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The map label for this gene is tlpC [H]

Identifier: 188586795

GI number: 188586795

Start: 2317096

End: 2318826

Strand: Reverse

Name: tlpC [H]

Synonym: Nther_2186

Alternate gene names: 188586795

Gene position: 2318826-2317096 (Counterclockwise)

Preceding gene: 188586796

Following gene: 188586794

Centisome position: 73.25

GC content: 34.14

Gene sequence:

>1731_bases
ATGAAAAGGTTTTTAGTAAATAGTATCAGAAATAAGTTGGTTGTGGGTGTAATCATAATGGTAGTTATTATTGCAGTAGC
TTTAAATTTTTTAAATGATTACATAATTGAAGATGTAATAGACACAACAGTTAATGCAAAATTACAAGGAGATCAAGAGA
TGGGCCTTTATGCACTAGAACAGGAGTACTCAGGTAACTGGCATATTCAAGATGAGGAGTTATATAAAGGAACTGTACCT
GCAGAACAAATGACTGGAACTTTGGATAATATCGAAGAAAGAACGGGAGCTGTAGTCACTTTATTTAAAGGGGCTACGAG
AGTTGCTACCAGCATTACAGACGAAACCGGAGAACGAATTGTTGGTACTCAATCCGAAGAACAAGTAGCAGAAACCGTAT
TGGAACAAGGGGATAACTATGAAGGGGAAGCTGAAATATTAGGAAAACCATATGAGTCGGTATATGTCCCAATAGAAAAT
GAAAACGGAGAAGCTATTGGAATGTTGTTTGTGGGTGTACCGGTGGAAGATATCAATAATATTGTCAATCAAGGTAATAC
TTATTTTATCATGTTTTCTGGTTTGTTAGTAATAATATTTTTAATCATTTCTGTTATCGTACTAAATAAAATTATTGCAC
CTATAGGTGTTTTGACAGGGTTAATTAATAAACTTGCTGAATATGATTTCACTTTTGATGAAGAACATAAAGCTAATGAT
TATTTAAAAAGACAAGACGAAATTGGTGTTATAACAAATGCTTTAGTTCAAATGCAGTCAAAAATCACTGAACTAATTAA
AACTATAAAAGAAACCAGTGAACAGTTAGCGTCTTCCTCCGAAGAATTGAGTGCAAATACTGAAGAGAATACCAGCGCTG
CTAACGAAGTATCTAAAGCAGTAGAAGATATAGCAAGTGGAGCGAGTAATCAAGCGGAAAAAACAGAAAAATGTTCAGAT
AGTGCCCAAAAATTAGGTGAAATTATTGATGCAGACCAGGAAAACGTACAAAAATTAATTGATATAACTCAAGAAGTGAT
TGAATCTAAAGATGAAGGTTTAGAGACAGTAAATAGTCTCACTTCAGAAACAGAAAAGGTGAGTGAAGCTACTGATACAA
TGTATAACGTTGTTAACCAAACTAAAGAGAGTTCTAACATGATACAATCTGTTACTGATACAATTAAAGATATAGCTGAA
CAAACAAACTTACTTGCCCTTAATGCAAGCATAGAAGCTGCCAGAGCCGGAGAAGATGGAAAAGGTTTTGCTGTAGTTGC
AGATGAGATTAGAAAGCTAGCGGAGCAAAGCAATAAACACTCGGAAGAAATAGAAAATGCTGTTAAAGAATTAAAAGAAA
AATCTGAAGAAACAGTCAATACCATGGAAGAGACTAAAGAGTTGATAACTAATCAACACAATAATGTAGATAACACTAAA
GATAAATTCCAAGATATTGCTGATAAAATATCAAAAATTAAGCAGAAAACCGAAGAATTTCAAGATACGGGAGGGGAAAT
GGATACTAAGAAACAAGAGATTATAGATGCATTACAAGATTTATCTGCTATTGCTGAAGAGAATTCATCTAGTACTGAAG
AAATTTCTTCTTCTGTAGAGGAGCAAACTGCAAGTATGGATGAAATAGCTAAAGCCAGTGAACAGCTTGCCAAACAGGCT
GAAGAAATGCAAGAAGAAATTTCTAAATTGTGCGCCATGCATGACGATTAG

