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The map label for this gene is pth [H]

Identifier: 188528268

GI number: 188528268

Start: 1489520

End: 1490080

Strand: Direct

Name: pth [H]

Synonym: HPSH_07670

Alternate gene names: 188528268

Gene position: 1489520-1490080 (Clockwise)

Preceding gene: 188528267

Following gene: 188528269

Centisome position: 92.6

GC content: 37.08

Gene sequence:

>561_bases
ATGACGCTTTTAGTAGGTTTAGGCAACCCTACTTTGCGTTACGCTCACACCAGACACAACGCTGGTTTTGATATTTTAGA
TTCGCTTATTAGCGAATTGGATCTTTCTTTCACTTTTTCTTCCAAACACAACGCTTGTTTATGCGTTTATAAGGACTTTA
TCTTACTCAAGCCCCAAACTTACATGAATTTAAGCGGCGAGAGCGTTTTAAGCGCTAAAAATTTTTACAAAACTGAAGAG
CTTTTAATTGTCCATGACGACTTGGATTTGGATTTAGGCGTTGTGAGGTTTAAAAATGGTGGGGGGAATGGAGGGCATAA
CGGCCTAAAATCCATTGATTTATTGTGTTCTAATTCTTATTATCGCTTGAGAGTGGGGATTTCTAAAGGAATGGGCGTGA
TTGAGCATGTGCTTTCAAAATTCCACAAAAACGAAGAGCCTTTAAAAAACGCTGCGTTTGAACATGCCAAAAACGCCTTA
AAATTTTTTATAGAAAGCCATGATTTTAACGCCATGCAAAATCGTTTCACGCTTAAAAAACCTTTAAAAATAGAAAGTTA
A

Upstream 100 bases:

>100_bases
TATTTTGGTGCGCGATTTAGAAAAACACGAGAATGTTAAGATTTTAGATCATGATTCTATCGCTGTGATCGGTGTGATTA
AGGCGAAGTGATTTCAGGTT

Downstream 100 bases:

>100_bases
ATGCACTCTATCAAGAATTTCAAGTTTTTATCGTGGTTTGAATAAGGGCTTAAAATGCGTCTGTTTAGATTTGTGGGGTG
GTATTATTTCAAATACTTTT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTLLVGLGNPTLRYAHTRHNAGFDILDSLISELDLSFTFSSKHNACLCVYKDFILLKPQTYMNLSGESVLSAKNFYKTEE
LLIVHDDLDLDLGVVRFKNGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGMGVIEHVLSKFHKNEEPLKNAAFEHAKNAL
KFFIESHDFNAMQNRFTLKKPLKIES

Sequences:

>Translated_186_residues
MTLLVGLGNPTLRYAHTRHNAGFDILDSLISELDLSFTFSSKHNACLCVYKDFILLKPQTYMNLSGESVLSAKNFYKTEE
LLIVHDDLDLDLGVVRFKNGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGMGVIEHVLSKFHKNEEPLKNAAFEHAKNAL
KFFIESHDFNAMQNRFTLKKPLKIES
>Mature_185_residues
TLLVGLGNPTLRYAHTRHNAGFDILDSLISELDLSFTFSSKHNACLCVYKDFILLKPQTYMNLSGESVLSAKNFYKTEEL
LIVHDDLDLDLGVVRFKNGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGMGVIEHVLSKFHKNEEPLKNAAFEHAKNALK
FFIESHDFNAMQNRFTLKKPLKIES

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=158, Percent_Identity=37.9746835443038, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1787455, Length=174, Percent_Identity=37.9310344827586, Blast_Score=80, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20922; Mature: 20791

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLVGLGNPTLRYAHTRHNAGFDILDSLISELDLSFTFSSKHNACLCVYKDFILLKPQT
CEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEEECEEEECCCH
YMNLSGESVLSAKNFYKTEELLIVHDDLDLDLGVVRFKNGGGNGGHNGLKSIDLLCSNSY
HCCCCCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHEEEEECCCE
YRLRVGISKGMGVIEHVLSKFHKNEEPLKNAAFEHAKNALKFFIESHDFNAMQNRFTLKK
EEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEECCC
PLKIES
CCCCCC
>Mature Secondary Structure 
TLLVGLGNPTLRYAHTRHNAGFDILDSLISELDLSFTFSSKHNACLCVYKDFILLKPQT
EEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEEECEEEECCCH
YMNLSGESVLSAKNFYKTEELLIVHDDLDLDLGVVRFKNGGGNGGHNGLKSIDLLCSNSY
HCCCCCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHEEEEECCCE
YRLRVGISKGMGVIEHVLSKFHKNEEPLKNAAFEHAKNALKFFIESHDFNAMQNRFTLKK
EEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEECCC
PLKIES
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA