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The map label for this gene is moeA [H]

Identifier: 188585284

GI number: 188585284

Start: 669297

End: 670595

Strand: Direct

Name: moeA [H]

Synonym: Nther_0646

Alternate gene names: 188585284

Gene position: 669297-670595 (Clockwise)

Preceding gene: 188585283

Following gene: 188585285

Centisome position: 21.14

GC content: 37.11

Gene sequence:

>1299_bases
ATGATTTCACCAGAAGAAGCATGTCAGAAGATTTATAATTTAATGCCTGATAGAAACATAGAAAGTGTATCTCTGTTAAG
TTGTGTGGAAAGTTGCATATCAGAGAACATAATTGCTCAAGAAGACGTCCCTTCTTTTTGTAGATCACCATATGATGGAT
ACGCATTTAATTCTGAAGCTACCCGTAATGTTACTTCTACTAACCCGGTAGAAATCGATATAATTGATACAGTACCTGCA
GGAAAAAATTTTGAATACTTTAATAACTTGGAAGATGCAGATCTAAATTCACCTTCCAAACCAAAATTAAATGACCGGAA
AAAACAAGATTGGAAACAAACAGGCATGAAAGTCATGACAGGGGGTATGATTCCTGATATATACGACGCTGTTCTGCCCT
GGGAACAAGTAGGAATTAAAGATAAAGAGCAAAAGATTTTAATCAATAAAGAAATACCCTCTCAACACAATATCATTCCC
AAAGGTGAAGACATAAAAAAAGGAGAACTAGTAATTAAGGAAGGAGAGAAGTTAACCCCTTATCATATTGGGGTTTTAGC
ATCTCTAGGGTTTACTCATCCTAGAGTGTATGCACCGTACAAAATAGGAATATTAGTTACGGGGACAGAGCTAGTTAATC
CAGAAAATGACATAAGCCCAGGAAAGATTAGAAGTAGTAATAACTTTTCCCTTGGTGCTACTTTGCAGTGTATGGGACAT
GAAGTTCTAGACTTTGGAATTGTTGGTGACAGTAAGAAAAAATTGGCCGAAAAAATTGAAGAAGCTGTTAGTAAAGTTGA
TATTTTACTTACTACCGGAGGGGTTTCGAGGGGAGATTATGACTTTGTTCCTTATGTATTGGAGGAGATGAAAGCAAAAA
GATTATTTTGGAGAGTGAAAATGAAACCCGGCACTCCATTGCATGTTTCACAATATCAAGGAACTCCCGTAATATCATTA
TCAGGTAACCCGGCAGCATCCATGGCATCTTTTCATTTATTGCTAGCACCGGCTCTTCAAAATAATGGCAAACGACAAAC
TGCTACTAGTCTTAAAGAGCGTAGCCATGCTTCTTTCCTTGCAAAGGATATTAAAAAGAAAACCTCTTCATTATGGAGAT
TTGTTCGAGGTAAAGCATGGATAGGAAATGATGGAGTATTTTATAGTACTCCTATTGCCAAGGAAAAGCCTAATATGTTG
AAGACTATGATTTGGGCCAATGGATATATAGTTGTTCCCCCGGATAGCCAGGCGATAAGGGCCGGTGATAAAGTTAATTT
TATCCCAATAGATAAGTGA

Upstream 100 bases:

>100_bases
CAGAAATTTTAGAGTTATTTCACAAATATGAAATGAATTACTACAAAACAACCGTCTTCAGTTGCTGAAGGCGGTTGTTA
ACTATTGAAAGGGGATCAAA

Downstream 100 bases:

>100_bases
AGTGATGTGAAATGATATGGCAGAGATTAATTTGGAAAAAATTAATTCATGGAACTGTTCCTAGAATTAATCCTGGAAAA
TGTATTAATAAAAAAGTCAA

Product: molybdenum cofactor synthesis domain protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MISPEEACQKIYNLMPDRNIESVSLLSCVESCISENIIAQEDVPSFCRSPYDGYAFNSEATRNVTSTNPVEIDIIDTVPA
GKNFEYFNNLEDADLNSPSKPKLNDRKKQDWKQTGMKVMTGGMIPDIYDAVLPWEQVGIKDKEQKILINKEIPSQHNIIP
KGEDIKKGELVIKEGEKLTPYHIGVLASLGFTHPRVYAPYKIGILVTGTELVNPENDISPGKIRSSNNFSLGATLQCMGH
EVLDFGIVGDSKKKLAEKIEEAVSKVDILLTTGGVSRGDYDFVPYVLEEMKAKRLFWRVKMKPGTPLHVSQYQGTPVISL
SGNPAASMASFHLLLAPALQNNGKRQTATSLKERSHASFLAKDIKKKTSSLWRFVRGKAWIGNDGVFYSTPIAKEKPNML
KTMIWANGYIVVPPDSQAIRAGDKVNFIPIDK

Sequences:

>Translated_432_residues
MISPEEACQKIYNLMPDRNIESVSLLSCVESCISENIIAQEDVPSFCRSPYDGYAFNSEATRNVTSTNPVEIDIIDTVPA
GKNFEYFNNLEDADLNSPSKPKLNDRKKQDWKQTGMKVMTGGMIPDIYDAVLPWEQVGIKDKEQKILINKEIPSQHNIIP
KGEDIKKGELVIKEGEKLTPYHIGVLASLGFTHPRVYAPYKIGILVTGTELVNPENDISPGKIRSSNNFSLGATLQCMGH
EVLDFGIVGDSKKKLAEKIEEAVSKVDILLTTGGVSRGDYDFVPYVLEEMKAKRLFWRVKMKPGTPLHVSQYQGTPVISL
SGNPAASMASFHLLLAPALQNNGKRQTATSLKERSHASFLAKDIKKKTSSLWRFVRGKAWIGNDGVFYSTPIAKEKPNML
KTMIWANGYIVVPPDSQAIRAGDKVNFIPIDK
>Mature_432_residues
MISPEEACQKIYNLMPDRNIESVSLLSCVESCISENIIAQEDVPSFCRSPYDGYAFNSEATRNVTSTNPVEIDIIDTVPA
GKNFEYFNNLEDADLNSPSKPKLNDRKKQDWKQTGMKVMTGGMIPDIYDAVLPWEQVGIKDKEQKILINKEIPSQHNIIP
KGEDIKKGELVIKEGEKLTPYHIGVLASLGFTHPRVYAPYKIGILVTGTELVNPENDISPGKIRSSNNFSLGATLQCMGH
EVLDFGIVGDSKKKLAEKIEEAVSKVDILLTTGGVSRGDYDFVPYVLEEMKAKRLFWRVKMKPGTPLHVSQYQGTPVISL
SGNPAASMASFHLLLAPALQNNGKRQTATSLKERSHASFLAKDIKKKTSSLWRFVRGKAWIGNDGVFYSTPIAKEKPNML
KTMIWANGYIVVPPDSQAIRAGDKVNFIPIDK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=449, Percent_Identity=27.8396436525612, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI66932975, Length=431, Percent_Identity=28.3062645011601, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1787049, Length=396, Percent_Identity=27.2727272727273, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25147659, Length=363, Percent_Identity=26.7217630853994, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562606, Length=402, Percent_Identity=24.6268656716418, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136978, Length=306, Percent_Identity=26.797385620915, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24638841, Length=306, Percent_Identity=26.797385620915, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47947; Mature: 47947

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPEEACQKIYNLMPDRNIESVSLLSCVESCISENIIAQEDVPSFCRSPYDGYAFNSEA
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEECCCC
TRNVTSTNPVEIDIIDTVPAGKNFEYFNNLEDADLNSPSKPKLNDRKKQDWKQTGMKVMT
CCCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEE
GGMIPDIYDAVLPWEQVGIKDKEQKILINKEIPSQHNIIPKGEDIKKGELVIKEGEKLTP
CCCCHHHHHHHCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
YHIGVLASLGFTHPRVYAPYKIGILVTGTELVNPENDISPGKIRSSNNFSLGATLQCMGH
HHHHHHHHCCCCCCEEECCEEEEEEEECCEECCCCCCCCCCEEECCCCCCCCEEHEECCC
EVLDFGIVGDSKKKLAEKIEEAVSKVDILLTTGGVSRGDYDFVPYVLEEMKAKRLFWRVK
CCEEEEEECCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEEEEE
MKPGTPLHVSQYQGTPVISLSGNPAASMASFHLLLAPALQNNGKRQTATSLKERSHASFL
ECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHH
AKDIKKKTSSLWRFVRGKAWIGNDGVFYSTPIAKEKPNMLKTMIWANGYIVVPPDSQAIR
HHHHHHHHHHHHHHHHCCEEECCCCCEEECCCCCCCCHHHHHHHEECCEEEECCCCHHHH
AGDKVNFIPIDK
CCCCEEEEECCC
>Mature Secondary Structure
MISPEEACQKIYNLMPDRNIESVSLLSCVESCISENIIAQEDVPSFCRSPYDGYAFNSEA
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEECCCC
TRNVTSTNPVEIDIIDTVPAGKNFEYFNNLEDADLNSPSKPKLNDRKKQDWKQTGMKVMT
CCCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEE
GGMIPDIYDAVLPWEQVGIKDKEQKILINKEIPSQHNIIPKGEDIKKGELVIKEGEKLTP
CCCCHHHHHHHCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
YHIGVLASLGFTHPRVYAPYKIGILVTGTELVNPENDISPGKIRSSNNFSLGATLQCMGH
HHHHHHHHCCCCCCEEECCEEEEEEEECCEECCCCCCCCCCEEECCCCCCCCEEHEECCC
EVLDFGIVGDSKKKLAEKIEEAVSKVDILLTTGGVSRGDYDFVPYVLEEMKAKRLFWRVK
CCEEEEEECCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEEEEE
MKPGTPLHVSQYQGTPVISLSGNPAASMASFHLLLAPALQNNGKRQTATSLKERSHASFL
ECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHH
AKDIKKKTSSLWRFVRGKAWIGNDGVFYSTPIAKEKPNMLKTMIWANGYIVVPPDSQAIR
HHHHHHHHHHHHHHHHCCEEECCCCCEEECCCCCCCCHHHHHHHEECCEEEECCCCHHHH
AGDKVNFIPIDK
CCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]