Upstream 100 bases:

>100_bases
GAAAAAGGAGGTGTGCATAGATCTAATAAATTTACAACTAAAAGATGGTCTAATGTCTTAGTTTATGGTTTATCTAGTTA
TTTTACAGGAGGTGATTTGA

Downstream 100 bases:

>100_bases
CTAGGTGGTGTAAGTCCACTATGGGGGTTTGTAGTTACCAACCATTAGCCAAGAGCAAGGGTGCCCATCGTGAGGTGGGA
TCTGAAGGAAGCTTAAGGCA

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MKRFLVNSIRNKLVVGVIIMVVIIAVALNFLNDYIIEDVIDTTVNAKLQGDQEMGLYALEQEYSGNWHIQDEELYKGTVP
AEQMTGTLDNIEERTGAVVTLFKGATRVATSITDETGERIVGTQSEEQVAETVLEQGDNYEGEAEILGKPYESVYVPIEN
ENGEAIGMLFVGVPVEDINNIVNQGNTYFIMFSGLLVIIFLIISVIVLNKIIAPIGVLTGLINKLAEYDFTFDEEHKAND
YLKRQDEIGVITNALVQMQSKITELIKTIKETSEQLASSSEELSANTEENTSAANEVSKAVEDIASGASNQAEKTEKCSD
SAQKLGEIIDADQENVQKLIDITQEVIESKDEGLETVNSLTSETEKVSEATDTMYNVVNQTKESSNMIQSVTDTIKDIAE
QTNLLALNASIEAARAGEDGKGFAVVADEIRKLAEQSNKHSEEIENAVKELKEKSEETVNTMEETKELITNQHNNVDNTK
DKFQDIADKISKIKQKTEEFQDTGGEMDTKKQEIIDALQDLSAIAEENSSSTEEISSSVEEQTASMDEIAKASEQLAKQA
EEMQEEISKLCAMHDD

Sequences:

>Translated_576_residues
MKRFLVNSIRNKLVVGVIIMVVIIAVALNFLNDYIIEDVIDTTVNAKLQGDQEMGLYALEQEYSGNWHIQDEELYKGTVP
AEQMTGTLDNIEERTGAVVTLFKGATRVATSITDETGERIVGTQSEEQVAETVLEQGDNYEGEAEILGKPYESVYVPIEN
ENGEAIGMLFVGVPVEDINNIVNQGNTYFIMFSGLLVIIFLIISVIVLNKIIAPIGVLTGLINKLAEYDFTFDEEHKAND
YLKRQDEIGVITNALVQMQSKITELIKTIKETSEQLASSSEELSANTEENTSAANEVSKAVEDIASGASNQAEKTEKCSD
SAQKLGEIIDADQENVQKLIDITQEVIESKDEGLETVNSLTSETEKVSEATDTMYNVVNQTKESSNMIQSVTDTIKDIAE
QTNLLALNASIEAARAGEDGKGFAVVADEIRKLAEQSNKHSEEIENAVKELKEKSEETVNTMEETKELITNQHNNVDNTK
DKFQDIADKISKIKQKTEEFQDTGGEMDTKKQEIIDALQDLSAIAEENSSSTEEISSSVEEQTASMDEIAKASEQLAKQA
EEMQEEISKLCAMHDD
>Mature_576_residues
MKRFLVNSIRNKLVVGVIIMVVIIAVALNFLNDYIIEDVIDTTVNAKLQGDQEMGLYALEQEYSGNWHIQDEELYKGTVP
AEQMTGTLDNIEERTGAVVTLFKGATRVATSITDETGERIVGTQSEEQVAETVLEQGDNYEGEAEILGKPYESVYVPIEN
ENGEAIGMLFVGVPVEDINNIVNQGNTYFIMFSGLLVIIFLIISVIVLNKIIAPIGVLTGLINKLAEYDFTFDEEHKAND
YLKRQDEIGVITNALVQMQSKITELIKTIKETSEQLASSSEELSANTEENTSAANEVSKAVEDIASGASNQAEKTEKCSD
SAQKLGEIIDADQENVQKLIDITQEVIESKDEGLETVNSLTSETEKVSEATDTMYNVVNQTKESSNMIQSVTDTIKDIAE
QTNLLALNASIEAARAGEDGKGFAVVADEIRKLAEQSNKHSEEIENAVKELKEKSEETVNTMEETKELITNQHNNVDNTK
DKFQDIADKISKIKQKTEEFQDTGGEMDTKKQEIIDALQDLSAIAEENSSSTEEISSSVEEQTASMDEIAKASEQLAKQA
EEMQEEISKLCAMHDD

Specific function: Mediates Taxis To The Sugars Ribose And Galactose VIa An Interaction With The Periplasmic Ribose- Or Galactose-Binding Proteins. Chemotactic-Signal Transducers Respond To Changes In The Concentration Of Attractants And Repellents In The Environment, Trans

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=364, Percent_Identity=26.6483516483516, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788194, Length=310, Percent_Identity=25.8064516129032, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788195, Length=247, Percent_Identity=28.7449392712551, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789453, Length=374, Percent_Identity=25.1336898395722, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI2367378, Length=260, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 63535; Mature: 63535

Theoretical pI: Translated: 3.98; Mature: 3.98

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS50192 T_SNARE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFLVNSIRNKLVVGVIIMVVIIAVALNFLNDYIIEDVIDTTVNAKLQGDQEMGLYALE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCHHHHH
QEYSGNWHIQDEELYKGTVPAEQMTGTLDNIEERTGAVVTLFKGATRVATSITDETGERI
HHCCCCCCCCHHHHHCCCCCHHHHHCCHHHHHHHCCCEEEEHHCHHHHHHHHHHHHCCHH
VGTQSEEQVAETVLEQGDNYEGEAEILGKPYESVYVPIENENGEAIGMLFVGVPVEDINN
CCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHH
IVNQGNTYFIMFSGLLVIIFLIISVIVLNKIIAPIGVLTGLINKLAEYDFTFDEEHKAND
HHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YLKRQDEIGVITNALVQMQSKITELIKTIKETSEQLASSSEELSANTEENTSAANEVSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
VEDIASGASNQAEKTEKCSDSAQKLGEIIDADQENVQKLIDITQEVIESKDEGLETVNSL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TSETEKVSEATDTMYNVVNQTKESSNMIQSVTDTIKDIAEQTNLLALNASIEAARAGEDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCC
KGFAVVADEIRKLAEQSNKHSEEIENAVKELKEKSEETVNTMEETKELITNQHNNVDNTK
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DKFQDIADKISKIKQKTEEFQDTGGEMDTKKQEIIDALQDLSAIAEENSSSTEEISSSVE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EQTASMDEIAKASEQLAKQAEEMQEEISKLCAMHDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRFLVNSIRNKLVVGVIIMVVIIAVALNFLNDYIIEDVIDTTVNAKLQGDQEMGLYALE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCHHHHH
QEYSGNWHIQDEELYKGTVPAEQMTGTLDNIEERTGAVVTLFKGATRVATSITDETGERI
HHCCCCCCCCHHHHHCCCCCHHHHHCCHHHHHHHCCCEEEEHHCHHHHHHHHHHHHCCHH
VGTQSEEQVAETVLEQGDNYEGEAEILGKPYESVYVPIENENGEAIGMLFVGVPVEDINN
CCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHH
IVNQGNTYFIMFSGLLVIIFLIISVIVLNKIIAPIGVLTGLINKLAEYDFTFDEEHKAND
HHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YLKRQDEIGVITNALVQMQSKITELIKTIKETSEQLASSSEELSANTEENTSAANEVSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
VEDIASGASNQAEKTEKCSDSAQKLGEIIDADQENVQKLIDITQEVIESKDEGLETVNSL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TSETEKVSEATDTMYNVVNQTKESSNMIQSVTDTIKDIAEQTNLLALNASIEAARAGEDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCC
KGFAVVADEIRKLAEQSNKHSEEIENAVKELKEKSEETVNTMEETKELITNQHNNVDNTK
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DKFQDIADKISKIKQKTEEFQDTGGEMDTKKQEIIDALQDLSAIAEENSSSTEEISSSVE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EQTASMDEIAKASEQLAKQAEEMQEEISKLCAMHDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]