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The map label for this gene is patB [H]

Identifier: 188584930

GI number: 188584930

Start: 302049

End: 303230

Strand: Direct

Name: patB [H]

Synonym: Nther_0289

Alternate gene names: 188584930

Gene position: 302049-303230 (Clockwise)

Preceding gene: 188584929

Following gene: 188584932

Centisome position: 9.54

GC content: 35.79

Gene sequence:

>1182_bases
GTGACAGGGGCTAGATTTGATCAGATCATCGATAGGACAGGCACCCATTCTTATAAATGGGATGATGTAGGGGAAGTTTT
TGGATCCAATGAGCTATTACCTATGTGGGTGGCAGATATGGATTTTCAATCTCCTGATTCTGTTATTGAGGCTGTTGTAG
AGAGAGCCCAACACGGGGTTTATGGTTATGCGGGTGATTTTGACGGTTATTTCAATTCAGTGAAAGACTGGTTTAATAAA
AGATTCAATTGTAAAATTGAGAAAGATTGGATAAAAACTACTCCTGGCGTAGTACCAGCCCTTAATATGGCTGTCAGAAC
CTATACTAATCCCGGTGATAAAGTAATAATACAGTCACCTGTCTATCCACCTTTTTTTAATGTGGTTAGAAACAATGGCT
GTCATGTAATTAATAATGAACTTATTGAAGAAAAGGGGAAATATTATATTGACTTTGAGGACTTAGATAAAAAAGCTAGT
GATAGTCGGGCTAAAATTTTAATGCTATGTAGTCCCCATAATCCCGTAGGAAGAGTTTGGAGTCGTGAAGAGCTTAAAAA
AATCGGCGAAATCTGCCAAAAGAATAATTTAATACTAATTTCAGATGAAATTCATGGAGATCTGACCTTCCCGGGAAATA
ATAATATTCCCTACTTTAAAATAATGTCTGAATTAAACTTTAATAATGTAATTTTGTGTACTTCTCCGGCCAAAACCTTT
AATGTGGCTGGGCTACAAACATCTAGTGTTATCATACCGGACCAATGCTTGCGATCATCCTTTAATAACACCTTAGAAGC
AAATGGATTTTCAAAGCCAAATATTTTTGGTTTAATTGCTGCTGAATCCTGTTACAATTATGGTGAAGATTGGTTAGATG
AGCTGAGAGAATACCTGTATCAAAACTTTTTATTTATAGAAGATTACTTAAAAAATAATATACCTGCCTTGGAAGTGACA
AAGTCCCAGGGTACTTATCTGGCCTGGTTAGATATCAGGAAAACAGGTAAAACAACTAAAGAAATTCAAAAGTTGTTAGT
ATCTCAAGGAAAAGTTGCTTTAATTCCCGGTACAAAATTTGGCCCTAATGGAGAAGGTTTTTTAAGACTGAATTTCGGAT
GTCCTCAAAAACAGCTCCACCAAGGTCTTGATAGGATAGCAAAGGTGATTAATAGTTTATAA

Upstream 100 bases:

>100_bases
TCTTTGGTTTTTTATTAGACAGTCATTAATTTTGGGCCTATAATATAGATGAATAGATATACTGTGTTAATGATACAAAT
TTTTATAGGGAGGGGTATAT

Downstream 100 bases:

>100_bases
ATTACGGAAATTAAATCAATTCTAGAAAAACATAAAAATGCTCCCCTTTATTTGGTGACAGCTTTTATTTTCTTAGCTGT
CTACCGAATGGGGGAGCATA

Product: aminotransferase class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTGARFDQIIDRTGTHSYKWDDVGEVFGSNELLPMWVADMDFQSPDSVIEAVVERAQHGVYGYAGDFDGYFNSVKDWFNK
RFNCKIEKDWIKTTPGVVPALNMAVRTYTNPGDKVIIQSPVYPPFFNVVRNNGCHVINNELIEEKGKYYIDFEDLDKKAS
DSRAKILMLCSPHNPVGRVWSREELKKIGEICQKNNLILISDEIHGDLTFPGNNNIPYFKIMSELNFNNVILCTSPAKTF
NVAGLQTSSVIIPDQCLRSSFNNTLEANGFSKPNIFGLIAAESCYNYGEDWLDELREYLYQNFLFIEDYLKNNIPALEVT
KSQGTYLAWLDIRKTGKTTKEIQKLLVSQGKVALIPGTKFGPNGEGFLRLNFGCPQKQLHQGLDRIAKVINSL

Sequences:

>Translated_393_residues
MTGARFDQIIDRTGTHSYKWDDVGEVFGSNELLPMWVADMDFQSPDSVIEAVVERAQHGVYGYAGDFDGYFNSVKDWFNK
RFNCKIEKDWIKTTPGVVPALNMAVRTYTNPGDKVIIQSPVYPPFFNVVRNNGCHVINNELIEEKGKYYIDFEDLDKKAS
DSRAKILMLCSPHNPVGRVWSREELKKIGEICQKNNLILISDEIHGDLTFPGNNNIPYFKIMSELNFNNVILCTSPAKTF
NVAGLQTSSVIIPDQCLRSSFNNTLEANGFSKPNIFGLIAAESCYNYGEDWLDELREYLYQNFLFIEDYLKNNIPALEVT
KSQGTYLAWLDIRKTGKTTKEIQKLLVSQGKVALIPGTKFGPNGEGFLRLNFGCPQKQLHQGLDRIAKVINSL
>Mature_392_residues
TGARFDQIIDRTGTHSYKWDDVGEVFGSNELLPMWVADMDFQSPDSVIEAVVERAQHGVYGYAGDFDGYFNSVKDWFNKR
FNCKIEKDWIKTTPGVVPALNMAVRTYTNPGDKVIIQSPVYPPFFNVVRNNGCHVINNELIEEKGKYYIDFEDLDKKASD
SRAKILMLCSPHNPVGRVWSREELKKIGEICQKNNLILISDEIHGDLTFPGNNNIPYFKIMSELNFNNVILCTSPAKTFN
VAGLQTSSVIIPDQCLRSSFNNTLEANGFSKPNIFGLIAAESCYNYGEDWLDELREYLYQNFLFIEDYLKNNIPALEVTK
SQGTYLAWLDIRKTGKTTKEIQKLLVSQGKVALIPGTKFGPNGEGFLRLNFGCPQKQLHQGLDRIAKVINSL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=345, Percent_Identity=22.8985507246377, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI95147551, Length=237, Percent_Identity=27.8481012658228, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI169881279, Length=237, Percent_Identity=27.8481012658228, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI56713254, Length=178, Percent_Identity=29.7752808988764, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI56713256, Length=178, Percent_Identity=29.7752808988764, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=33.5897435897436, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI1788627, Length=339, Percent_Identity=22.4188790560472, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71994476, Length=173, Percent_Identity=30.0578034682081, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=172, Percent_Identity=30.2325581395349, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17567369, Length=287, Percent_Identity=25.0871080139373, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=350, Percent_Identity=23.7142857142857, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28573069, Length=178, Percent_Identity=29.2134831460674, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646114, Length=178, Percent_Identity=29.2134831460674, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573067, Length=178, Percent_Identity=29.2134831460674, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573065, Length=178, Percent_Identity=29.2134831460674, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859735, Length=379, Percent_Identity=20.0527704485488, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44517; Mature: 44386

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGARFDQIIDRTGTHSYKWDDVGEVFGSNELLPMWVADMDFQSPDSVIEAVVERAQHGV
CCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCC
YGYAGDFDGYFNSVKDWFNKRFNCKIEKDWIKTTPGVVPALNMAVRTYTNPGDKVIIQSP
CEECCCCHHHHHHHHHHHCCCCCCEEECCHHHCCCCHHHHHHHHEEEECCCCCEEEEECC
VYPPFFNVVRNNGCHVINNELIEEKGKYYIDFEDLDKKASDSRAKILMLCSPHNPVGRVW
CCCHHHHHHHCCCCEEECHHHHHCCCCEEEEHHHHCCCCCCCCEEEEEEECCCCCHHHCC
SREELKKIGEICQKNNLILISDEIHGDLTFPGNNNIPYFKIMSELNFNNVILCTSPAKTF
CHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCEEEEECCCCCCEEEEECCCCEE
NVAGLQTSSVIIPDQCLRSSFNNTLEANGFSKPNIFGLIAAESCYNYGEDWLDELREYLY
EECCCCCCCEECCHHHHHHHHCCCEECCCCCCCCEEEEEEHHHHHCCCHHHHHHHHHHHH
QNFLFIEDYLKNNIPALEVTKSQGTYLAWLDIRKTGKTTKEIQKLLVSQGKVALIPGTKF
HHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCC
GPNGEGFLRLNFGCPQKQLHQGLDRIAKVINSL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGARFDQIIDRTGTHSYKWDDVGEVFGSNELLPMWVADMDFQSPDSVIEAVVERAQHGV
CCHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCC
YGYAGDFDGYFNSVKDWFNKRFNCKIEKDWIKTTPGVVPALNMAVRTYTNPGDKVIIQSP
CEECCCCHHHHHHHHHHHCCCCCCEEECCHHHCCCCHHHHHHHHEEEECCCCCEEEEECC
VYPPFFNVVRNNGCHVINNELIEEKGKYYIDFEDLDKKASDSRAKILMLCSPHNPVGRVW
CCCHHHHHHHCCCCEEECHHHHHCCCCEEEEHHHHCCCCCCCCEEEEEEECCCCCHHHCC
SREELKKIGEICQKNNLILISDEIHGDLTFPGNNNIPYFKIMSELNFNNVILCTSPAKTF
CHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCEEEEECCCCCCEEEEECCCCEE
NVAGLQTSSVIIPDQCLRSSFNNTLEANGFSKPNIFGLIAAESCYNYGEDWLDELREYLY
EECCCCCCCEECCHHHHHHHHCCCEECCCCCCCCEEEEEEHHHHHCCCHHHHHHHHHHHH
QNFLFIEDYLKNNIPALEVTKSQGTYLAWLDIRKTGKTTKEIQKLLVSQGKVALIPGTKF
HHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCC
GPNGEGFLRLNFGCPQKQLHQGLDRIAKVINSL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]