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The map label for this gene is polC [H]

Identifier: 188528322

GI number: 188528322

Start: 1553522

End: 1554385

Strand: Reverse

Name: polC [H]

Synonym: HPSH_07970

Alternate gene names: 188528322

Gene position: 1554385-1553522 (Counterclockwise)

Preceding gene: 188528323

Following gene: 188528314

Centisome position: 96.63

GC content: 40.28

Gene sequence:

>864_bases
ATGTCAGACAGCCTCTTGCATAAAGACATTCAAGCCCTAATCGCTCGCTTAAAGCACCAGGATTTAAGCTTGGGCATGCT
AGAAAAATCGCTCTCTCGCCTTATTTATGATGAAGTCAATTTGGAATATTTAAAAGCATGCGGGCTTAATTTCGTAGAAA
CGAGTGAAAATTTAATCACGCTCAAAAACCTTAAAACCCCCCTTAAAGATGAGGTTTTTTCCTTTATTGATTTAGAAACC
ACCGGCTCTTGCCCCCTAAAACATGAGATTTTAGAAATCGGAGCCGTGCAAGTGAAGGGGGGGGAAATCATCAATCGTTT
TGAAACCCTTGTGAAAGTCAAAAGCGTGCCTGATTATATCACTGAGCTTACAGGCATCGCTTATGAAGACACCCTAAACG
CCCCAAGCGCGCATGAAGCTTTGCAAGAATTGCGCCTTTTTTTAGGCAACAGCGTGTTTGTAGCCCATAACGCTAATTTT
GATTACAACTTTTTAGGGCGTTATTTTGTAGAAAAATTGCATTGCCCCTTATTGAATTTAAAGCTTTGCACTTTGGATTT
ATCCAAACGGGCCATTTTGTCCATGCGTTATTCTTTGAGCTTTTTAAAAGAGCTTTTGGGGTTTGGTATAGAAGTCAGCC
ATAGAGCCTATGCGGACGCTTTAGCGAGCTATAAGCTCTTTGAAATATGCTTATTAAACTTGCCCAGTTACATCAAAACG
ACGATGGATTTGATTGATTTTTCCAAATGCGCTAACACCTTGATCAAAAGACCTCCAAGAGCCAGACACCAAGAGACTCC
ACCGCCATTTTCTCTTTTTGAGAGGACAAAGGGTTTGTTAAATATCATAAAAGCAACTAGTTAA

Upstream 100 bases:

>100_bases
AATATCTTTGAACTCCAACAAGCGGGCGTGGATGTGGTGGTTTCAGGGAGTTATATTTTTAAATCTAAAGATCGTAAGCT
GGCTATTGAAGGCTTACAGA

Downstream 100 bases:

>100_bases
ACGAAAATTGTTTAATTGGGTTTGATTACGGATTATCTTTAGCATATCCATTTGATACTTCTGAATGTTGCCTAGCACTT
TTATTTTATCTTGGACTTCA

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSDSLLHKDIQALIARLKHQDLSLGMLEKSLSRLIYDEVNLEYLKACGLNFVETSENLITLKNLKTPLKDEVFSFIDLET
TGSCPLKHEILEIGAVQVKGGEIINRFETLVKVKSVPDYITELTGIAYEDTLNAPSAHEALQELRLFLGNSVFVAHNANF
DYNFLGRYFVEKLHCPLLNLKLCTLDLSKRAILSMRYSLSFLKELLGFGIEVSHRAYADALASYKLFEICLLNLPSYIKT
TMDLIDFSKCANTLIKRPPRARHQETPPPFSLFERTKGLLNIIKATS

Sequences:

>Translated_287_residues
MSDSLLHKDIQALIARLKHQDLSLGMLEKSLSRLIYDEVNLEYLKACGLNFVETSENLITLKNLKTPLKDEVFSFIDLET
TGSCPLKHEILEIGAVQVKGGEIINRFETLVKVKSVPDYITELTGIAYEDTLNAPSAHEALQELRLFLGNSVFVAHNANF
DYNFLGRYFVEKLHCPLLNLKLCTLDLSKRAILSMRYSLSFLKELLGFGIEVSHRAYADALASYKLFEICLLNLPSYIKT
TMDLIDFSKCANTLIKRPPRARHQETPPPFSLFERTKGLLNIIKATS
>Mature_286_residues
SDSLLHKDIQALIARLKHQDLSLGMLEKSLSRLIYDEVNLEYLKACGLNFVETSENLITLKNLKTPLKDEVFSFIDLETT
GSCPLKHEILEIGAVQVKGGEIINRFETLVKVKSVPDYITELTGIAYEDTLNAPSAHEALQELRLFLGNSVFVAHNANFD
YNFLGRYFVEKLHCPLLNLKLCTLDLSKRAILSMRYSLSFLKELLGFGIEVSHRAYADALASYKLFEICLLNLPSYIKTT
MDLIDFSKCANTLIKRPPRARHQETPPPFSLFERTKGLLNIIKATS

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 32473; Mature: 32342

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSLLHKDIQALIARLKHQDLSLGMLEKSLSRLIYDEVNLEYLKACGLNFVETSENLIT
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEECCCCEEE
LKNLKTPLKDEVFSFIDLETTGSCPLKHEILEIGAVQVKGGEIINRFETLVKVKSVPDYI
HHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEECCHHHHHHHHHHHHHHCCHHHH
TELTGIAYEDTLNAPSAHEALQELRLFLGNSVFVAHNANFDYNFLGRYFVEKLHCPLLNL
HHHHCCCHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCE
KLCTLDLSKRAILSMRYSLSFLKELLGFGIEVSHRAYADALASYKLFEICLLNLPSYIKT
EEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
TMDLIDFSKCANTLIKRPPRARHQETPPPFSLFERTKGLLNIIKATS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDSLLHKDIQALIARLKHQDLSLGMLEKSLSRLIYDEVNLEYLKACGLNFVETSENLIT
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEECCCCEEE
LKNLKTPLKDEVFSFIDLETTGSCPLKHEILEIGAVQVKGGEIINRFETLVKVKSVPDYI
HHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEECCHHHHHHHHHHHHHHCCHHHH
TELTGIAYEDTLNAPSAHEALQELRLFLGNSVFVAHNANFDYNFLGRYFVEKLHCPLLNL
HHHHCCCHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCE
KLCTLDLSKRAILSMRYSLSFLKELLGFGIEVSHRAYADALASYKLFEICLLNLPSYIKT
EEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
TMDLIDFSKCANTLIKRPPRARHQETPPPFSLFERTKGLLNIIKATS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9826752; 10360571 [H]