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The map label for this gene is rnr [H]

Identifier: 188586620

GI number: 188586620

Start: 2118239

End: 2120368

Strand: Reverse

Name: rnr [H]

Synonym: Nther_2010

Alternate gene names: 188586620

Gene position: 2120368-2118239 (Counterclockwise)

Preceding gene: 188586621

Following gene: 188586619

Centisome position: 66.98

GC content: 36.48

Gene sequence:

>2130_bases
ATGATACTTAGAGACAAAATTATCAACTTCATGAAAGCAGATGCTTATAAACCTATGACCTTTGAAGAGTTAAAAGATGA
ATTTAAAATTAACAAACCTAGACAGGTCAAACGGTTTAAAAAGATATTGAAAAAGATGACTCGAGATGGACAGATTGTGA
AAACTAGATATGGCTATTATGGTTTACCGGAGCGTATGAATTTGCAAATAGGAACAATCCAGGGTCATCCTAAAGGATAT
GCTTTTCTTTTACCAGATAAGCCTGGTAGTCCTGATGTGTTTTTAAGCCCTAAAAGTCTAAATGGAGCCCTACACAATGA
CAAAGTATTAGTAAGAATACATAAAGAGGAGATGCTGAACCAAAAACCTGAAGGAGAAGTAGTACGAATTATTTCCCGGG
GAATGTCCGAAGTAGTTGGTACATTTGATAAAAGTGATCGATTTGGTTTTGTGGTTCCAGATGATGATAGATTCTTCAGA
GATGTGTTTATAAATAAAGCAGATGCCAATGGTGCTAAAAATGGCCAAAAGGTTGTTGCTCAAATCACAGGTTGGCCCGA
TACTCCGGCCAAAAACCCTGAAGGTGAGATCATTAAAGTAATTGGAAATCCTAGTGATCCTGGTGTGGATATTGAGACTA
TTATAAATAAATACGGTCTGTCAGAAGATTATCCGCCAAAAGTCAAAGAACAATTAGAGGAAGTTCCTAATGAGATTAGC
CCGAAAGATTACGAAGGAAGAGAGTTGATTCAAGGGTTACCAACTGTAACCATTGATGGTAGCGATGCTAAGGACTTGGA
TGATGCAGTCTCTTTAGAGAAACTCGATAATGGAAATATGGAACTAGGTGTACATATAGCTGATGTCAGTTACTATGTCA
GAGAAGGAACTCCACTAGATAAAGAAGCTCGTCAAAGGGGTACTAGTGTTTATTTGGTGGATCGTGTTTTACCTATGTTA
CCACCAAAGTTATCAAATAATATTTGTAGTCTAAACCCAGGAGTAGAACGCTTGACTATGAGCGCTTTTGTAGAACTAAC
AGAAGAAGGAGACATTGCAAATTATAGATTGACTCCTAGTGTAATCAAGAGTAACTACCGCTTAACCTATGAAGAGGTCA
ATGAGTTATTTGATGGTAGTAAAGAGATAGAAGAAAAATATCCAGATGTAGCCTGGATGTTATTTGAAATGAAAACAATC
TCTGAAAAACTTAGGGAACGAAGATTTGATGAAGGGGCTATAGACTTTGAATTTGATGAACCAGTTGTGGTATTAGATGA
TCAAGGGAAACCAGAAAGTGTTGAAAAACGAGCAAGAGGATCCGCAGAAAAGTTGATAGAAGAATTTATGCTACTAGCTA
ATAGAGTTGTAGCCGAACACCATTATAACCTTGATATGCCTTTTATTTACAGAGTCCACGAACAGCCTGATGATGAAAAA
GTTTCAACTTTCAGGGAGTTTGCGTCAAAGTTTGGGTATTATTTGCCTAAACCGGAAGGGGAAGAAATATATCCCATCGA
ATTTCAAAAAGTTTTAGAAGAAGCAAAGGATACTAGAGAGGAACGTGCTATTAGCACTATGATGCTCAGGTCAATGAAAC
AGGCTAGATATGCAGCTGAAAGCCTGGGCCACTTTGGGCTATCTTTTCAATATTATACTCACTTTACTTCACCTATTAGA
AGATATCCCGACTTAGTAGTTCATAGGATTATGAGAGAAATTATTACCAAGAAAGACTTAAAAGAGGCCAGACAAAAGAA
ATTACAAAGTAAATTAGAAGAAATAGCCTATCAATCTTCTTTGAGGGAACAAGAAGCTACAGAAGCAGAGAGAGAATCAG
TTGATTATAAAATGGCCGAGTATATGGAACAATTTGTAGGGGATGATTTTCCAGGAATAGTAAGTTCTGTAACTTCCTTT
GGTATATTCATAGAGTTACCAAATTTAGTTGAAGGTCTTGTGCATGTAAGTTCTATGACTGATGATTACTATTACTTTGA
CGAAGAAAAATTTGCTTTAATTGGTGAACAGACAAGAAAAACTTATCGAATCGGGGATGAAGTTAAAGTTAAAGTGGTTA
AAACCTCAAAGGAAGATTGTCAAGTTGACTTTGAACTAGTTGAAGATTAG

Upstream 100 bases:

>100_bases
ATCTGATGACCTGGGGTTGTAACCCCAGGTTTTTGTTGATATTATAAACAAAAAGCGGGAAAATTAATAAGACAAAAGTA
TTAGTTATCGAGGTGGTGTG

Downstream 100 bases:

>100_bases
ATAAATAACGATTGTAGGGATCAAAGGTCAATTTGTGGGGATCAAAAGTTTAAAAAAAGTTTATTTACTAGCAGTTGACT
CAATTTAGGGTTAATGTTAT

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MILRDKIINFMKADAYKPMTFEELKDEFKINKPRQVKRFKKILKKMTRDGQIVKTRYGYYGLPERMNLQIGTIQGHPKGY
AFLLPDKPGSPDVFLSPKSLNGALHNDKVLVRIHKEEMLNQKPEGEVVRIISRGMSEVVGTFDKSDRFGFVVPDDDRFFR
DVFINKADANGAKNGQKVVAQITGWPDTPAKNPEGEIIKVIGNPSDPGVDIETIINKYGLSEDYPPKVKEQLEEVPNEIS
PKDYEGRELIQGLPTVTIDGSDAKDLDDAVSLEKLDNGNMELGVHIADVSYYVREGTPLDKEARQRGTSVYLVDRVLPML
PPKLSNNICSLNPGVERLTMSAFVELTEEGDIANYRLTPSVIKSNYRLTYEEVNELFDGSKEIEEKYPDVAWMLFEMKTI
SEKLRERRFDEGAIDFEFDEPVVVLDDQGKPESVEKRARGSAEKLIEEFMLLANRVVAEHHYNLDMPFIYRVHEQPDDEK
VSTFREFASKFGYYLPKPEGEEIYPIEFQKVLEEAKDTREERAISTMMLRSMKQARYAAESLGHFGLSFQYYTHFTSPIR
RYPDLVVHRIMREIITKKDLKEARQKKLQSKLEEIAYQSSLREQEATEAERESVDYKMAEYMEQFVGDDFPGIVSSVTSF
GIFIELPNLVEGLVHVSSMTDDYYYFDEEKFALIGEQTRKTYRIGDEVKVKVVKTSKEDCQVDFELVED

Sequences:

