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The map label for this gene is lldD [H]

Identifier: 188586641

GI number: 188586641

Start: 2143317

End: 2144327

Strand: Reverse

Name: lldD [H]

Synonym: Nther_2031

Alternate gene names: 188586641

Gene position: 2144327-2143317 (Counterclockwise)

Preceding gene: 188586642

Following gene: 188586640

Centisome position: 67.74

GC content: 40.36

Gene sequence:

>1011_bases
ATGGAATTAACTAACATTAGAAAAAAAGCTAAAAATCGTCTTGCTGAATTTTGTAGCTCTTGTTGGGAATGCAATGGAGA
AGTGTGTCGTGGCCAAGTGCCTGGTATGGGTGGTGTTGGTACGGGACGAAGTTTTATAAACAACTTCAGGGCTTTAAACA
TGTATCAACTAAATCTTCGCTCCATGCATCAAGCCATCAGCCCTGAAACAGAACTTATATTATTTGGCGAAAGGATAGCC
ACACCAATACTGCCAGCACCCATTGGGGGAATGAATGTAAACTTTAACAATGTTATCTCTGAAAAGGAATATGCTGACAG
TGTATCATATGGTGCTAAACAGGCAGGAACAATTTCCACATGTGGTGATGGTTCCCTGGACGAAGTCTTTGAAAGTGGAT
TACAATCTTTTCAAAAAGCGGGAGTTCCAGGTATTGCTATGATTAAACCACGATCCGTAGAAGGGATAATTAACAGAATT
AGGCAAGCGGAAGAATCAGGAGCCATTGCTGTTGGAGTAGATGTGGATGCTTGTGCATTTAATATGGCTGAAAAAGGAGC
TCCAGTAGGTCCAAAATCTTTTTATCAGATGCGTAGAATTGTTCAAAGTACTTCTTTACCTTTTATTATTAAGGGAGTTA
TGACTGTTCAGGAAGCAGAAATGGCTGTTGAAATGGGAGCTGCTGGGATTGTTGTATCAAATCATGGTGGCAGGGCTTTG
GATTATACTCCGGGCACAGCAGAAGTCTTACCTGAAATCGCCGAAAAGGTAAAAGGTGAAATAGTGATCATGGTTGATGG
AGGAATTCGTAGTGGAATAGATGTCTTAAAAGTTTTAGCTCTAGGGGCTGAATTTGTACTTGTAGGTAGACCAGTGTTAC
ATGGTGTGTTTGCAGATTATAATAATGGGGTGTCTACTGTCTTAGAACAAATGACCAGTGAATTAAGGCGTACAATGATG
CTGACTGGTTGTGCTCATGTAAAAGCCATTGATGAACGAGTGATTTATTAA

Upstream 100 bases:

>100_bases
GTGAAGGATGTTGCTGATACCATTGTCAGTGCAAATGATGAAAGCGGAGTATCTGAAGCGATTGAAAGATTTGTTCTGAG
CGATTCTGGGAGGGAGATGA

Downstream 100 bases:

>100_bases
TATAAAGGTTGTGTTAAAGTTGAATGTTGATAGTTGAACTCAATCGAAGAGTTCAACTATCAACAACGGAGTAAAACAGA
GCTAATATAAAAATTTACAA

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MELTNIRKKAKNRLAEFCSSCWECNGEVCRGQVPGMGGVGTGRSFINNFRALNMYQLNLRSMHQAISPETELILFGERIA
TPILPAPIGGMNVNFNNVISEKEYADSVSYGAKQAGTISTCGDGSLDEVFESGLQSFQKAGVPGIAMIKPRSVEGIINRI
RQAEESGAIAVGVDVDACAFNMAEKGAPVGPKSFYQMRRIVQSTSLPFIIKGVMTVQEAEMAVEMGAAGIVVSNHGGRAL
DYTPGTAEVLPEIAEKVKGEIVIMVDGGIRSGIDVLKVLALGAEFVLVGRPVLHGVFADYNNGVSTVLEQMTSELRRTMM
LTGCAHVKAIDERVIY

Sequences:

>Translated_336_residues
MELTNIRKKAKNRLAEFCSSCWECNGEVCRGQVPGMGGVGTGRSFINNFRALNMYQLNLRSMHQAISPETELILFGERIA
TPILPAPIGGMNVNFNNVISEKEYADSVSYGAKQAGTISTCGDGSLDEVFESGLQSFQKAGVPGIAMIKPRSVEGIINRI
RQAEESGAIAVGVDVDACAFNMAEKGAPVGPKSFYQMRRIVQSTSLPFIIKGVMTVQEAEMAVEMGAAGIVVSNHGGRAL
DYTPGTAEVLPEIAEKVKGEIVIMVDGGIRSGIDVLKVLALGAEFVLVGRPVLHGVFADYNNGVSTVLEQMTSELRRTMM
LTGCAHVKAIDERVIY
>Mature_336_residues
MELTNIRKKAKNRLAEFCSSCWECNGEVCRGQVPGMGGVGTGRSFINNFRALNMYQLNLRSMHQAISPETELILFGERIA
TPILPAPIGGMNVNFNNVISEKEYADSVSYGAKQAGTISTCGDGSLDEVFESGLQSFQKAGVPGIAMIKPRSVEGIINRI
RQAEESGAIAVGVDVDACAFNMAEKGAPVGPKSFYQMRRIVQSTSLPFIIKGVMTVQEAEMAVEMGAAGIVVSNHGGRAL
DYTPGTAEVLPEIAEKVKGEIVIMVDGGIRSGIDVLKVLALGAEFVLVGRPVLHGVFADYNNGVSTVLEQMTSELRRTMM
LTGCAHVKAIDERVIY

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=340, Percent_Identity=28.8235294117647, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI54234014, Length=337, Percent_Identity=30.2670623145401, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI7705393, Length=337, Percent_Identity=30.2670623145401, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790033, Length=140, Percent_Identity=41.4285714285714, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI193208036, Length=137, Percent_Identity=44.5255474452555, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323587, Length=140, Percent_Identity=38.5714285714286, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363140, Length=132, Percent_Identity=42.4242424242424, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI78707190, Length=132, Percent_Identity=42.4242424242424, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI78707188, Length=132, Percent_Identity=42.4242424242424, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 36040; Mature: 36040

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTNIRKKAKNRLAEFCSSCWECNGEVCRGQVPGMGGVGTGRSFINNFRALNMYQLNLR
CCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHEEHHHH
SMHQAISPETELILFGERIATPILPAPIGGMNVNFNNVISEKEYADSVSYGAKQAGTIST
HHHHHHCCCCEEEEECHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
CGDGSLDEVFESGLQSFQKAGVPGIAMIKPRSVEGIINRIRQAEESGAIAVGVDVDACAF
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCHHHHHH
NMAEKGAPVGPKSFYQMRRIVQSTSLPFIIKGVMTVQEAEMAVEMGAAGIVVSNHGGRAL
HHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEE
DYTPGTAEVLPEIAEKVKGEIVIMVDGGIRSGIDVLKVLALGAEFVLVGRPVLHGVFADY
ECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHC
NNGVSTVLEQMTSELRRTMMLTGCAHVKAIDERVIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELTNIRKKAKNRLAEFCSSCWECNGEVCRGQVPGMGGVGTGRSFINNFRALNMYQLNLR
CCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHEEHHHH
SMHQAISPETELILFGERIATPILPAPIGGMNVNFNNVISEKEYADSVSYGAKQAGTIST
HHHHHHCCCCEEEEECHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
CGDGSLDEVFESGLQSFQKAGVPGIAMIKPRSVEGIINRIRQAEESGAIAVGVDVDACAF
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCHHHHHH
NMAEKGAPVGPKSFYQMRRIVQSTSLPFIIKGVMTVQEAEMAVEMGAAGIVVSNHGGRAL
HHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEE
DYTPGTAEVLPEIAEKVKGEIVIMVDGGIRSGIDVLKVLALGAEFVLVGRPVLHGVFADY
ECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHC
NNGVSTVLEQMTSELRRTMMLTGCAHVKAIDERVIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA