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The map label for this gene is nrdZ [H]

Identifier: 188584791

GI number: 188584791

Start: 173364

End: 175622

Strand: Direct

Name: nrdZ [H]

Synonym: Nther_0149

Alternate gene names: 188584791

Gene position: 173364-175622 (Clockwise)

Preceding gene: 188584789

Following gene: 188584793

Centisome position: 5.48

GC content: 38.25

Gene sequence:

>2259_bases
ATGGAATTGACAAAGAACGCCAAAATGGTCCTTGAAAAGAGGTACTTAAAGACCAATGAGAAAGGTGAAACTGAAAATCC
AGAAGATATGCTGAAACGAGTAGCTGATAATATTGCTCAAGTTGAAAAAGATGTTTATCAAAAAGATAAACAGGAAGTAT
CGAAAGTTTCCCAGAATTTTTTTGACCTTATGGACAATCAATATTTTATGCCAAACTCTCCTACTTTGATGAACGCTGGG
AGAGAATTGCAACAATTGGCTGCTTGTTTTGTTTTACCTATAGAAGATTCTATGGAGAGTATATTTGAAGCGATTAAAAA
TGCAGCGTTAATTCATAAGAGTGGAGGAGGTACAGGCTTTTCCTTCTCAAACTTACGCCCTAAAAATGATATAGTTTTAT
CTACAGGTGGTGTAGCCAGCGGGCCTGTATCCTTTATGAAAGTTTTTAACTCGGCAACTGAAGCTGTAAAACAAGGTGGT
ACTAGACGTGGAGCCAATATGGGTATTCTCAGGGTGGATCATCCAGATATACAGGAATTTATTACATGCAAACGTGACAG
TGATGAAATCAATAATTTTAATATCTCTGTTGGAATAACCGAAGAATTTATGGAAGCCGTAAAACAAGATGGTGAATACT
CCCTTAAAAACCCCAAAAATGGTCAAGCAGTTAAAACTCTCAGGGCAAGAGAAGTTTTTGATAAAATAGTAGAAATGGCT
TGGGGAAATGGCGAACCCGGGATAGTTTTTATTGACAAGATGAATGAAAATAATCCCACTCCCCATATTGGTGAAATTGA
ATCAACAAACCCTTGTGGTGAACAACCTTTATTGCCCTTTGAATCTTGTAATTTGGGATCTGTCAATCTTTCAAAGATGG
TAAACAATGGTGCAGTGGACTATCAATTATTAAAGGAAACTGTCCATACTGCAGTTCATTTTCTTGATAATGTAATTGAT
GCCAATAGATATCCTTTACCAGAGATTGAAAAGACGTCAAAGGAAAATAGAAAAATTGGTTTAGGAGTAATGGGTTTTGG
AGATATGTTGTTTAAACTAAGAATACCTTATAACTCTCAAGAAGCCCTGGATTTAGCCGAAAAAGTCATGGGTTATATTG
ATCAAGAATCAAAAGCCAAATCTCAAGAACTAGCTAAAGAAAGAGGAGCTTTTCCCAACTTTAAAGGCAGTATATATGAT
CAAAAAGGTGAAGAACCCATTAGAAATGCAACAACTACTACCATTGCTCCCACTGGAACCATTTCCATTTTATGTGGAAC
CTCTAGCGGAATAGAGCCATTATTTGCCCTGGCATTTACAAGAAATGTGCTCGATAATGATAAACTAGTGGAAGTAAACC
CTGTATTTAAAGAGGCAACTGAAGAAGCGGGTTGTTATAGTTCTGAATTGATGGAAAAAGTGGCAGATAAGGGAAGTATA
CAGGATATTGATGAAATTCCGGATAGTATCAAAAAGGTATTTGTAACATCTCATGATATATCCCCAGAATGGCACTTGAA
GATGCAGGCAGCTTTCCAGAAAGCAACCGACAATGCGGTAAGCAAAACTGTTAATCTGCCTAATGAAGCTGACCTAAAAG
ATGTTTATGAAATTTATAATCTGGCTCACGAATTAAACTGTAAAGGCGTTACAGTTTACAGAGACGGTAGTCGTGATACC
CAAGTACTGCAGACAAGTAAAGCTAAATCAAAGCAAGAAGAACAAAAACAACAAAAACCACAAAAAAGTGAACCTAAAGA
AGGCCGAGCCGGTGAAATTGTTCCCAGAAAACGACCCGATGCCACTATCGGCCGGACTGAGAGAATAAAAACTGGTTGTG
GTAATTTATATGTTACGATTAATGAAGATGAAGAAGGTCTTTGTGAAGTTTTTGCGTCCATGGGTAAATCCGGAGGTTGT
GCTGCTAGTCAATCCGAAGCTACTGCCAGGCTGGTAAGTATGGCCTTGAGGTCCGGTTTAAAAGGTGAATCCATAGTAAA
AGAATTGAGAGGTATTCGGTGCCCAAGCCCTGCCTGGAACAAAGGAGGGGGAATGGTACTAAGCTGTCCAGATGCCATTG
GCATCGTCTTAGACCGTTATCTTATTAGAAAAGAACAAGGAGAAGAACCGGTTCAATCTAATAATGGTATAGACAAATTA
GATATGTTAATGGGTGCTTGTCCTGATTGTGGTAGCCCAGTTTCCCATGAAAGTGGGTGCATTACATGCTATTATTGTGG
ATACTCTAAATGTAGCTAG

Upstream 100 bases:

>100_bases
TTAATTAATATCTAATTATTATTTTTACCAATAAACTTAGGTTCTACAACAGAATAATAGATTTTTGTGAGGAAATTTAA
TACACAGGAGGGATGAATGA

Downstream 100 bases:

>100_bases
TTAATAGATATTTCAAATAAAAGAGGCAGCTTAAACTGCCTCTTTTTGACACTTTGTTATTTTCTTAATTTTATCATTCG
ACTTGGATAGTTAAATTATC

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MELTKNAKMVLEKRYLKTNEKGETENPEDMLKRVADNIAQVEKDVYQKDKQEVSKVSQNFFDLMDNQYFMPNSPTLMNAG
RELQQLAACFVLPIEDSMESIFEAIKNAALIHKSGGGTGFSFSNLRPKNDIVLSTGGVASGPVSFMKVFNSATEAVKQGG
TRRGANMGILRVDHPDIQEFITCKRDSDEINNFNISVGITEEFMEAVKQDGEYSLKNPKNGQAVKTLRAREVFDKIVEMA
WGNGEPGIVFIDKMNENNPTPHIGEIESTNPCGEQPLLPFESCNLGSVNLSKMVNNGAVDYQLLKETVHTAVHFLDNVID
ANRYPLPEIEKTSKENRKIGLGVMGFGDMLFKLRIPYNSQEALDLAEKVMGYIDQESKAKSQELAKERGAFPNFKGSIYD
QKGEEPIRNATTTTIAPTGTISILCGTSSGIEPLFALAFTRNVLDNDKLVEVNPVFKEATEEAGCYSSELMEKVADKGSI
QDIDEIPDSIKKVFVTSHDISPEWHLKMQAAFQKATDNAVSKTVNLPNEADLKDVYEIYNLAHELNCKGVTVYRDGSRDT
QVLQTSKAKSKQEEQKQQKPQKSEPKEGRAGEIVPRKRPDATIGRTERIKTGCGNLYVTINEDEEGLCEVFASMGKSGGC
AASQSEATARLVSMALRSGLKGESIVKELRGIRCPSPAWNKGGGMVLSCPDAIGIVLDRYLIRKEQGEEPVQSNNGIDKL
DMLMGACPDCGSPVSHESGCITCYYCGYSKCS

Sequences:

>Translated_752_residues
MELTKNAKMVLEKRYLKTNEKGETENPEDMLKRVADNIAQVEKDVYQKDKQEVSKVSQNFFDLMDNQYFMPNSPTLMNAG
RELQQLAACFVLPIEDSMESIFEAIKNAALIHKSGGGTGFSFSNLRPKNDIVLSTGGVASGPVSFMKVFNSATEAVKQGG
TRRGANMGILRVDHPDIQEFITCKRDSDEINNFNISVGITEEFMEAVKQDGEYSLKNPKNGQAVKTLRAREVFDKIVEMA
WGNGEPGIVFIDKMNENNPTPHIGEIESTNPCGEQPLLPFESCNLGSVNLSKMVNNGAVDYQLLKETVHTAVHFLDNVID
ANRYPLPEIEKTSKENRKIGLGVMGFGDMLFKLRIPYNSQEALDLAEKVMGYIDQESKAKSQELAKERGAFPNFKGSIYD
QKGEEPIRNATTTTIAPTGTISILCGTSSGIEPLFALAFTRNVLDNDKLVEVNPVFKEATEEAGCYSSELMEKVADKGSI
QDIDEIPDSIKKVFVTSHDISPEWHLKMQAAFQKATDNAVSKTVNLPNEADLKDVYEIYNLAHELNCKGVTVYRDGSRDT
QVLQTSKAKSKQEEQKQQKPQKSEPKEGRAGEIVPRKRPDATIGRTERIKTGCGNLYVTINEDEEGLCEVFASMGKSGGC
AASQSEATARLVSMALRSGLKGESIVKELRGIRCPSPAWNKGGGMVLSCPDAIGIVLDRYLIRKEQGEEPVQSNNGIDKL
DMLMGACPDCGSPVSHESGCITCYYCGYSKCS
>Mature_752_residues
MELTKNAKMVLEKRYLKTNEKGETENPEDMLKRVADNIAQVEKDVYQKDKQEVSKVSQNFFDLMDNQYFMPNSPTLMNAG
RELQQLAACFVLPIEDSMESIFEAIKNAALIHKSGGGTGFSFSNLRPKNDIVLSTGGVASGPVSFMKVFNSATEAVKQGG
TRRGANMGILRVDHPDIQEFITCKRDSDEINNFNISVGITEEFMEAVKQDGEYSLKNPKNGQAVKTLRAREVFDKIVEMA
WGNGEPGIVFIDKMNENNPTPHIGEIESTNPCGEQPLLPFESCNLGSVNLSKMVNNGAVDYQLLKETVHTAVHFLDNVID
ANRYPLPEIEKTSKENRKIGLGVMGFGDMLFKLRIPYNSQEALDLAEKVMGYIDQESKAKSQELAKERGAFPNFKGSIYD
QKGEEPIRNATTTTIAPTGTISILCGTSSGIEPLFALAFTRNVLDNDKLVEVNPVFKEATEEAGCYSSELMEKVADKGSI
QDIDEIPDSIKKVFVTSHDISPEWHLKMQAAFQKATDNAVSKTVNLPNEADLKDVYEIYNLAHELNCKGVTVYRDGSRDT
QVLQTSKAKSKQEEQKQQKPQKSEPKEGRAGEIVPRKRPDATIGRTERIKTGCGNLYVTINEDEEGLCEVFASMGKSGGC
AASQSEATARLVSMALRSGLKGESIVKELRGIRCPSPAWNKGGGMVLSCPDAIGIVLDRYLIRKEQGEEPVQSNNGIDKL
DMLMGACPDCGSPVSHESGCITCYYCGYSKCS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=588, Percent_Identity=28.7414965986395, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1789030, Length=434, Percent_Identity=29.4930875576037, Blast_Score=151, Evalue=2e-37,
Organism=Escherichia coli, GI2367133, Length=445, Percent_Identity=22.247191011236, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17555242, Length=576, Percent_Identity=28.125, Blast_Score=226, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322123, Length=584, Percent_Identity=27.0547945205479, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320914, Length=562, Percent_Identity=28.1138790035587, Blast_Score=211, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17352481, Length=587, Percent_Identity=27.7683134582624, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 82826; Mature: 82826

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTKNAKMVLEKRYLKTNEKGETENPEDMLKRVADNIAQVEKDVYQKDKQEVSKVSQNF
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDLMDNQYFMPNSPTLMNAGRELQQLAACFVLPIEDSMESIFEAIKNAALIHKSGGGTGF
HHHHCCCEECCCCCHHHHCCHHHHHHHHHEEEECHHHHHHHHHHHHHCEEEEECCCCCCC
SFSNLRPKNDIVLSTGGVASGPVSFMKVFNSATEAVKQGGTRRGANMGILRVDHPDIQEF
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHH
ITCKRDSDEINNFNISVGITEEFMEAVKQDGEYSLKNPKNGQAVKTLRAREVFDKIVEMA
HHCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHH
WGNGEPGIVFIDKMNENNPTPHIGEIESTNPCGEQPLLPFESCNLGSVNLSKMVNNGAVD
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHH
YQLLKETVHTAVHFLDNVIDANRYPLPEIEKTSKENRKIGLGVMGFGDMLFKLRIPYNSQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEECCCCEEEEEECCCCCH
EALDLAEKVMGYIDQESKAKSQELAKERGAFPNFKGSIYDQKGEEPIRNATTTTIAPTGT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCEECCCCE
ISILCGTSSGIEPLFALAFTRNVLDNDKLVEVNPVFKEATEEAGCYSSELMEKVADKGSI
EEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCC
QDIDEIPDSIKKVFVTSHDISPEWHLKMQAAFQKATDNAVSKTVNLPNEADLKDVYEIYN
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAHELNCKGVTVYRDGSRDTQVLQTSKAKSKQEEQKQQKPQKSEPKEGRAGEIVPRKRPD
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
ATIGRTERIKTGCGNLYVTINEDEEGLCEVFASMGKSGGCAASQSEATARLVSMALRSGL
CCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC
KGESIVKELRGIRCPSPAWNKGGGMVLSCPDAIGIVLDRYLIRKEQGEEPVQSNNGIDKL
CHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
DMLMGACPDCGSPVSHESGCITCYYCGYSKCS
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MELTKNAKMVLEKRYLKTNEKGETENPEDMLKRVADNIAQVEKDVYQKDKQEVSKVSQNF
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDLMDNQYFMPNSPTLMNAGRELQQLAACFVLPIEDSMESIFEAIKNAALIHKSGGGTGF
HHHHCCCEECCCCCHHHHCCHHHHHHHHHEEEECHHHHHHHHHHHHHCEEEEECCCCCCC
SFSNLRPKNDIVLSTGGVASGPVSFMKVFNSATEAVKQGGTRRGANMGILRVDHPDIQEF
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHH
ITCKRDSDEINNFNISVGITEEFMEAVKQDGEYSLKNPKNGQAVKTLRAREVFDKIVEMA
HHCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHH
WGNGEPGIVFIDKMNENNPTPHIGEIESTNPCGEQPLLPFESCNLGSVNLSKMVNNGAVD
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHH
YQLLKETVHTAVHFLDNVIDANRYPLPEIEKTSKENRKIGLGVMGFGDMLFKLRIPYNSQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEECCCCEEEEEECCCCCH
EALDLAEKVMGYIDQESKAKSQELAKERGAFPNFKGSIYDQKGEEPIRNATTTTIAPTGT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCEECCCCE
ISILCGTSSGIEPLFALAFTRNVLDNDKLVEVNPVFKEATEEAGCYSSELMEKVADKGSI
EEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCC
QDIDEIPDSIKKVFVTSHDISPEWHLKMQAAFQKATDNAVSKTVNLPNEADLKDVYEIYN
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAHELNCKGVTVYRDGSRDTQVLQTSKAKSKQEEQKQQKPQKSEPKEGRAGEIVPRKRPD
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
ATIGRTERIKTGCGNLYVTINEDEEGLCEVFASMGKSGGCAASQSEATARLVSMALRSGL
CCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC
KGESIVKELRGIRCPSPAWNKGGGMVLSCPDAIGIVLDRYLIRKEQGEEPVQSNNGIDKL
CHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
DMLMGACPDCGSPVSHESGCITCYYCGYSKCS
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]