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The map label for this gene is mutL [H]

Identifier: 188586123

GI number: 188586123

Start: 1570359

End: 1572401

Strand: Direct

Name: mutL [H]

Synonym: Nther_1497

Alternate gene names: 188586123

Gene position: 1570359-1572401 (Clockwise)

Preceding gene: 188586122

Following gene: 188586124

Centisome position: 49.61

GC content: 34.31

Gene sequence:

>2043_bases
ATGGGTCGGATAAACATATTGAGACATGAAATATCAGAAAAAATAGCTGCTGGTGAAGTGGTGGAACGTCCCGCCTCTGT
AGTTAAAGAATTAATTGAAAACTCCATTGATGCAGGTAGTGATAATATCCAAATATTCTTATCTAAGGCCGGCAAAGAAT
TGATTCGCGTGATTGACAATGGCCTAGGGATTCATCCCGAAGATGTAGAGCTAGCTTTCTCTAGGCATGCCACAAGTAAG
GTTAATAGTATCAAGGACCTTGATAAAATAAATACATTAGGTTTTCGGGGTGAAGCCCTGGCTAGTATTGCTGCAGTAAG
TAAAATTGAAATGAATACCAGGCGCCACGATAGTAAAGAGGGAACTAGAGTGTTCCTTGAAGAGGGGAAAGTTCAACAAC
GAGGTAGTGCGGGGTGTCCACCTGGGACCGATATTGCAGTGAAAGATTTATTTTACAACACCCCCGCCAGGTTAAAATTT
CTCAGCAAAGAAAGTACTGAAATTGCGTTAATCCATGATATAATTAATAAATTTGCACTGGCAAATCCTAATATTAGATT
CAGGGCATTAAACGGGAATAAAAAGCTTTTGCAGACCTCAGGCAGAAACGATATGCTAGAAGTGATAGCTAATATATACG
GCTATCAAACTGCGAAAAAACTGTTACCAATAAAATATTCTCAAGATGGTATTACCATTACAGGTTACATAGCAAAGCCG
GAACTGACCCGATCTAATAGAAGTTATCAAACTTTTTTCGTAAACGATAGATATGTAAAAAGCACCTTTTTATCCGAAAG
ATTAGAAAAAGGGTATCATACATTGCTTCCAAAACATAGATATCCTTTTTCAATATTGAAACTTCAAGTACCTGATGAGA
TATTAGATGTAAATGTGCACCCAGCGAAAATACATGTTAGATTCATAAATGAAAAACAAATTGGAAATATGTTAACAAAA
GCTGTGACAGAGAAATTAAAACAAGAACAATTGATTTTTCAAGCTCCCAAAGTTAATAATACTAAGAAAAACCAAACTAA
ACCGGAAGGCTCTCAACTTCGTTTTAGAGGTGTTAACAAGAATAATGCTCCCAGTTTCGAGAAAACCTCAAGTAAGTTTA
AAAGTCAATTAAATAATAATGTTTATGATAACATTTCTTCTAAAACTAGTAACAACTACTTAAAAGAAAAACAGGAATAT
GATATTCCAAGAATTAATAATAAAGTAGACCACACAAAAAACCATATAGAAAACCAAACAGAAAACCATATAGAAACACA
TCAAAAAACACAAGAAATAGGTGATCAAGAAAAGACTAGTGATAGTGTTCATTACGGTAGTAATCCAAGTAGTAAACCAA
TTGGTGATTCAAGTGGTAAACTAAGTGATGATTCAAGTGGTGAATCATATAGTGATCATATAGATACCATAGATTTAGCT
GATAATAATGAAAACTTTTTACATGATTTACTTGAATATCGCGTCGTTGGCCAAATTTTTACTACTTATTGGATTCTAGA
ATCTAGTGATGAAATTTATTTAATAGATCAACATGCTGCCCATGAACGAATAAATTATCAATTATTAATGGATAGATATC
GCTCTTCTCAACTAAAAAGCCAACAGGTTATTCCCTATACATTAGAGTTGGACAGTGCTGGTATAACAGCCCTAGAAGAT
AATTTAGATAAACTGCGCCAGTGTGGCTTGGAATTCGAATTCTTTGGTCAAAACACTTTATTAGTGAGAGGAGTTCCCTT
TGCAATTAAAGATATCTTCGATCAAGATGCAATTTATGATCTGATTGATCAGTTGATAAAACATCCTGATAACGATCTGG
ATATAACAAGCCTGGAAGAAATGTTAATTACCATTGCTTGTAAAAAAAGTATTAAAGCTAATGAAAAGATCGGAGCAAAA
GAATTAAAATCTTTGTTAAAGTCCCTTGTGGAAACACCTACGCCTTTTACCTGTCCTCATGGACGGCCTACAATTATAAA
CTTAACCAGAACAGATGTAGAAAAACTGTTTTACCGAGTTTAA

Upstream 100 bases:

>100_bases
GATAAAGCTCAGAAATTTAAAGAATAGGCGACTATAACTTAAAAAACGCCAAAGAGATAAAAAGCTAAAGGGGATCAAAA
GGGATAGGGGGTTAGCTCAA

Downstream 100 bases:

>100_bases
TAAACTTAGCAGAATGCTATAAAAAATTTTGCTAGTTATTGGGGTGAAAAAATTTATGATGAACACATATGACAATCAAC
ACCGTGAACAACAAAAGTTG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MGRINILRHEISEKIAAGEVVERPASVVKELIENSIDAGSDNIQIFLSKAGKELIRVIDNGLGIHPEDVELAFSRHATSK
VNSIKDLDKINTLGFRGEALASIAAVSKIEMNTRRHDSKEGTRVFLEEGKVQQRGSAGCPPGTDIAVKDLFYNTPARLKF
LSKESTEIALIHDIINKFALANPNIRFRALNGNKKLLQTSGRNDMLEVIANIYGYQTAKKLLPIKYSQDGITITGYIAKP
ELTRSNRSYQTFFVNDRYVKSTFLSERLEKGYHTLLPKHRYPFSILKLQVPDEILDVNVHPAKIHVRFINEKQIGNMLTK
AVTEKLKQEQLIFQAPKVNNTKKNQTKPEGSQLRFRGVNKNNAPSFEKTSSKFKSQLNNNVYDNISSKTSNNYLKEKQEY
DIPRINNKVDHTKNHIENQTENHIETHQKTQEIGDQEKTSDSVHYGSNPSSKPIGDSSGKLSDDSSGESYSDHIDTIDLA
DNNENFLHDLLEYRVVGQIFTTYWILESSDEIYLIDQHAAHERINYQLLMDRYRSSQLKSQQVIPYTLELDSAGITALED
NLDKLRQCGLEFEFFGQNTLLVRGVPFAIKDIFDQDAIYDLIDQLIKHPDNDLDITSLEEMLITIACKKSIKANEKIGAK
ELKSLLKSLVETPTPFTCPHGRPTIINLTRTDVEKLFYRV

Sequences:

>Translated_680_residues
MGRINILRHEISEKIAAGEVVERPASVVKELIENSIDAGSDNIQIFLSKAGKELIRVIDNGLGIHPEDVELAFSRHATSK
VNSIKDLDKINTLGFRGEALASIAAVSKIEMNTRRHDSKEGTRVFLEEGKVQQRGSAGCPPGTDIAVKDLFYNTPARLKF
LSKESTEIALIHDIINKFALANPNIRFRALNGNKKLLQTSGRNDMLEVIANIYGYQTAKKLLPIKYSQDGITITGYIAKP
ELTRSNRSYQTFFVNDRYVKSTFLSERLEKGYHTLLPKHRYPFSILKLQVPDEILDVNVHPAKIHVRFINEKQIGNMLTK
AVTEKLKQEQLIFQAPKVNNTKKNQTKPEGSQLRFRGVNKNNAPSFEKTSSKFKSQLNNNVYDNISSKTSNNYLKEKQEY
DIPRINNKVDHTKNHIENQTENHIETHQKTQEIGDQEKTSDSVHYGSNPSSKPIGDSSGKLSDDSSGESYSDHIDTIDLA
DNNENFLHDLLEYRVVGQIFTTYWILESSDEIYLIDQHAAHERINYQLLMDRYRSSQLKSQQVIPYTLELDSAGITALED
NLDKLRQCGLEFEFFGQNTLLVRGVPFAIKDIFDQDAIYDLIDQLIKHPDNDLDITSLEEMLITIACKKSIKANEKIGAK
ELKSLLKSLVETPTPFTCPHGRPTIINLTRTDVEKLFYRV
>Mature_679_residues
GRINILRHEISEKIAAGEVVERPASVVKELIENSIDAGSDNIQIFLSKAGKELIRVIDNGLGIHPEDVELAFSRHATSKV
NSIKDLDKINTLGFRGEALASIAAVSKIEMNTRRHDSKEGTRVFLEEGKVQQRGSAGCPPGTDIAVKDLFYNTPARLKFL
SKESTEIALIHDIINKFALANPNIRFRALNGNKKLLQTSGRNDMLEVIANIYGYQTAKKLLPIKYSQDGITITGYIAKPE
LTRSNRSYQTFFVNDRYVKSTFLSERLEKGYHTLLPKHRYPFSILKLQVPDEILDVNVHPAKIHVRFINEKQIGNMLTKA
VTEKLKQEQLIFQAPKVNNTKKNQTKPEGSQLRFRGVNKNNAPSFEKTSSKFKSQLNNNVYDNISSKTSNNYLKEKQEYD
IPRINNKVDHTKNHIENQTENHIETHQKTQEIGDQEKTSDSVHYGSNPSSKPIGDSSGKLSDDSSGESYSDHIDTIDLAD
NNENFLHDLLEYRVVGQIFTTYWILESSDEIYLIDQHAAHERINYQLLMDRYRSSQLKSQQVIPYTLELDSAGITALEDN
LDKLRQCGLEFEFFGQNTLLVRGVPFAIKDIFDQDAIYDLIDQLIKHPDNDLDITSLEEMLITIACKKSIKANEKIGAKE
LKSLLKSLVETPTPFTCPHGRPTIINLTRTDVEKLFYRV

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=337, Percent_Identity=35.3115727002967, Blast_Score=193, Evalue=6e-49,
Organism=Homo sapiens, GI4505913, Length=326, Percent_Identity=31.5950920245399, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI310128478, Length=326, Percent_Identity=31.5950920245399, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI189458898, Length=314, Percent_Identity=29.2993630573248, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI4505911, Length=314, Percent_Identity=29.2993630573248, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=29.6928327645051, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI91992162, Length=359, Percent_Identity=28.4122562674095, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI91992160, Length=359, Percent_Identity=28.4122562674095, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI189458896, Length=312, Percent_Identity=28.2051282051282, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=30.7053941908714, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1790612, Length=334, Percent_Identity=37.4251497005988, Blast_Score=210, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71991825, Length=399, Percent_Identity=31.8295739348371, Blast_Score=185, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=347, Percent_Identity=30.835734870317, Blast_Score=146, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323819, Length=320, Percent_Identity=32.1875, Blast_Score=170, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=358, Percent_Identity=28.2122905027933, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325093, Length=761, Percent_Identity=22.2076215505913, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=194, Percent_Identity=29.8969072164948, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=34.6504559270517, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17136970, Length=363, Percent_Identity=28.3746556473829, Blast_Score=133, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 77136; Mature: 77005

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRINILRHEISEKIAAGEVVERPASVVKELIENSIDAGSDNIQIFLSKAGKELIRVIDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHC
GLGIHPEDVELAFSRHATSKVNSIKDLDKINTLGFRGEALASIAAVSKIEMNTRRHDSKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GTRVFLEEGKVQQRGSAGCPPGTDIAVKDLFYNTPARLKFLSKESTEIALIHDIINKFAL
CCEEEEECCCHHCCCCCCCCCCCCHHHHHHHHCCCHHEEEECCCCCCCHHHHHHHHHHHC
ANPNIRFRALNGNKKLLQTSGRNDMLEVIANIYGYQTAKKLLPIKYSQDGITITGYIAKP
CCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEEECC
ELTRSNRSYQTFFVNDRYVKSTFLSERLEKGYHTLLPKHRYPFSILKLQVPDEILDVNVH
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCHHHHCCCCC
PAKIHVRFINEKQIGNMLTKAVTEKLKQEQLIFQAPKVNNTKKNQTKPEGSQLRFRGVNK
CEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCC
NNAPSFEKTSSKFKSQLNNNVYDNISSKTSNNYLKEKQEYDIPRINNKVDHTKNHIENQT
CCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCH
ENHIETHQKTQEIGDQEKTSDSVHYGSNPSSKPIGDSSGKLSDDSSGESYSDHIDTIDLA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEC
DNNENFLHDLLEYRVVGQIFTTYWILESSDEIYLIDQHAAHERINYQLLMDRYRSSQLKS
CCCHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCC
QQVIPYTLELDSAGITALEDNLDKLRQCGLEFEFFGQNTLLVRGVPFAIKDIFDQDAIYD
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHCCHHHHH
LIDQLIKHPDNDLDITSLEEMLITIACKKSIKANEKIGAKELKSLLKSLVETPTPFTCPH
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GRPTIINLTRTDVEKLFYRV
CCCEEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
GRINILRHEISEKIAAGEVVERPASVVKELIENSIDAGSDNIQIFLSKAGKELIRVIDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHC
GLGIHPEDVELAFSRHATSKVNSIKDLDKINTLGFRGEALASIAAVSKIEMNTRRHDSKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GTRVFLEEGKVQQRGSAGCPPGTDIAVKDLFYNTPARLKFLSKESTEIALIHDIINKFAL
CCEEEEECCCHHCCCCCCCCCCCCHHHHHHHHCCCHHEEEECCCCCCCHHHHHHHHHHHC
ANPNIRFRALNGNKKLLQTSGRNDMLEVIANIYGYQTAKKLLPIKYSQDGITITGYIAKP
CCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEEECC
ELTRSNRSYQTFFVNDRYVKSTFLSERLEKGYHTLLPKHRYPFSILKLQVPDEILDVNVH
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCHHHHCCCCC
PAKIHVRFINEKQIGNMLTKAVTEKLKQEQLIFQAPKVNNTKKNQTKPEGSQLRFRGVNK
CEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCC
NNAPSFEKTSSKFKSQLNNNVYDNISSKTSNNYLKEKQEYDIPRINNKVDHTKNHIENQT
CCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCH
ENHIETHQKTQEIGDQEKTSDSVHYGSNPSSKPIGDSSGKLSDDSSGESYSDHIDTIDLA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEC
DNNENFLHDLLEYRVVGQIFTTYWILESSDEIYLIDQHAAHERINYQLLMDRYRSSQLKS
CCCHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCC
QQVIPYTLELDSAGITALEDNLDKLRQCGLEFEFFGQNTLLVRGVPFAIKDIFDQDAIYD
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHCCHHHHH
LIDQLIKHPDNDLDITSLEEMLITIACKKSIKANEKIGAKELKSLLKSLVETPTPFTCPH
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GRPTIINLTRTDVEKLFYRV
CCCEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]