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The map label for this gene is lspA

Identifier: 188585949

GI number: 188585949

Start: 1395583

End: 1396041

Strand: Direct

Name: lspA

Synonym: Nther_1323

Alternate gene names: 188585949

Gene position: 1395583-1396041 (Clockwise)

Preceding gene: 188585948

Following gene: 188585950

Centisome position: 44.09

GC content: 31.81

Gene sequence:

>459_bases
GTGGGATTTGTTTTATTTGTCATAATTGCATTAACTATTGTTTTAGATCAAATATCCAAACTAATAGTTGCAAGAACTAT
GAGTTTAGGTGATAGTATCCCGGTGTTGGAGAACATTTTTCATATAACTTACTCAGTTAATCCCGGTGCTGCTTTTGGAA
TAATGGCTTATCAGACTACCTTTTTCATCGTGACTACCATTTTGTTATTACTCGTAATGGTATTTTTATTTTATCGACTA
GGACAAGAATTTCAAATAGTAAAAATAGCTCTGGCTTTACAGTTTGGTGGCGCAGTAGGTAATTTGATTGACAGGATTAG
AACAGGCTATGTGATAGATTTTTTTGATTTTAGGATCTGGCCAATTTTTAATATTGCAGATATGGCTATTGTGCTAGGTG
TGTCTATTTTAATTTATTTTATATTGTTTATGTCCAAAGATTATGGATGTTTTGATTAG

Upstream 100 bases:

>100_bases
AATGATCAATCATAGTATTTATCTTCATCTAAATTGTCAAGCATGTTCTGTTGTGCTAGAATAAATTGAGATTATTACTA
TTAGAGGGGGGACTGGTGGA

Downstream 100 bases:

>100_bases
TGGAAGTTGCCAGTAAGGGAGGGCTTGTATTGGAAAGATATAAAAAGGCCCAGTCTATAAATACAGACTATGAATTGATC
CCTAAAGAGAAAGATGAGGG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MGFVLFVIIALTIVLDQISKLIVARTMSLGDSIPVLENIFHITYSVNPGAAFGIMAYQTTFFIVTTILLLLVMVFLFYRL
GQEFQIVKIALALQFGGAVGNLIDRIRTGYVIDFFDFRIWPIFNIADMAIVLGVSILIYFILFMSKDYGCFD

Sequences:

>Translated_152_residues
MGFVLFVIIALTIVLDQISKLIVARTMSLGDSIPVLENIFHITYSVNPGAAFGIMAYQTTFFIVTTILLLLVMVFLFYRL
GQEFQIVKIALALQFGGAVGNLIDRIRTGYVIDFFDFRIWPIFNIADMAIVLGVSILIYFILFMSKDYGCFD
>Mature_151_residues
GFVLFVIIALTIVLDQISKLIVARTMSLGDSIPVLENIFHITYSVNPGAAFGIMAYQTTFFIVTTILLLLVMVFLFYRLG
QEFQIVKIALALQFGGAVGNLIDRIRTGYVIDFFDFRIWPIFNIADMAIVLGVSILIYFILFMSKDYGCFD

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=145, Percent_Identity=31.7241379310345, Blast_Score=77, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_NATTJ (B2A2J1)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917494.1
- MEROPS:   A08.001
- GeneID:   6315561
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1323
- HOGENOM:   HBG724422
- OMA:   SGFFQIV
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17143; Mature: 17012

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 104-104 ACT_SITE 127-127

Signals:

None

Transmembrane regions:

HASH(0x211b6860)-; HASH(0x218b34b4)-; HASH(0x20c574d4)-; HASH(0x2106c388)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFVLFVIIALTIVLDQISKLIVARTMSLGDSIPVLENIFHITYSVNPGAAFGIMAYQTT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHH
FFIVTTILLLLVMVFLFYRLGQEFQIVKIALALQFGGAVGNLIDRIRTGYVIDFFDFRIW
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHH
PIFNIADMAIVLGVSILIYFILFMSKDYGCFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
GFVLFVIIALTIVLDQISKLIVARTMSLGDSIPVLENIFHITYSVNPGAAFGIMAYQTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHH
FFIVTTILLLLVMVFLFYRLGQEFQIVKIALALQFGGAVGNLIDRIRTGYVIDFFDFRIW
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHH
PIFNIADMAIVLGVSILIYFILFMSKDYGCFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA