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The map label for this gene is pbpE [H]

Identifier: 188585356

GI number: 188585356

Start: 747252

End: 748787

Strand: Reverse

Name: pbpE [H]

Synonym: Nther_0723

Alternate gene names: 188585356

Gene position: 748787-747252 (Counterclockwise)

Preceding gene: 188585359

Following gene: 188585353

Centisome position: 23.65

GC content: 36.98

Gene sequence:

>1536_bases
TTGAAAAACAAATTGTTGCCACTAACTCTGGCATTTGCTCTTATTATTTCATTTATTGGGTATCATGAAGAGAATATTTC
CAAAGCCCTGGGTTTTGATGTACAATGGAATCAAAAAGCTCATGAAATAAAAACAAAAATCGTTGACCAGAACAAGGAAG
TGAATTATTCAGTAGGTGGTGAACAAGAAATGAATGCAGTTTTACAAAAACAGCTTGAAGATATAGTTGAAGAGTATGAA
TTAGCTGGTGTGCAAGTTGCCGCCGTCAATGAGAAAGGCACTATCGTCTCCGGCAATGCAGGAAAACATAGCCTGGAAGA
TAAAACAGAGATTGACGATAATACTATCTTGAGGAGTGCTTCTGTTTCAAAAGCTTTTACGGCAGTTGCCACTATGCAGC
TTGTTGAACAGCAACAAATTGATTTGGATGCTGATATAAATGACTATCTTGAACTGGAAGTTGATATCAAACACCCTGAA
TATCCTGACACTAATATAACTCCCAGAATGTTACTAAACCACAGTTCTGGCATGACTAACGGTACTTACGTTAGTTTTGC
ATCGAATTCTATAAATCGCGGCAATCGCCAAAAAACGCCCCCTTCCCTTTCAGAAGTTTTTGATGAAGAAGGTGAATTTT
ATTCAAATTCCATCTGGTCAGAATATAAACCGGGGGAGAAATTTATATATACTAATTTAGGTTATATAGTCTTAGGAGCA
ATTGTTGAAAATGTGTCAGGAATGAATTTTGATGAGTATACTAATGAAAATATTTTCAATCCTTTGGGGATGAATTCTTC
AAGTTTTAATATTAATGACCTGAGAAATTCTAGAAGAGGCCGAGATCGAGATAGGATAGCTCCTCTATATCGAAGGACAG
TAGAATATATAGATCAGGAAGAATCCGTTGAATCCAAAAAAAGCACAATCAAAGATAATGAAAAAACACTAGAGAATAAA
GATCAGCAACATAACAGGCAAAGACAAGTTCATTTTAGAGGAACAAATTTTGGTGACCTGCCGGAGTTTTCCAATTATAG
GCCTGGTAGAAACGGTTCACTGTATTCACCCCAGGGGGGGTTATTTACTACCGCCACGGACCTGGCTAAGTTTGCATCGG
CTATGATAAATGGAGGAGAATATCAAGGAAATAGAATTTTAGAACAAGAAACCATTGAATTGATGAAACAAGTCAGTGTC
AGCTCCTGTGCCCAAGATTGGACAGATTTTGATGGTCTTTTTAAGAAGCAGGGGTTAGGTCTTCATATCACCGATGAGTT
GTTAGAAGATGGAATAACACTTTATGGCCATCCGGGAATTGCTTATGGATTATTAAGTGGTGTTTATTTCACAGATCATA
CAGAGCAGACGGAGCAATCGAGACGGGAAAATAATTTCGGCATCGTATATCTGATCAATGGAGCCAATACAGAAATTCCC
GGTTCTAGTGATACTTTTTATGAAATTGAAGAAGAAATTGCAAAAACAGTATATGATTCTCTCTATGATTCCATTAAAAA
AGCTGGAGAACATTAA

Upstream 100 bases:

>100_bases
TCTATCACCTTGAAAAGCATCTTGCAAAACCCCACGGTATTATGTAAACTTAAATTGATTTAATAGATTACACTATGGTG
TTATGAGGAGGAAGTTTCCA

Downstream 100 bases:

>100_bases
TCTCCAGCTTTTTTAATGCCGTAATTTCATTATAGAGGTCCTTTTTGGTAAAATGAGGAATACCATCTATCATATTCTTT
TTCTAATAGGTATGCTCTCT

Product: beta-lactamase

Products: NA

Alternate protein names: PBP 4*; PBP 4A; Penicillin-binding protein E [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKNKLLPLTLAFALIISFIGYHEENISKALGFDVQWNQKAHEIKTKIVDQNKEVNYSVGGEQEMNAVLQKQLEDIVEEYE
LAGVQVAAVNEKGTIVSGNAGKHSLEDKTEIDDNTILRSASVSKAFTAVATMQLVEQQQIDLDADINDYLELEVDIKHPE
YPDTNITPRMLLNHSSGMTNGTYVSFASNSINRGNRQKTPPSLSEVFDEEGEFYSNSIWSEYKPGEKFIYTNLGYIVLGA
IVENVSGMNFDEYTNENIFNPLGMNSSSFNINDLRNSRRGRDRDRIAPLYRRTVEYIDQEESVESKKSTIKDNEKTLENK
DQQHNRQRQVHFRGTNFGDLPEFSNYRPGRNGSLYSPQGGLFTTATDLAKFASAMINGGEYQGNRILEQETIELMKQVSV
SSCAQDWTDFDGLFKKQGLGLHITDELLEDGITLYGHPGIAYGLLSGVYFTDHTEQTEQSRRENNFGIVYLINGANTEIP
GSSDTFYEIEEEIAKTVYDSLYDSIKKAGEH

Sequences:

>Translated_511_residues
MKNKLLPLTLAFALIISFIGYHEENISKALGFDVQWNQKAHEIKTKIVDQNKEVNYSVGGEQEMNAVLQKQLEDIVEEYE
LAGVQVAAVNEKGTIVSGNAGKHSLEDKTEIDDNTILRSASVSKAFTAVATMQLVEQQQIDLDADINDYLELEVDIKHPE
YPDTNITPRMLLNHSSGMTNGTYVSFASNSINRGNRQKTPPSLSEVFDEEGEFYSNSIWSEYKPGEKFIYTNLGYIVLGA
IVENVSGMNFDEYTNENIFNPLGMNSSSFNINDLRNSRRGRDRDRIAPLYRRTVEYIDQEESVESKKSTIKDNEKTLENK
DQQHNRQRQVHFRGTNFGDLPEFSNYRPGRNGSLYSPQGGLFTTATDLAKFASAMINGGEYQGNRILEQETIELMKQVSV
SSCAQDWTDFDGLFKKQGLGLHITDELLEDGITLYGHPGIAYGLLSGVYFTDHTEQTEQSRRENNFGIVYLINGANTEIP
GSSDTFYEIEEEIAKTVYDSLYDSIKKAGEH
>Mature_511_residues
MKNKLLPLTLAFALIISFIGYHEENISKALGFDVQWNQKAHEIKTKIVDQNKEVNYSVGGEQEMNAVLQKQLEDIVEEYE
LAGVQVAAVNEKGTIVSGNAGKHSLEDKTEIDDNTILRSASVSKAFTAVATMQLVEQQQIDLDADINDYLELEVDIKHPE
YPDTNITPRMLLNHSSGMTNGTYVSFASNSINRGNRQKTPPSLSEVFDEEGEFYSNSIWSEYKPGEKFIYTNLGYIVLGA
IVENVSGMNFDEYTNENIFNPLGMNSSSFNINDLRNSRRGRDRDRIAPLYRRTVEYIDQEESVESKKSTIKDNEKTLENK
DQQHNRQRQVHFRGTNFGDLPEFSNYRPGRNGSLYSPQGGLFTTATDLAKFASAMINGGEYQGNRILEQETIELMKQVSV
SSCAQDWTDFDGLFKKQGLGLHITDELLEDGITLYGHPGIAYGLLSGVYFTDHTEQTEQSRRENNFGIVYLINGANTEIP
GSSDTFYEIEEEIAKTVYDSLYDSIKKAGEH

Specific function: Probably involved in peptidoglycan modification during cortex synthesis [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17550934, Length=202, Percent_Identity=26.7326732673267, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533026, Length=230, Percent_Identity=28.695652173913, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17565630, Length=211, Percent_Identity=25.1184834123223, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR021860 [H]

Pfam domain/function: PF00144 Beta-lactamase; PF11954 DUF3471 [H]

EC number: NA

Molecular weight: Translated: 57584; Mature: 57584

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLLPLTLAFALIISFIGYHEENISKALGFDVQWNQKAHEIKTKIVDQNKEVNYSVGG
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCC
EQEMNAVLQKQLEDIVEEYELAGVQVAAVNEKGTIVSGNAGKHSLEDKTEIDDNTILRSA
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHH
SVSKAFTAVATMQLVEQQQIDLDADINDYLELEVDIKHPEYPDTNITPRMLLNHSSGMTN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHEEECCCCCCC
GTYVSFASNSINRGNRQKTPPSLSEVFDEEGEFYSNSIWSEYKPGEKFIYTNLGYIVLGA
CEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCEEEEECHHHHHHHH
IVENVSGMNFDEYTNENIFNPLGMNSSSFNINDLRNSRRGRDRDRIAPLYRRTVEYIDQE
HHHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCH
ESVESKKSTIKDNEKTLENKDQQHNRQRQVHFRGTNFGDLPEFSNYRPGRNGSLYSPQGG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
LFTTATDLAKFASAMINGGEYQGNRILEQETIELMKQVSVSSCAQDWTDFDGLFKKQGLG
CEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LHITDELLEDGITLYGHPGIAYGLLSGVYFTDHTEQTEQSRRENNFGIVYLINGANTEIP
EEEEHHHHHCCCEEECCCCHHHHHHHCCEECCCCHHHHHHHHCCCCEEEEEECCCCCCCC
GSSDTFYEIEEEIAKTVYDSLYDSIKKAGEH
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNKLLPLTLAFALIISFIGYHEENISKALGFDVQWNQKAHEIKTKIVDQNKEVNYSVGG
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCC
EQEMNAVLQKQLEDIVEEYELAGVQVAAVNEKGTIVSGNAGKHSLEDKTEIDDNTILRSA
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHH
SVSKAFTAVATMQLVEQQQIDLDADINDYLELEVDIKHPEYPDTNITPRMLLNHSSGMTN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHEEECCCCCCC
GTYVSFASNSINRGNRQKTPPSLSEVFDEEGEFYSNSIWSEYKPGEKFIYTNLGYIVLGA
CEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCEEEEECHHHHHHHH
IVENVSGMNFDEYTNENIFNPLGMNSSSFNINDLRNSRRGRDRDRIAPLYRRTVEYIDQE
HHHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCH
ESVESKKSTIKDNEKTLENKDQQHNRQRQVHFRGTNFGDLPEFSNYRPGRNGSLYSPQGG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
LFTTATDLAKFASAMINGGEYQGNRILEQETIELMKQVSVSSCAQDWTDFDGLFKKQGLG
CEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LHITDELLEDGITLYGHPGIAYGLLSGVYFTDHTEQTEQSRRENNFGIVYLINGANTEIP
EEEEHHHHHCCCEEECCCCHHHHHHHCCEECCCCHHHHHHHHCCCCEEEEEECCCCCCCC
GSSDTFYEIEEEIAKTVYDSLYDSIKKAGEH
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491712; 9384377 [H]