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The map label for this gene is msrA [H]

Identifier: 188585368

GI number: 188585368

Start: 762061

End: 762603

Strand: Reverse

Name: msrA [H]

Synonym: Nther_0735

Alternate gene names: 188585368

Gene position: 762603-762061 (Counterclockwise)

Preceding gene: 188585370

Following gene: 188585367

Centisome position: 24.09

GC content: 34.44

Gene sequence:

>543_bases
TTGGATGGAGTAGTAAGTACTAGAGTCGGTTATGCCGGTGGTGAAAAGGAAAACCCTACATATTATAATCTTGGGGATCA
TTCAGAAACAATAGAAATAGATTACGTGCCATCACAAATCACTCTTGAACAGCTTTTGGATATCTTTTGGAAGAGCCACA
ATCCCAGAGTGAAAGCACCTACCCGTCAGTATATGTCTATAATTTTTTATCACAATGAAGATCAAAAATATATTGCACAA
AAATCTAGGAAAACTCAAGAAACTAAATTAGGTACACAAATATATACAGAGATCAATCCAGTAACTAAATTTTATCAAGC
CGAAAACTATCATCAAAAGTTTTATTTACAAAACACTCCGGTACTTATGAATGAATTGAGAGGTTACTATAAAGATTTTC
AAGAATTTGTTGATTCAACAGCCACTGCACGTATTAACGGTTATGTGGCTGGTTTTGGAACTTTAACACAATTAGAACGA
GAGTTCCCCTTATTCGGACTATCCCAGAAAACTCAGGAATATTTAAAAGCTGGTGTTAAATGA

Upstream 100 bases:

>100_bases
CACATCTAAACCTTTGATAGATCAAAAGAATTCCGCAAAAATCACCACTGCTACTTTTGCCATGGGATGATTCTGGGGAC
CTGATGCCCAGTTTGGGCAG

Downstream 100 bases:

>100_bases
GTATTAATTGCAAATTTGCATTGTAAAAAGTACTGTCATAAGTTATACTACATATACCAATAATATTACATTATTTTATA
ATTTTATAATTGAAAGAAAG

Product: Methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MDGVVSTRVGYAGGEKENPTYYNLGDHSETIEIDYVPSQITLEQLLDIFWKSHNPRVKAPTRQYMSIIFYHNEDQKYIAQ
KSRKTQETKLGTQIYTEINPVTKFYQAENYHQKFYLQNTPVLMNELRGYYKDFQEFVDSTATARINGYVAGFGTLTQLER
EFPLFGLSQKTQEYLKAGVK

Sequences:

>Translated_180_residues
MDGVVSTRVGYAGGEKENPTYYNLGDHSETIEIDYVPSQITLEQLLDIFWKSHNPRVKAPTRQYMSIIFYHNEDQKYIAQ
KSRKTQETKLGTQIYTEINPVTKFYQAENYHQKFYLQNTPVLMNELRGYYKDFQEFVDSTATARINGYVAGFGTLTQLER
EFPLFGLSQKTQEYLKAGVK
>Mature_180_residues
MDGVVSTRVGYAGGEKENPTYYNLGDHSETIEIDYVPSQITLEQLLDIFWKSHNPRVKAPTRQYMSIIFYHNEDQKYIAQ
KSRKTQETKLGTQIYTEINPVTKFYQAENYHQKFYLQNTPVLMNELRGYYKDFQEFVDSTATARINGYVAGFGTLTQLER
EFPLFGLSQKTQEYLKAGVK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=131, Percent_Identity=32.824427480916, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI208609995, Length=131, Percent_Identity=32.824427480916, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1790665, Length=132, Percent_Identity=37.8787878787879, Blast_Score=71, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17533973, Length=182, Percent_Identity=42.3076923076923, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320881, Length=135, Percent_Identity=35.5555555555556, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664627, Length=175, Percent_Identity=41.7142857142857, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45553131, Length=175, Percent_Identity=41.7142857142857, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24664631, Length=175, Percent_Identity=41.1428571428571, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20954; Mature: 20954

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVVSTRVGYAGGEKENPTYYNLGDHSETIEIDYVPSQITLEQLLDIFWKSHNPRVKAP
CCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCC
TRQYMSIIFYHNEDQKYIAQKSRKTQETKLGTQIYTEINPVTKFYQAENYHQKFYLQNTP
HHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
VLMNELRGYYKDFQEFVDSTATARINGYVAGFGTLTQLEREFPLFGLSQKTQEYLKAGVK
HHHHHHHHHHHHHHHHHCCHHEEEECEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDGVVSTRVGYAGGEKENPTYYNLGDHSETIEIDYVPSQITLEQLLDIFWKSHNPRVKAP
CCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCC
TRQYMSIIFYHNEDQKYIAQKSRKTQETKLGTQIYTEINPVTKFYQAENYHQKFYLQNTP
HHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
VLMNELRGYYKDFQEFVDSTATARINGYVAGFGTLTQLEREFPLFGLSQKTQEYLKAGVK
HHHHHHHHHHHHHHHHHCCHHEEEECEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]