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The map label for this gene is fumC

Identifier: 188528113

GI number: 188528113

Start: 1330793

End: 1332184

Strand: Reverse

Name: fumC

Synonym: HPSH_06850

Alternate gene names: 188528113

Gene position: 1332184-1330793 (Counterclockwise)

Preceding gene: 188528118

Following gene: 188528112

Centisome position: 82.82

GC content: 43.61

Gene sequence:

>1392_bases
ATGCAATTTAGAATTGAACATGACACGATGGGCGAAATTCAAGTGAATGACAGCCAATACTGGGGGGCTCAAACGCAACG
CAGTCTTGAAAACTTTAAAATCGGCACCGAAAAAATGCCTAAAGAACTCATTGGCGCGTTTGCCAAACTCAAAAGGAGTC
TGGCGGTTGTCAATCACAAGTTAGGGAAATTAAGCCTGGAAAAATCCCAAGCCATTATCAAGGCATGCGATTGCATTTTA
AAAGGCGAGTTGTGCGGCGAGTTTCCCCTAGCGATATGGCAAACAGGGAGTGGGACTCAAACGAATATGAATCTCAATGA
AGTCATTGCCAATAAGGCTACAGAAATTTTAGGGGGCAATTTCAGGGAGAAAAAACTCATCCACCCTAACGATGATGTGA
ACATGTCTCAAAGCTCTAACGACACTTTCCCTACCGCAATGCATATTGTGAGCGTGCTAGAAATCACGCGCAAGTTATTG
CCCAGTTTAGAGAATCTGTTAAAGACCTTTAAAGACAAAAGCCAACAATTTAAAGAGATTGTCAAAATCGGGCGCACGCA
TTTACAAGACGCTACGCCTTTAACTTTGGGGCAAGAATTTAGCGGGTATGCGAGCATGTTAGAGCATTCTAAACAACAAA
TTTTAGAGAGCTTGGAGCATTTAAGAGAATTAGCCATAGGCGGGACTGCCGTAGGCACAGGGCTAAACGCTCATAAAGAA
TTGAGTGAAAAAGTGGCTGAAGAATTGAGCCAGTTTAGCGGCGTGAAATTCATTTCTGCGCCCAATAAATTCCATGCGCT
CACTAGCCATGACGCTATCGCTTATGCGCATGGGGCTTTTAAGGCTTTAGCGGCGAATTTAATGAAAATCGCTAACGATA
TTAGATGGCTTGCGAGCGGGCCGCGCTGTGGTTTGGGCGAGCTTAATATCCCTGAAAACGAGCCGGGCAGTTCTATTATG
CCCGGTAAAGTCAATCCCACGCAATGCGAAGCGATGACAATGGTAGCCGTGCAAGTGATGGGGAATGATACCGCTATTGG
CATTGCGGCCAGTCAGGGTAATTTTGAATTGAATGTGTTTAAACCGGTGATTATTTATAATTTCTTGCAAAGTTTAAGGC
TGTTGAGCGACAGCATGGAAAGTTTTAATACCCATTGCGCAAGCGGTATTGAGCCTAATAGAGAAAAAATTGATTATTAC
TTGCACCATTCTTTAATGCTAGTAACCGCCCTAAACCCGCATGTAGGCTATGAAAACGCCGCTAAAATCGCTAAAAACGC
CCACAAAAAAGGCATTTCTTTAAAAGAAAGCGCGTTGGAATTGAAACTCTTGAGCGCTGAAGATTTTGACAAATTCGTAG
TTCCTGAAAAGATGATCGGGCCTAAGGCTTGA

Upstream 100 bases:

>100_bases
TTGTGGAAATTGTTTTTAAAAAATTAGGGTTTTTAAGTGGAAGGTATAAGAGTTTATGCTATTTTTTTAAGGTTTTAAAA
TCAAATTTCAAAGGATTAGT

Downstream 100 bases:

>100_bases
AAATCTTGAGTGGGCGCATGAGATGAAAAAAGATATTCGTAAGATTTTAAAAGAAGCATTGCATGACAATAAAGATTTGA
ATCTTTATTTGGAATCTGGA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQFRIEHDTMGEIQVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITRKLL
PSLENLLKTFKDKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA

Sequences:

>Translated_463_residues
MQFRIEHDTMGEIQVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITRKLL
PSLENLLKTFKDKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA
>Mature_463_residues
MQFRIEHDTMGEIQVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITRKLL
PSLENLLKTFKDKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=58.2251082251082, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=53.968253968254, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=63.1004366812227, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=37.8787878787879, Blast_Score=323, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=57.6673866090713, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=59.7560975609756, Blast_Score=422, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=59.7402597402597, Blast_Score=552, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.25, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.25, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=55.3879310344828, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=54.4086021505376, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=48.5961123110151, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50954; Mature: 50954

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFRIEHDTMGEIQVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITRKLLPSLENLLKTFKDKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNREKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHH
AKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA
HHHHHHHHHCCCCHHHHHHHEEEECCCCCCHHCCCHHHCCCCC
>Mature Secondary Structure
MQFRIEHDTMGEIQVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITRKLLPSLENLLKTFKDKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNREKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHH
AKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA
HHHHHHHHHCCCCHHHHHHHEEEECCCCCCHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]