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The map label for this gene is uppS [H]

Identifier: 188586059

GI number: 188586059

Start: 1499421

End: 1500164

Strand: Direct

Name: uppS [H]

Synonym: Nther_1433

Alternate gene names: 188586059

Gene position: 1499421-1500164 (Clockwise)

Preceding gene: 188586058

Following gene: 188586060

Centisome position: 47.37

GC content: 34.27

Gene sequence:

>744_bases
TTGGAGAGCTTGCAAACTTATTTAAATAAAATAGATTATCAAAATGTACCCCGACATATAGCAATTATTATGGATGGCAA
TGGAAGATGGGCTAAGTCCCGTGCTCTACCGAGGATAGCTGGTCACAGGGCTGGAGTCGAAGCCATCAAAAGAGTATCGG
AAATTAGTCAAGAAATAGGAATAGAAATTATTACTATGTTCGCCTTTTCCACAGAAAATTGGAAAAGACCTAAAAAAGAA
GTAGAATTTTTAATGTCACTTCCAAAAGAATATCTCAAAAAAGAACTACAAAATTTAAAAGAAAATAATATAAAAATAAC
TATTATGGGCGATACTAGTGCTATTCCTGCTAAAACATTAGAGGTGATTGAACAAGGGGTTGAAGAAACTAAAAATAATA
CAGCTTTAAATTTGAATTTTGCGCTAAATTATGGAGGAAGAGCGGAAATAGTACAGGCAGTCAGGAAAATAGCCGCTAAA
GCATCTGATCGGGAAATTGACCCTAAAACTATTTCTGAAGATATTATTTCGCAACATCTGTATAACCCTGAAATACCAGA
TCCAGATTTAATGATACGTTCTAGTGGTGAGCAAAGATTAAGTAATTTTTTATTATGGCAACTTGCTTATTCCGAACTCT
GGTTTCCAGAAGTTTATTGGCCAGACTTTCAAAAAGAGCATTTATTACAAGCCGTATTAGCTTATCAAAATAGAGAACGA
AAATTTGGCGGAGTAAATTCCTAG

Upstream 100 bases:

>100_bases
CCCTACTGATGCTATTGTTGAAGAGTAAAAATCACTACCCCCTCACCCTCATTGAGGGGGTATTAGTTTCTATAGACAGA
GTGGATTGAGGTGGATAACT

Downstream 100 bases:

>100_bases
GAGGAAGACAATTGATTACGAGAATTATTACAGCTTTAATAGGAATTCCCCTGGGATTATTCATTTTATACCAGGGTGGA
CTAATCTTTTTAATATTAGC

Product: Undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MESLQTYLNKIDYQNVPRHIAIIMDGNGRWAKSRALPRIAGHRAGVEAIKRVSEISQEIGIEIITMFAFSTENWKRPKKE
VEFLMSLPKEYLKKELQNLKENNIKITIMGDTSAIPAKTLEVIEQGVEETKNNTALNLNFALNYGGRAEIVQAVRKIAAK
ASDREIDPKTISEDIISQHLYNPEIPDPDLMIRSSGEQRLSNFLLWQLAYSELWFPEVYWPDFQKEHLLQAVLAYQNRER
KFGGVNS

Sequences:

>Translated_247_residues
MESLQTYLNKIDYQNVPRHIAIIMDGNGRWAKSRALPRIAGHRAGVEAIKRVSEISQEIGIEIITMFAFSTENWKRPKKE
VEFLMSLPKEYLKKELQNLKENNIKITIMGDTSAIPAKTLEVIEQGVEETKNNTALNLNFALNYGGRAEIVQAVRKIAAK
ASDREIDPKTISEDIISQHLYNPEIPDPDLMIRSSGEQRLSNFLLWQLAYSELWFPEVYWPDFQKEHLLQAVLAYQNRER
KFGGVNS
>Mature_247_residues
MESLQTYLNKIDYQNVPRHIAIIMDGNGRWAKSRALPRIAGHRAGVEAIKRVSEISQEIGIEIITMFAFSTENWKRPKKE
VEFLMSLPKEYLKKELQNLKENNIKITIMGDTSAIPAKTLEVIEQGVEETKNNTALNLNFALNYGGRAEIVQAVRKIAAK
ASDREIDPKTISEDIISQHLYNPEIPDPDLMIRSSGEQRLSNFLLWQLAYSELWFPEVYWPDFQKEHLLQAVLAYQNRER
KFGGVNS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=39.7321428571429, Blast_Score=170, Evalue=9e-43,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=39.7321428571429, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=46.4912280701754, Blast_Score=227, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=34.9557522123894, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=36.6197183098592, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=30.3738317757009, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=38.1578947368421, Blast_Score=167, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28375; Mature: 28375

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLQTYLNKIDYQNVPRHIAIIMDGNGRWAKSRALPRIAGHRAGVEAIKRVSEISQEIG
CCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
IEIITMFAFSTENWKRPKKEVEFLMSLPKEYLKKELQNLKENNIKITIMGDTSAIPAKTL
HHEEHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHH
EVIEQGVEETKNNTALNLNFALNYGGRAEIVQAVRKIAAKASDREIDPKTISEDIISQHL
HHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
YNPEIPDPDLMIRSSGEQRLSNFLLWQLAYSELWFPEVYWPDFQKEHLLQAVLAYQNRER
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHH
KFGGVNS
CCCCCCC
>Mature Secondary Structure
MESLQTYLNKIDYQNVPRHIAIIMDGNGRWAKSRALPRIAGHRAGVEAIKRVSEISQEIG
CCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
IEIITMFAFSTENWKRPKKEVEFLMSLPKEYLKKELQNLKENNIKITIMGDTSAIPAKTL
HHEEHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHH
EVIEQGVEETKNNTALNLNFALNYGGRAEIVQAVRKIAAKASDREIDPKTISEDIISQHL
HHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
YNPEIPDPDLMIRSSGEQRLSNFLLWQLAYSELWFPEVYWPDFQKEHLLQAVLAYQNRER
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHH
KFGGVNS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]