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The map label for this gene is bcc [H]

Identifier: 188586117

GI number: 188586117

Start: 1562664

End: 1563098

Strand: Direct

Name: bcc [H]

Synonym: Nther_1491

Alternate gene names: 188586117

Gene position: 1562664-1563098 (Clockwise)

Preceding gene: 188586116

Following gene: 188586118

Centisome position: 49.36

GC content: 40.46

Gene sequence:

>435_bases
ATGAAGAAGTTTCGAGTAAATGTTGAGGGTAATACTTATGAAGTTGAAGTGGAAGAAGTTACTTCCCAGGGAACAACTTC
GGGCGCACAAGATAGTAGACCGGCGCCATCGAAACCTAGTCAAAGTACCCCTGAAAAATCTGCGAAACCAAGTCAAGTAC
AATCTAAACCAAAAGAAACTCAGACAGAAAATAAATCTCAAGATAGTGCTCCGGCTGGTGATGGTGAGGCTATTACAGCC
CCAATAGCAGGTAATGTTCTTGATATAAAAGTTAATTCAGGAGACGAAGTAGATAAAGGTCAAGTAGTTATGATTTTGGA
AGCAATGAAAATGGAAAACGAAATAACTGCAGACAGCCCAGGTAAAGTTAAAGAAGTTAGAGTCAACAAAGGGGCCACGG
TGAATTCAGGCGACACTTTAATAGTGTTAGAGTAG

Upstream 100 bases:

>100_bases
GAAATTTGTTGGTCGTCAGGAACAATTACAGGCCAGTAATAAACATTAAAATTATAATTAAAATTGTTATCCTTCAATTT
AATAAAAGGAGGACCTTGAT

Downstream 100 bases:

>100_bases
AGAGGGGGAATAATCGTGGTATTCGAGCAAATTGGAAATTTTTTAGAAACGACGGCCTTTTACAATGTCTCTTTTGATCA
ATTGATCATGATTGTTATTG

Product: biotin/lipoyl attachment domain-containing protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKKFRVNVEGNTYEVEVEEVTSQGTTSGAQDSRPAPSKPSQSTPEKSAKPSQVQSKPKETQTENKSQDSAPAGDGEAITA
PIAGNVLDIKVNSGDEVDKGQVVMILEAMKMENEITADSPGKVKEVRVNKGATVNSGDTLIVLE

Sequences:

>Translated_144_residues
MKKFRVNVEGNTYEVEVEEVTSQGTTSGAQDSRPAPSKPSQSTPEKSAKPSQVQSKPKETQTENKSQDSAPAGDGEAITA
PIAGNVLDIKVNSGDEVDKGQVVMILEAMKMENEITADSPGKVKEVRVNKGATVNSGDTLIVLE
>Mature_144_residues
MKKFRVNVEGNTYEVEVEEVTSQGTTSGAQDSRPAPSKPSQSTPEKSAKPSQVQSKPKETQTENKSQDSAPAGDGEAITA
PIAGNVLDIKVNSGDEVDKGQVVMILEAMKMENEITADSPGKVKEVRVNKGATVNSGDTLIVLE

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321376, Length=93, Percent_Identity=41.9354838709677, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319695, Length=94, Percent_Identity=35.1063829787234, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 15244; Mature: 15244

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFRVNVEGNTYEVEVEEVTSQGTTSGAQDSRPAPSKPSQSTPEKSAKPSQVQSKPKET
CCEEEEEECCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
QTENKSQDSAPAGDGEAITAPIAGNVLDIKVNSGDEVDKGQVVMILEAMKMENEITADSP
CCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCEEEEEEEHHCCCCCCCCCC
GKVKEVRVNKGATVNSGDTLIVLE
CCEEEEEECCCCEECCCCEEEEEC
>Mature Secondary Structure
MKKFRVNVEGNTYEVEVEEVTSQGTTSGAQDSRPAPSKPSQSTPEKSAKPSQVQSKPKET
CCEEEEEECCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
QTENKSQDSAPAGDGEAITAPIAGNVLDIKVNSGDEVDKGQVVMILEAMKMENEITADSP
CCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCEEEEEEEHHCCCCCCCCCC
GKVKEVRVNKGATVNSGDTLIVLE
CCEEEEEECCCCEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8431283; 12397186 [H]