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The map label for this gene is hom [H]

Identifier: 188585305

GI number: 188585305

Start: 692342

End: 693667

Strand: Reverse

Name: hom [H]

Synonym: Nther_0669

Alternate gene names: 188585305

Gene position: 693667-692342 (Counterclockwise)

Preceding gene: 188585306

Following gene: 188585304

Centisome position: 21.91

GC content: 36.65

Gene sequence:

>1326_bases
ATGACATCAACTATTAAAATTGGCTTTCTAGGCTTTGGTACAGTGGGGACAGGTACTGTGGAAGTTTTAACTGAAAATAA
AGATTTGCTAACTGAGCGAGTTAATGCCGTACTAGAAGTGGAAAAAATTCTTGTAAAGAATAAAACTAAATCTAGGACAA
CACAACTTAATCAGAACTTCATATCAGACAAGCTTACAGATGATCCAGAAGAAATACTGAGAAACCAAGATATTCAGATA
GTAGTTGAAGTAATGGGAACAGAAGAACCAGCTCTTAGTTACATGAAAAAAGCCATCAAAGCTGGTAAGCATGTAGTCAC
TGCCAATAAAGAAGTGATAGCCAAACACGGCGAAGATCTCACTTCTTTAGCCAAAAATAATGGTGTTAATTTCTTGTACG
AAGCCAGTGTAGCCGGTGGTGTTCCAGTAATAAGGCCCTTAAAAGCATGCCTAGCTGGAAATACAGTTAAGGAAATTTCC
GGTATATTGAACGGTACTACTAATTACATCTTGACCGAAATGGAGGAAAAGGAAGCAGAGTTCAATGAAGCCCTTAAAAA
AGCACAAGAGCTTGGTTATGCTGAAAGTGACCCTACTGATGATGTAGAAGGTTTTGACGCTGTAAGGAAACTTGCCATAA
TGACATCTATGGCAACAAATTCTACTGTATTACCCGAAGATATATACACTGAAGGCATTTCTGGTGTAACAAAGGAAGAT
CTCCAATTTTTAGGTGATCATGGGTACAAAATTAAACTTCTTGGACAGACAAAAATTAATGGTACGGAAGTAGAAAGTCG
GGTCGCACCTACTTTCTTACCCTGTGACAATCCGCTTTCATCAGTCTCCGGGGTTTATAATTCTATATTAATTAAGGGAG
AACCAGTGGGTTATCTTACATTTACCGGCGAAGGGGCTGGTAAAGAAGCAACCTCCAGTGCTGTCTTATCCGATATCATT
GAAGCTGCTAGGAATGGTAAGCATTCCAATAATTTCAATGGTTGGAGTAAAAATAATTTTTACAAAATCCTTGATAAGGA
AGAAACCAGTTCACTATTTTATCTCAGGCTAGTAAGTTCAAATCCTTCTCAGACAGAACAAGAACAGAAAGTTAACAAAT
CCGAAATCCAAAACCTATTAAATCATCACGGCATTGAGTTACAGCAGTTAGATAAAAAATCTAGTTCAAATGGAAAACAA
GAATTATTTATAATCACAGAATTAGCTAAAGAACAAAATGTACAAAACGCTATTTCTGATTTACAGGATAAGTCAGTTGA
ACTTATAAACATTATTAGAGGAGATAACAGTAACGGTGGAAGATAA

Upstream 100 bases:

>100_bases
GTAGTAGCTGATAACTTGAGACGAGGAGCTGCCTTTAATGCTTTGTTATTAACTGAATATTTAGCTAAATATATAATTTA
AATTCAAGGAGGATTATGAT

Downstream 100 bases:

>100_bases
AAAGCTGAAAGATGAAAGATAAAAAGTTATGCGTAGGAGGATAATGATGGAAATCTATGTGGAAAAATACGGAGGAAGTT
CCCTGGCTACTGTAGATAAA

Product: Homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTSTIKIGFLGFGTVGTGTVEVLTENKDLLTERVNAVLEVEKILVKNKTKSRTTQLNQNFISDKLTDDPEEILRNQDIQI
VVEVMGTEEPALSYMKKAIKAGKHVVTANKEVIAKHGEDLTSLAKNNGVNFLYEASVAGGVPVIRPLKACLAGNTVKEIS
GILNGTTNYILTEMEEKEAEFNEALKKAQELGYAESDPTDDVEGFDAVRKLAIMTSMATNSTVLPEDIYTEGISGVTKED
LQFLGDHGYKIKLLGQTKINGTEVESRVAPTFLPCDNPLSSVSGVYNSILIKGEPVGYLTFTGEGAGKEATSSAVLSDII
EAARNGKHSNNFNGWSKNNFYKILDKEETSSLFYLRLVSSNPSQTEQEQKVNKSEIQNLLNHHGIELQQLDKKSSSNGKQ
ELFIITELAKEQNVQNAISDLQDKSVELINIIRGDNSNGGR

Sequences:

>Translated_441_residues
MTSTIKIGFLGFGTVGTGTVEVLTENKDLLTERVNAVLEVEKILVKNKTKSRTTQLNQNFISDKLTDDPEEILRNQDIQI
VVEVMGTEEPALSYMKKAIKAGKHVVTANKEVIAKHGEDLTSLAKNNGVNFLYEASVAGGVPVIRPLKACLAGNTVKEIS
GILNGTTNYILTEMEEKEAEFNEALKKAQELGYAESDPTDDVEGFDAVRKLAIMTSMATNSTVLPEDIYTEGISGVTKED
LQFLGDHGYKIKLLGQTKINGTEVESRVAPTFLPCDNPLSSVSGVYNSILIKGEPVGYLTFTGEGAGKEATSSAVLSDII
EAARNGKHSNNFNGWSKNNFYKILDKEETSSLFYLRLVSSNPSQTEQEQKVNKSEIQNLLNHHGIELQQLDKKSSSNGKQ
ELFIITELAKEQNVQNAISDLQDKSVELINIIRGDNSNGGR
>Mature_440_residues
TSTIKIGFLGFGTVGTGTVEVLTENKDLLTERVNAVLEVEKILVKNKTKSRTTQLNQNFISDKLTDDPEEILRNQDIQIV
VEVMGTEEPALSYMKKAIKAGKHVVTANKEVIAKHGEDLTSLAKNNGVNFLYEASVAGGVPVIRPLKACLAGNTVKEISG
ILNGTTNYILTEMEEKEAEFNEALKKAQELGYAESDPTDDVEGFDAVRKLAIMTSMATNSTVLPEDIYTEGISGVTKEDL
QFLGDHGYKIKLLGQTKINGTEVESRVAPTFLPCDNPLSSVSGVYNSILIKGEPVGYLTFTGEGAGKEATSSAVLSDIIE
AARNGKHSNNFNGWSKNNFYKILDKEETSSLFYLRLVSSNPSQTEQEQKVNKSEIQNLLNHHGIELQQLDKKSSSNGKQE
LFIITELAKEQNVQNAISDLQDKSVELINIIRGDNSNGGR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=269, Percent_Identity=28.2527881040892, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790376, Length=362, Percent_Identity=23.7569060773481, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322599, Length=225, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 48209; Mature: 48078

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTIKIGFLGFGTVGTGTVEVLTENKDLLTERVNAVLEVEKILVKNKTKSRTTQLNQNF
CCCEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISDKLTDDPEEILRNQDIQIVVEVMGTEEPALSYMKKAIKAGKHVVTANKEVIAKHGEDL
HHHCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCCCHH
TSLAKNNGVNFLYEASVAGGVPVIRPLKACLAGNTVKEISGILNGTTNYILTEMEEKEAE
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHEEEHHHHHHHH
FNEALKKAQELGYAESDPTDDVEGFDAVRKLAIMTSMATNSTVLPEDIYTEGISGVTKED
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHH
LQFLGDHGYKIKLLGQTKINGTEVESRVAPTFLPCDNPLSSVSGVYNSILIKGEPVGYLT
HHHHCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHEEECCCCEEEEE
FTGEGAGKEATSSAVLSDIIEAARNGKHSNNFNGWSKNNFYKILDKEETSSLFYLRLVSS
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECC
NPSQTEQEQKVNKSEIQNLLNHHGIELQQLDKKSSSNGKQELFIITELAKEQNVQNAISD
CCCCHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHH
LQDKSVELINIIRGDNSNGGR
HHHCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
TSTIKIGFLGFGTVGTGTVEVLTENKDLLTERVNAVLEVEKILVKNKTKSRTTQLNQNF
CCEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISDKLTDDPEEILRNQDIQIVVEVMGTEEPALSYMKKAIKAGKHVVTANKEVIAKHGEDL
HHHCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCCCHH
TSLAKNNGVNFLYEASVAGGVPVIRPLKACLAGNTVKEISGILNGTTNYILTEMEEKEAE
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHEEEHHHHHHHH
FNEALKKAQELGYAESDPTDDVEGFDAVRKLAIMTSMATNSTVLPEDIYTEGISGVTKED
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHH
LQFLGDHGYKIKLLGQTKINGTEVESRVAPTFLPCDNPLSSVSGVYNSILIKGEPVGYLT
HHHHCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHEEECCCCEEEEE
FTGEGAGKEATSSAVLSDIIEAARNGKHSNNFNGWSKNNFYKILDKEETSSLFYLRLVSS
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECC
NPSQTEQEQKVNKSEIQNLLNHHGIELQQLDKKSSSNGKQELFIITELAKEQNVQNAISD
CCCCHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHH
LQDKSVELINIIRGDNSNGGR
HHHCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]