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The map label for this gene is ygcA [C]

Identifier: 188585106

GI number: 188585106

Start: 495086

End: 496450

Strand: Direct

Name: ygcA [C]

Synonym: Nther_0467

Alternate gene names: 188585106

Gene position: 495086-496450 (Clockwise)

Preceding gene: 188585104

Following gene: 188585108

Centisome position: 15.64

GC content: 35.9

Gene sequence:

>1365_bases
ATGCCAGATATTAGACCTGTGAAGAAGGAAGAAAAACTAACTTTAACTATACATGACTTAAATCACCAGGGTGAAGGAGT
AGGCAAGTATAGGAATTTCGCAATTTTTGTTCCTTTTGCCTTACCTGGTGAAAAAGTTAGAATAACCATTACAGAAGTTA
AAAAAAATTATGCCAGAGGCCAAGTCCTGCAACATCAAGATCGCTCAAGCCAGCGAGTTAAGCCTCCTTGTCCGTTCTTT
CAAGAATGTGGGGGATGTCAATTACAACACTTGTCTTATAAAGGTCAATTACAGTACAAAGAAAATTTAGTAGCTAATCA
GATGAAAAAGGTAGCTGGTTTAAAAAATCCACGAGTTTTGCCTGCCATTGGAATGGAAAGTCCTTGGTATTACAGAAATA
AATTTCAGATACCAGTGAAACCCATTGGTGGAAAACCAAGGCTTGGTTTATTTCAAAAAAGAAGCCAAAATTTAGTTGAA
ATTGACCACTGCATGATTCAGAAGCATGGAAACAATGAAGTATTAGAAAAAATGCGTAATTTAGTAGACAGCTACGAAAA
AGAATTTTATAACTGTGAGCTGAAACATATTATTTCTAGGGTGGGAGACAAAACTGATCAAGTGCAATTGACATTTGTAA
CAGGATCCGAAAAAATTGACAACAAACAAATGATTCTAGAGCCACTAAAGAATGGTATGGCTAACTTAGTCGGGATAGTA
CAGAATATTAATAAGAAACCAAGAGGAAACGTCTTAGGCGATAGATTTAAGACCCTATGGGGTCGAGAGTATTTGATGGA
TAATTTGCTTGATAAAAAATTTCGTGTATCTGCTGGTGCTTTTTATCAGGTTAATCCCAGTCAAACAGAAGTACTCTATC
AAAAAGTTTTTGAATTATGTAAACTCAAAGGTGTAGAGAATGTAATGGATATTTATTGTGGCATTGGAACCATCTCTTTA
CTTGCTGCTGAAAATGCAAGTAAGGTGGTGGGTATAGAGATAGCAGAGGAAGCAGTAAAGGATGCTAATATTAATAAGAA
TATCAATGGACAAGAGAATGCCTGGTTTTATCAGGCACGGGCGGAAGATGAAAAAACTGAATCCATAATTCAGGATTATT
CGCCTGAAATTGTGATTATGGACCCACCTAGAAAAGGATGTGATGAAAATCTGTTAACAAGCTTAGATTGGATCAGACCT
GAAAAGATAGCTTACGTTTCCTGTAACCCAGCTACTCTAGCTAGGGATGTAGGAAAATTGATTGAGTTTGGTTATTATCC
GGAATTATTTCAACCAGTTGATATGTTTCCACAAACCACTCATATAGAAGTGATTTGTATCCTAACTAAGATAGATTATC
TATAA

Upstream 100 bases:

>100_bases
GATTTGGATTCTAATGATATAGTTTAACAAAGGGTTAACAAAATGAAAATAGTTAGGGACTAAAAATTTTTATATGGTAA
AACAAAGGGGGTAATAAACT

Downstream 100 bases:

>100_bases
AGTTTTTAATAATTCTGGCTGTAAACCCCCAGATAACGTAATCACCGTAAATGTAAAAATAAGAGGGGTATTCCCCCTGT
TTAAAGGGATAGTTCTTACC

Product: RNA methyltransferase, TrmA family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MPDIRPVKKEEKLTLTIHDLNHQGEGVGKYRNFAIFVPFALPGEKVRITITEVKKNYARGQVLQHQDRSSQRVKPPCPFF
QECGGCQLQHLSYKGQLQYKENLVANQMKKVAGLKNPRVLPAIGMESPWYYRNKFQIPVKPIGGKPRLGLFQKRSQNLVE
IDHCMIQKHGNNEVLEKMRNLVDSYEKEFYNCELKHIISRVGDKTDQVQLTFVTGSEKIDNKQMILEPLKNGMANLVGIV
QNINKKPRGNVLGDRFKTLWGREYLMDNLLDKKFRVSAGAFYQVNPSQTEVLYQKVFELCKLKGVENVMDIYCGIGTISL
LAAENASKVVGIEIAEEAVKDANINKNINGQENAWFYQARAEDEKTESIIQDYSPEIVIMDPPRKGCDENLLTSLDWIRP
EKIAYVSCNPATLARDVGKLIEFGYYPELFQPVDMFPQTTHIEVICILTKIDYL

Sequences:

>Translated_454_residues
MPDIRPVKKEEKLTLTIHDLNHQGEGVGKYRNFAIFVPFALPGEKVRITITEVKKNYARGQVLQHQDRSSQRVKPPCPFF
QECGGCQLQHLSYKGQLQYKENLVANQMKKVAGLKNPRVLPAIGMESPWYYRNKFQIPVKPIGGKPRLGLFQKRSQNLVE
IDHCMIQKHGNNEVLEKMRNLVDSYEKEFYNCELKHIISRVGDKTDQVQLTFVTGSEKIDNKQMILEPLKNGMANLVGIV
QNINKKPRGNVLGDRFKTLWGREYLMDNLLDKKFRVSAGAFYQVNPSQTEVLYQKVFELCKLKGVENVMDIYCGIGTISL
LAAENASKVVGIEIAEEAVKDANINKNINGQENAWFYQARAEDEKTESIIQDYSPEIVIMDPPRKGCDENLLTSLDWIRP
EKIAYVSCNPATLARDVGKLIEFGYYPELFQPVDMFPQTTHIEVICILTKIDYL
>Mature_453_residues
PDIRPVKKEEKLTLTIHDLNHQGEGVGKYRNFAIFVPFALPGEKVRITITEVKKNYARGQVLQHQDRSSQRVKPPCPFFQ
ECGGCQLQHLSYKGQLQYKENLVANQMKKVAGLKNPRVLPAIGMESPWYYRNKFQIPVKPIGGKPRLGLFQKRSQNLVEI
DHCMIQKHGNNEVLEKMRNLVDSYEKEFYNCELKHIISRVGDKTDQVQLTFVTGSEKIDNKQMILEPLKNGMANLVGIVQ
NINKKPRGNVLGDRFKTLWGREYLMDNLLDKKFRVSAGAFYQVNPSQTEVLYQKVFELCKLKGVENVMDIYCGIGTISLL
AAENASKVVGIEIAEEAVKDANINKNINGQENAWFYQARAEDEKTESIIQDYSPEIVIMDPPRKGCDENLLTSLDWIRPE
KIAYVSCNPATLARDVGKLIEFGYYPELFQPVDMFPQTTHIEVICILTKIDYL

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=301, Percent_Identity=27.2425249169435, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI51173878, Length=301, Percent_Identity=27.2425249169435, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI269784680, Length=216, Percent_Identity=30.0925925925926, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI269784676, Length=216, Percent_Identity=30.0925925925926, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI20149688, Length=216, Percent_Identity=30.0925925925926, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI269784678, Length=209, Percent_Identity=30.1435406698565, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1789148, Length=460, Percent_Identity=26.5217391304348, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1787083, Length=326, Percent_Identity=27.6073619631902, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790403, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322909, Length=406, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666579, Length=420, Percent_Identity=26.6666666666667, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51906; Mature: 51774

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIRPVKKEEKLTLTIHDLNHQGEGVGKYRNFAIFVPFALPGEKVRITITEVKKNYARG
CCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEHHHHHHHHC
QVLQHQDRSSQRVKPPCPFFQECGGCQLQHLSYKGQLQYKENLVANQMKKVAGLKNPRVL
CHHHHCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEE
PAIGMESPWYYRNKFQIPVKPIGGKPRLGLFQKRSQNLVEIDHCMIQKHGNNEVLEKMRN
EECCCCCCCEECCEEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHH
LVDSYEKEFYNCELKHIISRVGDKTDQVQLTFVTGSEKIDNKQMILEPLKNGMANLVGIV
HHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QNINKKPRGNVLGDRFKTLWGREYLMDNLLDKKFRVSAGAFYQVNPSQTEVLYQKVFELC
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEECCCCEEEECCHHHHHHHHHHHHHH
KLKGVENVMDIYCGIGTISLLAAENASKVVGIEIAEEAVKDANINKNINGQENAWFYQAR
HHCCHHHHHHHHHCHHHHEEEECCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
AEDEKTESIIQDYSPEIVIMDPPRKGCDENLLTSLDWIRPEKIAYVSCNPATLARDVGKL
CCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHH
IEFGYYPELFQPVDMFPQTTHIEVICILTKIDYL
HHCCCCHHHHCHHHCCCCCCCEEEEEEEEHHCCC
>Mature Secondary Structure 
PDIRPVKKEEKLTLTIHDLNHQGEGVGKYRNFAIFVPFALPGEKVRITITEVKKNYARG
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEHHHHHHHHC
QVLQHQDRSSQRVKPPCPFFQECGGCQLQHLSYKGQLQYKENLVANQMKKVAGLKNPRVL
CHHHHCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEE
PAIGMESPWYYRNKFQIPVKPIGGKPRLGLFQKRSQNLVEIDHCMIQKHGNNEVLEKMRN
EECCCCCCCEECCEEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHH
LVDSYEKEFYNCELKHIISRVGDKTDQVQLTFVTGSEKIDNKQMILEPLKNGMANLVGIV
HHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QNINKKPRGNVLGDRFKTLWGREYLMDNLLDKKFRVSAGAFYQVNPSQTEVLYQKVFELC
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEECCCCEEEECCHHHHHHHHHHHHHH
KLKGVENVMDIYCGIGTISLLAAENASKVVGIEIAEEAVKDANINKNINGQENAWFYQAR
HHCCHHHHHHHHHCHHHHEEEECCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
AEDEKTESIIQDYSPEIVIMDPPRKGCDENLLTSLDWIRPEKIAYVSCNPATLARDVGKL
CCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHH
IEFGYYPELFQPVDMFPQTTHIEVICILTKIDYL
HHCCCCHHHHCHHHCCCCCCCEEEEEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]