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The map label for this gene is fixC [H]

Identifier: 188584771

GI number: 188584771

Start: 152709

End: 154019

Strand: Reverse

Name: fixC [H]

Synonym: Nther_0129

Alternate gene names: 188584771

Gene position: 154019-152709 (Counterclockwise)

Preceding gene: 188584773

Following gene: 188584770

Centisome position: 4.87

GC content: 36.38

Gene sequence:

>1311_bases
ATGAAGGAATATTACGATGCTATAGTAGTAGGAGCAGGTCCAGGAGGCTCTAGTGCAGCTTATCATATGGCTCAACAGGG
ATTAAATGTAGCTTTATTCGAAAAAGGTAATAAACCTGGTGACAAAAATGTTTATGGTGGTACAATTTATCGCAGATCAA
CCCAGGAAGCTTTTCCGGGTTTTTGGGAAGAAGCTCCCCTAGAAAGGACAGTCATCACTGATGAAGTCTGGTTTTTAGAA
CATGATTCAGCTGTCAAAATGGGATTTACTGGTTTAGAATTTAAAAAACCGCCTTATAATAAATTTACTGCTCTTCGATC
CAAATTTGATAATTGGCTAGCTGAACAAGCTAAGGATGTAGGAGCAGAATTATATACAAACACTTTAGTAACTGATCTAT
TATATCAAAAGGGTTTCTTGGCTTCAGGAAAGCGTATCAAAGGCGTCAAACTTTATGATGGTACACAAATAAAAGCTGGT
GTTGTAATATTAGCTGAAGGCGTGAATGCTCCTCTAGCGCATCAGGCGGGTTTAAGAAAAAAATTACCCACTAATGCCTT
TACTCTTTATACATGTGAAACTCTTGCTTTATCTCCTAAAACCATTGAAGAACGCTTTGAATTGGAATCAGGTGAAGGAG
CCACTATTGGTTTTGCAGGATTCCCTACTAGTGGTAGTTCAGGTAAAGGTGGTTTGTGGACGAATCATGATAACCTTTCG
ATTATCGTTGGTGGGCGTTTAAACGAAATGGTTTCAAAACAGCTCAATCCTCACCATATGCTAGAGCGCTTTAAATCACA
TCCTCTCATAAAACGCCTACTTCATGGAGCCGACTCTTTGGAATACAAAGCTTATATGATACCAAAAGGTGGTTATAGTC
TGATGCCTAAACTTTTTAGTGATGGAGTACTTATTGTAGGAGATGCAGCTATAATGATTAGTGGTCGTCGAGGTACAGAT
TTGGCTATGATATCAGGTAAAAAAGCCGCGGAAACGGTAGTTCAAGCTAAAGCTCGGGAAGATTTTTCAAAAAAATCTTT
AGCAAATTACAGCCATAAACTTAATCAACAATTTTTTATGAAAGACATCAAAAGTAAAACCAAGGAAAAAGATTACTATC
TTAAACATCCTGATGCAGATTATCTTGTTAACAGTCTCATGAATGAAATAGCTTATGAGTTTTTCACTGAAGATCTCAAG
GAACAAAATGAAAAACAAAAATTACTTTTTAGTAAAGTTTATCAAAAACAGCTACCTATAAAATCTTTTGTAGATTTAAT
TCAGGGTATCAATCATTGGAGATTTGGTTAA

Upstream 100 bases:

>100_bases
GTGTTAAAATTTAATCTTATGTACACACTAATAATGAAGATGAAATCTCAACACAATAACAACTACAACTAATCAAAAAA
TTGGCAGGTGTTTAGTTACT

Downstream 100 bases:

>100_bases
TTGGAGGTTTATTGCATGGATTCTCGCAATTTAAATTTAAGAGATATGGTACAGTTTGTTACTATAGTTCCTGATAGTCA
AACCCATATTTATTTAAAAG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKEYYDAIVVGAGPGGSSAAYHMAQQGLNVALFEKGNKPGDKNVYGGTIYRRSTQEAFPGFWEEAPLERTVITDEVWFLE
HDSAVKMGFTGLEFKKPPYNKFTALRSKFDNWLAEQAKDVGAELYTNTLVTDLLYQKGFLASGKRIKGVKLYDGTQIKAG
VVILAEGVNAPLAHQAGLRKKLPTNAFTLYTCETLALSPKTIEERFELESGEGATIGFAGFPTSGSSGKGGLWTNHDNLS
IIVGGRLNEMVSKQLNPHHMLERFKSHPLIKRLLHGADSLEYKAYMIPKGGYSLMPKLFSDGVLIVGDAAIMISGRRGTD
LAMISGKKAAETVVQAKAREDFSKKSLANYSHKLNQQFFMKDIKSKTKEKDYYLKHPDADYLVNSLMNEIAYEFFTEDLK
EQNEKQKLLFSKVYQKQLPIKSFVDLIQGINHWRFG

Sequences:

>Translated_436_residues
MKEYYDAIVVGAGPGGSSAAYHMAQQGLNVALFEKGNKPGDKNVYGGTIYRRSTQEAFPGFWEEAPLERTVITDEVWFLE
HDSAVKMGFTGLEFKKPPYNKFTALRSKFDNWLAEQAKDVGAELYTNTLVTDLLYQKGFLASGKRIKGVKLYDGTQIKAG
VVILAEGVNAPLAHQAGLRKKLPTNAFTLYTCETLALSPKTIEERFELESGEGATIGFAGFPTSGSSGKGGLWTNHDNLS
IIVGGRLNEMVSKQLNPHHMLERFKSHPLIKRLLHGADSLEYKAYMIPKGGYSLMPKLFSDGVLIVGDAAIMISGRRGTD
LAMISGKKAAETVVQAKAREDFSKKSLANYSHKLNQQFFMKDIKSKTKEKDYYLKHPDADYLVNSLMNEIAYEFFTEDLK
EQNEKQKLLFSKVYQKQLPIKSFVDLIQGINHWRFG
>Mature_436_residues
MKEYYDAIVVGAGPGGSSAAYHMAQQGLNVALFEKGNKPGDKNVYGGTIYRRSTQEAFPGFWEEAPLERTVITDEVWFLE
HDSAVKMGFTGLEFKKPPYNKFTALRSKFDNWLAEQAKDVGAELYTNTLVTDLLYQKGFLASGKRIKGVKLYDGTQIKAG
VVILAEGVNAPLAHQAGLRKKLPTNAFTLYTCETLALSPKTIEERFELESGEGATIGFAGFPTSGSSGKGGLWTNHDNLS
IIVGGRLNEMVSKQLNPHHMLERFKSHPLIKRLLHGADSLEYKAYMIPKGGYSLMPKLFSDGVLIVGDAAIMISGRRGTD
LAMISGKKAAETVVQAKAREDFSKKSLANYSHKLNQQFFMKDIKSKTKEKDYYLKHPDADYLVNSLMNEIAYEFFTEDLK
EQNEKQKLLFSKVYQKQLPIKSFVDLIQGINHWRFG

Specific function: Could be part of an electron transfer system required for anaerobic carnitine reduction [H]

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF-QO/fixC family [H]

Homologues:

Organism=Homo sapiens, GI119703746, Length=402, Percent_Identity=26.6169154228856, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787991, Length=412, Percent_Identity=36.6504854368932, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1786227, Length=401, Percent_Identity=37.1571072319202, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87082155, Length=392, Percent_Identity=31.3775510204082, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI25144720, Length=396, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324932, Length=365, Percent_Identity=24.9315068493151, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24652256, Length=398, Percent_Identity=24.8743718592965, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: 1.5.5.-

Molecular weight: Translated: 48686; Mature: 48686

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYYDAIVVGAGPGGSSAAYHMAQQGLNVALFEKGNKPGDKNVYGGTIYRRSTQEAFPG
CCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCHHHCCC
FWEEAPLERTVITDEVWFLEHDSAVKMGFTGLEFKKPPYNKFTALRSKFDNWLAEQAKDV
CCCCCCCCCEEEECEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GAELYTNTLVTDLLYQKGFLASGKRIKGVKLYDGTQIKAGVVILAEGVNAPLAHQAGLRK
HHHHHHHHHHHHHHHHCCCCCCCCEECEEEEECCCEEECCEEEEECCCCCCHHHHHCHHH
KLPTNAFTLYTCETLALSPKTIEERFELESGEGATIGFAGFPTSGSSGKGGLWTNHDNLS
CCCCCCEEEEEEHEEECCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCEE
IIVGGRLNEMVSKQLNPHHMLERFKSHPLIKRLLHGADSLEYKAYMIPKGGYSLMPKLFS
EEECCCHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHC
DGVLIVGDAAIMISGRRGTDLAMISGKKAAETVVQAKAREDFSKKSLANYSHKLNQQFFM
CCEEEEECEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDIKSKTKEKDYYLKHPDADYLVNSLMNEIAYEFFTEDLKEQNEKQKLLFSKVYQKQLPI
HHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KSFVDLIQGINHWRFG
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKEYYDAIVVGAGPGGSSAAYHMAQQGLNVALFEKGNKPGDKNVYGGTIYRRSTQEAFPG
CCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCHHHCCC
FWEEAPLERTVITDEVWFLEHDSAVKMGFTGLEFKKPPYNKFTALRSKFDNWLAEQAKDV
CCCCCCCCCEEEECEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GAELYTNTLVTDLLYQKGFLASGKRIKGVKLYDGTQIKAGVVILAEGVNAPLAHQAGLRK
HHHHHHHHHHHHHHHHCCCCCCCCEECEEEEECCCEEECCEEEEECCCCCCHHHHHCHHH
KLPTNAFTLYTCETLALSPKTIEERFELESGEGATIGFAGFPTSGSSGKGGLWTNHDNLS
CCCCCCEEEEEEHEEECCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCEE
IIVGGRLNEMVSKQLNPHHMLERFKSHPLIKRLLHGADSLEYKAYMIPKGGYSLMPKLFS
EEECCCHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHC
DGVLIVGDAAIMISGRRGTDLAMISGKKAAETVVQAKAREDFSKKSLANYSHKLNQQFFM
CCEEEEECEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDIKSKTKEKDYYLKHPDADYLVNSLMNEIAYEFFTEDLKEQNEKQKLLFSKVYQKQLPI
HHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KSFVDLIQGINHWRFG
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]