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The map label for this gene is ubiB [C]

Identifier: 188584936

GI number: 188584936

Start: 307215

End: 308891

Strand: Direct

Name: ubiB [C]

Synonym: Nther_0295

Alternate gene names: 188584936

Gene position: 307215-308891 (Clockwise)

Preceding gene: 188584935

Following gene: 188584937

Centisome position: 9.7

GC content: 35.24

Gene sequence:

>1677_bases
ATGTTTAAAAGAAGAATTAGACATTTTAATCGGTATCGAGAAATTGTAAGTATTTTAGCTAGGCATGGTTTTGGCTTTTT
GATTGAAGAGCTTGGCCTTCATCATATGCTTTCCTTGCCCAGTAGAATTAGAAAAGAATCTTCAAAACAAAAACCTAAAC
CTGTTGGGTTGAGAATGAGACTCGCCTTTCAAGAACTAGGGCCTACTTTTATTAAATTTGGTCAACTGTTAAGCACTCGT
CCTGACATGTTGCCAGAGCACATTATTAACGAACTTGATAAGTTACAGGATAGGGTTGATCCTTTTCCATATGAAGAAGC
AAAAGAAAATATTGAAGATGAAATGGAAACTTCTTTAGAAGAACTTTTTGCAGAATTTGATGAAGAGCCCTTGGCTGCCG
CTTCTATAGGGCAGGTTCATTCTGCTAGATTAAAAAATGGTGATGAAGTCGTAATTAAAGTTCAACGGCCCAATATATCT
TCTGTCATTGAAACGGATTTAGAAATTTTGGCTGACCTGATTAGTCTAGCAGAGACACGATTTAGTTTTGTTTCCCAATA
CAATTTAAAAGAAATAGTTGATGAATTTAGCATTTCTATTAGAAAAGAACTTAACTATACCCTTGAAGCTAGAAACGCCG
AAAAATTTAAATCCATTTTTTCTGAAGATGATAGTATTTATATACCAGGTATCTACTGGGATCTAACGTCAAAGCGTGTA
ATAACCATGGAGCGGGTTAAGGGTACTAATTTAAATAATTTAGAGGAGGTTGTTGCCAAGGGTTTTAAAACATCTGCAGT
AGCAAAAAACTTAACAGAATCTTTTTTAAACCAAATTTTAATTGAAGGCTTTTTCCATGGCGATCCCCATCCCGGAAACT
TCATACTGCTAGATGATGGTCGGCTGGCCTTTACCGATTTTGGTATAGTAGGGCAATTGACTCCAGAGCTAAAAGATAGT
TTTGCTTCATTAATGATCTCTGTAGTTAGGCAAGATGTAGATGATATTGTAAAAAACATCATGAAAGTTGGTTTTTTACC
TGACGAAGTCAATATTAACAGGTTGAAAAGAGATGTGATGACAGTCAGGGATAAATATTATCACCTTCCTTTAAAACAAA
TCAGTTTTAGCGAAGCTATTGAAGATTTTTTTGATATTGCCTTTCGACATAAAATCCAGATCCCTTCAGAATTGAGTTTG
TTAGGAAAGACTTTTCTAACTTTAGAAGGGGTTGTGAAAAATTTAGATCCTGATGTTAGTGTAGTTGAGATTGCAGAACC
CTTTGGTTCCAAAATCTTAAAAGAAAAATTACGCCCTGAGAATGTGTGGCAAAAATTCACCGATAATATCAAAGATTATG
GTGAGATGGTTTTAGAATTACCCGGTGAATTAAGGGATTTTGTGAGAATTCTAAAGAAGGGCAAAGGCACAGTTGAACTA
CAGATGCCTCAATTGGATTCACTTCAAAAAAAGTTGGACAGGGTGAGTAATAAGCTGTCTTTTAGTATAGTCCTACTTGC
CTTTAGTATCATAATGAGTGGTTTGATTATCGGTGCTTCTTTAGGTGGACAATCAATGGTGATTTGGCAGGTACCTGCTG
TTGAAATTGGTTTTTTAATTGCAATGTTTATGTTTTTTTGGTTATTGTTCTCAATATTTAGATCTGGCAGGTTCTGA

Upstream 100 bases:

>100_bases
TTCAAGAATTAAGAATTAAATTAGAGGAGCTTGAGCAAAGAATCGAGAAATTAGAACAAGATAACGGTGAAAATAACCTG
AGTTAAAGTTAGGTGGTTCT

Downstream 100 bases:

>100_bases
AATGGAGCGGATATGGATTGAATTTTGATGATGTAATAGAAGAATTAAAGAGATCATGGCAAAAATATCAAATTCAAACT
GTTTTAATAATTAATTTGGT

Product: ABC-1 domain protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MFKRRIRHFNRYREIVSILARHGFGFLIEELGLHHMLSLPSRIRKESSKQKPKPVGLRMRLAFQELGPTFIKFGQLLSTR
PDMLPEHIINELDKLQDRVDPFPYEEAKENIEDEMETSLEELFAEFDEEPLAAASIGQVHSARLKNGDEVVIKVQRPNIS
SVIETDLEILADLISLAETRFSFVSQYNLKEIVDEFSISIRKELNYTLEARNAEKFKSIFSEDDSIYIPGIYWDLTSKRV
ITMERVKGTNLNNLEEVVAKGFKTSAVAKNLTESFLNQILIEGFFHGDPHPGNFILLDDGRLAFTDFGIVGQLTPELKDS
FASLMISVVRQDVDDIVKNIMKVGFLPDEVNINRLKRDVMTVRDKYYHLPLKQISFSEAIEDFFDIAFRHKIQIPSELSL
LGKTFLTLEGVVKNLDPDVSVVEIAEPFGSKILKEKLRPENVWQKFTDNIKDYGEMVLELPGELRDFVRILKKGKGTVEL
QMPQLDSLQKKLDRVSNKLSFSIVLLAFSIIMSGLIIGASLGGQSMVIWQVPAVEIGFLIAMFMFFWLLFSIFRSGRF

Sequences:

>Translated_558_residues
MFKRRIRHFNRYREIVSILARHGFGFLIEELGLHHMLSLPSRIRKESSKQKPKPVGLRMRLAFQELGPTFIKFGQLLSTR
PDMLPEHIINELDKLQDRVDPFPYEEAKENIEDEMETSLEELFAEFDEEPLAAASIGQVHSARLKNGDEVVIKVQRPNIS
SVIETDLEILADLISLAETRFSFVSQYNLKEIVDEFSISIRKELNYTLEARNAEKFKSIFSEDDSIYIPGIYWDLTSKRV
ITMERVKGTNLNNLEEVVAKGFKTSAVAKNLTESFLNQILIEGFFHGDPHPGNFILLDDGRLAFTDFGIVGQLTPELKDS
FASLMISVVRQDVDDIVKNIMKVGFLPDEVNINRLKRDVMTVRDKYYHLPLKQISFSEAIEDFFDIAFRHKIQIPSELSL
LGKTFLTLEGVVKNLDPDVSVVEIAEPFGSKILKEKLRPENVWQKFTDNIKDYGEMVLELPGELRDFVRILKKGKGTVEL
QMPQLDSLQKKLDRVSNKLSFSIVLLAFSIIMSGLIIGASLGGQSMVIWQVPAVEIGFLIAMFMFFWLLFSIFRSGRF
>Mature_558_residues
MFKRRIRHFNRYREIVSILARHGFGFLIEELGLHHMLSLPSRIRKESSKQKPKPVGLRMRLAFQELGPTFIKFGQLLSTR
PDMLPEHIINELDKLQDRVDPFPYEEAKENIEDEMETSLEELFAEFDEEPLAAASIGQVHSARLKNGDEVVIKVQRPNIS
SVIETDLEILADLISLAETRFSFVSQYNLKEIVDEFSISIRKELNYTLEARNAEKFKSIFSEDDSIYIPGIYWDLTSKRV
ITMERVKGTNLNNLEEVVAKGFKTSAVAKNLTESFLNQILIEGFFHGDPHPGNFILLDDGRLAFTDFGIVGQLTPELKDS
FASLMISVVRQDVDDIVKNIMKVGFLPDEVNINRLKRDVMTVRDKYYHLPLKQISFSEAIEDFFDIAFRHKIQIPSELSL
LGKTFLTLEGVVKNLDPDVSVVEIAEPFGSKILKEKLRPENVWQKFTDNIKDYGEMVLELPGELRDFVRILKKGKGTVEL
QMPQLDSLQKKLDRVSNKLSFSIVLLAFSIIMSGLIIGASLGGQSMVIWQVPAVEIGFLIAMFMFFWLLFSIFRSGRF

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=281, Percent_Identity=28.4697508896797, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=29.6296296296296, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI217035081, Length=236, Percent_Identity=27.9661016949153, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI34147522, Length=270, Percent_Identity=27.4074074074074, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI27363457, Length=291, Percent_Identity=24.0549828178694, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI217416386, Length=275, Percent_Identity=24.3636363636364, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI2367309, Length=512, Percent_Identity=32.6171875, Blast_Score=247, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=28.6219081272085, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32565180, Length=284, Percent_Identity=27.8169014084507, Blast_Score=115, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323282, Length=243, Percent_Identity=33.7448559670782, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321319, Length=295, Percent_Identity=25.7627118644068, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325148, Length=439, Percent_Identity=22.7790432801822, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI22024280, Length=283, Percent_Identity=27.5618374558304, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24662575, Length=272, Percent_Identity=29.4117647058824, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18859849, Length=283, Percent_Identity=25.4416961130742, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63910; Mature: 63910

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRRIRHFNRYREIVSILARHGFGFLIEELGLHHMLSLPSRIRKESSKQKPKPVGLRMR
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LAFQELGPTFIKFGQLLSTRPDMLPEHIINELDKLQDRVDPFPYEEAKENIEDEMETSLE
HHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ELFAEFDEEPLAAASIGQVHSARLKNGDEVVIKVQRPNISSVIETDLEILADLISLAETR
HHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
FSFVSQYNLKEIVDEFSISIRKELNYTLEARNAEKFKSIFSEDDSIYIPGIYWDLTSKRV
HHHHHHCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHCCCCCEEECEEEEECCCCEE
ITMERVKGTNLNNLEEVVAKGFKTSAVAKNLTESFLNQILIEGFFHGDPHPGNFILLDDG
EEHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
RLAFTDFGIVGQLTPELKDSFASLMISVVRQDVDDIVKNIMKVGFLPDEVNINRLKRDVM
CEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TVRDKYYHLPLKQISFSEAIEDFFDIAFRHKIQIPSELSLLGKTFLTLEGVVKNLDPDVS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
VVEIAEPFGSKILKEKLRPENVWQKFTDNIKDYGEMVLELPGELRDFVRILKKGKGTVEL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEE
QMPQLDSLQKKLDRVSNKLSFSIVLLAFSIIMSGLIIGASLGGQSMVIWQVPAVEIGFLI
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
AMFMFFWLLFSIFRSGRF
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFKRRIRHFNRYREIVSILARHGFGFLIEELGLHHMLSLPSRIRKESSKQKPKPVGLRMR
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LAFQELGPTFIKFGQLLSTRPDMLPEHIINELDKLQDRVDPFPYEEAKENIEDEMETSLE
HHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ELFAEFDEEPLAAASIGQVHSARLKNGDEVVIKVQRPNISSVIETDLEILADLISLAETR
HHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
FSFVSQYNLKEIVDEFSISIRKELNYTLEARNAEKFKSIFSEDDSIYIPGIYWDLTSKRV
HHHHHHCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHCCCCCEEECEEEEECCCCEE
ITMERVKGTNLNNLEEVVAKGFKTSAVAKNLTESFLNQILIEGFFHGDPHPGNFILLDDG
EEHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
RLAFTDFGIVGQLTPELKDSFASLMISVVRQDVDDIVKNIMKVGFLPDEVNINRLKRDVM
CEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TVRDKYYHLPLKQISFSEAIEDFFDIAFRHKIQIPSELSLLGKTFLTLEGVVKNLDPDVS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
VVEIAEPFGSKILKEKLRPENVWQKFTDNIKDYGEMVLELPGELRDFVRILKKGKGTVEL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEE
QMPQLDSLQKKLDRVSNKLSFSIVLLAFSIIMSGLIIGASLGGQSMVIWQVPAVEIGFLI
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
AMFMFFWLLFSIFRSGRF
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA