Click here to switch to the map view.

The map label for this gene is lexA [H]

Identifier: 188586129

GI number: 188586129

Start: 1578361

End: 1579029

Strand: Reverse

Name: lexA [H]

Synonym: Nther_1504

Alternate gene names: 188586129

Gene position: 1579029-1578361 (Counterclockwise)

Preceding gene: 188586131

Following gene: 188586120

Centisome position: 49.88

GC content: 32.44

Gene sequence:

>669_bases
ATGAGCAAAAAATCAAATAAACCAATGCAAATATATAATTTTATAAATGACTACGCATCAAAAAATGGATACCCGCCTTC
TGTTAGAGAAATTTGCCAAGGGGTTGGATTGAGTTCTACATCAACTGTACATCTCCATTTATCTAGTTTAGAAAAACAAG
GTTATATTAGAAGAGATTCAACTAGACCCCGAGCCATTGAAATATTATCAAAGAATAATAATAAAAATACTGATCAAGAG
AAAAGTAACAACAATGAAAAAATCGATAATGAAGATTTGAATACTACGAAAATTCCTATAGTTGGCCAGGTAACCGCCGG
TGAACCTATATTAGCAGAAGAAAACATTTTAGAATACTTCCCCATACCAAAACAGTTGAGTTACGGAAAAGAGTTGTTTA
TGTTACAGATCAAGGGTGATAGCATGATAGAAGCAGGAATATACGATTCAGATTTGGTGATTGTCAATAAGCAGAATACT
GCTAATAATGGAGAGATAATCGTAGCTTTATTAGAAGATGAAGCAACAGTTAAGAGATTCTATAAAGAGAATGAATACAT
TAGGCTTCAGCCTGAAAACAAAGCTTATTCACCTATATATTCAAGAGATGTTAGCATAATAGGAAAAGTAGTTGGTCTAT
TTAGAAACTTTGCCGAACAAACACTATAA

Upstream 100 bases:

>100_bases
TACATTATCTGGAATGATATACTTAATTCAAAGATTTAGTGTATTGAAAACGTGGGAATTACGCTTGTCTATTATATCTT
ATTAAGGGGTGAGCATAATT

Downstream 100 bases:

>100_bases
GCAATTTAACTTGAAACTAACTCACAAAAAAACTCCCCAATCAGTTACTCAAGTTATCACTGATTGAGGAGTTTTTTATG
TATTTTACTTATGATTCTTT

Product: SOS-response transcriptional repressor, LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSKKSNKPMQIYNFINDYASKNGYPPSVREICQGVGLSSTSTVHLHLSSLEKQGYIRRDSTRPRAIEILSKNNNKNTDQE
KSNNNEKIDNEDLNTTKIPIVGQVTAGEPILAEENILEYFPIPKQLSYGKELFMLQIKGDSMIEAGIYDSDLVIVNKQNT
ANNGEIIVALLEDEATVKRFYKENEYIRLQPENKAYSPIYSRDVSIIGKVVGLFRNFAEQTL

Sequences:

>Translated_222_residues
MSKKSNKPMQIYNFINDYASKNGYPPSVREICQGVGLSSTSTVHLHLSSLEKQGYIRRDSTRPRAIEILSKNNNKNTDQE
KSNNNEKIDNEDLNTTKIPIVGQVTAGEPILAEENILEYFPIPKQLSYGKELFMLQIKGDSMIEAGIYDSDLVIVNKQNT
ANNGEIIVALLEDEATVKRFYKENEYIRLQPENKAYSPIYSRDVSIIGKVVGLFRNFAEQTL
>Mature_221_residues
SKKSNKPMQIYNFINDYASKNGYPPSVREICQGVGLSSTSTVHLHLSSLEKQGYIRRDSTRPRAIEILSKNNNKNTDQEK
SNNNEKIDNEDLNTTKIPIVGQVTAGEPILAEENILEYFPIPKQLSYGKELFMLQIKGDSMIEAGIYDSDLVIVNKQNTA
NNGEIIVALLEDEATVKRFYKENEYIRLQPENKAYSPIYSRDVSIIGKVVGLFRNFAEQTL

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=220, Percent_Identity=31.8181818181818, Blast_Score=120, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 25141; Mature: 25010

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKSNKPMQIYNFINDYASKNGYPPSVREICQGVGLSSTSTVHLHLSSLEKQGYIRRDS
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECHHHCCCEECCC
TRPRAIEILSKNNNKNTDQEKSNNNEKIDNEDLNTTKIPIVGQVTAGEPILAEENILEYF
CCCEEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCEECEEEEEECCCCCEECCCCHHHHC
PIPKQLSYGKELFMLQIKGDSMIEAGIYDSDLVIVNKQNTANNGEIIVALLEDEATVKRF
CCCHHHCCCCEEEEEEECCCCEEECCCCCCCEEEEECCCCCCCCCEEEEEECCCHHHHHH
YKENEYIRLQPENKAYSPIYSRDVSIIGKVVGLFRNFAEQTL
HCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKKSNKPMQIYNFINDYASKNGYPPSVREICQGVGLSSTSTVHLHLSSLEKQGYIRRDS
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECHHHCCCEECCC
TRPRAIEILSKNNNKNTDQEKSNNNEKIDNEDLNTTKIPIVGQVTAGEPILAEENILEYF
CCCEEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCEECEEEEEECCCCCEECCCCHHHHC
PIPKQLSYGKELFMLQIKGDSMIEAGIYDSDLVIVNKQNTANNGEIIVALLEDEATVKRF
CCCHHHCCCCEEEEEEECCCCEEECCCCCCCEEEEECCCCCCCCCEEEEEECCCHHHHHH
YKENEYIRLQPENKAYSPIYSRDVSIIGKVVGLFRNFAEQTL
HCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA