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The map label for this gene is liaR [H]

Identifier: 188585327

GI number: 188585327

Start: 716471

End: 717112

Strand: Reverse

Name: liaR [H]

Synonym: Nther_0692

Alternate gene names: 188585327

Gene position: 717112-716471 (Counterclockwise)

Preceding gene: 188585328

Following gene: 188585326

Centisome position: 22.65

GC content: 33.8

Gene sequence:

>642_bases
ATGTACCAAGTGTTAATTGTGGATGACCATGAAATGATCCGCTTGGGCCTGAAAGAACATTTATTAAAAGGTGAGAAAAT
TTCCCATGTAAGTGATGCCGAAAATATATCAGAAGCTTTAAAACAAGTACAAGAACAATATTTTCACGTAATTATAATGG
ATGTAAGACTCAAAAGTGAAAGCGGAGTGCAAGGATGTCAAGAAGTCTTAGAATATAGCCCTGACAGTAAAGTTATAATG
TTAACGGCATTTGACGATGATGATGCCCTGATTGAATCAATTTTAGCCGGTGCTTCAGGTTATTTAATGAAAGAAGTACG
AATTAAATCCTTGGTTGAATCTGTGATCAAAGCTGCAGAAGGTGAACAAATAATGGATGCAAAAACTACGGAAAAAGTTC
TTGAATATATGAGAAATAAAAATCCTAATCGGGAAAATCCTACTGATATATTAACAAATCGAGAAATGGATATTCTGGAC
TTAGTCGCTAAAGGCAAAACTAATAGTGAAATTGGTGAAGAGTTACACTTAAGTGAAAAAACTGTCAGAAACCAGCTGAG
TAGAATTCTTAACAAACTGGATTTAAATAATCGGACTCAAGCAGCAGCTTATTATGTATCACAAATAAAAGAAGATAGTT
AA

Upstream 100 bases:

>100_bases
AACGAATTCATACCCTGGGCGGTGAATTCAATTTCCAAACCGAAAAAAGTAAAGGAACTAAGTTTTATTTAGAATTGCCA
AAGAAGGGAGGGTAAACCAA

Downstream 100 bases:

>100_bases
CAACTTGGTAAGCCGACCTTGAGTAACAAAGGTCGGTTTTTTTAACTTTAGAATCAGGGACAAATGTCCCTATCTAAGAC
GGATGAATACACCTATATTA

Product: two component transcriptional regulator, LuxR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MYQVLIVDDHEMIRLGLKEHLLKGEKISHVSDAENISEALKQVQEQYFHVIIMDVRLKSESGVQGCQEVLEYSPDSKVIM
LTAFDDDDALIESILAGASGYLMKEVRIKSLVESVIKAAEGEQIMDAKTTEKVLEYMRNKNPNRENPTDILTNREMDILD
LVAKGKTNSEIGEELHLSEKTVRNQLSRILNKLDLNNRTQAAAYYVSQIKEDS

Sequences:

>Translated_213_residues
MYQVLIVDDHEMIRLGLKEHLLKGEKISHVSDAENISEALKQVQEQYFHVIIMDVRLKSESGVQGCQEVLEYSPDSKVIM
LTAFDDDDALIESILAGASGYLMKEVRIKSLVESVIKAAEGEQIMDAKTTEKVLEYMRNKNPNRENPTDILTNREMDILD
LVAKGKTNSEIGEELHLSEKTVRNQLSRILNKLDLNNRTQAAAYYVSQIKEDS
>Mature_213_residues
MYQVLIVDDHEMIRLGLKEHLLKGEKISHVSDAENISEALKQVQEQYFHVIIMDVRLKSESGVQGCQEVLEYSPDSKVIM
LTAFDDDDALIESILAGASGYLMKEVRIKSLVESVIKAAEGEQIMDAKTTEKVLEYMRNKNPNRENPTDILTNREMDILD
LVAKGKTNSEIGEELHLSEKTVRNQLSRILNKLDLNNRTQAAAYYVSQIKEDS

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=209, Percent_Identity=29.6650717703349, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788222, Length=200, Percent_Identity=29, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787473, Length=201, Percent_Identity=26.3681592039801, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790102, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786747, Length=202, Percent_Identity=26.2376237623762, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24154; Mature: 24154

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVLIVDDHEMIRLGLKEHLLKGEKISHVSDAENISEALKQVQEQYFHVIIMDVRLKSE
CEEEEEECCHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCC
SGVQGCQEVLEYSPDSKVIMLTAFDDDDALIESILAGASGYLMKEVRIKSLVESVIKAAE
CCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
GEQIMDAKTTEKVLEYMRNKNPNRENPTDILTNREMDILDLVAKGKTNSEIGEELHLSEK
CCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
TVRNQLSRILNKLDLNNRTQAAAYYVSQIKEDS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYQVLIVDDHEMIRLGLKEHLLKGEKISHVSDAENISEALKQVQEQYFHVIIMDVRLKSE
CEEEEEECCHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCC
SGVQGCQEVLEYSPDSKVIMLTAFDDDDALIESILAGASGYLMKEVRIKSLVESVIKAAE
CCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
GEQIMDAKTTEKVLEYMRNKNPNRENPTDILTNREMDILDLVAKGKTNSEIGEELHLSEK
CCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
TVRNQLSRILNKLDLNNRTQAAAYYVSQIKEDS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]