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The map label for this gene is lhr [H]

Identifier: 188586146

GI number: 188586146

Start: 1601694

End: 1603829

Strand: Reverse

Name: lhr [H]

Synonym: Nther_1523

Alternate gene names: 188586146

Gene position: 1603829-1601694 (Counterclockwise)

Preceding gene: 188586147

Following gene: 188586145

Centisome position: 50.66

GC content: 29.96

Gene sequence:

>2136_bases
TTGAGCGAGACATTTTATTTATTGTCTGAAAGAATGCAAAAGAAAATATGGGAAATGGGTTGGGATGAATTCACTCCTGT
TCAAGATAAAACCATACCTATTGTTATGAACACTAATAAAGATGTTGTTGTTTCTTCTGGAACTGCATCAGGAAAGACAG
AAGCCGTCTTTTTACCAATTTTGAGCCAAATAGAAAAAGATGCAACCAAAGATTTAAAAATACTATATATTTCTCCCCTT
AAAGCTTTAATTAATGATCAGTTTGAGCGTATTATTAAACTTTGTGAAAAATCATATATTCCTATTCATCGTTGGCACGG
AGATGTAAACCAAAATAAAAAGAAACAGTTAACAAAAAATCCTGCTGGGATTCTTCAAATTACCCCAGAATCAATAGAAA
GTTTATTTATTAATCGAACAAATGAGCTAAATTACATTCTTAGTGATATAGAATTTATCATTATAGATGAATTACATGCT
TTTTTAGATAATGAAAGGGGAGTACATTTACGTTCCTTACTTTCTCGGTTAGAGAATTACATAAAAGAAAAACCTAGATA
CTTCGCACTTTCAGCAACTCTAAACAATTTTAAATTAATAAAAGAATGGATTAACTATAATGATATTAAAAATGTTGAAA
TAATAGATTCTAATGAAGACGACAAGGATTTATTACTTAGTTTAATGCATTTCGATAAAGGAAAAGACTATAAGAAACCT
ATTGATTTATATCAAGACCTTAGAGAATTAACTAAGAATGTACATTCCTTAATTTTCTGTAATAGCCGTGCCGAAGTAGA
AGAAACAACACTTTATTTAAATCGTCTAGCAAATAGAGAAGTTAATACAGAACTTTATCTTGCTCATCACTCTTCTATAG
ATAAGAAAGAAAGAGAATATGTAGAAAAAACTATGGCCAATTCTAAATCACCCAAAAGTGTAGTAACCACTAGTTCCCTT
GAATTAGGTATTGATATTGGAGCTATTGATTATGTTGTTCAAATTGATGATACGCATACCGTTTCTTCTTTAAAACAGAG
GTTAGGTAGATCTGGTAGAAAGCTTGGAACAAATCAGGTTTTACAAGTATATAGTACAACTAATGATAGTCTAGTTCAAT
CTTTAGCAGTAATTGATTTATTATTAGAAAAGTGGATTGAGCCAGCAACGGAATATCCTTTACCTTTAGATATTTTATTC
CATCAAATTATTTCTATTTGCCACGAAGCAAATGGAGTTAGACTTGATCCACTTATAGATAATATCAAAGCAAATGCAGC
TTTTTATAAACTAAAAGAAGAAGATATTAATCATGTTATTAATTACATGATAGAAAACGACTTTTTGCAGTTAATTAGAA
ATAGTGCTGAATTAATTGTAGGACTAGAAGGGGAAAGATTATTGAGGGGTAAAGAATTCTATGCTGTTTTTATGACTCAA
GAAGAATTTGAAGTGCGGGAAGGTATCAGAAAAATTGGAAGTATAGACAAAAGTTTAATGGTATCTGAAGGTGACAATAT
TATATTGGCAGGACAATTATGGACTATAAAAAATATCGATATTGAGCGTGATATTATTTATGTAGCTAAAGCTGTTGACG
GAAAACCTCCTAAATACTCTGGAGGAGGTTTTATATTAAATCCCAAAATACCTGAAAGAATGCACAAAATACTGTGTGAA
AGGAAAAACTTCGAGTTTATTGATAATATGGCTCAAAACCACTTAGAAGAACAGAGAAAACCTTTTGAGTTATACAATAT
AAAACCAAACGAACGAGTAATTTGGAATAATGGTGATGAAATCTTATTTGAAACCTATACTGGAACAAAAATATTTCAAA
CTTTGGCATGGATTTTACGATCTTATAATGTGAATATAAAAGAGATTGATGGAATTGGTAGGATTAACATTGAAGGTGGT
ATTGATTTACCAGGGGTTTTACAAGATATAAAAGAAACAGATTGGCGACCAGAATATTTACTTGATTTTACATTAGAGCA
AGAAAAGTTCAAATCAAAATTCAGTCCATATTTACCTAAAGATTTACAAGATAAAATGCATATAGCACACCTTGTAGATA
TTGAAGGGGTTAAGACTTTTTTAGAAAATAAAAAGATTAAGGAAATTAAGCTATAA

Upstream 100 bases:

>100_bases
GCGAAATTAATATGGAAACTTCTCAAGAAACTTCAATGACTAATCAAACTACTGATTTGAATAACCGTTTTAAAAAAGAA
AGCTATTAGGAGGTTAAGGC

Downstream 100 bases:

>100_bases
AATGAATACGAGTATTCGTTGGACTAGCATTGATTTACAGAGAAATATTTATCAAATCTTGTCTGTGTTGAAACTTATAA
TATTAGGACAACCTTTTAGT

Product: DEAD/DEAH box helicase domain protein

Products: NA

Alternate protein names: Large helicase-related protein [H]

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MSETFYLLSERMQKKIWEMGWDEFTPVQDKTIPIVMNTNKDVVVSSGTASGKTEAVFLPILSQIEKDATKDLKILYISPL
KALINDQFERIIKLCEKSYIPIHRWHGDVNQNKKKQLTKNPAGILQITPESIESLFINRTNELNYILSDIEFIIIDELHA
FLDNERGVHLRSLLSRLENYIKEKPRYFALSATLNNFKLIKEWINYNDIKNVEIIDSNEDDKDLLLSLMHFDKGKDYKKP
IDLYQDLRELTKNVHSLIFCNSRAEVEETTLYLNRLANREVNTELYLAHHSSIDKKEREYVEKTMANSKSPKSVVTTSSL
ELGIDIGAIDYVVQIDDTHTVSSLKQRLGRSGRKLGTNQVLQVYSTTNDSLVQSLAVIDLLLEKWIEPATEYPLPLDILF
HQIISICHEANGVRLDPLIDNIKANAAFYKLKEEDINHVINYMIENDFLQLIRNSAELIVGLEGERLLRGKEFYAVFMTQ
EEFEVREGIRKIGSIDKSLMVSEGDNIILAGQLWTIKNIDIERDIIYVAKAVDGKPPKYSGGGFILNPKIPERMHKILCE
RKNFEFIDNMAQNHLEEQRKPFELYNIKPNERVIWNNGDEILFETYTGTKIFQTLAWILRSYNVNIKEIDGIGRINIEGG
IDLPGVLQDIKETDWRPEYLLDFTLEQEKFKSKFSPYLPKDLQDKMHIAHLVDIEGVKTFLENKKIKEIKL

Sequences:

>Translated_711_residues
MSETFYLLSERMQKKIWEMGWDEFTPVQDKTIPIVMNTNKDVVVSSGTASGKTEAVFLPILSQIEKDATKDLKILYISPL
KALINDQFERIIKLCEKSYIPIHRWHGDVNQNKKKQLTKNPAGILQITPESIESLFINRTNELNYILSDIEFIIIDELHA
FLDNERGVHLRSLLSRLENYIKEKPRYFALSATLNNFKLIKEWINYNDIKNVEIIDSNEDDKDLLLSLMHFDKGKDYKKP
IDLYQDLRELTKNVHSLIFCNSRAEVEETTLYLNRLANREVNTELYLAHHSSIDKKEREYVEKTMANSKSPKSVVTTSSL
ELGIDIGAIDYVVQIDDTHTVSSLKQRLGRSGRKLGTNQVLQVYSTTNDSLVQSLAVIDLLLEKWIEPATEYPLPLDILF
HQIISICHEANGVRLDPLIDNIKANAAFYKLKEEDINHVINYMIENDFLQLIRNSAELIVGLEGERLLRGKEFYAVFMTQ
EEFEVREGIRKIGSIDKSLMVSEGDNIILAGQLWTIKNIDIERDIIYVAKAVDGKPPKYSGGGFILNPKIPERMHKILCE
RKNFEFIDNMAQNHLEEQRKPFELYNIKPNERVIWNNGDEILFETYTGTKIFQTLAWILRSYNVNIKEIDGIGRINIEGG
IDLPGVLQDIKETDWRPEYLLDFTLEQEKFKSKFSPYLPKDLQDKMHIAHLVDIEGVKTFLENKKIKEIKL
>Mature_710_residues
SETFYLLSERMQKKIWEMGWDEFTPVQDKTIPIVMNTNKDVVVSSGTASGKTEAVFLPILSQIEKDATKDLKILYISPLK
ALINDQFERIIKLCEKSYIPIHRWHGDVNQNKKKQLTKNPAGILQITPESIESLFINRTNELNYILSDIEFIIIDELHAF
LDNERGVHLRSLLSRLENYIKEKPRYFALSATLNNFKLIKEWINYNDIKNVEIIDSNEDDKDLLLSLMHFDKGKDYKKPI
DLYQDLRELTKNVHSLIFCNSRAEVEETTLYLNRLANREVNTELYLAHHSSIDKKEREYVEKTMANSKSPKSVVTTSSLE
LGIDIGAIDYVVQIDDTHTVSSLKQRLGRSGRKLGTNQVLQVYSTTNDSLVQSLAVIDLLLEKWIEPATEYPLPLDILFH
QIISICHEANGVRLDPLIDNIKANAAFYKLKEEDINHVINYMIENDFLQLIRNSAELIVGLEGERLLRGKEFYAVFMTQE
EFEVREGIRKIGSIDKSLMVSEGDNIILAGQLWTIKNIDIERDIIYVAKAVDGKPPKYSGGGFILNPKIPERMHKILCER
KNFEFIDNMAQNHLEEQRKPFELYNIKPNERVIWNNGDEILFETYTGTKIFQTLAWILRSYNVNIKEIDGIGRINIEGGI
DLPGVLQDIKETDWRPEYLLDFTLEQEKFKSKFSPYLPKDLQDKMHIAHLVDIEGVKTFLENKKIKEIKL

Specific function: Unknown

COG id: COG1201

COG function: function code R; Lhr-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI38569503, Length=395, Percent_Identity=23.0379746835443, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI38569505, Length=395, Percent_Identity=23.0379746835443, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI76880486, Length=386, Percent_Identity=27.2020725388601, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI262118318, Length=400, Percent_Identity=21.5, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI262231852, Length=400, Percent_Identity=21.5, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI216548263, Length=400, Percent_Identity=21.5, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI13518015, Length=400, Percent_Identity=21.5, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI130484567, Length=445, Percent_Identity=22.4719101123595, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI40217847, Length=391, Percent_Identity=24.0409207161125, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI169218225, Length=391, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787942, Length=607, Percent_Identity=25.7001647446458, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787016, Length=387, Percent_Identity=22.9974160206718, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17537519, Length=422, Percent_Identity=21.563981042654, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17552114, Length=349, Percent_Identity=22.6361031518625, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71999646, Length=350, Percent_Identity=25.1428571428571, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71999644, Length=350, Percent_Identity=25.1428571428571, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI9755332, Length=376, Percent_Identity=25, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321710, Length=358, Percent_Identity=22.0670391061453, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324217, Length=370, Percent_Identity=22.972972972973, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321020, Length=386, Percent_Identity=22.7979274611399, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647182, Length=411, Percent_Identity=22.6277372262774, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574898, Length=396, Percent_Identity=23.2323232323232, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17985987, Length=398, Percent_Identity=23.8693467336683, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28575014, Length=365, Percent_Identity=25.4794520547945, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17136814, Length=494, Percent_Identity=20.8502024291498, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584399, Length=358, Percent_Identity=21.5083798882682, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014001
- InterPro:   IPR013701
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF08494 DEAD_assoc; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 82333; Mature: 82201

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETFYLLSERMQKKIWEMGWDEFTPVQDKTIPIVMNTNKDVVVSSGTASGKTEAVFLPI
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCEEHHHH
LSQIEKDATKDLKILYISPLKALINDQFERIIKLCEKSYIPIHRWHGDVNQNKKKQLTKN
HHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHCC
PAGILQITPESIESLFINRTNELNYILSDIEFIIIDELHAFLDNERGVHLRSLLSRLENY
CCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IKEKPRYFALSATLNNFKLIKEWINYNDIKNVEIIDSNEDDKDLLLSLMHFDKGKDYKKP
HHCCCCEEEEEEHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCH
IDLYQDLRELTKNVHSLIFCNSRAEVEETTLYLNRLANREVNTELYLAHHSSIDKKEREY
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
VEKTMANSKSPKSVVTTSSLELGIDIGAIDYVVQIDDTHTVSSLKQRLGRSGRKLGTNQV
HHHHHHCCCCCCCEEEECCEEECEEECCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
LQVYSTTNDSLVQSLAVIDLLLEKWIEPATEYPLPLDILFHQIISICHEANGVRLDPLID
EEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCEECHHHH
NIKANAAFYKLKEEDINHVINYMIENDFLQLIRNSAELIVGLEGERLLRGKEFYAVFMTQ
HHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCEEEEEEEEC
EEFEVREGIRKIGSIDKSLMVSEGDNIILAGQLWTIKNIDIERDIIYVAKAVDGKPPKYS
HHHHHHHHHHHHHCCCHHHEEECCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCCCCCC
GGGFILNPKIPERMHKILCERKNFEFIDNMAQNHLEEQRKPFELYNIKPNERVIWNNGDE
CCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCE
ILFETYTGTKIFQTLAWILRSYNVNIKEIDGIGRINIEGGIDLPGVLQDIKETDWRPEYL
EEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCHHHHHHHHCCCCCCEE
LDFTLEQEKFKSKFSPYLPKDLQDKMHIAHLVDIEGVKTFLENKKIKEIKL
EEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure 
SETFYLLSERMQKKIWEMGWDEFTPVQDKTIPIVMNTNKDVVVSSGTASGKTEAVFLPI
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCEEHHHH
LSQIEKDATKDLKILYISPLKALINDQFERIIKLCEKSYIPIHRWHGDVNQNKKKQLTKN
HHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHCC
PAGILQITPESIESLFINRTNELNYILSDIEFIIIDELHAFLDNERGVHLRSLLSRLENY
CCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IKEKPRYFALSATLNNFKLIKEWINYNDIKNVEIIDSNEDDKDLLLSLMHFDKGKDYKKP
HHCCCCEEEEEEHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCH
IDLYQDLRELTKNVHSLIFCNSRAEVEETTLYLNRLANREVNTELYLAHHSSIDKKEREY
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
VEKTMANSKSPKSVVTTSSLELGIDIGAIDYVVQIDDTHTVSSLKQRLGRSGRKLGTNQV
HHHHHHCCCCCCCEEEECCEEECEEECCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
LQVYSTTNDSLVQSLAVIDLLLEKWIEPATEYPLPLDILFHQIISICHEANGVRLDPLID
EEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCEECHHHH
NIKANAAFYKLKEEDINHVINYMIENDFLQLIRNSAELIVGLEGERLLRGKEFYAVFMTQ
HHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCEEEEEEEEC
EEFEVREGIRKIGSIDKSLMVSEGDNIILAGQLWTIKNIDIERDIIYVAKAVDGKPPKYS
HHHHHHHHHHHHHCCCHHHEEECCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCCCCCC
GGGFILNPKIPERMHKILCERKNFEFIDNMAQNHLEEQRKPFELYNIKPNERVIWNNGDE
CCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCE
ILFETYTGTKIFQTLAWILRSYNVNIKEIDGIGRINIEGGIDLPGVLQDIKETDWRPEYL
EEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCHHHHHHHHCCCCCCEE
LDFTLEQEKFKSKFSPYLPKDLQDKMHIAHLVDIEGVKTFLENKKIKEIKL
EEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559321; 9097039; 9278503; 1460056 [H]