>Translated_709_residues
MILRDKIINFMKADAYKPMTFEELKDEFKINKPRQVKRFKKILKKMTRDGQIVKTRYGYYGLPERMNLQIGTIQGHPKGY
AFLLPDKPGSPDVFLSPKSLNGALHNDKVLVRIHKEEMLNQKPEGEVVRIISRGMSEVVGTFDKSDRFGFVVPDDDRFFR
DVFINKADANGAKNGQKVVAQITGWPDTPAKNPEGEIIKVIGNPSDPGVDIETIINKYGLSEDYPPKVKEQLEEVPNEIS
PKDYEGRELIQGLPTVTIDGSDAKDLDDAVSLEKLDNGNMELGVHIADVSYYVREGTPLDKEARQRGTSVYLVDRVLPML
PPKLSNNICSLNPGVERLTMSAFVELTEEGDIANYRLTPSVIKSNYRLTYEEVNELFDGSKEIEEKYPDVAWMLFEMKTI
SEKLRERRFDEGAIDFEFDEPVVVLDDQGKPESVEKRARGSAEKLIEEFMLLANRVVAEHHYNLDMPFIYRVHEQPDDEK
VSTFREFASKFGYYLPKPEGEEIYPIEFQKVLEEAKDTREERAISTMMLRSMKQARYAAESLGHFGLSFQYYTHFTSPIR
RYPDLVVHRIMREIITKKDLKEARQKKLQSKLEEIAYQSSLREQEATEAERESVDYKMAEYMEQFVGDDFPGIVSSVTSF
GIFIELPNLVEGLVHVSSMTDDYYYFDEEKFALIGEQTRKTYRIGDEVKVKVVKTSKEDCQVDFELVED
>Mature_709_residues
MILRDKIINFMKADAYKPMTFEELKDEFKINKPRQVKRFKKILKKMTRDGQIVKTRYGYYGLPERMNLQIGTIQGHPKGY
AFLLPDKPGSPDVFLSPKSLNGALHNDKVLVRIHKEEMLNQKPEGEVVRIISRGMSEVVGTFDKSDRFGFVVPDDDRFFR
DVFINKADANGAKNGQKVVAQITGWPDTPAKNPEGEIIKVIGNPSDPGVDIETIINKYGLSEDYPPKVKEQLEEVPNEIS
PKDYEGRELIQGLPTVTIDGSDAKDLDDAVSLEKLDNGNMELGVHIADVSYYVREGTPLDKEARQRGTSVYLVDRVLPML
PPKLSNNICSLNPGVERLTMSAFVELTEEGDIANYRLTPSVIKSNYRLTYEEVNELFDGSKEIEEKYPDVAWMLFEMKTI
SEKLRERRFDEGAIDFEFDEPVVVLDDQGKPESVEKRARGSAEKLIEEFMLLANRVVAEHHYNLDMPFIYRVHEQPDDEK
VSTFREFASKFGYYLPKPEGEEIYPIEFQKVLEEAKDTREERAISTMMLRSMKQARYAAESLGHFGLSFQYYTHFTSPIR
RYPDLVVHRIMREIITKKDLKEARQKKLQSKLEEIAYQSSLREQEATEAERESVDYKMAEYMEQFVGDDFPGIVSSVTSF
GIFIELPNLVEGLVHVSSMTDDYYYFDEEKFALIGEQTRKTYRIGDEVKVKVVKTSKEDCQVDFELVED

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=619, Percent_Identity=29.4022617124394, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI190014625, Length=619, Percent_Identity=29.4022617124394, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI19115966, Length=579, Percent_Identity=29.706390328152, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI219521928, Length=579, Percent_Identity=29.706390328152, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI134288890, Length=415, Percent_Identity=32.7710843373494, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI156105695, Length=367, Percent_Identity=25.8855585831063, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI156105693, Length=132, Percent_Identity=38.6363636363636, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI87082383, Length=701, Percent_Identity=37.3751783166904, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1787542, Length=592, Percent_Identity=25.1689189189189, Blast_Score=160, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI212645896, Length=544, Percent_Identity=30.8823529411765, Blast_Score=202, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17553506, Length=518, Percent_Identity=29.3436293436293, Blast_Score=201, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324552, Length=642, Percent_Identity=28.6604361370716, Blast_Score=210, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6320499, Length=416, Percent_Identity=27.4038461538462, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323943, Length=405, Percent_Identity=22.7160493827161, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24649634, Length=522, Percent_Identity=32.183908045977, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24654592, Length=490, Percent_Identity=28.9795918367347, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19922976, Length=490, Percent_Identity=28.9795918367347, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24654597, Length=490, Percent_Identity=28.9795918367347, Blast_Score=178, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 81563; Mature: 81563

