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The map label for this gene is dinB [H]

Identifier: 188584923

GI number: 188584923

Start: 294982

End: 296247

Strand: Reverse

Name: dinB [H]

Synonym: Nther_0282

Alternate gene names: 188584923

Gene position: 296247-294982 (Counterclockwise)

Preceding gene: 188584931

Following gene: 188584922

Centisome position: 9.36

GC content: 39.57

Gene sequence:

>1266_bases
ATGAGCGACCCCATAATATTTCACATTGACGTTAATTCTGCGTATTTATCATGGGAGGCTGCTTACAGGCTGCAAAAAGG
TGCACAACTTGATTTGAGGCAAGTCCCCTCAGTAGTTGGTGGAGATTCACAAAAACGTCGTGGAATTGTACTGGCTAAAT
CCATACCAGCAAAAAGCAAGTTTAAAATTCAAACCGGAGAGCTGTTGAGCAGTGCTCGAAAAAAGTGCCCTGACCTGTTT
GTAGTACCACCCAATTATGATCTATACCTTCGATGCAGTAATGCCATGGTCGAATTGCTGTACGAATACTCCCCTTTTAT
TCAACGCTATTCGGTTGATGAAGTCTTCCTGGATTTCACCAATATGGAAAAACAATTTGGGGATTATCTTACCGCCGCTA
ATACTATTAAGGCCAGAGTAAAAGAAGAACTCGGGTTCACAGTGAACATAGGAATTGGCCCCAATAAGCTCTTAGCTAAG
CTGGCATCAGAATTTAAAAAACCCGACCGAGTTCACACATTATTCCCTGAAGAAATTCCTACTAAGTTGTGGCCACTACC
TGTAGGAGAATTATTTATGGTGGGAAGGGCTACAGAAAAAAAGTTACTTGATCGAGGAATCACTACCATTGGGGAACTGG
CTAAAACTCCTCGCAATAAATTGAAACTTTGGTTGAAAAGTCACGGGCTTTTGATCTGGGATTTTGCCAATGGAATTGAG
GAGTCTTCCGTTAGGCCAGAAGGTTTTCCTATGAAGGGTTTAGGAAATTCTACTACTACTCCCGAAAATGTGGCTGATAA
AGAGACAGCACGGCTTTGGTTATTATCTTTAACTGAAAAGGTCAGTAGCCGATTACGTGATGCTCATTGTTACGCACAAG
TAGTCAATTTATCAATTAAAACCTCACAGTTTATTTCCTACGGTAAACAAAAAAAATTACTCAATCCCACAAATTCTACT
AAAGTTATTTTCGAAACTGGTAAAAAACTTTTAAATGAATTATGGGATGAAGAAGAACCCTTAAGACACATAGGAATTTC
ACTATCTTCCCTTTCATCGAGTAAGTCTTACCAACTATCGATGTTTGACAAATTGTCTATTGATACGGATTCAGAAGAGT
CTTTTTATAAAGCTATCGATAAAATCAGGGCTAAACACGGGGAAACTTCTTTAATCCGGTCCTGTTTTTTACATTCAACA
GTTCCTCCCTTGGCAGGAGGAGTAGATGCAGAAGAAGAGTATCCCATGATGTCTAGCTTATTATAG

Upstream 100 bases:

>100_bases
AGCTTTTTACAACTATAATTTAACAGTAATATGTGCGAATCACTTCACTTTACTTCGAACATGTGTTCTGCTATAATGTT
TTCTACAGGAGTGATGCACA

Downstream 100 bases:

>100_bases
AAGGGAGAATTACTGTGAAGGTAATAATGAAACCTATAGAAATGATTGCCTGGTTTAAAGAAGATGGAATTCCTAAACCT
TTAAAATATCGTATCACCAC

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSDPIIFHIDVNSAYLSWEAAYRLQKGAQLDLRQVPSVVGGDSQKRRGIVLAKSIPAKSKFKIQTGELLSSARKKCPDLF
VVPPNYDLYLRCSNAMVELLYEYSPFIQRYSVDEVFLDFTNMEKQFGDYLTAANTIKARVKEELGFTVNIGIGPNKLLAK
LASEFKKPDRVHTLFPEEIPTKLWPLPVGELFMVGRATEKKLLDRGITTIGELAKTPRNKLKLWLKSHGLLIWDFANGIE
ESSVRPEGFPMKGLGNSTTTPENVADKETARLWLLSLTEKVSSRLRDAHCYAQVVNLSIKTSQFISYGKQKKLLNPTNST
KVIFETGKKLLNELWDEEEPLRHIGISLSSLSSSKSYQLSMFDKLSIDTDSEESFYKAIDKIRAKHGETSLIRSCFLHST
VPPLAGGVDAEEEYPMMSSLL

Sequences:

>Translated_421_residues
MSDPIIFHIDVNSAYLSWEAAYRLQKGAQLDLRQVPSVVGGDSQKRRGIVLAKSIPAKSKFKIQTGELLSSARKKCPDLF
VVPPNYDLYLRCSNAMVELLYEYSPFIQRYSVDEVFLDFTNMEKQFGDYLTAANTIKARVKEELGFTVNIGIGPNKLLAK
LASEFKKPDRVHTLFPEEIPTKLWPLPVGELFMVGRATEKKLLDRGITTIGELAKTPRNKLKLWLKSHGLLIWDFANGIE
ESSVRPEGFPMKGLGNSTTTPENVADKETARLWLLSLTEKVSSRLRDAHCYAQVVNLSIKTSQFISYGKQKKLLNPTNST
KVIFETGKKLLNELWDEEEPLRHIGISLSSLSSSKSYQLSMFDKLSIDTDSEESFYKAIDKIRAKHGETSLIRSCFLHST
VPPLAGGVDAEEEYPMMSSLL
>Mature_420_residues
SDPIIFHIDVNSAYLSWEAAYRLQKGAQLDLRQVPSVVGGDSQKRRGIVLAKSIPAKSKFKIQTGELLSSARKKCPDLFV
VPPNYDLYLRCSNAMVELLYEYSPFIQRYSVDEVFLDFTNMEKQFGDYLTAANTIKARVKEELGFTVNIGIGPNKLLAKL
ASEFKKPDRVHTLFPEEIPTKLWPLPVGELFMVGRATEKKLLDRGITTIGELAKTPRNKLKLWLKSHGLLIWDFANGIEE
SSVRPEGFPMKGLGNSTTTPENVADKETARLWLLSLTEKVSSRLRDAHCYAQVVNLSIKTSQFISYGKQKKLLNPTNSTK
VIFETGKKLLNELWDEEEPLRHIGISLSSLSSSKSYQLSMFDKLSIDTDSEESFYKAIDKIRAKHGETSLIRSCFLHSTV
PPLAGGVDAEEEYPMMSSLL

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=334, Percent_Identity=27.2455089820359, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI7706681, Length=334, Percent_Identity=27.2455089820359, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786425, Length=259, Percent_Identity=30.5019305019305, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787432, Length=401, Percent_Identity=28.428927680798, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17537959, Length=379, Percent_Identity=23.2189973614776, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19923006, Length=331, Percent_Identity=23.2628398791541, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 47364; Mature: 47233

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPIIFHIDVNSAYLSWEAAYRLQKGAQLDLRQVPSVVGGDSQKRRGIVLAKSIPAKSK
CCCCEEEEEECCCEEEHHHHHHHHHCCCCCCHHHCCHHHCCCCCCCCCEEEEECCCCCCC
FKIQTGELLSSARKKCPDLFVVPPNYDLYLRCSNAMVELLYEYSPFIQRYSVDEVFLDFT
EEEEHHHHHHHHHHHCCCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NMEKQFGDYLTAANTIKARVKEELGFTVNIGIGPNKLLAKLASEFKKPDRVHTLFPEEIP
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCHHCC
TKLWPLPVGELFMVGRATEKKLLDRGITTIGELAKTPRNKLKLWLKSHGLLIWDFANGIE
CCCCCCCCCHHHEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCCC
ESSVRPEGFPMKGLGNSTTTPENVADKETARLWLLSLTEKVSSRLRDAHCYAQVVNLSIK
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TSQFISYGKQKKLLNPTNSTKVIFETGKKLLNELWDEEEPLRHIGISLSSLSSSKSYQLS
HHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHCCCHHHCCCCCCEEEE
MFDKLSIDTDSEESFYKAIDKIRAKHGETSLIRSCFLHSTVPPLAGGVDAEEEYPMMSSL
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHC
L
C
>Mature Secondary Structure 
SDPIIFHIDVNSAYLSWEAAYRLQKGAQLDLRQVPSVVGGDSQKRRGIVLAKSIPAKSK
CCCEEEEEECCCEEEHHHHHHHHHCCCCCCHHHCCHHHCCCCCCCCCEEEEECCCCCCC
FKIQTGELLSSARKKCPDLFVVPPNYDLYLRCSNAMVELLYEYSPFIQRYSVDEVFLDFT
EEEEHHHHHHHHHHHCCCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NMEKQFGDYLTAANTIKARVKEELGFTVNIGIGPNKLLAKLASEFKKPDRVHTLFPEEIP
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCHHCC
TKLWPLPVGELFMVGRATEKKLLDRGITTIGELAKTPRNKLKLWLKSHGLLIWDFANGIE
CCCCCCCCCHHHEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCCC
ESSVRPEGFPMKGLGNSTTTPENVADKETARLWLLSLTEKVSSRLRDAHCYAQVVNLSIK
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TSQFISYGKQKKLLNPTNSTKVIFETGKKLLNELWDEEEPLRHIGISLSSLSSSKSYQLS
HHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHCCCHHHCCCCCCEEEE
MFDKLSIDTDSEESFYKAIDKIRAKHGETSLIRSCFLHSTVPPLAGGVDAEEEYPMMSSL
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]