCACTATTATCCTAGCTGAAGGTGAGGGTATCACTGGAAAAGTTAGTCACCGCAAGACCCCCTTATTTATCAATAAC
ATTAATCATCCAGAATGGCAGGAGGCTGCCAGTGCAGAAGGATTATACGATAAAGAGGAATCAATTCTGGTAACTCCCTT
AATTTGTCAAAACAAAATTATTGGGGCTCTGTCTTTAACCAGAAATAATTTTATAGAGCATTTGGAAAAGGATGAACTTA
TCCAACTGACAGAAATTTTTTCTGCTCAGGTAGCTTCTGCTCTTTCCAATGCTCTGCATCATCAGAAAGTGGAGGATTTA
GCAGTGACTGACGAGAAGACCAATTTGTATAATTATAGGTACTTTTATAAACAGCTAGAACAGGCAATTTACGATTATCC
AGAACGATCTTTGACCATGTTGATGATAGACATTGATGACTTCAAACTTTATAATGATAGATTCGGACACCCGGCAGGGG
ATGAAGTCTTAGAAATTATATCCAAATTATTAAAAGATAATATTCGGGACAGGGACATTGCTTGTCGCTATGGTGGAGAG
GAGTTTAGTGTTTTATTATTGGGAGCACGAGGAATAGAAGCGGAAAAAATTGCCGAGCGAATTCGCAGTGCCATAGCAAA
TTATCCTTTCCCAGGGGATGAGAAAACTCCCAAAGTCAAATTAACAGTCAGTATTGGTGGGGCTGAATATCCCCAGGATG
GCACTAGCTCTATGGATTTGATGAGAAAATCTGATCAGGCTCTGTACTTAGGGTCCAAAAAGCAAGGTAAAAACAGGGTC
AGCATGTTTAAAAAAATAACTGAACTTCATTCAGTACAGGACGATGAAAAAAAAATTGTGGGATTCCCCAATAGAGGGGT
GGATGGAAATGGCTCAAATCGAGGGGATAATTAA

Upstream 100 bases:

>100_bases
AATGGGTTTTTAAAAATTATAGTATATTCATACCTAAAGCTATATTAGGGATTGATAGGGAATGAGTAAGTAAGTTTCTA
AGTTCGGGTATAATACGGGG

Downstream 100 bases:

>100_bases
ACGAGTAACATATCATAATCCGGAAAATATGTTTACAGTAGCCAAACTGGTCACTCAAGAGACGAGAAATGAAATTACTA
TAGTAGGCAATATGCCTCAT

Product: diguanylate cyclase with GAF sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MGKILEKRLNQGVALASSLVLLTLLWITLVNAGYRENVFTYEFIVLLALTIVMERIRIPAGRISLSLNFALVFSALVILG
FYPSIWIATVGIAFHSAVFSNRPGSVALFNGAMFGVTFYVAGLAYQQAGGVVGLGEMTGPLPVIIYGLVSLAVNHTILTT
YIKFVVSYREYSFSDVLKNVGWDVVTYGVSLPVAVLMIMLYNNIGILGIVVMVMALGLNSYIFRLYKKLDQFHQELHSLQ
KTSVNLIESMELDDVLQAITRASKTMFDTKKCGIWIYDDKQGFKLTLINGESPERTIILAEGEGITGKVSHRKTPLFINN
INHPEWQEAASAEGLYDKEESILVTPLICQNKIIGALSLTRNNFIEHLEKDELIQLTEIFSAQVASALSNALHHQKVEDL
AVTDEKTNLYNYRYFYKQLEQAIYDYPERSLTMLMIDIDDFKLYNDRFGHPAGDEVLEIISKLLKDNIRDRDIACRYGGE
EFSVLLLGARGIEAEKIAERIRSAIANYPFPGDEKTPKVKLTVSIGGAEYPQDGTSSMDLMRKSDQALYLGSKKQGKNRV
SMFKKITELHSVQDDEKKIVGFPNRGVDGNGSNRGDN

Sequences:

>Translated_597_residues
MGKILEKRLNQGVALASSLVLLTLLWITLVNAGYRENVFTYEFIVLLALTIVMERIRIPAGRISLSLNFALVFSALVILG
FYPSIWIATVGIAFHSAVFSNRPGSVALFNGAMFGVTFYVAGLAYQQAGGVVGLGEMTGPLPVIIYGLVSLAVNHTILTT
YIKFVVSYREYSFSDVLKNVGWDVVTYGVSLPVAVLMIMLYNNIGILGIVVMVMALGLNSYIFRLYKKLDQFHQELHSLQ
KTSVNLIESMELDDVLQAITRASKTMFDTKKCGIWIYDDKQGFKLTLINGESPERTIILAEGEGITGKVSHRKTPLFINN
INHPEWQEAASAEGLYDKEESILVTPLICQNKIIGALSLTRNNFIEHLEKDELIQLTEIFSAQVASALSNALHHQKVEDL
AVTDEKTNLYNYRYFYKQLEQAIYDYPERSLTMLMIDIDDFKLYNDRFGHPAGDEVLEIISKLLKDNIRDRDIACRYGGE
EFSVLLLGARGIEAEKIAERIRSAIANYPFPGDEKTPKVKLTVSIGGAEYPQDGTSSMDLMRKSDQALYLGSKKQGKNRV
SMFKKITELHSVQDDEKKIVGFPNRGVDGNGSNRGDN
>Mature_596_residues
GKILEKRLNQGVALASSLVLLTLLWITLVNAGYRENVFTYEFIVLLALTIVMERIRIPAGRISLSLNFALVFSALVILGF
YPSIWIATVGIAFHSAVFSNRPGSVALFNGAMFGVTFYVAGLAYQQAGGVVGLGEMTGPLPVIIYGLVSLAVNHTILTTY
IKFVVSYREYSFSDVLKNVGWDVVTYGVSLPVAVLMIMLYNNIGILGIVVMVMALGLNSYIFRLYKKLDQFHQELHSLQK
TSVNLIESMELDDVLQAITRASKTMFDTKKCGIWIYDDKQGFKLTLINGESPERTIILAEGEGITGKVSHRKTPLFINNI
NHPEWQEAASAEGLYDKEESILVTPLICQNKIIGALSLTRNNFIEHLEKDELIQLTEIFSAQVASALSNALHHQKVEDLA
VTDEKTNLYNYRYFYKQLEQAIYDYPERSLTMLMIDIDDFKLYNDRFGHPAGDEVLEIISKLLKDNIRDRDIACRYGGEE
FSVLLLGARGIEAEKIAERIRSAIANYPFPGDEKTPKVKLTVSIGGAEYPQDGTSSMDLMRKSDQALYLGSKKQGKNRVS
MFKKITELHSVQDDEKKIVGFPNRGVDGNGSNRGDN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1787262, Length=182, Percent_Identity=32.4175824175824, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786584, Length=181, Percent_Identity=30.939226519337, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI145693134, Length=135, Percent_Identity=38.5185185185185, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI87082007, Length=163, Percent_Identity=34.3558282208589, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787802, Length=165, Percent_Identity=33.9393939393939, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788085, Length=167, Percent_Identity=32.9341317365269, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081881, Length=169, Percent_Identity=37.8698224852071, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788381, Length=167, Percent_Identity=32.9341317365269, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1787816, Length=160, Percent_Identity=30.625, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081974, Length=170, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787541, Length=170, Percent_Identity=27.6470588235294, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 66655; Mature: 66524

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKILEKRLNQGVALASSLVLLTLLWITLVNAGYRENVFTYEFIVLLALTIVMERIRIPA
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GRISLSLNFALVFSALVILGFYPSIWIATVGIAFHSAVFSNRPGSVALFNGAMFGVTFYV
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
AGLAYQQAGGVVGLGEMTGPLPVIIYGLVSLAVNHTILTTYIKFVVSYREYSFSDVLKNV
HHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GWDVVTYGVSLPVAVLMIMLYNNIGILGIVVMVMALGLNSYIFRLYKKLDQFHQELHSLQ
CCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
KTSVNLIESMELDDVLQAITRASKTMFDTKKCGIWIYDDKQGFKLTLINGESPERTIILA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCEEEEEE
EGEGITGKVSHRKTPLFINNINHPEWQEAASAEGLYDKEESILVTPLICQNKIIGALSLT
CCCCCEEECCCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEHHHCCCHHHHHHHH
RNNFIEHLEKDELIQLTEIFSAQVASALSNALHHQKVEDLAVTDEKTNLYNYRYFYKQLE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
QAIYDYPERSLTMLMIDIDDFKLYNDRFGHPAGDEVLEIISKLLKDNIRDRDIACRYGGE
HHHHHCCCCCEEEEEEECCCCEEHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
EFSVLLLGARGIEAEKIAERIRSAIANYPFPGDEKTPKVKLTVSIGGAEYPQDGTSSMDL
EEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHH
MRKSDQALYLGSKKQGKNRVSMFKKITELHSVQDDEKKIVGFPNRGVDGNGSNRGDN
HHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKILEKRLNQGVALASSLVLLTLLWITLVNAGYRENVFTYEFIVLLALTIVMERIRIPA
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GRISLSLNFALVFSALVILGFYPSIWIATVGIAFHSAVFSNRPGSVALFNGAMFGVTFYV
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
AGLAYQQAGGVVGLGEMTGPLPVIIYGLVSLAVNHTILTTYIKFVVSYREYSFSDVLKNV
HHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GWDVVTYGVSLPVAVLMIMLYNNIGILGIVVMVMALGLNSYIFRLYKKLDQFHQELHSLQ
CCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
KTSVNLIESMELDDVLQAITRASKTMFDTKKCGIWIYDDKQGFKLTLINGESPERTIILA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCEEEEEE
EGEGITGKVSHRKTPLFINNINHPEWQEAASAEGLYDKEESILVTPLICQNKIIGALSLT
CCCCCEEECCCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEHHHCCCHHHHHHHH
RNNFIEHLEKDELIQLTEIFSAQVASALSNALHHQKVEDLAVTDEKTNLYNYRYFYKQLE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
QAIYDYPERSLTMLMIDIDDFKLYNDRFGHPAGDEVLEIISKLLKDNIRDRDIACRYGGE
HHHHHCCCCCEEEEEEECCCCEEHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
EFSVLLLGARGIEAEKIAERIRSAIANYPFPGDEKTPKVKLTVSIGGAEYPQDGTSSMDL
EEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHH
MRKSDQALYLGSKKQGKNRVSMFKKITELHSVQDDEKKIVGFPNRGVDGNGSNRGDN
HHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]