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILRDKIINFMKADAYKPMTFEELKDEFKINKPRQVKRFKKILKKMTRDGQIVKTRYGYY
CCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
GLPERMNLQIGTIQGHPKGYAFLLPDKPGSPDVFLSPKSLNGALHNDKVLVRIHKEEMLN
CCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCHHCCCCCCCCEEEEEECHHHHCC
QKPEGEVVRIISRGMSEVVGTFDKSDRFGFVVPDDDRFFRDVFINKADANGAKNGQKVVA
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEE
QITGWPDTPAKNPEGEIIKVIGNPSDPGVDIETIINKYGLSEDYPPKVKEQLEEVPNEIS
EEECCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHCC
PKDYEGRELIQGLPTVTIDGSDAKDLDDAVSLEKLDNGNMELGVHIADVSYYVREGTPLD
CCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEEEECCCCCCC
KEARQRGTSVYLVDRVLPMLPPKLSNNICSLNPGVERLTMSAFVELTEEGDIANYRLTPS
HHHHHCCCEEEEHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECHH
VIKSNYRLTYEEVNELFDGSKEIEEKYPDVAWMLFEMKTISEKLRERRFDEGAIDFEFDE
HHHCCCEEEHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
PVVVLDDQGKPESVEKRARGSAEKLIEEFMLLANRVVAEHHYNLDMPFIYRVHEQPDDEK
CEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHH
VSTFREFASKFGYYLPKPEGEEIYPIEFQKVLEEAKDTREERAISTMMLRSMKQARYAAE
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGHFGLSFQYYTHFTSPIRRYPDLVVHRIMREIITKKDLKEARQKKLQSKLEEIAYQSS
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREQEATEAERESVDYKMAEYMEQFVGDDFPGIVSSVTSFGIFIELPNLVEGLVHVSSMT
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCEEEEECHHHHHHHHHHHHCC
DDYYYFDEEKFALIGEQTRKTYRIGDEVKVKVVKTSKEDCQVDFELVED
CCCEEECCCCEEECCHHHHHHEECCCCEEEEEEECCCCCCEEEEEEECC
>Mature Secondary Structure
MILRDKIINFMKADAYKPMTFEELKDEFKINKPRQVKRFKKILKKMTRDGQIVKTRYGYY
CCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
GLPERMNLQIGTIQGHPKGYAFLLPDKPGSPDVFLSPKSLNGALHNDKVLVRIHKEEMLN
CCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCHHCCCCCCCCEEEEEECHHHHCC
QKPEGEVVRIISRGMSEVVGTFDKSDRFGFVVPDDDRFFRDVFINKADANGAKNGQKVVA
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEE
QITGWPDTPAKNPEGEIIKVIGNPSDPGVDIETIINKYGLSEDYPPKVKEQLEEVPNEIS
EEECCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHCC
PKDYEGRELIQGLPTVTIDGSDAKDLDDAVSLEKLDNGNMELGVHIADVSYYVREGTPLD
CCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEEEECCCCCCC
KEARQRGTSVYLVDRVLPMLPPKLSNNICSLNPGVERLTMSAFVELTEEGDIANYRLTPS
HHHHHCCCEEEEHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECHH
VIKSNYRLTYEEVNELFDGSKEIEEKYPDVAWMLFEMKTISEKLRERRFDEGAIDFEFDE
HHHCCCEEEHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
PVVVLDDQGKPESVEKRARGSAEKLIEEFMLLANRVVAEHHYNLDMPFIYRVHEQPDDEK
CEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHH
VSTFREFASKFGYYLPKPEGEEIYPIEFQKVLEEAKDTREERAISTMMLRSMKQARYAAE
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGHFGLSFQYYTHFTSPIRRYPDLVVHRIMREIITKKDLKEARQKKLQSKLEEIAYQSS
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREQEATEAERESVDYKMAEYMEQFVGDDFPGIVSSVTSFGIFIELPNLVEGLVHVSSMT
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCEEEEECHHHHHHHHHHHHCC
DDYYYFDEEKFALIGEQTRKTYRIGDEVKVKVVKTSKEDCQVDFELVED
CCCEEECCCCEEECCHHHHHHEECCCCEEEEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]