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The map label for this gene is comC [H]

Identifier: 188586700

GI number: 188586700

Start: 2208371

End: 2209108

Strand: Reverse

Name: comC [H]

Synonym: Nther_2090

Alternate gene names: 188586700

Gene position: 2209108-2208371 (Counterclockwise)

Preceding gene: 188586701

Following gene: 188586699

Centisome position: 69.79

GC content: 34.55

Gene sequence:

>738_bases
ATGATGGAATTATTTTTGATATTTATTTTGGGTACTTGTTTAGGTAGTTTTTATAATGTGGTGGCACTTAGATTAATGGA
TGGGAAAGAAGTGAATCACTTTATCTTTGGCAGGTCAAGTTGTCCAAAATGTGAGGAAATATTAGCTCCCTTGGAACTGA
TCCCTTTGATTAGTTTTTTAGCTTTAAGGGGGAGGTGTCGTCATTGTAGGGGAAAGATTTCTCCAATCTATTTTGTAGGT
GAAATGATTACTGGTATCACATTTGTGATTATATTTGTGAGTATAGGTGCCAGCTTATCCTTAATTCCTCACTTGCTTTT
GGGTTCTTTATTGGTTATATCGGTAATCACGGATCTATTAAAAGGAATAGTACTTAATAAAATGATATTCTTTTTTGGGA
TATTAATTTTATTGACTAGAATAGTAATAATAGAAGAGCTGTTTTATCATTTAATAAGTGGTTTGTTCAGCTTTTTATTA
TTATTTGCGGTAATGGTACTTAGTGGTCATAAGATGGGGGGAGGAGACGTTAAGTTGTATGGCATTATAGGTCTTGGTGT
AGGGCTACTGGATTCTTTGGCTAGTTTATTTTTTGCTTCCTTGATTGGATTGGCCGTAATGCTCCCTGGTTTGATTAGCG
GCCGTATAAGTAGAAAAACTGAAATTCCTTTTGTTCCTTTTATCTGGGCGGGGGTTATGGTAACTTATATGGTAGATGTG
TTGACAATTTTTATATGA

Upstream 100 bases:

>100_bases
TTTAAACTCTAGTTCAGCTGGTGGCTATAAATTAATTAAAATAGAACATTAGCTAAGTTCATAAATCGAGTGGACAAGTT
TTATTAAAATGGAGGAGTAG

Downstream 100 bases:

>100_bases
CAGAAGTCAGTATAACTTAAGTATAGTCAAGGAGTTAAGGAGGATTTTTTATTTTTGGTACAACTAACTGTAAAAATTGT
GGAGAATTCTTTAAGGAAGA

Product: peptidase A24A domain protein

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MMELFLIFILGTCLGSFYNVVALRLMDGKEVNHFIFGRSSCPKCEEILAPLELIPLISFLALRGRCRHCRGKISPIYFVG
EMITGITFVIIFVSIGASLSLIPHLLLGSLLVISVITDLLKGIVLNKMIFFFGILILLTRIVIIEELFYHLISGLFSFLL
LFAVMVLSGHKMGGGDVKLYGIIGLGVGLLDSLASLFFASLIGLAVMLPGLISGRISRKTEIPFVPFIWAGVMVTYMVDV
LTIFI

Sequences:

>Translated_245_residues
MMELFLIFILGTCLGSFYNVVALRLMDGKEVNHFIFGRSSCPKCEEILAPLELIPLISFLALRGRCRHCRGKISPIYFVG
EMITGITFVIIFVSIGASLSLIPHLLLGSLLVISVITDLLKGIVLNKMIFFFGILILLTRIVIIEELFYHLISGLFSFLL
LFAVMVLSGHKMGGGDVKLYGIIGLGVGLLDSLASLFFASLIGLAVMLPGLISGRISRKTEIPFVPFIWAGVMVTYMVDV
LTIFI
>Mature_245_residues
MMELFLIFILGTCLGSFYNVVALRLMDGKEVNHFIFGRSSCPKCEEILAPLELIPLISFLALRGRCRHCRGKISPIYFVG
EMITGITFVIIFVSIGASLSLIPHLLLGSLLVISVITDLLKGIVLNKMIFFFGILILLTRIVIIEELFYHLISGLFSFLL
LFAVMVLSGHKMGGGDVKLYGIIGLGVGLLDSLASLFFASLIGLAVMLPGLISGRISRKTEIPFVPFIWAGVMVTYMVDV
LTIFI

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=241, Percent_Identity=26.9709543568465, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 26938; Mature: 26938

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMELFLIFILGTCLGSFYNVVALRLMDGKEVNHFIFGRSSCPKCEEILAPLELIPLISFL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
ALRGRCRHCRGKISPIYFVGEMITGITFVIIFVSIGASLSLIPHLLLGSLLVISVITDLL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KGIVLNKMIFFFGILILLTRIVIIEELFYHLISGLFSFLLLFAVMVLSGHKMGGGDVKLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEH
GIIGLGVGLLDSLASLFFASLIGLAVMLPGLISGRISRKTEIPFVPFIWAGVMVTYMVDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LTIFI
HHHHC
>Mature Secondary Structure
MMELFLIFILGTCLGSFYNVVALRLMDGKEVNHFIFGRSSCPKCEEILAPLELIPLISFL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
ALRGRCRHCRGKISPIYFVGEMITGITFVIIFVSIGASLSLIPHLLLGSLLVISVITDLL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KGIVLNKMIFFFGILILLTRIVIIEELFYHLISGLFSFLLLFAVMVLSGHKMGGGDVKLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEH
GIIGLGVGLLDSLASLFFASLIGLAVMLPGLISGRISRKTEIPFVPFIWAGVMVTYMVDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LTIFI
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]