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The map label for this gene is nuoI [H]

Identifier: 188528057

GI number: 188528057

Start: 1291051

End: 1291713

Strand: Direct

Name: nuoI [H]

Synonym: HPSH_06570

Alternate gene names: 188528057

Gene position: 1291051-1291713 (Clockwise)

Preceding gene: 188528056

Following gene: 188528058

Centisome position: 80.26

GC content: 45.7

Gene sequence:

>663_bases
ATGGCCAAACAAGAATACAAGCAACTTCCTAAACGAGCCGAAGTCCATAGCGCGACCGAGCAATTTAAAGACACCATTAA
AACGAGCTTGGGTTTGGATCTATTCAAAGGGCTAGGGCTTACGATCAAGGAATTTTTTAGCCCAAGCGTAACCATCCATT
ACCCTATGGAGCAACTCCCCTTAAGCCCTCGTTATCGCGCGGTGCATAACTTGCAACGGCTTTTAGACTCAGGCTCTGAA
AGGTGTATTGGCTGCGGGCTGTGCGAAAAGATTTGCACGAGCAATTGCATAAGGATCATCACGCATAAGGGCGAAGACAA
CCGCAAAAAGATCGATTCTTACACGATCAATTTGGGGCGTTGCATTTATTGCGGATTGTGCGCAGAAGTTTGCCCAGAAT
TAGCGATTGTTATGGGGAATCGGTTTGAAAACGCCAGCACCCAACGCTCCCAATACGGCTCTAAAAGCGAGTTTCTAACG
AGCGAACAAGACGCTAAAAACTGCTCGCATGCCGAGTTTTTAGGTTTTGGTGCGGTAAGCCCTAATTACAACGAACGCAT
GCAAGCCACCCCTTTAGATTATGTCCAAGAGCCTTCAAAAGAAGAATCAAAAGAAGAAACTCCAACAAACCCAGAAAGCA
ATAAGGGAGATGAAAATGTTTGA

Upstream 100 bases:

>100_bases
CCAGACCAACTGATGAATATGTGTTGGAAGATCATGCTGCCTTTAGCGTTATTAAACATTGTGCTAACAGGCATTATCAT
TTTAATTTAAAGGAGGTTTT

Downstream 100 bases:

>100_bases
AACCATTGCCTTTTATTTCTTTGCGATCCTTACTTTAAGCATGGCGTTAGTGGTGATCACCACCACGAATATTCTCTATG
CCATTACCGCTCTTGCTAGC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLPLSPRYRAVHNLQRLLDSGSE
RCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGRCIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLT
SEQDAKNCSHAEFLGFGAVSPNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV

Sequences:

>Translated_220_residues
MAKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLPLSPRYRAVHNLQRLLDSGSE
RCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGRCIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLT
SEQDAKNCSHAEFLGFGAVSPNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV
>Mature_219_residues
AKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLPLSPRYRAVHNLQRLLDSGSER
CIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGRCIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLTS
EQDAKNCSHAEFLGFGAVSPNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=117, Percent_Identity=47.008547008547, Blast_Score=114, Evalue=5e-26,
Organism=Escherichia coli, GI1788617, Length=124, Percent_Identity=36.2903225806452, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555194, Length=114, Percent_Identity=44.7368421052632, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17864306, Length=111, Percent_Identity=45.045045045045, Blast_Score=106, Evalue=9e-24,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 24729; Mature: 24598

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLP
CCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCHHHCC
LSPRYRAVHNLQRLLDSGSERCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGR
CCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHEECHHH
CIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLTSEQDAKNCSHAEFLGFGAVS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHCCHHHHHCCCHHHHHCCCCCC
PNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV
CCCCCCCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLP
CHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCHHHCC
LSPRYRAVHNLQRLLDSGSERCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGR
CCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHEECHHH
CIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLTSEQDAKNCSHAEFLGFGAVS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHCCHHHHHCCCHHHHHCCCCCC
PNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV
CCCCCCCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA